메뉴 건너뛰기




Volumn 10, Issue 5, 2015, Pages

Towards elucidating carnosic acid biosynthesis in Lamiaceae: Functional characterization of the three first steps of the pathway in Salvia fruticosa and Rosmarinus officinalis

(18)  Božić, Dragana a,j   Papaefthimiou, Dimitra a   Brückner, Kathleen b   De Vos, Ric C H c,i   Tsoleridis, Constantinos A a   Katsarou, Dimitra a   Papanikolaou, Antigoni a   Pateraki, Irini d,k   Chatzopoulou, Fani M a   Dimitriadou, Eleni a   Kostas, Stefanos f   Manzano, David d   Scheler, Ulschan b   Ferrer, Albert d,e   Tissier, Alain b   Makris, Antonios M g   Kampranis, Sotirios C h   Kanellis, Angelos K a  


Author keywords

[No Author keywords available]

Indexed keywords

CARNOSIC ACID; CYTOCHROME P450; TRANSCRIPTOME; ABIETANE DERIVATIVE; PLANT PROTEIN; TERPENE SYNTHASE; TRANSFERASE;

EID: 84932604670     PISSN: None     EISSN: 19326203     Source Type: Journal    
DOI: 10.1371/journal.pone.0124106     Document Type: Article
Times cited : (65)

References (59)
  • 1
    • 84862489794 scopus 로고    scopus 로고
    • Carnosol and carnosic acids from Salvia officinalis inhibit microsomal prostaglandin E2 synthase-1
    • PMID: 22511203
    • Bauer J, Kuehnl S, Rollinger JM, Scherer O, Northoff H, Stuppner H, et al. Carnosol and carnosic acids from Salvia officinalis inhibit microsomal prostaglandin E2 synthase-1. J Pharmacol Exp Ther. 2012; 342(1):169-176. doi: 10.1124/jpet.112.193847 PMID: 22511203
    • (2012) J Pharmacol Exp Ther , vol.342 , Issue.1 , pp. 169-176
    • Bauer, J.1    Kuehnl, S.2    Rollinger, J.M.3    Scherer, O.4    Northoff, H.5    Stuppner, H.6
  • 2
    • 45049087994 scopus 로고    scopus 로고
    • Carnosic acid and carnosol potently inhibit human 5-lipoxygenase and suppress pro-inflammatory responses of stimulated human polymorphonuclear leukocytes
    • PMID: 18508031
    • Poeckel D, Greiner C, Verhoff M, Rau O, Tausch L, Hörnig C, et al. Carnosic acid and carnosol potently inhibit human 5-lipoxygenase and suppress pro-inflammatory responses of stimulated human polymorphonuclear leukocytes. Biochem Pharmacol. 2008; 76(1):91-97. doi: 10.1016/j.bcp.2008.04.013 PMID: 18508031
    • (2008) Biochem Pharmacol , vol.76 , Issue.1 , pp. 91-97
    • Poeckel, D.1    Greiner, C.2    Verhoff, M.3    Rau, O.4    Tausch, L.5    Hörnig, C.6
  • 3
    • 84866170346 scopus 로고    scopus 로고
    • In vitro antioxidant and antiproliferative activity of three rosemary (Rosmarinus officinalis L.) extract formulations
    • Dilas S, Knez Ž, Četojević-Simin D, Tumbas V, Škerget M, Čanadanović-Brunet J, et al. In vitro antioxidant and antiproliferative activity of three rosemary (Rosmarinus officinalis L.) extract formulations. Int J Food Sci Technol. 2012; 47(10):2052-2062.
