Cortical serotonin type-2 receptor density in parents of children with autism spectrum disorders

Journal of Autism and Developmental Disorders

Volumn 39, Issue 1, 2009, Pages 97-104

  Goldberg, Jeremy ^a,b   Anderson, George M ^c   Zwaigenbaum, Lonnie ^a,d   Hall, Geoffrey B C ^a   Nahmias, Claude ^a   Thompson, Ann ^b,e   Szatmari, Peter ^a  

^a MCMASTER UNIVERSITY   (Canada)

^b HAMILTON HEALTH SCIENCES   (Canada)

^c YALE UNIVERSITY SCHOOL OF MEDICINE   (United States)

^d UNIVERSITY OF ALBERTA   (Canada)

^e McMaster University and Hamilton Health Sciences McMaster Innovation Park   (Canada)

Author keywords

18Fluoro setoperone; Autism; Endophenotype; Positron emission tomography; Serotonin; Setoperone

Indexed keywords

BRAIN PROTEIN; SEROTONIN 2 RECEPTOR; SETOPERONE;

ARTICLE; AUTISM; BRAIN REGION; CHILD PSYCHIATRY; CONTROLLED STUDY; FEMALE; HUMAN; MALE; PARENT; POSITRON EMISSION TOMOGRAPHY; PRIORITY JOURNAL; PROTEIN ANALYSIS; PROTEIN BINDING; PROTEIN EXPRESSION; PROTEIN FUNCTION;

ADULT; AUTISTIC DISORDER; CEREBRAL CORTEX; CHILD; FEMALE; GENETIC PREDISPOSITION TO DISEASE; HUMANS; MALE; MIDDLE AGED; PHENOTYPE; PYRIMIDINONES; RECEPTORS, SEROTONIN, 5-HT2; REFERENCE VALUES; SEROTONIN ANTAGONISTS;

EID: 57849094951     PISSN: 01623257     EISSN: 15733432     Source Type: Journal    
DOI: 10.1007/s10803-008-0604-4     Document Type: Article

References (72)

