Cytotoxicity of crystals involves RIPK3-MLKL-mediated necroptosis

Nature Communications

Volumn 7, Issue , 2016, Pages

  Mulay, Shrikant R ^a   Desai, Jyaysi ^a   Kumar, Santhosh V ^a   Eberhard, Jonathan N ^a   Thomasova, Dana ^a   Romoli, Simone ^a   Grigorescu, Melissa ^a   Kulkarni, Onkar P ^a   Popper, Bastian ^b   Vielhauer, Volker ^a   Zuchtriegel, Gabriele ^a   Reichel, Christoph ^a   Bräsen, Jan Hinrich ^c   Romagnani, Paola ^d   Bilyy, Rostyslav ^e   Munoz, Luis E ^f   Herrmann, Martin ^f   Liapis, Helen ^g,h   Krautwald, Stefan ⁱ   Linkermann, Andreas ⁱ   Anders, Hans Joachim ^a   more..

^a LUDWIG MAXIMILIANS UNIVERSITY   (Germany)

^b UNIVERSITY OF MUNICH   (Germany)

^c HANNOVER MEDICAL SCHOOL   (Germany)

^d UNIVERSITY OF FLORENCE   (Italy)

^e DANYLO HALYTSKY LVIV NATIONAL MEDICAL UNIVERSITY   (Ukraine)

^f UNIVERSITY HOSPITAL ERLANGEN   (Germany)

^g WASHINGTON UNIVERSITY SCHOOL OF MEDICINE   (United States)

^h Nephropath   (United States)

ⁱ UNIVERSITY OF KIEL   (Germany)

Author keywords

[No Author keywords available]

Indexed keywords

CALCIUM OXALATE; CALCIUM PYROPHOSPHATE; CASPASE; CORE PROTEIN; CYSTINE; ETANERCEPT; MIXED LINEAGE KINASE; MIXED LINEAGE KINASE DOMAIN LIKE; NECROSTATIN 1; NECROSULFONAMIDE; OXALIC ACID; PROTEIN KINASE; PROTEIN KINASE INHIBITOR; RNA INTERFERENCE FOR RECEPTOR INTERACTING PROTEIN KINASE 1; RNA INTERFERENCE FOR RECEPTOR INTERACTING PROTEIN KINASE 3; TUMOR NECROSIS FACTOR ALPHA; TUMOR NECROSIS FACTOR RECEPTOR 1; UNCLASSIFIED DRUG; URATE; MLKL PROTEIN, MOUSE; RECEPTOR INTERACTING PROTEIN SERINE THREONINE KINASE; RIPK3 PROTEIN, MOUSE; TUMOR NECROSIS FACTOR; URIC ACID;

AMINO ACID; APOPTOSIS; CALCIUM; CELLS AND CELL COMPONENTS; CRYSTAL STRUCTURE; ENZYME ACTIVITY; GENE EXPRESSION; HOMINID; INJURY; PROTEIN; RNA; SODIUM; TOXICITY;

ACUTE KIDNEY FAILURE; ANIMAL EXPERIMENT; ANIMAL MODEL; ARTICLE; CELL DEATH; CLINICAL ASSESSMENT; CLINICAL EVALUATION; CONTROLLED STUDY; CRYSTAL STRUCTURE; CYTOTOXICITY; HUMAN; HUMAN CELL; INFLAMMATION; KIDNEY TUBULE CELL; MOUSE; MULTIPLE ORGAN FAILURE; NECROPTOSIS; NECROSIS; NEPHRITIS; NONHUMAN; PROTEIN PHOSPHORYLATION; RNA INTERFERENCE; SIGNAL TRANSDUCTION; STEM CELL; TISSUE INJURY; ANIMAL; APOPTOSIS; BAGG ALBINO MOUSE; C57BL MOUSE; CHEMISTRY; GENETICS; KIDNEY DISEASE; METABOLISM; PATHOPHYSIOLOGY; PHOSPHORYLATION;

ANIMALS; APOPTOSIS; CALCIUM OXALATE; CALCIUM PYROPHOSPHATE; HUMANS; KIDNEY DISEASES; MICE; MICE, INBRED BALB C; MICE, INBRED C57BL; NECROSIS; PHOSPHORYLATION; PROTEIN KINASES; RECEPTOR-INTERACTING PROTEIN SERINE-THREONINE KINASES; TUMOR NECROSIS FACTOR-ALPHA; URIC ACID;

EID: 84961380738     PISSN: None     EISSN: 20411723     Source Type: Journal    
DOI: 10.1038/ncomms10274     Document Type: Article

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