    • (2012) Int J Food Sci Technol , vol.47 , Issue.10 , pp. 2052-2062
    • Dilas, S.1    Knez Ž.2    Četojević-Simin, D.3    Tumbas, V.4    Škerget, M.5    Čanadanović-Brunet, J.6
  • 4
    • 84881517986 scopus 로고    scopus 로고
    • Polyphenols from the Mediterranean herb rosemary (Rosmarinus officinalis) for prostate cancer
    • PMID: 23531917
    • Petiwala SM, Puthenveetil AG, Johnson JJ. Polyphenols from the Mediterranean herb rosemary (Rosmarinus officinalis) for prostate cancer. Front Pharmacol. 2013; 4:29. doi: 10.3389/fphar.2013.00029 PMID: 23531917
    • (2013) Front Pharmacol , vol.4 , pp. 29
    • Petiwala, S.M.1    Puthenveetil, A.G.2    Johnson, J.J.3
  • 5
    • 84876119497 scopus 로고    scopus 로고
    • Structure activity relationship of phenolic diterpenes from Salvia officinalis as activators of the nuclear factor E2-related factor 2 pathway
    • PMID: 23507152
    • Fischedick JT, Standiford M, Johnson DA, Johnson JA. Structure activity relationship of phenolic diterpenes from Salvia officinalis as activators of the nuclear factor E2-related factor 2 pathway. Bioorg Med Chem; 2013; 21(9):2618-2622. doi: 10.1016/j.bmc.2013.02.019 PMID: 23507152
    • (2013) Bioorg Med Chem , vol.21 , Issue.9 , pp. 2618-2622
    • Fischedick, J.T.1    Standiford, M.2    Johnson, D.A.3    Johnson, J.A.4
  • 6
    • 84876860944 scopus 로고    scopus 로고
    • Carnosic acid, a phenolic diterpene from rosemary, prevents UV-induced expression of matrix metalloproteinases in human skin fibroblasts and keratinocytes
    • PMID: 23614740
    • Park M, Han J, Lee CS, Soo BH, Lim K-M, Ha H. Carnosic acid, a phenolic diterpene from rosemary, prevents UV-induced expression of matrix metalloproteinases in human skin fibroblasts and keratinocytes. Exp Dermatol. 2013; 22(5):336-341. doi: 10.1111/exd.12138 PMID: 23614740
    • (2013) Exp Dermatol , vol.22 , Issue.5 , pp. 336-341
    • Park, M.1    Han, J.2    Lee, C.S.3    Soo, B.H.4    Lim, K.-M.5    Ha, H.6
  • 7
    • 84866682726 scopus 로고    scopus 로고
    • Relevance of carnosic acid, carnosol, and rosmarinic acid concentrations in the in vitro antioxidant and antimicrobial activities of Rosmarinus officinalis L.) methanolic extracts
    • PMID: 22957812
    • Jordán MJ, Lax V, Rota MC, Lorán S, Sotomayor JA. Relevance of carnosic acid, carnosol, and rosmarinic acid concentrations in the in vitro antioxidant and antimicrobial activities of Rosmarinus officinalis (L.) methanolic extracts. J Agric Food Chem. 2012; 60(38):9603-9608. PMID: 22957812
    • (2012) J Agric Food Chem , vol.60 , Issue.38 , pp. 9603-9608
    • Jordán, M.J.1    Lax, V.2    Rota, M.C.3    Lorán, S.4    Sotomayor, J.A.5
  • 8
    • 84872674746 scopus 로고    scopus 로고
    • Anti-angiogenic properties of carnosol and carnosic acid, two major dietary compounds from rosemary
    • PMID: 22173778
    • López-Jiménez A, García-Caballero M, Medina MAÁ, Quesada AR. Anti-angiogenic properties of carnosol and carnosic acid, two major dietary compounds from rosemary. Eur J Nutr. 2013; 52(1):85-95. doi: 10.1007/s00394-011-0289-x PMID: 22173778
    • (2013) Eur J Nutr , vol.52 , Issue.1 , pp. 85-95
    • López-Jiménez, A.1    García-Caballero, M.2    Medina, M.A.A.3    Quesada, A.R.4
  • 9
    • 84887155976 scopus 로고    scopus 로고
    • Hepatoprotective effects of Thymus and Salvia essential oils on paracetamol-induced toxicity in rats
    • Banna H, Soliman M, Wabel N. Hepatoprotective effects of Thymus and Salvia essential oils on paracetamol-induced toxicity in rats. J Physiol Pharmacol Adv. 2013; 3(2):41.
    • (2013) J Physiol Pharmacol Adv , vol.3 , Issue.2 , pp. 41
    • Banna, H.1    Soliman, M.2    Wabel, N.3
  • 10
    • 84876195752 scopus 로고    scopus 로고
    • Antiadipogenic effect of carnosic acid a natural compound present in Rosmarinus officinalis is exerted through the C/EBPs and PPARγ pathways at the onset of the differentiation program
    • PMID: 23541989
    • Gaya M, Repetto V, Toneatto J, Anesini C, Piwien-Pilipuk G, Moreno S. Antiadipogenic effect of carnosic acid, a natural compound present in Rosmarinus officinalis, is exerted through the C/EBPs and PPARγ pathways at the onset of the differentiation program. Biochim Biophys Acta; 2013; 1830-(6):3796-3806. doi: 10.1016/j.bbagen.2013.03.021 PMID: 23541989
    • (2013) Biochim Biophys Acta , vol.1830 , Issue.6 , pp. 3796-3806
    • Gaya, M.1    Repetto, V.2    Toneatto, J.3    Anesini, C.4    Piwien-Pilipuk, G.5    Moreno, S.6
  • 11
    • 84884142887 scopus 로고    scopus 로고
    • Improved glycemic control and lipid profile in hyperlipidemic type 2 diabetic patients consuming Salvia officinalis L. Leaf extract: A randomized placebo. Controlled clinical trial
    • PMID: 24050577
    • Kianbakht S, Dabaghian FH. Improved glycemic control and lipid profile in hyperlipidemic type 2 diabetic patients consuming Salvia officinalis L. leaf extract: A randomized placebo. Controlled clinical trial. Complement Ther Med; 2013; 21(5):441-446. doi: 10.1016/j.ctim.2013.07.004 PMID: 24050577
    • (2013) Complement Ther Med , vol.21 , Issue.5 , pp. 441-446
    • Kianbakht, S.1    Dabaghian, F.H.2
  • 12
    • 0035183667 scopus 로고    scopus 로고
    • Antioxidant mechanism of carnosic acid: Structural identification of two oxidation products
    • PMID: 11714360
    • Masuda T, Inaba Y, Takeda Y. Antioxidant mechanism of carnosic acid: Structural identification of two oxidation products. J Agric Food Chem. 2001; 49(11):5560-5565. PMID: 11714360
    • (2001) J Agric Food Chem , vol.49 , Issue.11 , pp. 5560-5565
    • Masuda, T.1    Inaba, Y.2    Takeda, Y.3
  • 13
    • 0036829107 scopus 로고    scopus 로고
    • Antioxidant activity of sage (Salvia officinalis and S. Fruticosa) and oregano (Origanum onites and O. Indercedens) extracts related to their phenolic compound content
    • Pizzale L, Bortolomeazzi R, Vichi S, Überegger E, Conte LS. Antioxidant activity of sage (Salvia officinalis and S. fruticosa) and oregano (Origanum onites and O. indercedens) extracts related to their phenolic compound content. J Sci Food Agric. 2002; 82(14):1645-1651.
