Comparative study of pre- and postsynaptic 5-HT(1A) receptor modulation of anxiety in two ethological animal tests

Journal of Neuroscience

Volumn 16, Issue 15, 1996, Pages 4810-4815

  File, Sandra E ^a   Gonzalez, Luis E ^a   Andrews, Nick ^a  

^a KING'S COLLEGE LONDON   (United Kingdom)

Author keywords

5 HT(1A); anxiety; elevated plus maze; hippocampus; median raphe nucleus; social interaction

Indexed keywords

2 DIPROPYLAMINO 8 HYDROXYTETRALIN; N [2 [4 (2 METHOXYPHENYL) 1 PIPERAZINYL]ETHYL] N (2 PYRIDYL)CYCLOHEXANECARBOXAMIDE; SEROTONIN 1A RECEPTOR;

ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ANXIETY; ARTICLE; BEHAVIOR; CONTROLLED STUDY; HIPPOCAMPUS; MALE; MAZE TEST; MEDIAN RAPHE NUCLEUS; NEUROTRANSMISSION; NONHUMAN; PRESYNAPTIC NERVE; PRIORITY JOURNAL; RAT; SOCIAL INTERACTION;

EID: 0030010685     PISSN: 02706474     EISSN: None     Source Type: Journal    
DOI: 10.1523/jneurosci.16-15-04810.1996     Document Type: Article

References (32)

1. 1A receptors in the median raphé nucleus and dorsal hippocampus may mediate anxiolytic and anxiogenic behaviours respectively. Eur J Pharmacol 264:259-264.
2. 1A receptor mediation of the anxiogenic effect of hippocampal injection of 8-OH-DPAT. J Psychopharmacol 9:A29.
3. 1A receptor agonist. Psychopharmacology 94:84-91.
4. File SE (1980) The use of social interaction as a method for detecting anxiolytic activity of chlordiazepoxide-like drugs. J Neurosci Methods 2:219-238.
5. File SE (1990) One-trial tolerance to the anxiolytic effects of chlordiazepoxide in the plus-maze. Psychopharmacology 100:281-282.
6. File SE (1991) The biological basis of anxiety. In: Current practices and future developments in the pharmacotherapy of mental disorders (Meltzer HY, Nerozzi D, eds), pp 159-166. Amsterdam: Excerpta Medica.
7. File SE (1993) The interplay of learning and anxiety in the elevated plus-maze. Behav Brain Res 58:199-202.
8. 1A receptor ligands in dorsal raphé and central hippocampus. Pharmacol Biochem Behav 54:123-128.
9. File SE, Zangrossi Jr H (1993) "One-trial tolerance" to the anxiolytic actions of benzodiazepines in the elevated plus-maze, or the development of a phobic state? Psychopharmacology 110:240-244.
10. File SE, Mabbut PS, Hitchcott P (1990) Characterization of the phenomenon of "one-trial tolerance" to the anxiolytic effect of chlordiazepoxide in the elevated plus-maze. Psychopharmacology 102:98-101.
11. File SE, Zangrossi Jr H, Viana M, Graeff FG (1993) Trial 2 in the elevated plus-maze: a different form of fear? Psychopharmacology 111:491-494.
12. 1A receptors. Eur J Pharmacol 237:283-291.
13. 1A receptor antagonist, WAY-100635. Eur J Pharmacol 281:81-88.
14. 1A and benzodiazepine receptors in the basolateral amygdala modulate anxiety in the social interaction test, but not in the elevated plus-maze. Brain Res, in press.
15. Griebel G (1995) 5-hydroxytryptamine-interacting drugs in animal models of anxiety disorders: more than 30 years of research. Pharmacol Ther 65:319-395.
16. 1-like and GABA receptors in the dorsal raphé nucleus of the rat. Neuropharmacology 27:993-1001.
17. 3 receptor antagonists. Psychopharmacology 104:545-551.
18. Hodges H, Green S, Glenn B (1987) Evidence that the amygdala is involved in benzodiazepine and serotonergic effects on punished responding but not on discrimination. Psychopharmacology 92:491-504.
19. Hogg S, Andrews NA, File SE (1994) Contrasting behavioural effects of 8-OH-DPAT in the dorsal raphé nucleus and ventral hippocampus. Neuropharmacology 33:343-348.
20. Hutson PH, Sarna GS, O'Connell MT, Curzon G (1989) Hippocampal 5-HT synthesis and release in vivo is decreased by infusion of 8-OHDPAT into the nucleus raphe dorsalis. Neurosci Lett 100:276-280.
21. 1A receptors in the rat brain. Naunyn Schmiedebergs Arch Pharmacol 347:453-463.
22. 1A receptor agonists and in their inhibitory effects on the firing of serotonergic neurons in the rat? J Pharmacol Exp Ther 272:920-929.
23. Kostowski W, Plaznik A, Stefanski R (1989) Intra-hippocampal buspirone in animal models of anxiety. Eur J Pharmacol 168:393-396.
24. Paxinos G, Watson C (1986) The rat brain in stereotaxic coordinates. London: Academic.
25. Pellow S, Chopin P, File SE, Briley M (1985) Validation of open: closed arm entries in an elevated plus-maze as a measure of anxiety in the rat. J Neurosci Methods 14:149-167.
26. Pesold C, Treit D (1994) The septum and amygdala differentially mediate the anxiolytic effects of benzodiazepines. Brain Res 638:295-301.
27. 1A) receptor antagonist in rat brain. J Pharmacol Exp Ther 265:739-744.
28. Rodgers RJ, Shepherd JK (1993) Influence of prior maze experience on behaviour and response to diazepam in the elevated plus-maze and light/dark tests of anxiety in mice. Psychopharmacology 113:237-242.
29. 1A receptor agonists 8-OH-DPAT, ipsapirone and buspirone in the rat. Eur J Pharmacol 249:341-351.
30. Sharp T, Bramwell SR, Clark D, Grahame-Smith DG (1990) In vivo measurement of extracellular 5-hydroxytryptamine in hippocampus of the anaesthetized rat using microdialysis: changes in relation to 5-hydroxytryptaminergic neuronal activity. J Neurochem 53:234-240.
31. 1B agonists. Synapse 1:3-9.
32. Treit D, Pesold C, Rotzinger S (1993) Noninteractive effects of diazepam and amygdala lesions in two animal models of anxiety. Behav Neurosci 107:1099-1105.