메뉴 건너뛰기




Volumn 16, Issue 1, 2015, Pages

Combined metabolome and transcriptome profiling provides new insights into diterpene biosynthesis in S. pomifera glandular trichomes

Author keywords

Cytochrome P450; Diterpenes; Miltiradiene; S. pomifera

Indexed keywords

COPALYL DIPHOSPHATE SYNTHASE; CYTOCHROME P450; DITERPENE; MEMBRANE ENZYME; MILTIRADIENE SYNTHASE; TRANSCRIPTOME; UNCLASSIFIED DRUG; MILTIRADIENE; TERPENE;

EID: 84963593778     PISSN: None     EISSN: 14712164     Source Type: Journal    
DOI: 10.1186/s12864-015-2147-3     Document Type: Article
Times cited : (42)

References (73)
  • 1
    • 84869193062 scopus 로고    scopus 로고
    • Constituents from Salvia species and their biological activities
    • Wu YB, Ni ZY, Shi QW, Dong M, Kiyota H, Gu YC, et al. Constituents from Salvia species and their biological activities. Chem Rev. 2012;112(11):5967-6026.
    • (2012) Chem Rev , vol.112 , Issue.11 , pp. 5967-6026
    • Wu, Y.B.1    Ni, Z.Y.2    Shi, Q.W.3    Dong, M.4    Kiyota, H.5    Gu, Y.C.6
  • 2
    • 45049087994 scopus 로고    scopus 로고
    • Carnosic acid and carnosol potently inhibit human 5-lipoxygenase and suppress pro-inflammatory responses of stimulated human polymorphonuclear leukocytes
    • Poeckel D, Greiner C, Verhoff M, Rau O, Tausch L, Hornig C, et al. Carnosic acid and carnosol potently inhibit human 5-lipoxygenase and suppress pro-inflammatory responses of stimulated human polymorphonuclear leukocytes. Biochem Pharmacol. 2008;76(1):91-7.
    • (2008) Biochem Pharmacol , vol.76 , Issue.1 , pp. 91-97
    • Poeckel, D.1    Greiner, C.2    Verhoff, M.3    Rau, O.4    Tausch, L.5    Hornig, C.6
  • 3
    • 0036316905 scopus 로고    scopus 로고
    • Carnosol, an antioxidant in rosemary, suppresses inducible nitric oxide synthase through down-regulating nuclear factor-kappaB in mouse macrophages
    • Lo A-HH, Liang Y-CC, Lin-Shiau S-YY, Ho C-TT, Lin J-KK. Carnosol, an antioxidant in rosemary, suppresses inducible nitric oxide synthase through down-regulating nuclear factor-kappaB in mouse macrophages. Carcinogenesis. 2002;23(6):983-91.
    • (2002) Carcinogenesis , vol.23 , Issue.6 , pp. 983-991
    • Lo, A.-H.H.1    Liang, Y.-C.C.2    Lin-Shiau, S.-Y.Y.3    Ho, C.-T.T.4    Lin, J.-K.K.5
  • 4
    • 84928377727 scopus 로고    scopus 로고
    • Redox-dependent induction of antioxidant defenses by phenolic diterpenes confers stress tolerance in normal human skin fibroblasts: insights on replicative senescence
    • Carvalho AC, Gomes AC, Pereira-Wilson C, Lima CF. Redox-dependent induction of antioxidant defenses by phenolic diterpenes confers stress tolerance in normal human skin fibroblasts: insights on replicative senescence. Free Radic Biol Med. 2015;83:262-72.
    • (2015) Free Radic Biol Med , vol.83 , pp. 262-272
    • Carvalho, A.C.1    Gomes, A.C.2    Pereira-Wilson, C.3    Lima, C.F.4
  • 5
    • 49549117517 scopus 로고    scopus 로고
    • Carnosol, a dietary diterpene, displays growth inhibitory effects in human prostate cancer PC3 cells leading to G2-phase cell cycle arrest and targets the 5'-AMP-activated protein kinase (AMPK) pathway
    • Johnson JJ, Syed DN, Heren CR, Suh Y, Adhami VM, Mukhtar H. Carnosol, a dietary diterpene, displays growth inhibitory effects in human prostate cancer PC3 cells leading to G2-phase cell cycle arrest and targets the 5'-AMP-activated protein kinase (AMPK) pathway. Pharm Res. 2008;25(9):2125-34.
    • (2008) Pharm Res , vol.25 , Issue.9 , pp. 2125-2134
    • Johnson, J.J.1    Syed, D.N.2    Heren, C.R.3    Suh, Y.4    Adhami, V.M.5    Mukhtar, H.6
  • 6
    • 84862489794 scopus 로고    scopus 로고
    • Carnosol and carnosic acids from Salvia officinalis inhibit microsomal prostaglandin E2 synthase-1
    • Bauer J, Kuehnl S, Rollinger JM, Scherer O, Northoff H, Stuppner H, et al. Carnosol and carnosic acids from Salvia officinalis inhibit microsomal prostaglandin E2 synthase-1. J Pharmacol Exp Ther. 2012;342(1):169-76.
