메뉴 건너뛰기




Volumn 18, Issue 4, 2016, Pages 495-507

SIRT6 Controls Hematopoietic Stem Cell Homeostasis through Epigenetic Regulation of Wnt Signaling

Author keywords

epigenetic modification; hematopoietic stem cell; SIRT6; Wnt

Indexed keywords

LYMPHOID ENHANCER FACTOR 1; SIRTUIN 6; WNT PROTEIN; SIRT6 PROTEIN, MOUSE; SIRTUIN;

EID: 84962898781     PISSN: 19345909     EISSN: 18759777     Source Type: Journal    
DOI: 10.1016/j.stem.2016.03.005     Document Type: Article
Times cited : (118)

References (49)
  • 1
    • 84943796922 scopus 로고    scopus 로고
    • Epigenetic control of stem cell potential during homeostasis, aging, and disease
    • I. Beerman, and D.J. Rossi Epigenetic control of stem cell potential during homeostasis, aging, and disease Cell Stem Cell 16 2015 613 625
    • (2015) Cell Stem Cell , vol.16 , pp. 613-625
    • Beerman, I.1    Rossi, D.J.2
  • 6
    • 84861986053 scopus 로고    scopus 로고
    • Wnt/β-catenin signaling and disease
    • H. Clevers, and R. Nusse Wnt/β-catenin signaling and disease Cell 149 2012 1192 1205
    • (2012) Cell , vol.149 , pp. 1192-1205
    • Clevers, H.1    Nusse, R.2
  • 7
    • 33846036984 scopus 로고    scopus 로고
    • ICG-001, a novel small molecule regulator of TCF/beta-catenin transcription
    • M. Eguchi, C. Nguyen, S.C. Lee, and M. Kahn ICG-001, a novel small molecule regulator of TCF/beta-catenin transcription Med. Chem. 1 2005 467 472
    • (2005) Med. Chem. , vol.1 , pp. 467-472
    • Eguchi, M.1    Nguyen, C.2    Lee, S.C.3    Kahn, M.4
  • 14
    • 77956315551 scopus 로고    scopus 로고
    • Hepatic-specific disruption of SIRT6 in mice results in fatty liver formation due to enhanced glycolysis and triglyceride synthesis
    • H.S. Kim, C. Xiao, R.H. Wang, T. Lahusen, X. Xu, A. Vassilopoulos, G. Vazquez-Ortiz, W.I. Jeong, O. Park, S.H. Ki, and et al. Hepatic-specific disruption of SIRT6 in mice results in fatty liver formation due to enhanced glycolysis and triglyceride synthesis Cell Metab. 12 2010 224 236
    • (2010) Cell Metab. , vol.12 , pp. 224-236
    • Kim, H.S.1    Xiao, C.2    Wang, R.H.3    Lahusen, T.4    Xu, X.5    Vassilopoulos, A.6    Vazquez-Ortiz, G.7    Jeong, W.I.8    Park, O.9    Ki, S.H.10
  • 15
    • 33748850636 scopus 로고    scopus 로고
    • Activation of the canonical Wnt pathway leads to loss of hematopoietic stem cell repopulation and multilineage differentiation block
    • P. Kirstetter, K. Anderson, B.T. Porse, S.E. Jacobsen, and C. Nerlov Activation of the canonical Wnt pathway leads to loss of hematopoietic stem cell repopulation and multilineage differentiation block Nat. Immunol. 7 2006 1048 1056
    • (2006) Nat. Immunol. , vol.7 , pp. 1048-1056
    • Kirstetter, P.1    Anderson, K.2    Porse, B.T.3    Jacobsen, S.E.4    Nerlov, C.5
  • 16
    • 84892851452 scopus 로고    scopus 로고
    • Chromatin and beyond: The multitasking roles for SIRT6
    • S. Kugel, and R. Mostoslavsky Chromatin and beyond: the multitasking roles for SIRT6 Trends Biochem. Sci. 39 2014 72 81
