Pisiferdiol and pisiferic acid isolated from Chamaecyparis pisifera activate protein phosphatase 2C in vitro and induce caspase-3/7-dependent apoptosis via dephosphorylation of Bad in HL60 cells

Phytomedicine

Volumn 17, Issue 10, 2010, Pages 782-788

  Aburai, N ^a   Yoshida, M ^b   Ohnishi, M ^b   Kimura, K ^a  

^a IWATE UNIVERSITY   (Japan)

^b CHUBU UNIVERSITY   (Japan)

Author keywords

Apoptosis; Bad; Chamaecyparis pisifera; Pisiferdiol; Pisiferic acid; PP2C activator

Indexed keywords

ALPHA CASEIN; CASPASE 3; CASPASE 7; DITERPENE; OLEIC ACID; PHOSPHOPROTEIN PHOSPHATASE; PHOSPHOPROTEIN PHOSPHATASE 2C; PISIFERDIOL; PISIFERIC ACID; PLANT EXTRACT; PROTEIN BAD; UNCLASSIFIED DRUG;

APOPTOSIS; ARTICLE; CELL STRAIN HL 60; CHAMAECYPARIS; CHAMAECYPARIS PISIFERA; CONTROLLED STUDY; CYTOTOXICITY; DRUG ISOLATION; DRUG STRUCTURE; DRUG SYNTHESIS; HUMAN; HUMAN CELL; IC 50; IN VITRO STUDY; PRIORITY JOURNAL; PROMYELOCYTIC LEUKEMIA; PROTEIN DEPHOSPHORYLATION; REGULATORY MECHANISM; STRUCTURE ACTIVITY RELATION;

CHAMAECYPARIS PISIFERA;

EID: 79151472578     PISSN: 09447113     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.phymed.2009.12.015     Document Type: Article

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