MicroRNAs in rheumatoid arthritis

Clinical Rheumatology

Volumn 34, Issue 4, 2015, Pages 615-628

  Salehi, Eisa ^a   Eftekhari, Rahil ^a   Oraei, Mona ^b   Gharib, Alvand ^b   Bidad, Katayoon ^c  

^a TEHRAN UNIVERSITY OF MEDICAL SCIENCES   (Iran)

^b TEHRAN UNIVERSITY OF MEDICAL SCIENCES   (Iran)

^c TEHRAN UNIVERSITY OF MEDICAL SCIENCES   (Iran)

Author keywords

Autoimmunity; Biomarkers; Immunology; Inflammation; MicroRNA; miRNA; Rheumatoid arthritis

Indexed keywords

MICRORNA; MICRORNA 124A; MICRORNA 125; MICRORNA 132; MICRORNA 133A; MICRORNA 142 3P; MICRORNA 142 5P; MICRORNA 146A; MICRORNA 155; MICRORNA 16; MICRORNA 17 92; MICRORNA 203; MICRORNA 22; MICRORNA 221; MICRORNA 222; MICRORNA 223; MICRORNA 23B; MICRORNA 24; MICRORNA 30A; MICRORNA 323P; MICRORNA 34; MICRORNA 346; MICRORNA 363; MICRORNA 451; MICRORNA 498; UNCLASSIFIED DRUG; ANTIINFLAMMATORY AGENT; BIOLOGICAL MARKER;

ARTICLE; COMPUTER MODEL; GENE OVEREXPRESSION; GENE SILENCING; HUMAN; IN VITRO STUDY; IN VIVO STUDY; INVESTIGATIVE PROCEDURES; MEDLINE; PRIORITY JOURNAL; RHEUMATOID ARTHRITIS; AUTOIMMUNE DISEASE; GENE EXPRESSION REGULATION; GENETICS; IMMUNE SYSTEM; INFLAMMATION; METABOLISM; MULTIGENE FAMILY; PROGNOSIS; TREATMENT OUTCOME;

ANTI-INFLAMMATORY AGENTS; ARTHRITIS, RHEUMATOID; AUTOIMMUNE DISEASES; BIOMARKERS; GENE EXPRESSION REGULATION; HUMANS; IMMUNE SYSTEM; INFLAMMATION; MICRORNAS; MULTIGENE FAMILY; PROGNOSIS; TREATMENT OUTCOME;

EID: 84925501083     PISSN: 07703198     EISSN: 14349949     Source Type: Journal    
DOI: 10.1007/s10067-015-2898-x     Document Type: Article

References (48)