    • (2002) J Sci Food Agric , vol.82 , Issue.14 , pp. 1645-1651
    • Pizzale, L.1    Bortolomeazzi, R.2    Vichi, S.3    Überegger, E.4    Conte, L.S.5
  • 14
    • 0001635101 scopus 로고
    • Structure of a new antioxidative phenolic diterpene isolated from rosemary (Rosmarinus officinalis L
    • Inatani R, Fuwa H, Seto H, Nakatani N. Structure of a new antioxidative phenolic diterpene isolated from rosemary (Rosmarinus officinalis L.). Agric Biol Chem. 1982; 46(6):1661-1666.
    • (1982) Agric Biol Chem , vol.46 , Issue.6 , pp. 1661-1666
    • Inatani, R.1    Fuwa, H.2    Seto, H.3    Nakatani, N.4
  • 16
    • 0242331121 scopus 로고    scopus 로고
    • Antioxidant activity of organic extracts from aqueous infusions of sage
    • PMID: 14582962
    • Matsingou TC, Petrakis N, Kapsokefalou M, Salifoglou A. Antioxidant activity of organic extracts from aqueous infusions of sage. J Agric Food Chem. 2003; 51(23):6696-6701. PMID: 14582962
    • (2003) J Agric Food Chem , vol.51 , Issue.23 , pp. 6696-6701
    • Matsingou, T.C.1    Petrakis, N.2    Kapsokefalou, M.3    Salifoglou, A.4
  • 17
    • 84875371017 scopus 로고    scopus 로고
    • Polyphenolic characterization and chromatographic methods for fast assessment of culinary Salvia species from South East Europe
    • PMID: 23415138
    • Cvetkovikj I, Stefkov G, Acevska J, Stanoeva JP, Karapandzova M, Stefova M, et al. Polyphenolic characterization and chromatographic methods for fast assessment of culinary Salvia species from South East Europe. J Chromatogr A; 2013; 1282:38-45. doi: 10.1016/j.chroma.2012.12.068 PMID: 23415138
    • (2013) J Chromatogr A , vol.1282 , pp. 38-45
    • Cvetkovikj, I.1    Stefkov, G.2    Acevska, J.3    Stanoeva, J.P.4    Karapandzova, M.5    Stefova, M.6
  • 18
    • 70749152711 scopus 로고    scopus 로고
    • A functional genomics approach to tanshinone biosynthesis provides stereochemical insights
    • PMID: 19905026
    • Gao W, Hillwig ML, Huang L, Cui G, Wang X, Kong J, et al. A functional genomics approach to tanshinone biosynthesis provides stereochemical insights. Org Lett. 2009; 11(22):5170-5173. doi: 10.1021/ol902051v PMID: 19905026
    • (2009) Org Lett , vol.11 , Issue.22 , pp. 5170-5173
    • Gao, W.1    Hillwig, M.L.2    Huang, L.3    Cui, G.4    Wang, X.5    Kong, J.6
  • 19
    • 78049311312 scopus 로고    scopus 로고
    • Two rings in them all: The labdane-related diterpenoids
    • PMID: 20890488
    • Peters RJ. Two rings in them all: the labdane-related diterpenoids. Nat Prod Rep. 2010; 27(11):1521-1530. doi: 10.1039/c0np00019a PMID: 20890488
    • (2010) Nat Prod Rep , vol.27 , Issue.11 , pp. 1521-1530
    • Peters, R.J.1
  • 20
    • 77956656821 scopus 로고    scopus 로고
    • A copal-8-ol diphosphate synthase from the angiosperm Cistus creticus subsp creticus is a putative key enzyme for the formation of pharmacologically active, oxygencontaining labdane-type diterpenes
    • PMID: 20595348
    • Falara V, Pichersky E, Kanellis AK. A copal-8-ol diphosphate synthase from the angiosperm Cistus creticus subsp. creticus is a putative key enzyme for the formation of pharmacologically active, oxygencontaining labdane-type diterpenes. Plant Physiol. 2010; 154(1):301-310. doi: 10.1104/pp.110.159566 PMID: 20595348
    • (2010) Plant Physiol , vol.154 , Issue.1 , pp. 301-310
    • Falara, V.1    Pichersky, E.2    Kanellis, A.K.3
  • 21
