Use of selective serotonin reuptake inhibitors during pregnancy and risk of autism

New England Journal of Medicine

Volumn 369, Issue 25, 2013, Pages 2406-2415

  Hviid, Anders ^a   Melbye, Mads ^a   Pasternak, Bjor̈n ^a  

^a STATENS SERUM INSTITUT   (Denmark)

Author keywords

[No Author keywords available]

Indexed keywords

CITALOPRAM; ESCITALOPRAM; FLUOXETINE; FLUVOXAMINE; PAROXETINE; SEROTONIN UPTAKE INHIBITOR; SERTRALINE;

ADULT; ARTICLE; AUTISM; COHORT ANALYSIS; CONTROLLED STUDY; DENMARK; FEMALE; FOLLOW UP; HUMAN; INCIDENCE; MAJOR CLINICAL STUDY; PRENATAL DRUG EXPOSURE; PRIORITY JOURNAL;

EID: 84890423003     PISSN: 00284793     EISSN: 15334406     Source Type: Journal    
DOI: 10.1056/NEJMoa1301449     Document Type: Article

References (24)

1. Alder J, Fink N, Bitzer J, Hösli I, Holzgreve W. Depression and anxiety during pregnancy: a risk factor for obstetric, fetal and neonatal outcome? A critical review of the literature. J Matern Fetal Neonatal Med 2007;20:189-209.
2. Dipietro JA. Maternal stress in pregnancy: considerations for fetal development. J Adolesc Health 2012;51:Suppl:S3-S8.
3. Andrade SE, Raebel MA, Brown J, et al. Use of antidepressant medications during pregnancy: a multisite study. Am J Obstet Gynecol 2008;198(2):194.e1-194. e5.
4. Tuccori M, Testi A, Antonioli L, et al. Safety concerns associated with the use of serotonin reuptake inhibitors and other serotonergic/noradrenergic antidepressants during pregnancy: a review. Clin Ther 2009;31:1426-53.
5. Croen LA, Grether JK, Yoshida CK, Odouli R, Hendrick V. Antidepressant use during pregnancy and childhood autism spectrum disorders. Arch Gen Psychiatry 2011;68:1104-12.
6. Lam KS, Aman MG, Arnold LE. Neurochemical correlates of autistic disorder: a review of the literature. Res Dev Disabil 2006;27:254-89.
7. Ansorge MS, Zhou M, Lira A, Hen R, Gingrich JA. Early-life blockade of the 5-HT transporter alters emotional behavior in adult mice. Science 2004;306:879-81.
8. Simpson KL, Weaver KJ, de Villers-Sidani E, et al. Perinatal antidepressant exposure alters cortical network function in rodents. Proc Natl Acad Sci U S A 2011;108:18465-70.
9. Oberlander TF. Fetal serotonin signaling: setting pathways for early childhood development and behavior. J Adolesc Health 2012;51:Suppl:S9-S16.
10. Knudsen LB, Olsen J. The Danish Medical Birth Registry. Dan Med Bull 1998;45:320-3.
11. Pedersen CB. The Danish Civil Registration System. Scand J Public Health 2011;39:Suppl:22-5.
12. Jørgensen FS. Organization of obstetric ultrasound in Denmark 2000: description of the development since 1990. Ugeskr Laeger 2003;165:4404-9. (In Danish.)
13. Lynge E, Sandegaard JL, Rebolj M. The Danish National Patient Register. Scand J Public Health 2011;39:Suppl:30-3.
14. Kildemoes HW, Sørensen HT, Hallas J. The Danish National Prescription Registry. Scand J Public Health 2011;39:Suppl:38-41.
15. Mors O, Perto GP, Mortensen PB. The Danish Psychiatric Central Research Register. Scand J Public Health 2011;39:Suppl:54-7.
16. Jensen VM, Rasmussen AW. Danish Education Registers. Scand J Public Health 2011;39:Suppl:91-4.
17. Poisson and logistic regression. In: Clayton D, Hills M. Statistical models in epidemiology. Oxford, England: Oxford University Press, 1993;227-36.
18. Harrell HF. Regression modeling strategies. New York: Springer-Verlag, 2001.
19. Rai D, Lee BK, Dalman C, Golding J, Lewis G, Magnusson C. Parental depression, maternal antidepressant use during pregnancy, and risk of autism spectrum disorders: population based case-control study. BMJ 2013;346:f2059.
20. Lauritsen MB, Jørgensen M, Madsen KM, et al. Validity of childhood autism in the Danish Psychiatric Central Register: findings from a cohort sample born 1990-1999. J Autism Dev Disord 2010;40:139-48.
21. Parner ET, Thorsen P, Dixon G, et al. A comparison of autism prevalence trends in Denmark and Western Australia. J Autism Dev Disord 2011;41:1601-8.
22. Prevalence of autism spectrum disorders - Autism and Developmental Disabilities Monitoring Network, 14 sites, United States, 2008. MMWR Surveill Summ 2012;61:1-19.
23. Grzeskowiak LE, Gilbert AL, Morrison JL. Investigating outcomes following the use of selective serotonin reuptake inhibitors for treating depression in pregnancy: a focus on methodological issues. Drug Saf 2011;34:1027-48.
24. Fombonne E. Epidemiology of pervasive developmental disorders. Pediatr Res 2009;65:591-8.