Ontogeny of brain and blood serotonin levels in 5-HT1A receptor knockout mice: Potential relevance to the neurobiology of autism

Journal of Neurochemistry

Volumn 99, Issue 3, 2006, Pages 1019-1031

  Janušonis, Skirmantas ^a,c   Anderson, George M ^b   Shifrovich, Ilya ^b   Rakic, Pasko ^a  

^a YALE UNIVERSITY SCHOOL OF MEDICINE   (United States)

^b YALE UNIVERSITY SCHOOL OF MEDICINE   (United States)

^c UNIVERSITY OF CALIFORNIA   (United States)

Author keywords

5 HT1A; 5 hydroxytryptamine (serotonin); Autism; Blood platelets; Brain development; Hyperserotonemia

Indexed keywords

5 HYDROXYINDOLEACETIC ACID; SEROTONIN; SEROTONIN 1A RECEPTOR; TRYPTOPHAN;

ANIMAL EXPERIMENT; ANIMAL TISSUE; ARTICLE; AUTISM; BRAIN DEVELOPMENT; CONTROLLED STUDY; CORRELATION ANALYSIS; DUODENUM; FEMALE; KNOCKOUT MOUSE; MALE; MOUSE; NEUROBIOLOGY; NEUROCHEMISTRY; NEUROPATHOLOGY; NONHUMAN; ONTOGENY; PATHOGENESIS; PRIORITY JOURNAL; SEROTONIN BLOOD LEVEL; SEROTONIN BRAIN LEVEL; THROMBOCYTE; WILD TYPE;

ANIMALS; AUTISTIC DISORDER; BLOOD PLATELETS; BRAIN; BRAIN CHEMISTRY; CENTRAL NERVOUS SYSTEM; CHROMATOGRAPHY, HIGH PRESSURE LIQUID; FEMALE; GENOTYPE; HYDROXYINDOLEACETIC ACID; IMMUNOHISTOCHEMISTRY; MALE; MICE; MICE, INBRED C57BL; MICE, KNOCKOUT; PERIPHERAL NERVOUS SYSTEM; RECEPTOR, SEROTONIN, 5-HT1A; REVERSE TRANSCRIPTASE POLYMERASE CHAIN REACTION; SEROTONIN; TRYPTOPHAN;

EID: 33750044558     PISSN: 00223042     EISSN: 14714159     Source Type: Journal    
DOI: 10.1111/j.1471-4159.2006.04150.x     Document Type: Article

References (60)