    • 0028520249 scopus 로고
    • The Arabidopsis GA1 locus encodes the cyclase ent-kaurene synthetase A of gibberellin biosynthesis
    • PMID: 7994182
    • Sun T, Kamiya Y. The Arabidopsis GA1 locus encodes the cyclase ent-kaurene synthetase A of gibberellin biosynthesis. Plant Cell. 1994; 6(10): 1509-1518. PMID: 7994182
    • (1994) Plant Cell , vol.6 , Issue.10 , pp. 1509-1518
    • Sun, T.1    Kamiya, Y.2
  • 22
    • 0028145239 scopus 로고
    • Crystal structure of recombinant farnesyl diphosphate synthase at 2.6-A resolution
    • PMID: 8086404
    • Tarshis LC, Yan M, Poulter CD, Sacchettini JC. Crystal structure of recombinant farnesyl diphosphate synthase at 2.6-A resolution. Biochemistry. 1994; 33(36):10871-10877. PMID: 8086404
    • (1994) Biochemistry , vol.33 , Issue.36 , pp. 10871-10877
    • Tarshis, L.C.1    Yan, M.2    Poulter, C.D.3    Sacchettini, J.C.4
  • 23
    • 11144356535 scopus 로고    scopus 로고
    • An overview of gibberellin metabolism enzyme genes and their related mutants in rice
    • PMID: 15075394
    • Sakamoto T, Miura K, Itoh H, Tatsumi T, Ueguchi-Tanaka M, Ishiyama K, et al. An overview of gibberellin metabolism enzyme genes and their related mutants in rice. Plant Physiol. 2004; 134(4):1642-1653. PMID: 15075394
    • (2004) Plant Physiol , vol.134 , Issue.4 , pp. 1642-1653
    • Sakamoto, T.1    Miura, K.2    Itoh, H.3    Tatsumi, T.4    Ueguchi-Tanaka, M.5    Ishiyama, K.6
  • 24
    • 84897113492 scopus 로고    scopus 로고
    • Characterization of two genes for the biosynthesis of abietane-type diterpenes in rosemary (Rosmarinus officinalis) glandular trichomes
    • PMID: 24569175
    • Brückner K, Božić D, Manzano D, Papaefthimiou D, Pateraki I, Scheler U, et al. Characterization of two genes for the biosynthesis of abietane-type diterpenes in rosemary (Rosmarinus officinalis) glandular trichomes. Phytochemistry. 2014; 101:52-64. doi: 10.1016/j.phytochem.2014.01.021 PMID: 24569175
    • (2014) Phytochemistry , vol.101 , pp. 52-64
    • Brückner, K.1    Božić, D.2    Manzano, D.3    Papaefthimiou, D.4    Pateraki, I.5    Scheler, U.6
  • 25
    • 84880380223 scopus 로고    scopus 로고
    • CYP76AH1 catalyzes turnover of miltiradiene in tanshinones biosynthesis and enables heterologous production of ferruginol in yeasts
    • PMID: 23812755
    • Guo J, Zhou YJ, Hillwig ML, Shen Y, Yang L, Wang Y, et al. CYP76AH1 catalyzes turnover of miltiradiene in tanshinones biosynthesis and enables heterologous production of ferruginol in yeasts. Proc Natl Acad Sci U S A. 2013; 110(29):12108-12113. doi: 10.1073/pnas.1218061110 PMID: 23812755
    • (2013) Proc Natl Acad Sci U S A , vol.110 , Issue.29 , pp. 12108-12113
    • Guo, J.1    Zhou, Y.J.2    Hillwig, M.L.3    Shen, Y.4    Yang, L.5    Wang, Y.6
  • 26
    • 84886394800 scopus 로고    scopus 로고
    • Characterization of CYP76AH4 clarifies phenolic diterpenoid biosynthesis in the Lamiaceae
    • PMID: 24108414
    • Zi J, Peters RJ. Characterization of CYP76AH4 clarifies phenolic diterpenoid biosynthesis in the Lamiaceae. Org Biomol Chem. 2013; 11(44):7650-7652. doi: 10.1039/c3ob41885e PMID: 24108414
    • (2013) Org Biomol Chem , vol.11 , Issue.44 , pp. 7650-7652
    • Zi, J.1    Peters, R.J.2
  • 27
    • 77952430815 scopus 로고    scopus 로고
    • EST analysis and annotation of transcripts derived from a trichome-specific cDNA library from Salvia fruticosa
    • PMID: 20333525