1. Philippe L, Alsaleh G, Bahram S, Pfeffer S, Georgel P (2013) The miR-17 approximately 92 Cluster: a key player in the control of inflammation during rheumatoid arthritis. Front Immunol 4:70. doi:10.3389/fimmu.2013.00070
2. Nakamachi Y, Kawano S, Takenokuchi M, Nishimura K, Sakai Y, Chin T, Saura R, Kurosaka M, Kumagai S (2009) MicroRNA-124a is a key regulator of proliferation and monocyte chemoattractant protein 1 secretion in fibroblast-like synoviocytes from patients with rheumatoid arthritis. Arthritis Rheum 60(5):1294–1304. doi:10.1002/art.24475
3. Niederer F, Trenkmann M, Ospelt C, Karouzakis E, Neidhart M, Stanczyk J, Kolling C, Gay RE, Detmar M, Gay S, Jungel A, Kyburz D (2012) Down-regulation of microRNA-34a* in rheumatoid arthritis synovial fibroblasts promotes apoptosis resistance. Arthritis Rheum 64(6):1771–1779. doi:10.1002/art.34334
4. Niimoto T, Nakasa T, Ishikawa M, Okuhara A, Izumi B, Deie M, Suzuki O, Adachi N, Ochi M (2010) MicroRNA-146a expresses in interleukin-17 producing T cells in rheumatoid arthritis patients. BMC Musculoskelet Disord 11:209. doi:10.1186/1471-2474-11-209
5. Pauley KM, Satoh M, Chan AL, Bubb MR, Reeves WH, Chan EK (2008) Upregulated miR-146a expression in peripheral blood mononuclear cells from rheumatoid arthritis patients. Arthritis Res Ther 10(4):R101. doi:10.1186/ar2493
6. Murata K, Yoshitomi H, Tanida S, Ishikawa M, Nishitani K, Ito H, Nakamura T (2010) Plasma and synovial fluid microRNAs as potential biomarkers of rheumatoid arthritis and osteoarthritis. Arthritis Res Ther 12(3):R86. doi:10.1186/ar3013
7. Filkova M, Aradi B, Senolt L, Ospelt C, Vettori S, Mann H, Filer A, Raza K, Buckley CD, Snow M, Vencovsky J, Pavelka K, Michel BA, Gay RE, Gay S, Jungel A (2014) Association of circulating miR-223 and miR-16 with disease activity in patients with early rheumatoid arthritis. Ann Rheum Dis 73(10):1898–1904. doi:10.1136/annrheumdis-2012-202815
8. Trenkmann M, Brock M, Gay RE, Michel BA, Gay S, Huber LC (2013) Tumor necrosis factor alpha-induced microRNA-18a activates rheumatoid arthritis synovial fibroblasts through a feedback loop in NF-kappaB signaling. Arthritis Rheum 65(4):916–927. doi:10.1002/art.37834
9. Philippe L, Alsaleh G, Suffert G, Meyer A, Georgel P, Sibilia J, Wachsmann D, Pfeffer S (2012) TLR2 expression is regulated by microRNA miR-19 in rheumatoid fibroblast-like synoviocytes. J Immunol 188(1):454–461. doi:10.4049/jimmunol.1102348
10. Philippe L, Alsaleh G, Pichot A, Ostermann E, Zuber G, Frisch B, Sibilia J, Pfeffer S, Bahram S, Wachsmann D, Georgel P (2013) MiR-20a regulates ASK1 expression and TLR4-dependent cytokine release in rheumatoid fibroblast-like synoviocytes. Ann Rheum Dis 72(6):1071–1079. doi:10.1136/annrheumdis-2012-201654
11. Lin J, Huo R, Xiao L, Zhu X, Xie J, Sun S, He Y, Zhang J, Sun Y, Zhou Z, Wu P, Shen B, Li D, Li N (2014) A novel p53/microRNA-22/Cyr61 axis in synovial cells regulates inflammation in rheumatoid arthritis. Arthritis Rheum 66(1):49–59. doi:10.1002/art.38142
12. Zhu S, Pan W, Song X, Liu Y, Shao X, Tang Y, Liang D, He D, Wang H, Liu W, Shi Y, Harley JB, Shen N, Qian Y (2012) The microRNA miR-23b suppresses IL-17-associated autoimmune inflammation by targeting TAB2, TAB3 and IKK-alpha. Nat Med 18(7):1077–1086. doi:10.1038/nm.2815
