Interaction of 5-HTTLPR and a variation on the oxytocin receptor gene influences negative emotionality

Biological Psychiatry

Volumn 69, Issue 6, 2011, Pages 601-603

  Montag, Christian ^a   Fiebach, Christian J ^b,c   Kirsch, Peter ^d,e   Reuter, Martin ^a  

^a UNIVERSITY OF BONN   (Germany)

^b GOETHE UNIVERSITY   (Germany)

^c Bernstein Center for Computational Neurosciences   (Germany)

^d CENTRAL INSTITUTE OF MENTAL HEALTH   (Germany)

^e UNIVERSITY OF HEIDELBERG   (Germany)

Author keywords

5 HTTLPR; negative emotionality; oxytocin receptor gene; personality; serotonin

Indexed keywords

OXYTOCIN RECEPTOR; SEROTONIN TRANSPORTER;

ADULT; ARTICLE; EMOTIONALITY; FEAR; FEMALE; GENETIC POLYMORPHISM; GENETIC VARIABILITY; GENOTYPE; HOMOZYGOSITY; HUMAN; MALE; PRIORITY JOURNAL; RATING SCALE; SINGLE NUCLEOTIDE POLYMORPHISM;

ADOLESCENT; ADULT; BEREAVEMENT; FEAR; FEMALE; HUMANS; MALE; PERSONALITY ASSESSMENT; POLYMORPHISM, GENETIC; RECEPTORS, OXYTOCIN; SEROTONIN PLASMA MEMBRANE TRANSPORT PROTEINS; YOUNG ADULT;

EID: 79952020853     PISSN: 00063223     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.biopsych.2010.10.026     Document Type: Article

References (19)

1. Panksepp J (1998): Affective Neuroscience. Oxford: Oxford Publishing Group, 206-222, 261-279.
2. Vacher CM, Fretier P, Creminon C, Calas A, Hardin-Pouzet H (2002): Activation by serotonin and noradrenaline of vasopressin and oxytocin expression in the mouse paraventricular and supraoptic nuclei. J Neurosci 22:1513-1522. (Pubitemid 35386270)
3. Van de Kar LD, Javed A, Zhang Y, Serres F, Raap DK, Gray TS (2001): 5-HT2A receptors stimulate ACTH, corticosterone, oxytocin, renin, and prolactin release and activate hypothalamic CRF and oxytocin-expressing cells. J Neurosci 21:3572-3579. (Pubitemid 32422821)
4. Yoshida M, Takayanagi Y, Inoue K, Kimura T, Young LJ, Onaka T, Nishimori K (2009): Evidence that oxytocin exerts anxiolytic effects via oxytocin receptor expressed in serotonergic neurons in mice. J Neurosci 29: 2259-2271.
5. Emiliano AB, Cruz T, Pannoni V, Fudge JL (2007): The interface of oxytocin-labeled cells and serotonin transporter-containing fibers in the primate hypothalamus: A substrate for SSRIs therapeutic effects? Neuropsychopharmacology 32:977-988. (Pubitemid 46631974)
6. Lesch KP, Bengel D, Heils A, Sabol SZ, Greenberg BD, Petri S, et al. (1996): Association of anxiety-related traits with a polymorphism in the serotonin transporter gene regulatory region. Science 274:1527-1531. (Pubitemid 26403928)
7. Munafò MR, Freimer NB, Ng W, Ophoff R, Veijola J, Miettunen J, et al. (2009): 5-HTTLPR genotype and anxiety-related personality traits: A meta-analysis and new data. Am J Med Genet B Neuropsychiatr Genet 150B:271-281.
8. Terracciano A, Tanaka T, Sutin AR, Deiana B, Balaci L, Sanna S, et al. (2010): BDNF Val66Met is associated with introversion and interacts with 5-HTTLPR to influence neuroticism. Neuropsychopharmacology 35: 1083-1089.
9. Israel S, Lerer E, Shalev I, Uzefovsky F, Riebold M, Laiba E, et al. (2009): The oxytocin receptor (OXTR) contributes to prosocial fund allocations in the dictator game and the social value orientations task. PLoS ONE 4:e5535.
10. Israel S, Lerer E, Shalev I, Uzefovsky F, Reibold M, Bachner-Melman R, et al. (2008): Molecular genetic studies of the arginine vasopressin 1a receptor (AVPR1a) and the oxytocin receptor (OXTR) in human behaviour: From autism to altruism with some notes in between. Prog Brain Res 170:435-449. (Pubitemid 352010246)
11. Lerer E, Levi S, Salomon S, Darvasi A, Yirmiya N, Ebstein RP (2008): Association between the oxytocin receptor (OXTR) gene and autism: Relationship to Vineland Adaptive Behavior Scales and cognition. Mol Psychiatry 13:980-988.
12. Davis KL, Panksepp J, Normansell L (2003): The affective neuroscience personality scales: Normative data and implications. Neuro-Psychoanalysis 5:57-69.
13. Dohmen T, Falk A, Huffman D, Sunde U (2008): Representative trust and reciprocity: Prevalence and determinants. Econ Inq 46:84-90.
14. Craig I, Plomin R (2006): Quantitative trait loci for IQ and other complex traits: Single-nucleotide polymorphism genotyping using pooled DNA and microarrays. Genes Brain Behav 5:32-37.
15. Schmitz A, Küpper Y, Hennig J, Reuter M (2007): The association between neuroticism and the serotonin transporter polymorphism depends on structural differences between personality measures. Personal Individ Dif 42:789-799. (Pubitemid 44914549)
16. Caspi A, Sugden K, Moffitt TE, Taylor A, Craig IW, Harrington H, et al. (2003): Influence of life stress on depression: moderation by a polymorphism in the 5-HTT gene. Science 301:386-389. (Pubitemid 36877077)
17. Shankaran H, Wiley HS, Resat H (2007): Receptor downregulation and desensitization enhance the information processing ability of signalling receptors. BMC Syst Biol 1:48.
18. Kirsch P, Esslinger C, Chen Q, Mier D, Lis S, Siddhanti S, et al. (2005): Oxytocin modulates neural circuitry for social cognition and fear in humans. J Neurosci 25:11489-11493. (Pubitemid 43083720)
19. Huezo-Diaz P, Uher R, Smith R, Rietschel M, Henigsberg N, Marusic A, et al. (2009): Moderation of antidepressant response by the serotonin transporter gene. Br J Psychiatry 195:30-38.