    • Chatzopoulou FM, Makris AM, Argiriou A, Degenhardt J, Kanellis AK. EST analysis and annotation of transcripts derived from a trichome-specific cDNA library from Salvia fruticosa. Plant Cell Rep. 2010; 29(5):523-534. doi: 10.1007/s00299-010-0841-9 PMID: 20333525
    • (2010) Plant Cell Rep , vol.29 , Issue.5 , pp. 523-534
    • Chatzopoulou, F.M.1    Makris, A.M.2    Argiriou, A.3    Degenhardt, J.4    Kanellis, A.K.5
  • 28
    • 79953251042 scopus 로고    scopus 로고
    • The family of terpene synthases in plants: A mid-size family of genes for specialized metabolism that is highly diversified throughout the kingdom
    • PMID: 21443633
    • Chen F, Tholl D, Bohlmann J, Pichersky E. The family of terpene synthases in plants: a mid-size family of genes for specialized metabolism that is highly diversified throughout the kingdom. Plant J. 2011; 66-(1):212-229. doi: 10.1111/j.1365-313X.2011.04520.x PMID: 21443633
    • (2011) Plant J , vol.66 , Issue.1 , pp. 212-229
    • Chen, F.1    Tholl, D.2    Bohlmann, J.3    Pichersky, E.4
  • 29
    • 42749086594 scopus 로고    scopus 로고
    • Isolation and functional analysis of two Cistus creticus cDNAs encoding geranylgeranyl diphosphate synthase
    • PMID: 18402992
    • Pateraki I, Kanellis AK. Isolation and functional analysis of two Cistus creticus cDNAs encoding geranylgeranyl diphosphate synthase. Phytochemistry. 2008; 69(8):1641-1652. doi: 10.1016/j.phytochem.2008.02.005 PMID: 18402992
    • (2008) Phytochemistry , vol.69 , Issue.8 , pp. 1641-1652
    • Pateraki, I.1    Kanellis, A.K.2
  • 30
    • 79953234390 scopus 로고    scopus 로고
    • A P450-centric view of plant evolution
    • PMID: 21443632
    • Nelson D, Werck-Reichhart D. A P450-centric view of plant evolution. Plant J. 2011; 66(1):194-211. doi: 10.1111/j.1365-313X.2011.04529.x PMID: 21443632
    • (2011) Plant J , vol.66 , Issue.1 , pp. 194-211
    • Nelson, D.1    Werck-Reichhart, D.2
  • 31
    • 84908565348 scopus 로고    scopus 로고
    • Dual function of the cytochrome P450 CYP76 family from Arabidopsis thaliana in the metabolism of monoterpenols and phenylurea herbicides
    • PMID: 25082892
    • Höfer R, Boachon B, Renault H, Gavira C, Miesch L, Iglesias J, et al. Dual function of the cytochrome P450 CYP76 family from Arabidopsis thaliana in the metabolism of monoterpenols and phenylurea herbicides. Plant Physiol. 2014; 166(3):1149-1161. doi: 10.1104/pp.114.244814 PMID: 25082892
    • (2014) Plant Physiol , vol.166 , Issue.3 , pp. 1149-1161
    • Höfer, R.1    Boachon, B.2    Renault, H.3    Gavira, C.4    Miesch, L.5    Iglesias, J.6
  • 32
    • 0036918780 scopus 로고    scopus 로고
    • Cloning, functional expression, and subcellular localization of multiple NADPH-cytochrome P450 reductases from hybrid poplar
    • PMID: 12481067
    • Ro D, Ehlting J, Douglas C. Cloning, functional expression, and subcellular localization of multiple NADPH-cytochrome P450 reductases from hybrid poplar. Plant Physiol. 2002; 130:1837-1851. PMID: 12481067
    • (2002) Plant Physiol , vol.130 , pp. 1837-1851
    • Ro, D.1    Ehlting, J.2    Douglas, C.3
  • 33
    • 0026664734 scopus 로고
    • Antibacterial diterpenes from the leaves and seeds of Juniperus excelsa M. Bieb
    • Muhammad I, Mossa JS, El-Feraly FS. Antibacterial diterpenes from the leaves and seeds of Juniperus excelsa M. Bieb. Phyther Res. 1992; 6(5):261-264.