13. Ham O, Lee CY, Song BW, Lee SY, Kim R, Park JH, Lee J, Seo HH, Lee CY, Chung YA, Maeng LS, Lee MY, Kim J, Hwang J, Woo DK, Chang W (2014) Upregulation of miR-23b enhances the autologous therapeutic potential for degenerative arthritis by targeting PRKACB in synovial fluid-derived mesenchymal stem cells from patients. Mol Cells 37(6):449–456. doi:10.14348/molcells.2014.0023
14. Murata K, Furu M, Yoshitomi H, Ishikawa M, Shibuya H, Hashimoto M, Imura Y, Fujii T, Ito H, Mimori T, Matsuda S (2013) Comprehensive microRNA analysis identifies miR-24 and miR-125a-5p as plasma biomarkers for rheumatoid arthritis. PLoS One 8(7):e69118. doi:10.1371/journal.pone.0069118
15. Xu K, Xu P, Yao JF, Zhang YG, Hou WK, Lu SM (2013) Reduced apoptosis correlates with enhanced autophagy in synovial tissues of rheumatoid arthritis. Inflamm Res Off J Eur Histamine Res Soc 62(2):229–237. doi:10.1007/s00011-012-0572-1
16. Lu MC, Yu CL, Chen HC, Yu HC, Huang HB, Lai NS (2014) Increased miR-223 expression in T cells from patients with rheumatoid arthritis leads to decreased insulin-like growth factor-1-mediated interleukin-10 production. Clin Exp Immunol 177(3):641–651. doi:10.1111/cei.12374
17. Gantier MP, Stunden HJ, McCoy CE, Behlke MA, Wang D, Kaparakis-Liaskos M, Sarvestani ST, Yang YH, Xu D, Corr SC, Morand EF, Williams BR (2012) A miR-19 regulon that controls NF-kappaB signaling. Nucleic Acids Res 40(16):8048–8058. doi:10.1093/nar/gks521
18. Zhou Q, Long L, Shi G, Zhang J, Wu T, Zhou B (2013) Research of the methylation status of miR-124a gene promoter among rheumatoid arthritis patients. Clin Dev Immunol 2013:524204. doi:10.1155/2013/524204
19. Duroux-Richard I, Pers YM, Fabre S, Ammari M, Baeten D, Cartron G, Touitou I, Jorgensen C, Apparailly F (2014) Circulating miRNA-125b is a potential biomarker predicting response to rituximab in rheumatoid arthritis. Mediat Inflamm 2014:342524. doi:10.1155/2014/342524
20. Li J, Wan Y, Guo Q, Zou L, Zhang J, Fang Y, Zhang J, Zhang J, Fu X, Liu H, Lu L, Wu Y (2010) Altered microRNA expression profile with miR-146a upregulation in CD4+ T cells from patients with rheumatoid arthritis. Arthritis Res Ther 12(3):R81. doi:10.1186/ar3006
21. Nakasa T, Miyaki S, Okubo A, Hashimoto M, Nishida K, Ochi M, Asahara H (2008) Expression of microRNA-146 in rheumatoid arthritis synovial tissue. Arthritis Rheum 58(5):1284–1292. doi:10.1002/art.23429
22. Abou-Zeid A, Saad M, Soliman E (2011) MicroRNA 146a expression in rheumatoid arthritis: association with tumor necrosis factor-alpha and disease activity. Genet Test Mol Biomarkers 15(11):807–812. doi:10.1089/gtmb.2011.0026
23. Lu LF, Boldin MP, Chaudhry A, Lin LL, Taganov KD, Hanada T, Yoshimura A, Baltimore D, Rudensky AY (2010) Function of miR-146a in controlling Treg cell-mediated regulation of Th1 responses. Cell 142(6):914–929. doi:10.1016/j.cell.2010.08.012
24. Zhou Q, Haupt S, Kreuzer JT, Hammitzsch A, Proft F, Neumann C, Leipe J, Witt M, Schulze-Koops H, Skapenko A (2014) Decreased expression of miR-146a and miR-155 contributes to an abnormal Treg phenotype in patients with rheumatoid arthritis. Ann Rheum Dis. doi:10.1136/annrheumdis-2013-204377