1. Adell A., Celada P., Abellan M. T. and Artigas F. (2002) Origin and functional role of the extracellular serotonin in the midbrain raphe nuclei. Brain Res. Brain Res. Rev. 39, 154-180.
2. Anderson G. M. (2002) Genetics of childhood disorders: XLV. Autism, part 4: serotonin in autism. J. Am. Acad. Child Adolesc. Psychiatry 41, 1513-1516.
3. Anderson G. M., Stevenson J. M. and Cohen D. J. (1987) Steady-state model for plasma-free and platelet serotonin in man. Life Sci. 41, 1777-1785.
4. Anderson G. M., Horne W. C., Chatterjee D. and Cohen D. J. (1990) The hyperserotonemia of autism. Ann. NY Acad. Sci. 600, 331-340.
5. 1A receptors. Neurosci. Lett. 127, 173-176.
6. Bauman M. L. and Kemper T. L. (2005) Neuroanatomic observations of the brain in autism: a review and future directions. Int. J. Dev. Neurosci. 23, 183-187.
7. Beck O., Wallen N. H., Broijersen A., Larsson P. T. and Hjemdahl P. (1993) On the accurate determination of serotonin in human plasma. Biochem. Biophys. Res. Commun. 196, 260-266.
8. Bruning G., Liangos O. and Baumgarten H. G. (1997) Prenatal development of the serotonin transporter in mouse brain. Cell Tissue Res. 289, 211-221.
9. Casanova M. F., Buxhoeveden D. P., Switala A. E. and Roy E. (2002) Minicolumnar pathology in autism. Neurology 58, 428-432.
10. Christofi F. L., Kim M., Wunderlich J. E., Xue J., Suntres Z., Cardounel A., Javed N. H., Yu J. G., Grants I. and Cooke H. J. (2004) Endogenous adenosine differentially modulates 5-hydroxytryptamine release from a human enterochromaffin cell model. Gastroenterology 127, 188-202.
11. Chugani D. C. (2002) Role of altered brain serotonin mechanisms in autism. Mol. Psychiatry 7, S16-S17.
12. Courchesne E. (1997) Brainstem, cerebellar and limbic neuroanatomical abnormalities in autism. Curr. Opin. Neurobiol. 7, 269-278.
13. Croonenberghs J., Verkerk R., Scharpe S., Deboutte D. and Maes M. (2005) Serotonergic disturbances in autistic disorder: L-5-hydroxytryptophan administration to autistic youngsters increases the blood concentrations of serotonin in patients but not in controls. Life Sci. 76, 2171-2183.
14. D'Eufemia P., Finocchiaro R., Celli M., Viozzi L., Monteleone D. and Giardini O. (1995) Low serum tryptophan to large neutral amino acids ratio in idiopathic infantile autism. Biomed. Pharmacother. 49, 288-292.
15. Donovan S. L., Mamounas L. A., Andrews A. M., Blue M. E. and McCasland J. S. (2002) GAP-43 is critical for normal development of the serotonergic innervation in forebrain. J. Neurosci. 22, 3543-3552.
16. Field A. (2005) Discovering Statistics Using SPSS, 2nd edn. SAGE Publications, London.
17. Gershon M. D. (2003) Plasticity in serotonin control mechanisms in the gut. Curr. Opin. Pharmacol. 3, 600-607.
18. Gershon M. D. (2004) Review article: serotonin receptors and transporters - roles in normal and abnormal gastrointestinal motility. Aliment. Pharmacol. Ther. 20, 3-14.
19. 1A receptor acts during development to establish normal anxiety-like behaviour in the adult. Nature 416, 396-400.
20. 1A receptor mutant mice. Proc. Natl Acad. Sci. USA 95, 15 049-15 054.
21. Hendricks T. J., Fyodorov D. V., Wegman L. J., Lelutiu N. B., Pehek E. A., Yamamoto B., Silver J., Weeber E. J., Sweatt J. D. and Deneris E. S. (2003) Pet-1 ETS gene plays a critical role in 5-HT neuron development and is required for normal anxiety-like and aggressive behavior. Neuron 37, 233-247.
22. Janušonis S. (2005) Statistical distribution of blood serotonin as a predictor of early autistic brain abnormalities. Theor. Biol. Med. Model. 2, 27.
23. Janušonis S. and Fite K. V. (2001) Diurnal variation of c-Fos expression in subdivisions of the dorsal raphe nucleus of the Mongolian gerbil (Meriones unguiculatus). J. Comp. Neurol. 440, 31-42.
24. Kahne D., Tudorica A., Borella A., Shapiro L., Johnstone F., Huang W. and Whitaker-Azmitia P. M. (2002) Behavioral and magnetic resonance spectroscopic studies in the rat hyperserotonemic model of autism. Physiol. Behav. 75, 403-410.
25. 1A receptors in the nervous systems of the bowel and pancreas. J. Comp. Neurol. 364, 439-455.
26. 1 receptors. Curr. Drug Targets CNS. Neurol. Disord. 3, 1-10.
27. 4 receptors in the mouse enteric nervous system. Am. J. Physiol Gastrointest. Liver Physiol. 289, G1148-G1163.
28. 2 receptor in the mouse. J. Pharmacol. Exp. Ther. 268, 104-109.
29. McBride P. A., Anderson G. M., Hertzig M. E., Snow M. E., Thompson S. M., Khait V. D., Shapiro T. and Cohen D. J. (1998) Effects of diagnosis, race, and puberty on platelet serotonin levels in autism and mental retardation. J. Am. Acad. Child Adolesc. Psychiatry 37, 767-776.