    • (1992) Phyther Res , vol.6 , Issue.5 , pp. 261-264
    • Muhammad, I.1    Mossa, J.S.2    El-Feraly, F.S.3
  • 34
    • 0032708574 scopus 로고    scopus 로고
    • Diterpenes from the fruits of Vitex rotundifolia
    • PMID: 10579867
    • Ono M, Yamamoto M, Masuoka C, Ito Y, Yamashita M, Nohara T. Diterpenes from the fruits of Vitex rotundifolia. J Nat Prod. 1999; 62(11):1532-1537. PMID: 10579867
    • (1999) J Nat Prod , vol.62 , Issue.11 , pp. 1532-1537
    • Ono, M.1    Yamamoto, M.2    Masuoka, C.3    Ito, Y.4    Yamashita, M.5    Nohara, T.6
  • 35
    • 0037280442 scopus 로고    scopus 로고
    • Potential antitumor promoting diterpenoids from the stem bark of Thuja standishii
    • PMID: 12567284
    • Iwamoto M, Minami T, Tokuda H, Ohtsu H, Tanaka R. Potential antitumor promoting diterpenoids from the stem bark of Thuja standishii. Planta Med. 2003; 69(1):69-72. PMID: 12567284
    • (2003) Planta Med , vol.69 , Issue.1 , pp. 69-72
    • Iwamoto, M.1    Minami, T.2    Tokuda, H.3    Ohtsu, H.4    Tanaka, R.5
  • 36
    • 33645958241 scopus 로고    scopus 로고
    • Gastroprotective and ulcer healing effect of ferruginol in mice and rats: Assessment of its mechanism of action using in vitro models
    • PMID: 16309708
    • Rodríguez JA, Theoduloz C, Yáñez T, Becerra J, Schmeda-Hirschmann G. Gastroprotective and ulcer healing effect of ferruginol in mice and rats: assessment of its mechanism of action using in vitro models. Life Sci. 2006; 78(21):2503-2509. PMID: 16309708
    • (2006) Life Sci , vol.78 , Issue.21 , pp. 2503-2509
    • Rodríguez, J.A.1    Theoduloz, C.2    Yáñez, T.3    Becerra, J.4    Schmeda-Hirschmann, G.5
  • 37
    • 84864148741 scopus 로고    scopus 로고
    • Discovery and functional characterization of two diterpene synthases for sclareol biosynthesis in Salvia sclarea (L.) and their relevance for perfume manufacture
    • Caniard A, Zerbe P, Legrand S, Cohade A, Valot N, Magnard J-L, et al. Discovery and functional characterization of two diterpene synthases for sclareol biosynthesis in Salvia sclarea (L.) and their relevance for perfume manufacture. BMC Plant Biol. 2012; 12(1):119.
    • (2012) BMC Plant Biol , vol.12 , Issue.1 , pp. 119
    • Caniard, A.1    Zerbe, P.2    Legrand, S.3    Cohade, A.4    Valot, N.5    Magnard, J.-L.6
  • 38
    • 84866738568 scopus 로고    scopus 로고
    • Characterization of two genes for the biosynthesis of the labdane diterpene Z-abienol in tobacco (Nicotiana tabacum) glandular trichomes
    • PMID: 22672125
    • Sallaud C, Giacalone C, Töpfer R, Goepfert S, Bakaher N, Rösti S, et al. Characterization of two genes for the biosynthesis of the labdane diterpene Z-abienol in tobacco (Nicotiana tabacum) glandular trichomes. Plant J. 2012; 72(1):1-17. doi: 10.1111/j.1365-313X.2012.05068.x PMID: 22672125
    • (2012) Plant J , vol.72 , Issue.1 , pp. 1-17
    • Sallaud, C.1    Giacalone, C.2    Töpfer, R.3    Goepfert, S.4    Bakaher, N.5    Rösti, S.6
  • 40
    • 36348964360 scopus 로고    scopus 로고
    • Identification of a biosynthetic gene cluster in rice for momilactones
    • PMID: 17872948
    • Shimura K, Okada A, Okada K, Jikumaru Y, Ko K-W, Toyomasu T, et al. Identification of a biosynthetic gene cluster in rice for momilactones. J Biol Chem. 2007; 282(47):34013-34018. PMID: 17872948
    • (2007) J Biol Chem , vol.282 , Issue.47 , pp. 34013-34018
    • Shimura, K.1    Okada, A.2    Okada, K.3    Jikumaru, Y.4    Ko, K.-W.5    Toyomasu, T.6
  • 41
    • 84863143888 scopus 로고    scopus 로고
    • Characterization of CYP76M5-8 indicates metabolic plasticity within a plant biosynthetic gene cluster
    • PMID: 22215681
    • Wang Q, Hillwig ML, Okada K, Yamazaki K,Wu Y, Swaminathan S, et al. Characterization of CYP76M5-8 indicates metabolic plasticity within a plant biosynthetic gene cluster. J Biol Chem. 2012; 287(9):6159-6168. doi: 10.1074/jbc.M111.305599 PMID: 22215681
    • (2012) J Biol Chem , vol.287 , Issue.9 , pp. 6159-6168
    • Wang, Q.1    Hillwig, M.L.2    Okada, K.3    Yamazaki Kwu, Y.4    Swaminathan, S.5
  • 42
    • 83555163776 scopus 로고    scopus 로고
    • Domain loss has independently occurred multiple times in plant terpene synthase evolution
    • PMID: 21999670
    • Hillwig ML, Xu M, Toyomasu T, Tiernan MS, Wei G, Cui G, et al. Domain loss has independently occurred multiple times in plant terpene synthase evolution. Plant J. 2011; 68(6):1051-1060. doi: 10.1111/j.1365-313X.2011.04756.x PMID: 21999670
    • (2011) Plant J , vol.68 , Issue.6 , pp. 1051-1060
    • Hillwig, M.L.1    Xu, M.2    Toyomasu, T.3    Tiernan, M.S.4    Wei, G.5    Cui, G.6
  • 43
    • 0000580010 scopus 로고    scopus 로고
    • Distribution and clinal variation of Salvia fruticosa Mill. (Labiatae) on the island of Crete (Greece)
    • Karousou R, Kokkini S. Distribution and clinal variation of Salvia fruticosa Mill. (Labiatae) on the island of Crete (Greece). Willdenowia; 1997; 27(1):113-120.