25. Nakasa T, Shibuya H, Nagata Y, Niimoto T, Ochi M (2011) The inhibitory effect of microRNA-146a expression on bone destruction in collagen-induced arthritis. Arthritis Rheum 63(6):1582–1590. doi:10.1002/art.30321
26. Stanczyk J, Pedrioli DM, Brentano F, Sanchez-Pernaute O, Kolling C, Gay RE, Detmar M, Gay S, Kyburz D (2008) Altered expression of MicroRNA in synovial fibroblasts and synovial tissue in rheumatoid arthritis. Arthritis Rheum 58(4):1001–1009. doi:10.1002/art.23386
27. Lu LF, Thai TH, Calado DP, Chaudhry A, Kubo M, Tanaka K, Loeb GB, Lee H, Yoshimura A, Rajewsky K, Rudensky AY (2009) Foxp3-dependent microRNA155 confers competitive fitness to regulatory T cells by targeting SOCS1 protein. Immunity 30(1):80–91. doi:10.1016/j.immuni.2008.11.010
28. Smigielska-Czepiel K, van den Berg A, Jellema P, van der Lei RJ, Bijzet J, Kluiver J, Boots AM, Brouwer E, Kroesen BJ (2014) Comprehensive analysis of miRNA expression in T-cell subsets of rheumatoid arthritis patients reveals defined signatures of naive and memory Tregs. Genes Immun 15(2):115–125. doi:10.1038/gene.2013.69
29. Ceppi M, Pereira PM, Dunand-Sauthier I, Barras E, Reith W, Santos MA, Pierre P (2009) MicroRNA-155 modulates the interleukin-1 signaling pathway in activated human monocyte-derived dendritic cells. Proc Natl Acad Sci U S A 106(8):2735–2740. doi:10.1073/pnas.0811073106
30. Kurowska-Stolarska M, Alivernini S, Ballantine LE, Asquith DL, Millar NL, Gilchrist DS, Reilly J, Ierna M, Fraser AR, Stolarski B, McSharry C, Hueber AJ, Baxter D, Hunter J, Gay S, Liew FY, McInnes IB (2011) MicroRNA-155 as a proinflammatory regulator in clinical and experimental arthritis. Proc Natl Acad Sci U S A 108(27):11193–11198. doi:10.1073/pnas.1019536108
31. Long L, Yu P, Liu Y, Wang S, Li R, Shi J, Zhang X, Li Y, Sun X, Zhou B, Cui L, Li Z (2013) Upregulated microRNA-155 expression in peripheral blood mononuclear cells and fibroblast-like synoviocytes in rheumatoid arthritis. Clin Dev Immunol 2013:296139. doi:10.1155/2013/296139
32. Li X, Tian F, Wang F (2013) Rheumatoid arthritis-associated microRNA-155 targets SOCS1 and upregulates TNF-alpha and IL-1beta in PBMCs. Int J Mol Sci 14(12):23910–23921. doi:10.3390/ijms141223910
33. Bluml S, Bonelli M, Niederreiter B, Puchner A, Mayr G, Hayer S, Koenders MI, van den Berg WB, Smolen J, Redlich K (2011) Essential role of microRNA-155 in the pathogenesis of autoimmune arthritis in mice. Arthritis Rheum 63(5):1281–1288. doi:10.1002/art.30281
34. Zhou H, Huang X, Cui H, Luo X, Tang Y, Chen S, Wu L, Shen N (2010) miR-155 and its star-form partner miR-155* cooperatively regulate type I interferon production by human plasmacytoid dendritic cells. Blood 116(26):5885–5894. doi:10.1182/blood-2010-04-280156
35. Davis TE, Kis-Toth K, Tsokos GC (2014) A114: methylprednisolone-induced inhibition of miR-155 expression increases SOCS1-driven suppression of cytokine signaling. Arthritis Rheum 66(Suppl 11):S151. doi:10.1002/art.38535
36. Stanczyk J, Ospelt C, Karouzakis E, Filer A, Raza K, Kolling C, Gay R, Buckley CD, Tak PP, Gay S, Kyburz D (2011) Altered expression of microRNA-203 in rheumatoid arthritis synovial fibroblasts and its role in fibroblast activation. Arthritis Rheum 63(2):373–381. doi:10.1002/art.30115
