The histone deacetylase SIRT6 controls embryonic stem cell fate via TET-mediated production of 5-hydroxymethylcytosine

Nature Cell Biology

Volumn 17, Issue 5, 2015, Pages 545-557

  Etchegaray, Jean Pierre ^a   Chavez, Lukas ^b,g   Huang, Yun ^b,h   Ross, Kenneth N ^a   Choi, Jiho ^a   Martinez Pastor, Barbara ^a   Walsh, Ryan M ^a   Sommer, Cesar A ^c   Lienhard, Matthias ^b   Gladden, Adrianne ^d   Kugel, Sita ^a   Silberman, Dafne M ^e   Ramaswamy, Sridhar ^a   Mostoslavsky, Gustavo ^c   Hochedlinger, Konrad ^a,f   Goren, Alon ^d   Rao, Anjana ^b   Mostoslavsky, Raul ^a  

^a HARVARD MEDICAL SCHOOL   (United States)

^b LA JOLLA INSTITUTE FOR ALLERGY AND IMMUNOLOGY   (United States)

^c BOSTON UNIVERSITY SCHOOL OF MEDICINE   (United States)

^d BROAD INSTITUTE OF MIT AND HARVARD   (United States)

^e Facultad de Ciencias Naturales e Instituto M Lillo   (Argentina)

^f HOWARD HUGHES MEDICAL INSTITUTE   (United States)

^g GERMAN CANCER RESEARCH CENTER DKFZ   (Germany)

^h TEXAS A AND M HEALTH SCIENCE CENTER   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

5 HYDROXYMETHYLCYTOSINE; 5 METHYLCYTOSINE; HISTONE H3; OCTAMER TRANSCRIPTION FACTOR 4; SIRTUIN 6; TRANSCRIPTION FACTOR NANOG; TRANSCRIPTION FACTOR SOX2; 5-HYDROXYMETHYLCYTOSINE; CYTOSINE; DNA BINDING PROTEIN; HISTONE; HOMEODOMAIN PROTEIN; NANOG PROTEIN, MOUSE; ONCOPROTEIN; POU5F1 PROTEIN, MOUSE; SIRT6 PROTEIN, HUMAN; SIRT6 PROTEIN, MOUSE; SIRTUIN; SOX2 PROTEIN, MOUSE; TET1 PROTEIN, MOUSE; TET2 PROTEIN, MOUSE; TRANSCRIPTION FACTOR SOX;

ANIMAL CELL; ARTICLE; CELL DIFFERENTIATION; CELL FATE; CONTROLLED STUDY; EMBRYO; EMBRYONIC STEM CELL; ENZYME ACTIVITY; HISTONE ACETYLATION; IN VIVO STUDY; MOUSE; NEUROECTODERM; NONHUMAN; PRIORITY JOURNAL; PROTEIN EXPRESSION; UPREGULATION; 129 MOUSE; ACETYLATION; ANALOGS AND DERIVATIVES; ANIMAL; C57BL MOUSE; CELL CULTURE; CELL LINEAGE; CHROMATIN ASSEMBLY AND DISASSEMBLY; DEFICIENCY; ENZYMOLOGY; GENE EXPRESSION REGULATION; GENETIC TRANSFECTION; GENETICS; GENOTYPE; HUMAN; KNOCKOUT MOUSE; METABOLISM; NERVOUS SYSTEM DEVELOPMENT; PATHOLOGY; PHENOTYPE; PLURIPOTENT STEM CELL; RNA INTERFERENCE; SCID MOUSE; SIGNAL TRANSDUCTION; TERATOMA; TRANSPLANTATION;

MUS;

ACETYLATION; ANIMALS; CELL DIFFERENTIATION; CELL LINEAGE; CELLS, CULTURED; CHROMATIN ASSEMBLY AND DISASSEMBLY; CYTOSINE; DNA-BINDING PROTEINS; EMBRYONIC STEM CELLS; GENE EXPRESSION REGULATION, DEVELOPMENTAL; GENOTYPE; HISTONES; HOMEODOMAIN PROTEINS; HUMANS; INDUCED PLURIPOTENT STEM CELLS; MICE, 129 STRAIN; MICE, INBRED C57BL; MICE, KNOCKOUT; MICE, SCID; NEUROGENESIS; OCTAMER TRANSCRIPTION FACTOR-3; PHENOTYPE; PROTO-ONCOGENE PROTEINS; RNA INTERFERENCE; SIGNAL TRANSDUCTION; SIRTUINS; SOXB1 TRANSCRIPTION FACTORS; TERATOMA; TRANSFECTION;

EID: 84928938564     PISSN: 14657392     EISSN: 14764679     Source Type: Journal    
DOI: 10.1038/ncb3147     Document Type: Article

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