1. American Psychiatric Press. (1994). Diagnostic and statistical manual of mental disorders 4th edition (DSM-IV). Washington, DC: American Psychiatric Association.
2. GM Anderson 2002 Genetics of childhood disorders: XLV. Autism, Part 4: Serotonin in autism Journal of the American Academy of Child and Adolescent Psychiatry 41 1513 1516 10.1097/00004583-200212000-00025
3. GM Anderson FC Feibel DJ Cohen 1987 Determination of serotonin in whole blood, platelet-rich plasma, platelet-poor plasma and plasma ultra-filtrate Life Sciences 40 1063 1070 10.1016/0024-3205(87)90568-6
4. B Arranz A Eriksson E Mellerup P Plenge J Marcusson 1993 Effect of aging on human cortical pre and post synaptic serotonin binding sites Brain Research 620 163 166 10.1016/0006-8993(93)90286-V
5. A Bailey A Le Couteur I Gottesman P Bolten E Simonoff E Yuzda 1995 Autism is a strongly genetic disorder: Evidence from a British twin study Psychological Medicine 25 63 77
6. S Baron-Cohen RC Knickmeyer MK Belmonte 2005 Sex differences in the brain: Implications for explaining autism Science 310 819 823 10.1126/science.1115455
7. S Baron-Cohen H Ring X Chitnis S Wheelwright L Gregory 2006 fMRI of parents of children with Asperger's Syndrome: A pilot study Brain and Cognition 61 122 130 10.1016/j.bandc.2005.12.011
8. Z Bhagwagar R Hinz M Taylor S Fancy P Cowen P Grasby 2006 Increased 5-HT(2A) receptor binding in euthymic, medication-free patients recovered from depression: A positron emission study with [(11)C]MDL 100, 907 The American Journal of Psychiatry 163 1580 1587 10.1176/appi.ajp. 163.9.1580
9. J Blin G Sette M Fiorelli O Bletry JL Elghozi 1990 A method for the in vivo investigation of the serotonergic 5-HT2 receptors in the human cerebral cortex using positron emission tomography and 18F-labeled setoperone Journal of Neurochemistry 54 1744 1754 10.1111/j.1471-4159.1990.tb01229.x
10. P Bolton H Macdonald A Pickles P Rios S Goode M Crowson 1994 A case-control family history study of autism Journal of Child Psychology and Psychiatry, and Allied Disciplines 35 877 900 10.1111/j.1469-7610.1994.tb02300.x
11. A Bonnin M Torii L Wang P Rakic P Levitt 2007 Serotonin modulates the response of embryonic thalamocortical axons to netrin-1 Nature Neuroscience 10 588 597 10.1038/nn1896
12. PW Burnet SL Eastwood PJ Harrison 1996 5-HT1A and 5-HT2A receptor mRNAs and binding densities are differentially altered in schizophrenia Neuropsychophamacology 15 422 455
13. SR Chandana ME Behen C Juhasz O Muzik RD Rothermel TJ Mangner 2005 Significance of abnormalities in developmental trajectory and asymmetry of cortical serotonin synthesis in autism International Journal of Developmental Neuroscience 23 171 182 10.1016/j.ijdevneu.2004.08.002
14. IH Cho HJ Yoo M Park YS Lee SA Kim 2008 Family-based association study of 5-HTTLPR and the 5-HT2A receptor gene polymorphisms with autism spectrum disorder in Korean trios Brain Research 1139 34 41 10.1016/j.brainres.2007.01. 002
15. JN Constantino SA Davis 2003 Validation of a brief quantitative measure of autistic traits: Comparison of the social responsiveness scale with the autism diagnostic interview-revised Journal of Autism and Developmental Disorders 33 427 433 10.1023/A:1025014929212
16. EH Cook Jr RC Arora GM Anderson EM Berry-Kravis SY Yan HC Yeoh 1993 Platelet serotonin studies in hyperserotonemic relatives of children with autistic disorder Life Sciences 52 2005 2015 10.1016/0024-3205(93)90685-V
17. C Crouzel M Venet G Irie G Sanz C Boullais 1988 Labeling of a serotonergic ligand with 18-F Setoperone Journal of Labelled Compounds and Radiopharmaceuticals 25 403 414 10.1002/jlcr.2580250407
18. JP Danaceau GM Anderson WM McMahon DJ Crouch 2003 A liquid chromatographic-tandem mass spectrometric method for the analysis of serotonin and related indoles in human whole blood Journal of Analytical Toxicology 27 440 444
19. JA Duvall A Lu 2007 A quantitative trait locus analysis of social responsiveness in multiplex autism families The American Journal of Psychiatry 164 656 662 10.1176/appi.ajp. 164.4.656
20. AS Eison UL Mullins 1996 Regulation of central 5HT2A receptors: A review of in vivo studies Behavioural Brain Research 73 177 181 10.1016/0166-4328(96) 00092-7
21. CN Epperson KA Czarkowski D Ward-O'Brien E Weiss R Gueorguieva P Jatlow 2001 Maternal sertraline treatment and serotonin transport in breastfeeding mother-infant pairs The American Journal of Psychiatry 158 1631 1637 10.1176/appi.ajp. 158.10.1631
22. SH Fatemi JM Stary EA Egan 2002 Reduced blood levels of reelin as a vulnerability factor in pathophysiology of autistic disorder Cellular and Molecular Neurobiology 22 139 152 10.1023/A:1019857620251
23. Folstein, S. & Rutter, M. (1991). Family history interview for developmental disorders of cognition and social functioning (available from authors).