    • (2012) J Pharmacol Exp Ther , vol.342 , Issue.1 , pp. 169-176
    • Bauer, J.1    Kuehnl, S.2    Rollinger, J.M.3    Scherer, O.4    Northoff, H.5    Stuppner, H.6
  • 7
    • 84155164808 scopus 로고    scopus 로고
    • Cardiovascular actions and therapeutic potential of tanshinone IIA
    • Gao S, Liu Z, Li H, Little PJ, Liu P, Xu S. Cardiovascular actions and therapeutic potential of tanshinone IIA. Atherosclerosis. 2012;220(1):3-10.
    • (2012) Atherosclerosis , vol.220 , Issue.1 , pp. 3-10
    • Gao, S.1    Liu, Z.2    Li, H.3    Little, P.J.4    Liu, P.5    Xu, S.6
  • 8
    • 79955526513 scopus 로고    scopus 로고
    • Tanshinone IIA protects against cardiac hypertrophy via inhibiting calcineurin/NFATc3 pathway
    • Tan X, Li J, Wang X, Chen N, Cai B, Wang G, et al. Tanshinone IIA protects against cardiac hypertrophy via inhibiting calcineurin/NFATc3 pathway. Int J Biol Sci. 2011;7(3):383-9.
    • (2011) Int J Biol Sci , vol.7 , Issue.3 , pp. 383-389
    • Tan, X.1    Li, J.2    Wang, X.3    Chen, N.4    Cai, B.5    Wang, G.6
  • 9
    • 84897966464 scopus 로고    scopus 로고
    • Tanshinone IIA promotes pulmonary artery smooth muscle cell apoptosis in vitro by inhibiting the JAK2/STAT3 signaling pathway
    • Chen M, Liu Y, Yi D, Wei L, Li Y, Zhang L. Tanshinone IIA promotes pulmonary artery smooth muscle cell apoptosis in vitro by inhibiting the JAK2/STAT3 signaling pathway. Cell Physiol Biochem. 2014;33(4):1130-8.
    • (2014) Cell Physiol Biochem , vol.33 , Issue.4 , pp. 1130-1138
    • Chen, M.1    Liu, Y.2    Yi, D.3    Wei, L.4    Li, Y.5    Zhang, L.6
  • 10
    • 84896382045 scopus 로고    scopus 로고
    • A zebrafish compound screen reveals modulation of neutrophil reverse migration as an anti-inflammatory mechanism
    • Robertson AL, Holmes GR, Bojarczuk AN, Burgon J, Loynes CA, Chimen M, et al. A zebrafish compound screen reveals modulation of neutrophil reverse migration as an anti-inflammatory mechanism. Sci Transl Med. 2014;6(225):225-9.
    • (2014) Sci Transl Med , vol.6 , Issue.225 , pp. 225-229
    • Robertson, A.L.1    Holmes, G.R.2    Bojarczuk, A.N.3    Burgon, J.4    Loynes, C.A.5    Chimen, M.6
  • 11
    • 79953121603 scopus 로고    scopus 로고
    • Diterpenoid tanshinones and phenolic acids from cultured hairy roots of salvia miltiorrhiza Bunge and their antimicrobial activities
    • Zhao JL, Lou JF, Mou Y, Li PQ, Wu JY, Zhou LG. Diterpenoid tanshinones and phenolic acids from cultured hairy roots of salvia miltiorrhiza Bunge and their antimicrobial activities. Molecules. 2011;16(3):2259-67.
    • (2011) Molecules , vol.16 , Issue.3 , pp. 2259-2267
    • Zhao, J.L.1    Lou, J.F.2    Mou, Y.3    Li, P.Q.4    Wu, J.Y.5    Zhou, L.G.6
  • 12
    • 84887075665 scopus 로고    scopus 로고
    • Tanshinone I activates the Nrf2-dependent antioxidant response and protects against As(III)-induced lung inflammation in vitro and in vivo
    • Tao S, Zheng Y, Lau A, Jaramillo MC, Chau BT, Lantz RC, et al. Tanshinone I activates the Nrf2-dependent antioxidant response and protects against As(III)-induced lung inflammation in vitro and in vivo. Antioxid Redox Signal. 2013;19(14):1647-61.
    • (2013) Antioxid Redox Signal , vol.19 , Issue.14 , pp. 1647-1661
    • Tao, S.1    Zheng, Y.2    Lau, A.3    Jaramillo, M.C.4    Chau, B.T.5    Lantz, R.C.6
  • 13
    • 0344197546 scopus 로고    scopus 로고
    • In vitro cytotoxicity of tanshinones isolated from Salvia miltiorrhiza Bunge against P388 lymphocytic leukemia cells
    • Mosaddik MA. In vitro cytotoxicity of tanshinones isolated from Salvia miltiorrhiza Bunge against P388 lymphocytic leukemia cells. Phytomedicine. 2003;10(8):682-5.