37. Pandis I, Ospelt C, Karagianni N, Denis MC, Reczko M, Camps C, Hatzigeorgiou AG, Ragoussis J, Gay S, Kollias G (2012) Identification of microRNA-221/222 and microRNA-323-3p association with rheumatoid arthritis via predictions using the human tumour necrosis factor transgenic mouse model. Ann Rheum Dis 71(10):1716–1723. doi:10.1136/annrheumdis-2011-200803
38. Fulci V, Scappucci G, Sebastiani GD, Giannitti C, Franceschini D, Meloni F, Colombo T, Citarella F, Barnaba V, Minisola G, Galeazzi M, Macino G (2010) miR-223 is overexpressed in T-lymphocytes of patients affected by rheumatoid arthritis. Hum Immunol 71(2):206–211. doi:10.1016/j.humimm.2009.11.008
39. Shibuya H, Nakasa T, Adachi N, Nagata Y, Ishikawa M, Deie M, Suzuki O, Ochi M (2013) Overexpression of microRNA-223 in rheumatoid arthritis synovium controls osteoclast differentiation. Mod Rheumatol Jpn Rheum Assoc 23(4):674–685. doi:10.1007/s10165-012-0710-1
40. Li YT, Chen SY, Wang CR, Liu MF, Lin CC, Jou IM, Shiau AL, Wu CL (2012) Brief report: amelioration of collagen-induced arthritis in mice by lentivirus-mediated silencing of microRNA-223. Arthritis Rheum 64(10):3240–3245. doi:10.1002/art.34550
41. Alsaleh G, Suffert G, Semaan N, Juncker T, Frenzel L, Gottenberg JE, Sibilia J, Pfeffer S, Wachsmann D (2009) Bruton’s tyrosine kinase is involved in miR-346-related regulation of IL-18 release by lipopolysaccharide-activated rheumatoid fibroblast-like synoviocytes. J Immunol 182(8):5088–5097. doi:10.4049/jimmunol.0801613
42. Semaan N, Frenzel L, Alsaleh G, Suffert G, Gottenberg JE, Sibilia J, Pfeffer S, Wachsmann D (2011) miR-346 controls release of TNF-alpha protein and stability of its mRNA in rheumatoid arthritis via tristetraprolin stabilization. PloS One 6(5):e19827. doi:10.1371/journal.pone.0019827
43. Murata K, Yoshitomi H, Furu M, Ishikawa M, Shibuya H, Ito H, Matsuda S (2014) MicroRNA-451 down-regulates neutrophil chemotaxis via p38 MAPK. Arthritis Rheumatol 66(3):549–559. doi:10.1002/art.38269
44. Miao CG, Yang YY, He X, Li XF, Huang C, Huang Y, Zhang L, Lv XW, Jin Y, Li J (2013) Wnt signaling pathway in rheumatoid arthritis, with special emphasis on the different roles in synovial inflammation and bone remodeling. Cell Signal 25(10):2069–2078. doi:10.1016/j.cellsig.2013.04.002
45. Alevizos I, Illei GG (2010) MicroRNAs as biomarkers in rheumatic diseases. Nat Rev Rheumatol 6(7):391–398. doi:10.1038/nrrheum.2010.81
46. Mookherjee N, El-Gabalawy HS (2013) High degree of correlation between whole blood and PBMC expression levels of miR-155 and miR-146a in healthy controls and rheumatoid arthritis patients. J Immunol Methods 400–401:106–110. doi:10.1016/j.jim.2013.10.001
47. Kawano S, Nakamachi Y (2011) miR-124a as a key regulator of proliferation and MCP-1 secretion in synoviocytes from patients with rheumatoid arthritis. Ann Rheum Dis 70(Suppl 1):i88–i91. doi:10.1136/ard.2010.138669
48. Nakamachi Y, Ohnuma K, Uto K, Noguchi Y, Saegusa J, Kawano S (2015) MicroRNA-124 inhibits the progression of adjuvant-induced arthritis in rats. Ann Rheum Dis. doi:10.1136/annrheumdis-2014-206417