24. SE Folstein SL Santangelo SE Gilman J Piven R Landa J Lainhart 1999 Predictors of cognitive test patterns in autism families Journal of Child Psychology and Psychiatry, and Allied Disciplines 40 1117 1128 10.1017/S0021963099004461
25. K Gotham S Risi A Pickles C Lord 2007 The Autism Diagnostic Observation Schedule: Revised algorithms for improved diagnostic validity Journal of Autism and Developmental Disorders 37 613 627 10.1007/s10803-006-0280-1
26. II Gottesman TD Gould 2003 The enodphontype concept in psychiatry: Etymology and strategic intentions The American Journal of Psychiatry 160 636 645 10.1176/appi.ajp. 160.4.636
27. F Happe J Briskman U Frith 2001 Exploring the cognitive phenotype of autism: Weak "central coherence" in parents and siblings of children with autism: I. Experimental tests Journal of Child Psychology and Psychiatry, and Allied Disciplines 42 299 307 10.1017/S0021963001006916
28. F Happe A Ronald R Plomin 2006 Time to give up on a single explanation for autism Nature Neuroscience 9 1218 1220 10.1038/nn1770
29. J Herault E Petit J Martineau C Cherpi A Perrot C Barthelemy 1996 Serotonin and autism: Biochemical and molecular biology features Psychiatry Research 65 33 43 10.1016/0165-1781(96)02882-X
30. RS Hurley M Losh 2007 The broad autism phenotype questionnaire Journal of Autism and Developmental Disorders 37 1679 1690 10.1007/s10803-006-0299-3
31. RL Jakab PS Goldman-Rakic 1998 5-Hydroxytryptamine serotonin receptors in the primate cerebral cortex: Possible site of action of hallucinogenic and antipsychotic drugs in the pyramidal cell apical dendrites Proceedings of the National Academy of Sciences of the USA 95 735 740 10.1073/pnas.95.2.735
32. S Janusonis V Gluncic P Rakic 2004 Early serotonergic projections to Cajal-Retzius cells: Relevance for cortical development The Journal of Neuroscience 24 1652 1659 10.1523/JNEUROSCI.4651-03.2004
33. S Kapur C Jones J DaSilva A Wilson S Houle 1997 Reliability of a simple non-invasive method for the evaluation of 5-HT2 receptors using (18F) setoperone PET imaging Nuclear Medicine Communications 18 395 399 10.1097/00006231- 199705000-00002
34. A Kolevzon KA Mathewson E Hollander 2006 Selective serotonin reuptake inhibitors in autism: A review of efficacy and tolerability The Journal of Clinical Psychiatry 67 407 414
35. A Kugaya CN Epperson S Zoghbi CH van Dyck Y Hou M Fujita 2003 Increase in prefrontal cortex serotonin2A receptors following estrogen treatment in postmenopausal women The American Journal of Psychiatry 160 522 524 10.1176/appi.ajp. 160.8.1522
36. JE Lainhart S Ozonoff H Coon L Krasny E Dinh J Nice 2002 Autism, regression, and the broader autism phenotype American Journal of Medical Genetics 113 231 237 10.1002/ajmg.10615
37. M Laruelle A Abi-Dargham MF Casanova R Toti D Weinberger J Kleinman 1993 Selective abnormalities of prefrontal serotonergic receptors in schizophrenia: A postmortem study Archives of General Psychiatry 50 810 818
38. M Leboyer F Bellivier M Nosten-Bertrand R Jouvent D Pauls J Mallet 1998 Psychiatric genetics: Search for phenotypes Trends in Neurosciences 21 102 105 10.1016/S0166-2236(97)01187-9
39. Levine, M. (1986). Leiter international performance scale: A handbook. Los Angeles: Western Psychological Services.
40. 18 F] setoperone in neuroleptic-naive patients and normal subjects The American Journal of Psychiatry 156 72 78
41. AL Lopez-Figueroa CS Norton MO Lopez-Figueroa D Armellini-Dodel S Burke H Akil 2004 Serotonin 5-HT1A, 5-HT1B, and 5-HT2A receptor mRNA expression in subjects with major depression, bipolar disorder, and schizophrenia Biological Psychiatry 55 225 233 10.1016/j.biopsych.2003.09.017
42. C Lord M Rutter A Le Couteur 1994 Autism Diagnostic Interview-Revised: A revised version of a diagnostic interview for caregivers of individuals with possible pervasive developmental disorders Journal of Autism and Developmental Disorders 24 659 685 10.1007/BF02172145
43. M Losh J Piven 2007 Social-cognition and the broad autism phenotype: Identifying genetically meaningful phenotypes Journal of Child Psychology and Psychiatry, and Allied Disciplines 48 105 112 10.1111/j.1469-7610.2006.01594.x
44. JE MacLean P Szatmari MB Jones SE Bryson WJ Mahoney G Bartolucci 1999 Familial factors influence level of functioning in pervasive developmental disorder Journal of the American Academy of Child and Adolescent Psychiatry 38 746 753 10.1097/00004583-199906000-00023
45. JJ Mann D Brent V Arango 2001 The neurobiology and genetics of suicide and attempted suicide: A focus on the serotonergic system Neuropsychopharmacology 24 467 477 10.1016/S0893-133X(00)00228-1
46. PA McBride GM Anderson M Herzig J Sweeney J Kream DJ Cohen 1989 Serotonergic responsivity in male young adults with autistic disorder: Results of a pilot study Archives of General Psychiatry 46 213 221