    • (2003) Phytomedicine , vol.10 , Issue.8 , pp. 682-685
    • Mosaddik, M.A.1
  • 14
    • 84908212140 scopus 로고    scopus 로고
    • The prevention and treatment effects of tanshinone IIA on oestrogen/androgen-induced benign prostatic hyperplasia in rats
    • Wang C, Du X, Yang R, Liu J, Xu D, Shi J, et al. The prevention and treatment effects of tanshinone IIA on oestrogen/androgen-induced benign prostatic hyperplasia in rats. J Steroid Biochem Mol Biol. 2015;145:28-37.
    • (2015) J Steroid Biochem Mol Biol , vol.145 , pp. 28-37
    • Wang, C.1    Du, X.2    Yang, R.3    Liu, J.4    Xu, D.5    Shi, J.6
  • 15
    • 84882770622 scopus 로고    scopus 로고
    • Molecular evidence of cryptotanshinone for treatment and prevention of human cancer
    • Chen W, Lu Y, Chen G, Huang S. Molecular evidence of cryptotanshinone for treatment and prevention of human cancer. Anticancer Agents Med Chem. 2013;13(7):979-87.
    • (2013) Anticancer Agents Med Chem , vol.13 , Issue.7 , pp. 979-987
    • Chen, W.1    Lu, Y.2    Chen, G.3    Huang, S.4
  • 16
    • 84855987832 scopus 로고    scopus 로고
    • A service of the U.S. National Institutes of Health. Accessed 3 Apr 2015
    • ClinicalTrials.gov. Coronary heart disease. A service of the U.S. National Institutes of Health. https://clinicaltrials.gov/ct2/show/NCT01502943?term=NCT01502943&rank=1. Accessed 3 Apr 2015.
    • Coronary heart disease
  • 17
    • 84963580955 scopus 로고    scopus 로고
    • A service of the U.S. National Institutes of Health. Accessed 3 Apr 2015
    • ClinicalTrials.gov. Pulmonary hypertension. A service of the U.S. National Institutes of Health. https://clinicaltrials.gov/ct2/show/NCT01637675?term=NCT01637675&rank=1. Accessed 3 Apr 2015.
    • Pulmonary hypertension
  • 18
    • 84905495692 scopus 로고    scopus 로고
    • A service of the U.S. National Institutes of Health. Accessed 3 Apr 2015
    • ClinicalTrials.gov. Polycystic Ovary Syndrome. A service of the U.S. National Institutes of Health. https://clinicaltrials.gov/ct2/show/NCT01452477?term=NCT01452477&rank=1. Accessed 3 Apr 2015.
    • Polycystic Ovary Syndrome
  • 19
    • 0029328325 scopus 로고
    • Terpenoid metabolism
    • McGarvey DJ, Croteau R. Terpenoid metabolism. Plant Cell. 1995;7(7):1015-26.
    • (1995) Plant Cell , vol.7 , Issue.7 , pp. 1015-1026
    • McGarvey, D.J.1    Croteau, R.2
  • 20
    • 0038243185 scopus 로고    scopus 로고
    • Crosstalk between cytosolic and plastidial pathways of isoprenoid biosynthesis in Arabidopsis thaliana
    • Laule O, Furholz A, Chang HS, Zhu T, Wang X, Heifetz PB, et al. Crosstalk between cytosolic and plastidial pathways of isoprenoid biosynthesis in Arabidopsis thaliana. Proc Natl Acad Sci U S A. 2003;100(11):6866-71.
    • (2003) Proc Natl Acad Sci U S A , vol.100 , Issue.11 , pp. 6866-6871
    • Laule, O.1    Furholz, A.2    Chang, H.S.3    Zhu, T.4    Wang, X.5    Heifetz, P.B.6
  • 21
    • 70749152711 scopus 로고    scopus 로고
    • A functional genomics approach to tanshinone biosynthesis provides stereochemical insights
    • Gao W, Hillwig ML, Huang L, Cui G, Wang X, Kong J, et al. A functional genomics approach to tanshinone biosynthesis provides stereochemical insights. Org Lett. 2009;11(22):5170-3.
    • (2009) Org Lett , vol.11 , Issue.22 , pp. 5170-5173
    • Gao, W.1    Hillwig, M.L.2    Huang, L.3    Cui, G.4    Wang, X.5    Kong, J.6
  • 22
    • 84880380223 scopus 로고    scopus 로고
    • CYP76AH1 catalyzes turnover of miltiradiene in tanshinones biosynthesis and enables heterologous production of ferruginol in yeasts
    • Guo J, Zhou YJ, Hillwig ML, Shen Y, Yang L, Wang Y, et al. CYP76AH1 catalyzes turnover of miltiradiene in tanshinones biosynthesis and enables heterologous production of ferruginol in yeasts. Proc Natl Acad Sci U S A. 2013;110(29):12108-13.
