CYP76AH1 catalyzes turnover of miltiradiene in tanshinones biosynthesis and enables heterologous production of ferruginol in yeasts

Proceedings of the National Academy of Sciences of the United States of America

Volumn 110, Issue 29, 2013, Pages 12108-12113

  Guo, Juan ^a   Zhou, Yongjin J ^b   Hillwig, Matthew L ^c   Shen, Ye ^a   Yang, Lei ^d   Wang, Yajun ^a   Zhang, Xianan ^a   Liu, Wujun ^b   Peters, Reuben J ^c   Chen, Xiaoya ^d   Zhao, Zongbao K ^b   Huang, Luqi ^a  

^a INSTITUTE OF CHINESE MATERIA MEDICA   (China)

^b DALIAN INSTITUTE OF CHEMICAL PHYSICS   (China)

^c IOWA STATE UNIVERSITY   (United States)

^d INSTITUTE OF PLANT PHYSIOLOGY AND ECOLOGY   (China)

Author keywords

Gene Discovery; Metabolic Engineering; Phytoterpenoids Biosynthesis; Synthetic Pathway

Indexed keywords

ABIETANE DERIVATIVE; CYTOCHROME P450; CYTOCHROME P450 76AH1; CYTOCHROME P450 REDUCTASE; DITERPENE SYNTHASE; FERRUGINOL; MILTIRADIENE; SYNTHETASE; UNCLASSIFIED DRUG;

ARTICLE; CATALYSIS; CONTROLLED STUDY; DRUG DETERMINATION; DRUG ISOLATION; DRUG SYNTHESIS; FUNGAL GENE; FUNGAL METABOLISM; GENE FUNCTION; IN VITRO STUDY; IN VIVO STUDY; ISOTOPE LABELING; NONHUMAN; NUCLEOTIDE SEQUENCE; OXIDATION; PLANT ROOT; PRIORITY JOURNAL; RHIZOME; SACCHAROMYCES CEREVISIAE; SALVIA MILTIORRHIZA;

GENE DISCOVERY; METABOLIC ENGINEERING; PHYTOTERPENOIDS BIOSYNTHESIS; SYNTHETIC PATHWAY;

BASE SEQUENCE; CYTOCHROME P-450 ENZYME SYSTEM; DITERPENES; DITERPENES, ABIETANE; DNA PRIMERS; HIGH-THROUGHPUT NUCLEOTIDE SEQUENCING; ISOTOPE LABELING; KINETICS; MASS SPECTROMETRY; METABOLIC ENGINEERING; MOLECULAR SEQUENCE DATA; MOLECULAR STRUCTURE; REAL-TIME POLYMERASE CHAIN REACTION; SACCHAROMYCES CEREVISIAE; SALVIA MILTIORRHIZA;

EID: 84880380223     PISSN: 00278424     EISSN: 10916490     Source Type: Journal    
DOI: 10.1073/pnas.1218061110     Document Type: Article

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