30. Minderaa R. B., Anderson G. M., Volkmar F. R., Akkerhuis G. W. and Cohen D. J. (1987) Urinary 5-hydroxyindoleacetic acid and whole blood serotonin and tryptophan in autistic and normal subjects. Biol. Psychiatry 22, 933-940.
31. 1A receptor mRNA in rat forebrain and cerebellum. Brain Res. Dev. Brain Res. 80, 149-157.
32. Morcillo E. J. and Cortijo J. (1999) Species differences in the responses of pulmonary vascular preparations to 5-hydroxytryptamine. Therapie 54, 93-97.
33. Mulder E. J., Anderson G. M., De Kema I. P. B. A., Van Lang N. D., Den Boer J. A. and Minderaa R. B. (2004) Platelet serotonin levels in pervasive developmental disorders and mental retardation. Diagnostic group differences, within-group distribution, behavioral correlates. J. Am. Acad. Child Adolesc. Psychiatry 43, 491-499.
34. Nakamura K., Sugawara Y., Sawabe K. et al. (2006) Late developmental stage-specific role of tryptophan hydroxylase 1 in brain serotonin levels. J. Neurosci. 26, 530-534.
35. 1A receptors in human cerebellum during development. Neurosci. Lett. 166, 149-152.
36. Palmen S. J., Van E. H., Hof P. R. and Schmitz C. (2004) Neuropathological findings in autism. Brain 127, 2572-2583.
37. 1A receptor. Proc. Natl Acad. Sci. USA 95, 10 734-10 739.
38. 1A receptor expression in the developing hippocampus. Brain Res. Dev. Brain Res. 157, 42-57.
39. Polleux F., Dehay C. and Kennedy H. (1997) The timetable of laminar neurogenesis contributes to the specification of cortical areas in mouse isocortex. J. Comp. Neurol. 385, 95-116.
40. 1A receptor: a representative member of the serotonin receptor family. Cell Mol. Neurobiol. 25, 553-580.
41. Racke K. and Schworer H. (1992) Nicotinic and muscarinic modulation of 5-hydroxytryptamine (5-HT) release from porcine and canine small intestine. Clin. Invest. 70, 190-200.
42. Rakic P. (2000) Setting the stage for cognition, in Genesis of the Primate Cerebral Cortex, in the New Cognitive Neurosciences, 2nd edn. (Gazzaniga, M. S., ed.), pp. 7-21. The MIT Press, Cambridge, MA, USA.
43. 1A knockout: an animal model of anxiety-related disorder. Proc. Natl Acad. Sci. USA 95, 14 476-14 481.
44. 1A receptors in rat and human kidneys. Am. J. Physiol. 264, F9-F19.
45. 1A autoreceptor activation. Soc. Neurosci. Abstr. 943.4.
46. Rutter M. (2005) Incidence of autism spectrum disorders: changes over time and their meaning. Acta Paediatr. 94, 2-15.
47. Schafermeyer A., Gratzl M., Rad R., Dossumbekova A., Sachs G. and Prinz C. (2004) Isolation and receptor profiling of ileal enterochromaffin cells. Acta Physiol. Scand. 182, 53-62.
48. Schain R. J. and Freedman D. X. (1961) Studies on 5-hydroxyindole metabolism in autistic and other mentally retarded children. J. Pediatr. 58, 315-320.
49. Schworer H. and Ramadori G. (1998) Autoreceptors can modulate 5-hydroxytryptamine release from porcine and human small intestine in vitro. Naunyn Schmiedebergs Arch. Pharmacol. 357, 548-552.
50. Sparks B. F., Friedman S. D., Shaw D. W. et al. (2002) Brain structural abnormalities in young children with autism spectrum disorder. Neurology 59, 184-192.
51. Svenningsson P., Chergui K., Rachleff I., Flajolet M., Zhang X., Yacoubi M. E., Vaugeois J. M., Nomikos G. G. and Greengard P. (2006) Alterations in 5-HT1B receptor function by p11 in depression-like states. Science 311, 77-80.
52. Thomas D. P. and Vane J. R. (1967) 5-Hydroxytryptamine in the circulation of the dog. Nature 216, 335-338.
53. Verney C., Lebrand C. and Gaspar P. (2002) Changing distribution of monoaminergic markers in the developing human cerebral cortex with special emphasis on the serotonin transporter. Anat. Rec. 267, 87-93.
54. Walther D. J., Peter J. U., Bashammakh S., Hortnagl H., Voits M., Fink H. and Bader M. (2003) Synthesis of serotonin by a second tryptophan hydroxylase isoform. Science 299, 76.
55. Waterhouse L., Fein D. and Modahl C. (1996) Neurofunctional mechanisms in autism. Psychol. Rev. 103, 457-489.
56. Whitaker-Azmitia P. M. (2001) Serotonin and brain development: role in human developmental diseases. Brain Res. Bull. 56, 479-485.
57. 1a receptors and S-100β in development and plasticity. Perspect. Dev. Neurobiol. 2, 233-238.
58. Yan H. and Lewander T. (1999) Differential tissue distribution of the enantiomers of racemic pindolol in the rat. Eur. Neuropsychopharmacol. 10, 59-62.
59. Young S. N. and Teff K. L. (1989) Tryptophan availability, 5HT synthesis and 5HT function. Prog. Neuropsychopharmacol. Biol. Psychiatry 13, 373-379.
60. 1A binding sites. Brain Res. Mol. Brain Res. 69, 186-201.