Serotonin and the autisms a red flag or a red herring?

Archives of General Psychiatry

Volumn 68, Issue 11, 2011, Pages 1093-1094

  Levitt, Pat ^a  

^a UNIVERSITY OF SOUTHERN CALIFORNIA   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

4 AMINOBUTYRIC ACID; GLUTAMIC ACID; SEROTONIN; SEROTONIN TRANSPORTER; SEROTONIN UPTAKE INHIBITOR; TRYPTOPHAN;

ANXIETY; AUTISM; BRAIN DEVELOPMENT; CELL MIGRATION; CELL PROLIFERATION; COPY NUMBER VARIATION; DEPRESSION; DNA POLYMORPHISM; ENDOPHENOTYPE; ENVIRONMENTAL FACTOR; GENE MUTATION; HUMAN; MOOD DISORDER; NERVE CELL; NERVE CELL DIFFERENTIATION; NERVE FIBER; NONHUMAN; NOTE; OBSESSIVE COMPULSIVE DISORDER; RECURRENCE RISK;

AUTISTIC DISORDER; ENVIRONMENT; FEMALE; GENE-ENVIRONMENT INTERACTION; GENETIC PREDISPOSITION TO DISEASE; HUMANS; MATERNAL-FETAL EXCHANGE; PREGNANCY; PRENATAL EXPOSURE DELAYED EFFECTS; SEROTONIN; SEROTONIN UPTAKE INHIBITORS;

EID: 80755176332     PISSN: 0003990X     EISSN: 15383636     Source Type: Journal    
DOI: 10.1001/archgenpsychiatry.2011.98     Document Type: Note

References (11)

1. Brugha TS, McManus S, Bankart J, Scott F, Purdon S, Smith J, Bebbington P, Jenkins R, Meltzer H. Epidemiology of autism spectrum disorders in adults in the community in England. Arch Gen Psychiatry. 2011;68(5):459-465.
2. Kim YS, Leventhal BL, Koh Y-J, Fombonne E, Laska E, Lim EC, Cheon KA, Kim SJ, Kim YK, Lee H, Song DH, Grinker RR. Prevalence of autism spectrum disorders in a total population sample [published online May 9, 2011]. Am J Psychiatry. 2011. doi:10.1176/appi.ajp.2011.10101532.
3. Schaaf CP, Zoghbi HY. Solving the autism puzzle a few pieces at a time. Neuron. 2011;70(5):806-808.
4. Connors SL, Levitt P, Matthews SG, Slotkin TA, Johnston MV, Kinney HC, Johnson WG, Dailey RM, Zimmerman AW. Fetal mechanisms in neurodevelopmental disorders. Pediatr Neurol. 2008;38(3):163-176. (Pubitemid 351221226)
5. Karg K, Burmeister M, Shedden K, Sen S. The serotonin transporter promoter variant (5-HTTLPR), stress, and depression meta-analysis revisited: evidence of genetic moderation. Arch Gen Psychiatry. 2011;68(5):444-454.
6. Sutcliffe JS, Delahanty RJ, Prasad HC, McCauley JL, Han Q, Jiang L, Li C, Folstein SE, Blakely RD. Allelic heterogeneity at the serotonin transporter locus (SLC6A4) confers susceptibility to autism and rigid-compulsive behaviors. Am J Hum Genet. 2005;77(2):265-279. (Pubitemid 41022709)
7. Croen LA, Grether JK, Yoshida CK, Odouli R, Hendrick V. Antidepressant use during pregnancy and childhood autism spectrum disorders [published online July 4, 2011]. Arch Gen Psychiatry. 2011;68(11):1104-1112.
8. Ansorge MS, Hen R, Gingrich JA. Neurodevelopmental origins of depressive disorders. Curr Opin Pharmacol. 2007;7(1):8-17. (Pubitemid 46238045)
9. Shih JC. Monoamine oxidases: from tissue homogenates to transgenic mice. Neurochem Res. 2007;32(10):1757-1761. (Pubitemid 47428862)
10. Bonnin A, Torii M, Wang L, Rakic P, Levitt P. Serotonin modulates the response of embryonic thalamocortical axons to netrin-1. Nat Neurosci. 2007;10(5):588-597. (Pubitemid 46652450)
11. Bonnin A, Goeden N, Chen K, Wilson ML, King J, Shih JC, Blakely RD, Deneris ES, Levitt P. A transient placental source of serotonin for the fetal forebrain. Nature. 2011;472(7343):347-350.