47. PA McBride GM Anderson T Shapiro 1996 Autism research: Bringing together approaches to pull apart the disorder Archives of General Psychiatry 53 980 983
48. CC Meltzer JC Price CA Mathis PJ Greer MN Cantwell PR Houck 1999 PET imaging of serotonin type 2A receptors in late life neuropsychiatric disorders The American Journal of Psychiatry 156 1871 1878
49. 18F] setoperone PET imaging study The American Journal of Psychiatry 156 1029 1034
50. 18F]altanserin positron emission tomography Biological Psychiatry 55 217 224 10.1016/j.biopsych.2003.08.015
51. EJ Mulder GM Anderson IP Kema A de Bildt NDJ van Lang JA den Boer 2004 Platelet serotonin in pervasive developmental disorders and mental retardation: Diagnostic group differences, within-group distribution and behavioral correlates Journal of the American Academy of Child and Adolescent Psychiatry 43 491 499 10.1097/00004583-200404000-00016
52. DG Murphy N Schmitz F Toal K Murphy E Daly K Erlandsson 2006 Cortical 5-HT2A receptor binding and social communication in adults with Asperger's syndrome: An in vivo SPECT study The American Journal of Psychiatry 163 934 936 10.1176/appi.ajp. 163.5.934
53. M Murphy PF Bolton A Pickles E Fombonne J Piven M Rutter 2000 Personality traits of the relatives of autistic probands Psychological Medicine 30 1411 1424 10.1017/S0033291799002949
54. SJ Palmen HE Hulshoff Pol C Kemner HG Schnack MM Sitskoorn MC Appels 2005 Brain anatomy in non-affected parents of autistic probands: A MRI study Psychological Medicine 35 1411 1420 10.1017/S0033291705005015
55. A Pazos A Probst JM Palacio 1987 Serotonin receptors in the human brain-iv. autoradiographic mapping of serotonin-2 receptors NeuroImage 21 123 139
56. E Peterson GL Schmidt JR Tregellas E Winterrowd L Kopelioff S Hepburn 2006 A voxel-based morphometry study of gray matter in parents of children with autism Neuroreport 17 1289 1292 10.1097/01.wnr.0000233087.15710.87
57. MC Petit-Tabou B Landeau A Osmont I Tillet L Barre JC Baron 1996 Estimation of neo-cortical serotonin-2 receptor binding potential by single dose fluorine-18-Setoperone kinetic PET data analysis Journal of Nuclear Medicine 37 95 104
58. J Piven P Palmer D Jacobi D Childress S Arndt 1997 Broader autism phenotype: Evidence from a family history study of multiple-incidence autism families The American Journal of Psychiatry 154 185 190
59. F Polleux JM Lauder 2004 Toward a developmental neurobiology of autism Mental Retardation and Developmental Disabilities Research Reviews 10 303 317 10.1002/mrdd.20044
60. I Rapin 1997 Autism The New England Journal of Medicine 337 97 104 10.1056/NEJM199707103370206
61. DC Rojas JA Smith TL Benkers SL Camou ML Reite SJ Rogers 2004 Hippocampus and amygdala volumes in parents of children with autistic disorder The American Journal of Psychiatry 161 2038 2044 10.1176/appi.ajp. 161.11.2038
62. TF Ruser D Arin M Dowd S Putnam B Winklosky B Rosen-Sheidley 2008 Communicative competence in parents of children with autism and parents of children with specific language impairment Journal of Autism and Developmental Disorders 37 1323 1336 10.1007/s10803-006-0274-z
63. M Rutter 1999 Autism: Two-way interplay between research and clinical work Journal of Child Psychology and Psychiatry, and Allied Disciplines 40 169 188 10.1017/S0021963098003461
64. RJ Schain DX Freedman 1961 Studies on 5-hydroxyindole metabolism in autistic and other mentally retarded children The Journal of Pediatrics 58 315 320 10.1016/S0022-3476(61)80261-8
65. DH Skuse 2001 Endophenotypes and child psychiatry The British Journal of Psychiatry 178 395 396 10.1192/bjp. 178.5.395
66. Sparrow, S., Bala, D., & Cichetti, D. (1984). Vineland Adaptive Behaviour Scales (Survey Form). Circle Pines, MN: American Guidance Service.
67. WL Stone CR McMahon PJ Yoder TA Walden 2008 Early social-communicative and cognitive development of younger siblings of children with autism spectrum disorders Archives of Pediatrics and Adolescent Medicine 161 384 390 10.1001/archpedi.161.4.384
68. P Szatmari M Maziade L Zwaigenbaum C Merette MA Roy R Joober 2007 Informative phenotypes for genetic studies of psychiatric disorders American Journal of Medical Genetics. Part B 144 581 588
69. J Veenstra-Vander-Weele S Kim C Lord R Courchesne N Akshoomoff BL Levinthal 2002 Transmission disequillibrium studies of the serotonin 5ht2a receptor gene (htr2a) in autism American Journal of Medical Genetics 114 277 283 10.1002/ajmg.10192
70. P Whitaker-Azmitia 2001 Serotonin and brain development: Role in human developmental diseases Brain Research Bulletin 56 479 485 10.1016/S0361-9230(01) 00615-3
71. 18-labeled setoperone Archives of General Psychiatry 56 705 711 10.1001/archpsyc.56.8.705
72. SN Young M Leyton C Benkelfat 1999 PET studies of serotonin synthesis in the human brain Advances in Experimental Medicine and Biology 467 11 18