    • (2014) Trends Biochem. Sci. , vol.39 , pp. 72-81
    • Kugel, S.1    Mostoslavsky, R.2
  • 19
    • 78049496814 scopus 로고    scopus 로고
    • MTOR activation induces tumor suppressors that inhibit leukemogenesis and deplete hematopoietic stem cells after Pten deletion
    • J.Y. Lee, D. Nakada, O.H. Yilmaz, Z. Tothova, N.M. Joseph, M.S. Lim, D.G. Gilliland, and S.J. Morrison mTOR activation induces tumor suppressors that inhibit leukemogenesis and deplete hematopoietic stem cells after Pten deletion Cell Stem Cell 7 2010 593 605
    • (2010) Cell Stem Cell , vol.7 , pp. 593-605
    • Lee, J.Y.1    Nakada, D.2    Yilmaz, O.H.3    Tothova, Z.4    Joseph, N.M.5    Lim, M.S.6    Gilliland, D.G.7    Morrison, S.J.8
  • 22
    • 58049203043 scopus 로고    scopus 로고
    • Wnt-related molecules and signaling pathway equilibrium in hematopoiesis
    • S. Malhotra, and P.W. Kincade Wnt-related molecules and signaling pathway equilibrium in hematopoiesis Cell Stem Cell 4 2009 27 36
    • (2009) Cell Stem Cell , vol.4 , pp. 27-36
    • Malhotra, S.1    Kincade, P.W.2
  • 23
    • 84925265469 scopus 로고    scopus 로고
    • Stem cell aging. A mitochondrial UPR-mediated metabolic checkpoint regulates hematopoietic stem cell aging
    • M. Mohrin, J. Shin, Y. Liu, K. Brown, H. Luo, Y. Xi, C.M. Haynes, and D. Chen Stem cell aging. A mitochondrial UPR-mediated metabolic checkpoint regulates hematopoietic stem cell aging Science 347 2015 1374 1377
    • (2015) Science , vol.347 , pp. 1374-1377
    • Mohrin, M.1    Shin, J.2    Liu, Y.3    Brown, K.4    Luo, H.5    Xi, Y.6    Haynes, C.M.7    Chen, D.8
  • 25
    • 38349132624 scopus 로고    scopus 로고
    • Deconstructing stem cell self-renewal: Genetic insights into cell-cycle regulation
    • K.W. Orford, and D.T. Scadden Deconstructing stem cell self-renewal: genetic insights into cell-cycle regulation Nat. Rev. Genet. 9 2008 115 128
    • (2008) Nat. Rev. Genet. , vol.9 , pp. 115-128
    • Orford, K.W.1    Scadden, D.T.2
  • 26
    • 39349096526 scopus 로고    scopus 로고
    • Hematopoiesis: An evolving paradigm for stem cell biology
    • S.H. Orkin, and L.I. Zon Hematopoiesis: an evolving paradigm for stem cell biology Cell 132 2008 631 644
    • (2008) Cell , vol.132 , pp. 631-644
    • Orkin, S.H.1    Zon, L.I.2
  • 27
    • 80052983495 scopus 로고    scopus 로고
    • Cooperation between both Wnt/beta-catenin and PTEN/PI3K/Akt signaling promotes primitive hematopoietic stem cell self-renewal and expansion
    • J.M. Perry, X.C. He, R. Sugimura, J.C. Grindley, J.S. Haug, S. Ding, and L. Li Cooperation between both Wnt/beta-catenin and PTEN/PI3K/Akt signaling promotes primitive hematopoietic stem cell self-renewal and expansion Genes Dev. 25 2011 1928 1942
    • (2011) Genes Dev. , vol.25 , pp. 1928-1942
    • Perry, J.M.1    He, X.C.2    Sugimura, R.3    Grindley, J.C.4    Haug, J.S.5    Ding, S.6    Li, L.7
  • 28
    • 84893810137 scopus 로고    scopus 로고