    • (1997) Willdenowia , vol.27 , Issue.1 , pp. 113-120
    • Karousou, R.1    Kokkini, S.2
  • 44
    • 0033200881 scopus 로고    scopus 로고
    • Evaluation of the genetic diversity of Salvia fruticosa Mill clones using RAPD markers and comparison with the essential oil profiles
    • Skoula M, El Hilali I, Makris AM. Evaluation of the genetic diversity of Salvia fruticosa Mill. clones using RAPD markers and comparison with the essential oil profiles. Biochem Syst Ecol. 1999; 27(6):559-568.
    • (1999) Biochem Syst Ecol , vol.27 , Issue.6 , pp. 559-568
    • Skoula, M.1    El Hilali, I.2    Makris, A.M.3
  • 45
    • 0034039727 scopus 로고    scopus 로고
    • Genetic variation of volatiles and rosmarinic acid in populations of Salvia fruticosa mill growing in Crete
    • PMID: 10793255
    • Skoula M, Abbes JE, Johnson CB. Genetic variation of volatiles and rosmarinic acid in populations of Salvia fruticosa mill growing in Crete. Biochem Syst Ecol. 2000; 28(6):551-561. PMID: 10793255
    • (2000) Biochem Syst Ecol , vol.28 , Issue.6 , pp. 551-561
    • Skoula, M.1    Abbes, J.E.2    Johnson, C.B.3
  • 46
    • 0001724552 scopus 로고    scopus 로고
    • Determination of the carnosic acid content in wild and cultivated Rosmarinus officinalis
    • Hidalgo PJ, Ubera JL, Tena MT, Valcárcel M. Determination of the carnosic acid content in wild and cultivated Rosmarinus officinalis. J Agric Food Chem. 1998; 46(7):2624-2627.
    • (1998) J Agric Food Chem , vol.46 , Issue.7 , pp. 2624-2627
    • Hidalgo, P.J.1    Ubera, J.L.2    Tena, M.T.3    Valcárcel, M.4
  • 47
    • 84857128778 scopus 로고    scopus 로고
    • Canopy position determines the photoprotective demand and antioxidant protection of leaves in salt-stressed Salvia officinalis L plants
    • Tounekti T, Abreu ME, Khemira H, Munné-Bosch S. Canopy position determines the photoprotective demand and antioxidant protection of leaves in salt-stressed Salvia officinalis L. plants. Environ Exp Bot; 2012; 78:146-156.
    • (2012) Environ Exp Bot , vol.78 , pp. 146-156
    • Tounekti, T.1    Abreu, M.E.2    Khemira, H.3    Munné-Bosch, S.4
  • 48
    • 54849404456 scopus 로고    scopus 로고
    • Transcriptome analysis approaches for the isolation of trichome-specific genes from the medicinal plant Cistus creticus subsp creticus
    • PMID: 18819010
    • Falara V, Fotopoulos V, Margaritis T, Anastasaki T, Pateraki I, Bosabalidis AM, et al. Transcriptome analysis approaches for the isolation of trichome-specific genes from the medicinal plant Cistus creticus subsp. creticus. Plant Mol Biol. 2008; 68(6):633-651. doi: 10.1007/s11103-008-9399-0 PMID: 18819010
    • (2008) Plant Mol Biol , vol.68 , Issue.6 , pp. 633-651
    • Falara, V.1    Fotopoulos, V.2    Margaritis, T.3    Anastasaki, T.4    Pateraki, I.5    Bosabalidis, A.M.6
  • 49
    • 0002809950 scopus 로고    scopus 로고
    • Wound-inducible genes in plants
    • Reynolds PHS, editor
    • Zhou L, Thornburg R. Wound-inducible genes in plants. In: Reynolds PHS, editor. Inducible Gene Expr Plants. 1999. p. 127-158.
