Natural indoles, indole-3-carbinol (I3C) and 3,3′-diindolylmethane (DIM), attenuate staphylococcal enterotoxin B-mediated liver injury by downregulating miR-31 expression and promoting caspase-2-mediated apoptosis

PLoS ONE

Volumn 10, Issue 2, 2015, Pages

  Busbee, Philip B ^a   Nagarkatti, Mitzi ^a,b   Nagarkatti, Prakash S ^a  

^a UNIVERSITY OF SOUTH CAROLINA SCHOOL OF MEDICINE   (United States)

^b WJB Dorn VA Medical Center   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

3 INDOLEMETHANOL; 3,3' DIINDOLYLMETHANE; ASPARTATE AMINOTRANSFERASE; CASPASE 2; CASPASE 3; CASPASE 8; CASPASE 9; GALACTOSAMINE; MICRORNA 31; PROTEIN BCL 2; STAPHYLOCOCCUS ENTEROTOXIN B; AUTACOID; CYTOKINE; DIINDOLYLMETHANE; ENTEROTOXIN; ENTEROTOXIN B, STAPHYLOCOCCAL; INDOLE DERIVATIVE; INDOLE-3-CARBINOL; MICRORNA; MIRN31 MICRORNA, MOUSE;

ADULT; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ANTIINFLAMMATORY ACTIVITY; APOPTOSIS; ARTICLE; CELL INFILTRATION; CONTROLLED STUDY; CYTOKINE RELEASE; DOWN REGULATION; ENZYME ACTIVATION; FEMALE; IN VITRO STUDY; IN VIVO STUDY; LIVER INJURY; MOUSE; NONHUMAN; PROTEIN EXPRESSION; T LYMPHOCYTE ACTIVATION; ANIMAL; C57BL MOUSE; CHEMICAL AND DRUG INDUCED LIVER INJURY; DRUG EFFECTS; GENETICS; IMMUNOLOGY; LIVER; METABOLISM; REVERSE TRANSCRIPTION POLYMERASE CHAIN REACTION; T LYMPHOCYTE; WESTERN BLOTTING;

MUS;

ANIMALS; APOPTOSIS; ASPARTATE AMINOTRANSFERASES; BLOTTING, WESTERN; CASPASE 2; CHEMICAL AND DRUG INDUCED LIVER INJURY; CYTOKINES; DOWN-REGULATION; ENTEROTOXINS; FEMALE; INDOLES; INFLAMMATION MEDIATORS; LIVER; MICE, INBRED C57BL; MICRORNAS; PROTO-ONCOGENE PROTEINS C-BCL-2; REVERSE TRANSCRIPTASE POLYMERASE CHAIN REACTION; T-LYMPHOCYTES;

EID: 84923343158     PISSN: None     EISSN: 19326203     Source Type: Journal    
DOI: 10.1371/journal.pone.0118506     Document Type: Article

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