    • (2013) Proc Natl Acad Sci U S A , vol.110 , Issue.29 , pp. 12108-12113
    • Guo, J.1    Zhou, Y.J.2    Hillwig, M.L.3    Shen, Y.4    Yang, L.5    Wang, Y.6
  • 23
    • 84886394800 scopus 로고    scopus 로고
    • Characterization of CYP76AH4 clarifies phenolic diterpenoid biosynthesis in the Lamiaceae
    • Zi J, Peters RJ. Characterization of CYP76AH4 clarifies phenolic diterpenoid biosynthesis in the Lamiaceae. Org Biomol Chem. 2013;11(44):7650-2.
    • (2013) Org Biomol Chem , vol.11 , Issue.44 , pp. 7650-7652
    • Zi, J.1    Peters, R.J.2
  • 24
    • 84894207903 scopus 로고    scopus 로고
    • Transcriptome analysis of medicinal plant Salvia miltiorrhiza and identification of genes related to tanshinone biosynthesis
    • Yang L, Ding G, Lin H, Cheng H, Kong Y, Wei Y, et al. Transcriptome analysis of medicinal plant Salvia miltiorrhiza and identification of genes related to tanshinone biosynthesis. PLoS One. 2013;8(11):e80464.
    • (2013) PLoS One , vol.8 , Issue.11
    • Yang, L.1    Ding, G.2    Lin, H.3    Cheng, H.4    Kong, Y.5    Wei, Y.6
  • 25
    • 84861060144 scopus 로고    scopus 로고
    • Genome-wide identification and characterization of novel genes involved in terpenoid biosynthesis in Salvia miltiorrhiza
    • Ma Y, Yuan L, Wu B, Li X, Chen S, Lu S. Genome-wide identification and characterization of novel genes involved in terpenoid biosynthesis in Salvia miltiorrhiza. J Exp Bot. 2012;63(7):2809-23.
    • (2012) J Exp Bot , vol.63 , Issue.7 , pp. 2809-2823
    • Ma, Y.1    Yuan, L.2    Wu, B.3    Li, X.4    Chen, S.5    Lu, S.6
  • 26
    • 84897113492 scopus 로고    scopus 로고
    • Characterization of two genes for the biosynthesis of abietane-type diterpenes in rosemary (Rosmarinus officinalis) glandular trichomes
    • Bruckner K, Bozic D, Manzano D, Papaefthimiou D, Pateraki I, Scheler U, et al. Characterization of two genes for the biosynthesis of abietane-type diterpenes in rosemary (Rosmarinus officinalis) glandular trichomes. Phytochemistry. 2014;101:52-64.
    • (2014) Phytochemistry , vol.101 , pp. 52-64
    • Bruckner, K.1    Bozic, D.2    Manzano, D.3    Papaefthimiou, D.4    Pateraki, I.5    Scheler, U.6
  • 27
    • 84932604670 scopus 로고    scopus 로고
    • Towards elucidating carnosic acid biosynthesis in lamiaceae: functional characterization of the three first steps of the pathway in salvia fruticosa and Rosmarinus officinalis
    • Bozic D, Papaefthimiou D, Bruckner K, de Vos RC, Tsoleridis CA, Katsarou D, et al. Towards elucidating carnosic acid biosynthesis in lamiaceae: functional characterization of the three first steps of the pathway in salvia fruticosa and Rosmarinus officinalis. PLoS One. 2015;10(5):e0124106.
    • (2015) PLoS One , vol.10 , Issue.5
    • Bozic, D.1    Papaefthimiou, D.2    Bruckner, K.3    de Vos, R.C.4    Tsoleridis, C.A.5    Katsarou, D.6
  • 28
    • 0000414297 scopus 로고
    • Pisiferic acid, a new phenolic diterpene carboxylic acid from Chamaecyparis pisifera S. et Z
    • Yatagai M, Shirato T, Hayashi Y, Fukuhara N. Pisiferic acid, a new phenolic diterpene carboxylic acid from Chamaecyparis pisifera S. et Z. Mokuzai Gakkaishi. 1978;24:3.
    • (1978) Mokuzai Gakkaishi , vol.24 , pp. 3
    • Yatagai, M.1    Shirato, T.2    Hayashi, Y.3    Fukuhara, N.4
  • 29
    • 0001476764 scopus 로고
    • New diterpenes from chamaecyparis-pisifera
    • Yatagai M, Takahashi T. New diterpenes from chamaecyparis-pisifera. Phytochemistry. 1980;19(6):1149-51.
    • (1980) Phytochemistry , vol.19 , Issue.6 , pp. 1149-1151
    • Yatagai, M.1    Takahashi, T.2
  • 30
    • 0025958285 scopus 로고
    • Traditional medicine of Baja California Sur (Mexico). III. Carnosol: a diterpene antibiotic from Lepechinia hastata
    • Dimayuga RE, Garcia SK, Nielsen PH, Christophersen C. Traditional medicine of Baja California Sur (Mexico). III. Carnosol: a diterpene antibiotic from Lepechinia hastata. J Ethnopharmacol. 1991;31(1):43-8.
