Stimulation of 5-HT 2C receptors improves cognitive deficits induced by human tryptophan hydroxylase 2 loss of function mutation

Neuropsychopharmacology

Volumn 39, Issue 5, 2014, Pages 1125-1134

  Del'Guidice, Thomas ^a,b   Lemay, Francis ^b,c   Lemasson, Morgane ^a,b   Levasseur Moreau, Jean ^b   Manta, Stella ^a,b   Etievant, Adeline ^a,b   Escoffier, Guy ^d   Doré, François Y ^c   Roman, François S ^d   Beaulieu, Jean Martin ^a,b  

^a UNIVERSITÉ LAVAL   (Canada)

^b CENTRE DE RECHERCHE DE L INSTITUT UNIVERSITAIRE EN SANTÉ MENTALE DE QUÉBEC   (Canada)

^c UNIVERSITÉ LAVAL   (Canada)

^d Mediterranée University   (France)

Author keywords

5 HT2C receptor; cognitive flexibility; H maze; perseveration; R439H Tph2 KI mouse; reversal learning

Indexed keywords

5 CARBAMOYLTRYPTAMINE; 5 HYDROXYTRYPTOPHAN; CP 809 101; CP 809101; METHYLPHENIDATE; QUININE; SEROTONIN 2C AGONIST; SEROTONIN 2C RECEPTOR; SEROTONIN 5 RECEPTOR; SEROTONIN 7 RECEPTOR; TRYPTOPHAN HYDROXYLASE 2; UNCLASSIFIED DRUG; CP-809,101; DOPAMINE UPTAKE INHIBITOR; PIPERAZINE DERIVATIVE; PYRAZINE DERIVATIVE; SEROTONIN 2 AGONIST; SEROTONIN RECEPTOR AFFECTING AGENT; TPH2 PROTEIN, HUMAN; TRYPTOPHAN HYDROXYLASE;

ANIMAL EXPERIMENT; ANIMAL MODEL; ARTICLE; AVERSION; COGNITION; COGNITIVE DEFECT; CONTROLLED STUDY; DETERIORATION; FEMALE; GENE EXPRESSION; GENOTYPE; LEARNING; LOCOMOTION; LOSS OF FUNCTION MUTATION; MALE; MAZE TEST; MOTOR COORDINATION; MOTOR PERFORMANCE; MOUSE; NONHUMAN; PRIORITY JOURNAL; ROTAROD TEST; SINGLE NUCLEOTIDE POLYMORPHISM; SMELLING; TASK PERFORMANCE; ANIMAL; AVOIDANCE BEHAVIOR; COGNITION DISORDERS; DRUG EFFECTS; GENETICS; HUMAN; METABOLISM; MOTOR ACTIVITY; MUTATION; PATHOPHYSIOLOGY; PHYSIOLOGY; REWARD; TRANSGENIC MOUSE;

5-HYDROXYTRYPTOPHAN; ANIMALS; AVOIDANCE LEARNING; COGNITION; COGNITION DISORDERS; DOPAMINE UPTAKE INHIBITORS; HUMANS; MAZE LEARNING; METHYLPHENIDATE; MICE; MICE, TRANSGENIC; MOTOR ACTIVITY; MUTATION; OLFACTORY PERCEPTION; PIPERAZINES; PYRAZINES; RECEPTOR, SEROTONIN, 5-HT2C; REVERSAL LEARNING; REWARD; SEROTONIN 5-HT2 RECEPTOR AGONISTS; SEROTONIN AGENTS; TRYPTOPHAN HYDROXYLASE;

EID: 84896397981     PISSN: 0893133X     EISSN: 1740634X     Source Type: Journal    
DOI: 10.1038/npp.2013.313     Document Type: Article

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