Carnosol, a dietary diterpene, displays growth inhibitory effects in human prostate cancer PC3 cells leading to G2-phase cell cycle arrest and targets the 5′-AMP-activated protein kinase (AMPK) pathway

Pharmaceutical Research

Volumn 25, Issue 9, 2008, Pages 2125-2134

  Johnson, Jeremy J ^a   Syed, Deeba N ^a   Heren, Chenelle R ^a   Suh, Yewseok ^a   Adhami, Vaqar M ^a   Mukhtar, Hasan ^a,b  

^a UNIVERSITY OF WISCONSIN SCHOOL OF MEDICINE AND PUBLIC HEALTH   (United States)

^b UNIVERSITY OF WISCONSIN MADISON   (United States)

Author keywords

Akt; AMPK; Carnosol; Chemoprevention; MTOR; PC3; Prostate cancer; Rosemary

Indexed keywords

CARNOSOL; DITERPENE; HYDROXYMETHYLGLUTARYL COENZYME A REDUCTASE KINASE; PROTEIN SERINE THREONINE KINASE;

ANTINEOPLASTIC ACTIVITY; ARTICLE; CANCER INHIBITION; CELL CYCLE ARREST; CELL CYCLE G2 PHASE; CELL ENERGY; CELL VIABILITY; CONTROLLED STUDY; DOSE TIME EFFECT RELATION; DRUG TARGETING; ENERGY BALANCE; FLOW CYTOMETRY; HUMAN; HUMAN CELL; PRIORITY JOURNAL; PROSTATE CANCER; WESTERN BLOTTING;

1-PHOSPHATIDYLINOSITOL 3-KINASE; ANTICARCINOGENIC AGENTS; APOPTOSIS REGULATORY PROTEINS; BLOTTING, WESTERN; CELL CYCLE PROTEINS; CELL LINE, TUMOR; CELL PROLIFERATION; CELL SURVIVAL; DITERPENES, ABIETANE; DOSE-RESPONSE RELATIONSHIP, DRUG; FLOW CYTOMETRY; G2 PHASE; HUMANS; MALE; MULTIENZYME COMPLEXES; PROSTATIC NEOPLASMS; PROTEIN ARRAY ANALYSIS; PROTEIN-SERINE-THREONINE KINASES; PROTO-ONCOGENE PROTEINS C-AKT; SIGNAL TRANSDUCTION; TIME FACTORS;

EID: 49549117517     PISSN: 07248741     EISSN: 1573904X     Source Type: Journal    
DOI: 10.1007/s11095-008-9552-0     Document Type: Article

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