    • (1991) J Ethnopharmacol , vol.31 , Issue.1 , pp. 43-48
    • Dimayuga, R.E.1    Garcia, S.K.2    Nielsen, P.H.3    Christophersen, C.4
  • 33
    • 84876119497 scopus 로고    scopus 로고
    • Structure activity relationship of phenolic diterpenes from Salvia officinalis as activators of the nuclear factor E2-related factor 2 pathway
    • Fischedick JT, Standiford M, Johnson DA, Johnson JA. Structure activity relationship of phenolic diterpenes from Salvia officinalis as activators of the nuclear factor E2-related factor 2 pathway. Bioorg Med Chem. 2013;21(9):2618-22.
    • (2013) Bioorg Med Chem , vol.21 , Issue.9 , pp. 2618-2622
    • Fischedick, J.T.1    Standiford, M.2    Johnson, D.A.3    Johnson, J.A.4
  • 35
    • 84901689537 scopus 로고    scopus 로고
    • RNA sequencing on Solanum lycopersicum trichomes identifies transcription factors that activate terpene synthase promoters
    • Spyropoulou EA, Haring MA, Schuurink RC. RNA sequencing on Solanum lycopersicum trichomes identifies transcription factors that activate terpene synthase promoters. BMC Genomics. 2014;15:402.
    • (2014) BMC Genomics , vol.15 , pp. 402
    • Spyropoulou, E.A.1    Haring, M.A.2    Schuurink, R.C.3
  • 36
    • 34547696794 scopus 로고    scopus 로고
    • Rational conversion of substrate and product specificity in a Salvia monoterpene synthase: structural insights into the evolution of terpene synthase function
    • Kampranis SC, Ioannidis D, Purvis A, Mahrez W, Ninga E, Katerelos NA, et al. Rational conversion of substrate and product specificity in a Salvia monoterpene synthase: structural insights into the evolution of terpene synthase function. Plant Cell. 2007;19(6):1994-2005.
    • (2007) Plant Cell , vol.19 , Issue.6 , pp. 1994-2005
    • Kampranis, S.C.1    Ioannidis, D.2    Purvis, A.3    Mahrez, W.4    Ninga, E.5    Katerelos, N.A.6
  • 37
    • 84920807143 scopus 로고    scopus 로고
    • Next generation sequencing unravels the biosynthetic ability of spearmint (Mentha spicata) peltate glandular trichomes through comparative transcriptomics
    • Jin J, Panicker D, Wang Q, Kim MJ, Liu J, Yin JL, et al. Next generation sequencing unravels the biosynthetic ability of spearmint (Mentha spicata) peltate glandular trichomes through comparative transcriptomics. BMC Plant Biol. 2014;14:292.
    • (2014) BMC Plant Biol , vol.14 , pp. 292
    • Jin, J.1    Panicker, D.2    Wang, Q.3    Kim, M.J.4    Liu, J.5    Yin, J.L.6
  • 38
    • 78049311312 scopus 로고    scopus 로고
    • Two rings in them all: the labdane-related diterpenoids
    • Peters RJ. Two rings in them all: the labdane-related diterpenoids. Nat Prod Rep. 2010;27(11):1521-30.
    • (2010) Nat Prod Rep , vol.27 , Issue.11 , pp. 1521-1530
    • Peters, R.J.1
  • 39
    • 84871384382 scopus 로고    scopus 로고
    • Positive genetic interactors of HMG2 identify a new set of genetic perturbations for improving sesquiterpene production in Saccharomyces cerevisiae
    • Ignea C, Trikka FA, Kourtzelis I, Argiriou A, Kanellis AK, Kampranis SC, et al. Positive genetic interactors of HMG2 identify a new set of genetic perturbations for improving sesquiterpene production in Saccharomyces cerevisiae. Microb Cell Fact. 2012;11:162.
    • (2012) Microb Cell Fact , vol.11 , pp. 162
    • Ignea, C.1    Trikka, F.A.2    Kourtzelis, I.3    Argiriou, A.4    Kanellis, A.K.5    Kampranis, S.C.6
  • 40
    • 84928555036 scopus 로고    scopus 로고
    • Iterative carotenogenic screens identify combinations of yeast gene deletions that enhance sclareol production
    • Trikka FA, Nikolaidis A, Athanasakoglou A, Andreadelli A, Ignea C, Kotta K, et al. Iterative carotenogenic screens identify combinations of yeast gene deletions that enhance sclareol production. Microb Cell Fact. 2015;14(1):60.
    • (2015) Microb Cell Fact , vol.14 , Issue.1 , pp. 60
    • Trikka, F.A.1    Nikolaidis, A.2    Athanasakoglou, A.3    Andreadelli, A.4    Ignea, C.5    Kotta, K.6
  • 41
    • 84912120800 scopus 로고    scopus 로고
    • Efficient diterpene production in yeast by engineering Erg20p into a geranylgeranyl diphosphate synthase
    • Ignea C, Trikka FA, Nikolaidis AK, Georgantea P, Ioannou E, Loupassaki S, et al. Efficient diterpene production in yeast by engineering Erg20p into a geranylgeranyl diphosphate synthase. Metab Eng. 2015;27:65-75.