    • Re-entry into quiescence protects hematopoietic stem cells from the killing effect of chronic exposure to type I interferons
    • E.M. Pietras, R. Lakshminarasimhan, J.M. Techner, S. Fong, J. Flach, M. Binnewies, and E. Passegué Re-entry into quiescence protects hematopoietic stem cells from the killing effect of chronic exposure to type I interferons J. Exp. Med. 211 2014 245 262
    • (2014) J. Exp. Med. , vol.211 , pp. 245-262
    • Pietras, E.M.1    Lakshminarasimhan, R.2    Techner, J.M.3    Fong, S.4    Flach, J.5    Binnewies, M.6    Passegué, E.7
  • 34
    • 84879591586 scopus 로고    scopus 로고
    • Sirt1 ablation promotes stress-induced loss of epigenetic and genomic hematopoietic stem and progenitor cell maintenance
    • S.K. Singh, C.A. Williams, K. Klarmann, S.S. Burkett, J.R. Keller, and P. Oberdoerffer Sirt1 ablation promotes stress-induced loss of epigenetic and genomic hematopoietic stem and progenitor cell maintenance J. Exp. Med. 210 2013 987 1001
    • (2013) J. Exp. Med. , vol.210 , pp. 987-1001
    • Singh, S.K.1    Williams, C.A.2    Klarmann, K.3    Burkett, S.S.4    Keller, J.R.5    Oberdoerffer, P.6
  • 36
    • 84882436729 scopus 로고    scopus 로고
    • Deletion of the NF-κB subunit p65/RelA in the hematopoietic compartment leads to defects in hematopoietic stem cell function
    • S.J. Stein, and A.S. Baldwin Deletion of the NF-κB subunit p65/RelA in the hematopoietic compartment leads to defects in hematopoietic stem cell function Blood 121 2013 5015 5024
    • (2013) Blood , vol.121 , pp. 5015-5024
    • Stein, S.J.1    Baldwin, A.S.2
  • 37
    • 84899768899 scopus 로고    scopus 로고
    • Epigenomic profiling of young and aged HSCs reveals concerted changes during aging that reinforce self-renewal
    • D. Sun, M. Luo, M. Jeong, B. Rodriguez, Z. Xia, R. Hannah, H. Wang, T. Le, K.F. Faull, R. Chen, and et al. Epigenomic profiling of young and aged HSCs reveals concerted changes during aging that reinforce self-renewal Cell Stem Cell 14 2014 673 688
    • (2014) Cell Stem Cell , vol.14 , pp. 673-688
    • Sun, D.1    Luo, M.2    Jeong, M.3    Rodriguez, B.4    Xia, Z.5    Hannah, R.6    Wang, H.7    Le, T.8    Faull, K.F.9    Chen, R.10
  • 42
    • 30044444251 scopus 로고    scopus 로고
    • Glycogen synthase kinase-3 is an in vivo regulator of hematopoietic stem cell repopulation
    • J.J. Trowbridge, A. Xenocostas, R.T. Moon, and M. Bhatia Glycogen synthase kinase-3 is an in vivo regulator of hematopoietic stem cell repopulation Nat. Med. 12 2006 89 98
    • (2006) Nat. Med. , vol.12 , pp. 89-98
    • Trowbridge, J.J.1    Xenocostas, A.2    Moon, R.T.3    Bhatia, M.4
  • 47
    • 79952274786 scopus 로고    scopus 로고
    • SIRT6: A master epigenetic gatekeeper of glucose metabolism
    • L. Zhong, and R. Mostoslavsky SIRT6: a master epigenetic gatekeeper of glucose metabolism Transcription 1 2010 17 21
    • (2010) Transcription , vol.1 , pp. 17-21
    • Zhong, L.1    Mostoslavsky, R.2


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.