    • (1999) Inducible Gene Expr Plants , pp. 127-158
    • Zhou, L.1    Thornburg, R.2
  • 50
    • 0035710746 scopus 로고    scopus 로고
    • Analysis of relative gene expression data using real-time quantitative PCR and the 2-ΔΔCT method
    • PMID: 11846609
    • Livak KJ, Schmittgen TD. Analysis of relative gene expression data using real-time quantitative PCR and the 2-ΔΔCT method. Methods. 2001; 25(4):402-408. PMID: 11846609
    • (2001) Methods , vol.25 , Issue.4 , pp. 402-408
    • Livak, K.J.1    Schmittgen, T.D.2
  • 51
    • 0042093607 scopus 로고    scopus 로고
    • Q-Gene: Processing quantitative real-time RT-PCR data
    • PMID: 12874059
    • Simon P. Q-Gene: processing quantitative real-time RT-PCR data. Bioinformatics. 2003; 19(11):1439-1440. PMID: 12874059
    • (2003) Bioinformatics , vol.19 , Issue.11 , pp. 1439-1440
    • Simon, P.1
  • 52
    • 79957613599 scopus 로고    scopus 로고
    • MEGA5: Molecular evolutionary genetics analysis using maximum likelihood, evolutionary distance, and maximum parsimony methods
    • PMID: 21546353
    • Tamura K, Peterson D, Peterson N, Stecher G, Nei M, Kumar S. MEGA5: molecular evolutionary genetics analysis using maximum likelihood, evolutionary distance, and maximum parsimony methods. Mol Biol Evol. 2011; 28(10):2731-2739. doi: 10.1093/molbev/msr121 PMID: 21546353
    • (2011) Mol Biol Evol , vol.28 , Issue.10 , pp. 2731-2739
    • Tamura, K.1    Peterson, D.2    Peterson, N.3    Stecher, G.4    Nei, M.5    Kumar, S.6
  • 53
    • 0034697980 scopus 로고    scopus 로고
    • Predicting subcellular localization of proteins based on their N-terminal amino acid sequence
    • PMID: 10891285
    • Emanuelsson O, Nielsen H, Brunak S, von Heijne G. Predicting subcellular localization of proteins based on their N-terminal amino acid sequence. J Mol Biol. 2000; 300(4):1005-1016. PMID: 10891285
    • (2000) J Mol Biol , vol.300 , Issue.4 , pp. 1005-1016
    • Emanuelsson, O.1    Nielsen, H.2    Brunak, S.3    Von Heijne, G.4
  • 54
    • 84871384382 scopus 로고    scopus 로고
    • Positive genetic interactors of HMG2 identify a new set of genetic perturbations for improving sesquiterpene production in Saccharomyces cerevisiae
    • Ignea C, Trikka FA, Kourtzelis I, Argiriou A, Kanellis AK, Kampranis SC, et al. Positive genetic interactors of HMG2 identify a new set of genetic perturbations for improving sesquiterpene production in Saccharomyces cerevisiae. Microb Cell Fact. 2012; 11(1):162.
    • (2012) Microb Cell Fact , vol.11 , Issue.1 , pp. 162
    • Ignea, C.1    Trikka, F.A.2    Kourtzelis, I.3    Argiriou, A.4    Kanellis, A.K.5    Kampranis, S.C.6
  • 55
    • 79251574154 scopus 로고    scopus 로고
    • Improving yeast strains using recyclable integration cassettes for the production of plant terpenoids
    • Ignea C, Cvetkovic I, Loupassaki S, Kefalas P, Johnson CB, Kampranis SC, et al. Improving yeast strains using recyclable integration cassettes, for the production of plant terpenoids. Microb Cell Fact; 2011; 10(1):4.
    • (2011) Microb Cell Fact , vol.10 , Issue.1 , pp. 4
    • Ignea, C.1    Cvetkovic, I.2    Loupassaki, S.3    Kefalas, P.4    Johnson, C.B.5    Kampranis, S.C.6
  • 57
    • 0027012738 scopus 로고
    • A versatile binary vector system with a T-DNA organisational structure conducive to efficient integration of cloned DNA into the plant genome
    • PMID: 1463857
    • Gleave AP. A versatile binary vector system with a T-DNA organisational structure conducive to efficient integration of cloned DNA into the plant genome. Plant Mol Biol. 1992; 20(6):1203-1207. PMID: 1463857
    • (1992) Plant Mol Biol , vol.20 , Issue.6 , pp. 1203-1207
    • Gleave, A.P.1
  • 58
    • 0037342553 scopus 로고    scopus 로고
    • An enhanced transient expression system in plants based on suppression of gene silencing by the p19 protein of tomato bushy stunt virus
    • PMID: 12609035
    • Voinnet O, Rivas S, Mestre P, Baulcombe D. An enhanced transient expression system in plants based on suppression of gene silencing by the p19 protein of tomato bushy stunt virus. Plant J. 2003; 33-(5):949-956. PMID: 12609035
    • (2003) Plant J , vol.33 , Issue.5 , pp. 949-956
    • Voinnet, O.1    Rivas, S.2    Mestre, P.3    Baulcombe, D.4
  • 59
    • 83355166952 scopus 로고    scopus 로고
    • Enzymatic 13)C labeling and multidimensional NMR analysis of miltiradiene synthesized by bifunctional diterpene cyclase in Selaginella moellendorffii
    • PMID: 22027823
    • Sugai Y, Ueno Y, Hayashi K, Oogami S, Toyomasu T, Matsumoto S, et al. Enzymatic (13)C labeling and multidimensional NMR analysis of miltiradiene synthesized by bifunctional diterpene cyclase in Selaginella moellendorffii. J Biol Chem. 2011; 286(50):42840-42847. doi: 10.1074/jbc.M111.302703 PMID: 22027823
    • (2011) J Biol Chem , vol.286 , Issue.50 , pp. 42840-42847
    • Sugai, Y.1    Ueno, Y.2    Hayashi, K.3    Oogami, S.4    Toyomasu, T.5    Matsumoto, S.6


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.