    • (2015) Metab Eng , vol.27 , pp. 65-75
    • Ignea, C.1    Trikka, F.A.2    Nikolaidis, A.K.3    Georgantea, P.4    Ioannou, E.5    Loupassaki, S.6
  • 42
    • 67649392816 scopus 로고    scopus 로고
    • Alkaline pH enhances farnesol production by Saccharomyces cerevisiae
    • Muramatsu M, Ohto C, Obata S, Sakuradani E, Shimizu S. Alkaline pH enhances farnesol production by Saccharomyces cerevisiae. J Biosci Bioeng. 2009;108(1):52-5.
    • (2009) J Biosci Bioeng , vol.108 , Issue.1 , pp. 52-55
    • Muramatsu, M.1    Ohto, C.2    Obata, S.3    Sakuradani, E.4    Shimizu, S.5
  • 43
    • 84863116515 scopus 로고    scopus 로고
    • Modular pathway engineering of diterpenoid synthases and the mevalonic acid pathway for miltiradiene production
    • Zhou YJ, Gao W, Rong Q, Jin G, Chu H, Liu W, et al. Modular pathway engineering of diterpenoid synthases and the mevalonic acid pathway for miltiradiene production. J Am Chem Soc. 2012;134(6):3234-41.
    • (2012) J Am Chem Soc , vol.134 , Issue.6 , pp. 3234-3241
    • Zhou, Y.J.1    Gao, W.2    Rong, Q.3    Jin, G.4    Chu, H.5    Liu, W.6
  • 45
    • 79953234390 scopus 로고    scopus 로고
    • A P450-centric view of plant evolution
    • Nelson D, Werck-Reichhart D. A P450-centric view of plant evolution. PlantJ. 2011;66(1):194-211.
    • (2011) PlantJ , vol.66 , Issue.1 , pp. 194-211
    • Nelson, D.1    Werck-Reichhart, D.2
  • 46
  • 47
    • 73249132581 scopus 로고    scopus 로고
    • The cytochrome p450 homepage
    • Nelson DR. The cytochrome p450 homepage. Hum Genomics. 2009;4(1):59-65.
    • (2009) Hum Genomics , vol.4 , Issue.1 , pp. 59-65
    • Nelson, D.R.1
  • 48
    • 84916627604 scopus 로고    scopus 로고
    • Computational identification and systematic classification of novel cytochrome P450 genes in salvia miltiorrhiza
    • Chen H, Wu B, Nelson DR, Wu K, Liu C. Computational identification and systematic classification of novel cytochrome P450 genes in salvia miltiorrhiza. PLoS One. 2014;9(12):e115149.
    • (2014) PLoS One , vol.9 , Issue.12
    • Chen, H.1    Wu, B.2    Nelson, D.R.3    Wu, K.4    Liu, C.5
  • 49
    • 35748931196 scopus 로고    scopus 로고
    • Functional characterization of premnaspirodiene oxygenase, a cytochrome P450 catalyzing regio-and stereo-specific hydroxylations of diverse sesquiterpene substrates
    • Takahashi S, Yeo YS, Zhao Y, O'Maille PE, Greenhagen BT, Noel JP, et al. Functional characterization of premnaspirodiene oxygenase, a cytochrome P450 catalyzing regio-and stereo-specific hydroxylations of diverse sesquiterpene substrates. J Biol Chem. 2007;282(43):31744-54.
    • (2007) J Biol Chem , vol.282 , Issue.43 , pp. 31744-31754
    • Takahashi, S.1    Yeo, Y.S.2    Zhao, Y.3    O'Maille, P.E.4    Greenhagen, B.T.5    Noel, J.P.6
  • 50
    • 84872171321 scopus 로고    scopus 로고
    • Plant P450s as versatile drivers for evolution of speciesspecific chemical diversity
    • Hamberger B, Bak S. Plant P450s as versatile drivers for evolution of speciesspecific chemical diversity. Philos Trans R Soc Lond B Biol Sci. 2013;368(1612):20120426.
    • (2013) Philos Trans R Soc Lond B Biol Sci , vol.368 , Issue.1612
    • Hamberger, B.1    Bak, S.2
  • 52
    • 0023021864 scopus 로고
    • Biological activities of pisiferic acid and O-methylpisiferic acid
    • Kobayashi K, Nishino C. Biological activities of pisiferic acid and O-methylpisiferic acid. Agric Biol Chem. 1986;50(9):3.
    • (1986) Agric Biol Chem , vol.50 , Issue.9 , pp. 3
    • Kobayashi, K.1    Nishino, C.2
  • 53
    • 0011347892 scopus 로고
    • Antifungal activity of pisiferic acid-derivatives against the rice blast fungus
    • Kobayashi K, Nishino C, Tomita H, Fukushima M. Antifungal activity of pisiferic acid-derivatives against the rice blast fungus. Phytochemistry. 1987;26(12):3175-9.
