Sirt1 ablation promotes stress-induced loss of epigenetic and genomic hematopoietic stem and progenitor cell maintenance

Journal of Experimental Medicine

Volumn 210, Issue 5, 2013, Pages 987-1001

  Singh, Satyendra K ^a   Williams, Carrie A ^a   Klarmann, Kimberly ^a   Burkett, Sandra S ^a   Keller, Jonathan R ^a   Oberdoerffer, Philipp ^a  

^a SAIC FREDERICK INC   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

HISTONE; LYSINE; PROTEIN P53; SIRTUIN 1; HOMEODOMAIN PROTEIN; SIRT1 PROTEIN, MOUSE; TRANSCRIPTION FACTOR HOXA9;

ACETYLATION; ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ARTICLE; CELL LOSS; CELL STRESS; CONTROLLED STUDY; DNA DAMAGE; EPIGENETICS; GENE; GENOMIC INSTABILITY; GENOMICS; HEMATOPOIETIC STEM CELL; HISTONE MODIFICATION; HOMEOSTASIS; HOXA9 GENE; MOUSE; NONHUMAN; PRIORITY JOURNAL; STEM CELL EXPANSION; UPREGULATION; ADULT STEM CELL; ANIMAL; BIOLOGICAL MODEL; BONE MARROW TRANSPLANTATION; C57BL MOUSE; CELL PROLIFERATION; CELL PROTECTION; CHROMATIN; CYTOLOGY; GENE DELETION; GENE LOCUS; GENETIC EPIGENESIS; GENETICS; GENOME; METABOLISM; PHYSIOLOGICAL STRESS; PROTEIN BINDING;

ADULT STEM CELLS; ANIMALS; BONE MARROW TRANSPLANTATION; CELL PROLIFERATION; CHROMATIN; CYTOPROTECTION; DNA DAMAGE; EPIGENESIS, GENETIC; GENE DELETION; GENETIC LOCI; GENOME; GENOMIC INSTABILITY; HEMATOPOIETIC STEM CELLS; HISTONES; HOMEODOMAIN PROTEINS; MICE; MICE, INBRED C57BL; MODELS, BIOLOGICAL; PROTEIN BINDING; SIRTUIN 1; STRESS, PHYSIOLOGICAL; TUMOR SUPPRESSOR PROTEIN P53;

MLCS; MLOWN;

EID: 84879591586     PISSN: 00221007     EISSN: 15409538     Source Type: Journal    
DOI: 10.1084/jem.20121608     Document Type: Article

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