    • (1987) Phytochemistry , vol.26 , Issue.12 , pp. 3175-3179
    • Kobayashi, K.1    Nishino, C.2    Tomita, H.3    Fukushima, M.4
  • 54
    • 79151472578 scopus 로고    scopus 로고
    • Pisiferdiol and pisiferic acid isolated from Chamaecyparis pisifera activate protein phosphatase 2C in vitro and induce caspase-3/7-dependent apoptosis via dephosphorylation of Bad in HL60 cells
    • Aburai N, Yoshida M, Ohnishi M, Kimura K. Pisiferdiol and pisiferic acid isolated from Chamaecyparis pisifera activate protein phosphatase 2C in vitro and induce caspase-3/7-dependent apoptosis via dephosphorylation of Bad in HL60 cells. Phytomedicine. 2010;17(10):782-8.
    • (2010) Phytomedicine , vol.17 , Issue.10 , pp. 782-788
    • Aburai, N.1    Yoshida, M.2    Ohnishi, M.3    Kimura, K.4
  • 55
    • 84888117192 scopus 로고    scopus 로고
    • Antileishmanial activity of 12-methoxycarnosic acid from Salvia repens Burch. ex Benth. (Lamiaceae)
    • Mokoka TA, Peter XK, Fouche G, Moodley N, Adams M, Hamburger M, et al. Antileishmanial activity of 12-methoxycarnosic acid from Salvia repens Burch. ex Benth. (Lamiaceae). S Afr J Bot. 2014;90:93-5.
    • (2014) S Afr J Bot , vol.90 , pp. 93-95
    • Mokoka, T.A.1    Peter, X.K.2    Fouche, G.3    Moodley, N.4    Adams, M.5    Hamburger, M.6
  • 56
    • 0041965870 scopus 로고    scopus 로고
    • Determination of the most bioactive phenolic compounds from rosemary against Listeria monocytogenes: influence of concentration, pH, and NaCl
    • Campo JD, Nguyen-The C, Sergent M, Amiot MJ. Determination of the most bioactive phenolic compounds from rosemary against Listeria monocytogenes: influence of concentration, pH, and NaCl. J Food Sci. 2003;68(6):2066-71.
    • (2003) J Food Sci , vol.68 , Issue.6 , pp. 2066-2071
    • Campo, J.D.1    Nguyen-The, C.2    Sergent, M.3    Amiot, M.J.4
  • 57
    • 84919460678 scopus 로고    scopus 로고
    • Tanshinone IIA inhibits viral oncogene expression leading to apoptosis and inhibition of cervical cancer
    • Munagala R, Aqil F, Jeyabalan J, Gupta RC. Tanshinone IIA inhibits viral oncogene expression leading to apoptosis and inhibition of cervical cancer. Cancer Lett. 2015;356(2 Pt B):536-46. doi:10.1016/j.canlet.2014.09.037.
    • (2015) Cancer Lett , vol.356 , Issue.2 , pp. 536-546
    • Munagala, R.1    Aqil, F.2    Jeyabalan, J.3    Gupta, R.C.4
  • 58
    • 70449516453 scopus 로고    scopus 로고
    • Global characterization of Artemisia annua glandular trichome transcriptome using 454 pyrosequencing
    • Wang W, Wang Y, Zhang Q, Qi Y, Guo D. Global characterization of Artemisia annua glandular trichome transcriptome using 454 pyrosequencing. BMC Genomics. 2009;10:465.
    • (2009) BMC Genomics , vol.10 , pp. 465
    • Wang, W.1    Wang, Y.2    Zhang, Q.3    Qi, Y.4    Guo, D.5
  • 59
    • 78651060921 scopus 로고    scopus 로고
    • Comparative functional genomic analysis of Solanum glandular trichome types
    • McDowell ET, Kapteyn J, Schmidt A, Li C, Kang JH, Descour A, et al. Comparative functional genomic analysis of Solanum glandular trichome types. Plant Physiol. 2011;155(1):524-39.
    • (2011) Plant Physiol , vol.155 , Issue.1 , pp. 524-539
    • McDowell, E.T.1    Kapteyn, J.2    Schmidt, A.3    Li, C.4    Kang, J.H.5    Descour, A.6
  • 61
    • 79953251042 scopus 로고    scopus 로고
    • The family of terpene synthases in plants: a mid-size family of genes for specialized metabolism that is highly diversified throughout the kingdom
    • Chen F, Tholl D, Bohlmann J, Pichersky E. The family of terpene synthases in plants: a mid-size family of genes for specialized metabolism that is highly diversified throughout the kingdom. Plant J. 2011;66(1):212-29.
    • (2011) Plant J , vol.66 , Issue.1 , pp. 212-229
    • Chen, F.1    Tholl, D.2    Bohlmann, J.3    Pichersky, E.4
  • 63
    • 84908565348 scopus 로고    scopus 로고
    • Dual function of the cytochrome P450 CYP76 family from Arabidopsis thaliana in the metabolism of monoterpenols and phenylurea herbicides
    • Hofer R, Boachon B, Renault H, Gavira C, Miesch L, Iglesias J, et al. Dual function of the cytochrome P450 CYP76 family from Arabidopsis thaliana in the metabolism of monoterpenols and phenylurea herbicides. Plant Physiol. 2014;166(3):1149-61.
    • (2014) Plant Physiol , vol.166 , Issue.3 , pp. 1149-1161
    • Hofer, R.1    Boachon, B.2    Renault, H.3    Gavira, C.4    Miesch, L.5    Iglesias, J.6
  • 64
    • 84929493482 scopus 로고    scopus 로고
    • The gymnosperm cytochrome P450 CYP750B1 catalyzes stereospecific monoterpene hydroxylation of (+)-sabinene in thujone biosynthesis in Thuja plicata
    • Bohlmann J, Gesell A, Blaukopf M, Madilao L, Yuen MM, Withers SG, et al. The gymnosperm cytochrome P450 CYP750B1 catalyzes stereospecific monoterpene hydroxylation of (+)-sabinene in thujone biosynthesis in Thuja plicata. Plant Physiol. 2015;168(1):94-106. doi:10.1104/pp.15.00315.
    • (2015) Plant Physiol , vol.168 , Issue.1 , pp. 94-106
    • Bohlmann, J.1    Gesell, A.2    Blaukopf, M.3    Madilao, L.4    Yuen, M.M.5    Withers, S.G.6
  • 66
    • 0033290515 scopus 로고    scopus 로고
    • ESTScan: a program for detecting, evaluating, and reconstructing potential coding regions in EST sequences
    • Iseli C, Jongeneel CV, Bucher P. ESTScan: a program for detecting, evaluating, and reconstructing potential coding regions in EST sequences. Proc Int Conf Intell Syst Mol Biol. 1999;7:138-48.
    • (1999) Proc Int Conf Intell Syst Mol Biol , vol.7 , pp. 138-148
    • Iseli, C.1    Jongeneel, C.V.2    Bucher, P.3
  • 67
    • 24644503098 scopus 로고    scopus 로고
    • Blast2GO: a universal tool for annotation, visualization and analysis in functional genomics research
    • Conesa A, Gotz S, Garcia-Gomez JM, Terol J, Talon M, Robles M. Blast2GO: a universal tool for annotation, visualization and analysis in functional genomics research. Bioinformatics. 2005;21(18):3674-6.
    • (2005) Bioinformatics , vol.21 , Issue.18 , pp. 3674-3676
    • Conesa, A.1    Gotz, S.2    Garcia-Gomez, J.M.3    Terol, J.4    Talon, M.5    Robles, M.6
  • 68
    • 33747846582 scopus 로고    scopus 로고
    • WEGO: a web tool for plotting GO annotations
    • Ye J, Fang L, Zheng H, Zhang Y, Chen J, Zhang Z, et al. WEGO: a web tool for plotting GO annotations. Nucleic Acids Res. 2006;34(Web Server issue):W293-7.
    • (2006) Nucleic Acids Res , vol.34 , Issue.Web Server Issue , pp. W293-W297
    • Ye, J.1    Fang, L.2    Zheng, H.3    Zhang, Y.4    Chen, J.5    Zhang, Z.6
  • 69
    • 0023375195 scopus 로고
    • The neighbor-joining method: a new method for reconstructing phylogenetic trees
    • Saitou N, Nei M. The neighbor-joining method: a new method for reconstructing phylogenetic trees. Mol Biol Evol. 1987;4(4):406-25.
    • (1987) Mol Biol Evol , vol.4 , Issue.4 , pp. 406-425
    • Saitou, N.1    Nei, M.2
  • 70
    • 0000461280 scopus 로고
    • Confidence-limits on phylogenies-an approach using the bootstrap
    • Felsenstein J. Confidence-limits on phylogenies-an approach using the bootstrap. Evolution. 1985;39(4):783-91.
    • (1985) Evolution , vol.39 , Issue.4 , pp. 783-791
    • Felsenstein, J.1
  • 72
    • 84890330527 scopus 로고    scopus 로고
    • MEGA6: Molecular Evolutionary Genetics Analysis version 6.0
    • Tamura K, Stecher G, Peterson D, Filipski A, Kumar S. MEGA6: Molecular Evolutionary Genetics Analysis version 6.0. Mol Biol Evol. 2013;30(12):2725-9.
    • (2013) Mol Biol Evol , vol.30 , Issue.12 , pp. 2725-2729
    • Tamura, K.1    Stecher, G.2    Peterson, D.3    Filipski, A.4    Kumar, S.5
  • 73
    • 0035710746 scopus 로고    scopus 로고
    • Analysis of relative gene expression data using real-time quantitative PCR and the 2-CT method
    • Livak KJ, Schmittgen TD. Analysis of relative gene expression data using real-time quantitative PCR and the 2-CT method. Methods. 2001;25(4):402-8.
    • (2001) Methods , vol.25 , Issue.4 , pp. 402-408
    • Livak, K.J.1    Schmittgen, T.D.2


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.