Axin cancer mutants form nanoaggregates to rewire the Wnt signaling network

Nature Structural and Molecular Biology

Volumn 23, Issue 4, 2016, Pages 324-332

  Anvarian, Zeinab ^a   Nojima, Hisashi ^b   Van Kappel, Eline C ^a   Madl, Tobias ^c,d,e,f   Spit, Maureen ^a   Viertler, Martin ^d   Jordens, Ingrid ^a   Low, Teck Y ^c,g   Van Scherpenzeel, Revina C ^a   Kuper, Ineke ^a   Richter, Klaus ^h   Heck, Albert J R ^c,g   Boelens, Rolf ^c   Vincent, Jean Paul ^b   Rüdiger, Stefan G D ^c   Maurice, Madelon M ^a  

^a UNIVERSITY MEDICAL CENTER UTRECHT   (Netherlands)

^b THE FRANCIS CRICK INSTITUTE   (United Kingdom)

^c UTRECHT UNIVERSITY   (Netherlands)

^d INSTITUTE OF EPIDEMIOLOGY   (Germany)

^e MEDICAL UNIVERSITY OF GRAZ   (Austria)

^f BIOTECHMED GRAZ   (Austria)

^g NETHERLANDS PROTEOMICS CENTRE   (Netherlands)

^h TECHNICAL UNIVERSITY OF MUNICH   (Germany)

Author keywords

[No Author keywords available]

Indexed keywords

AXIN; BETA CATENIN; MOLECULAR SCAFFOLD; DROSOPHILA PROTEIN; PROTEIN AGGREGATE;

ALLOSTERISM; ANIMAL EXPERIMENT; ANIMAL MODEL; ARTICLE; CANCER THERAPY; CIRCULAR DICHROISM; CONTROLLED STUDY; CYTOSOLIC FRACTION; DNA DAMAGE; GAIN OF FUNCTION MUTATION; GLUCOSE METABOLISM; HOMOLOGOUS RECOMBINATION; HYDROPHOBICITY; IN VIVO STUDY; NEOPLASM; NONHUMAN; PARTICLE SIZE; PHENOTYPE; POINT MUTATION; POLYMERIZATION; PRIORITY JOURNAL; TUMOR GROWTH; WILD TYPE; WNT SIGNALING PATHWAY; X RAY CRYSTALLOGRAPHY; AMINO ACID SEQUENCE; ANIMAL; CELL LINE; CHEMICAL STRUCTURE; CHEMISTRY; DROSOPHILA; GENETICS; HEK293 CELL LINE; HUMAN; METABOLISM; MISSENSE MUTATION; MOLECULAR GENETICS; MOUSE; PATHOLOGY; PROTEIN CONFORMATION; PROTEIN PROTEIN INTERACTION; SEQUENCE ALIGNMENT; SMALL ANGLE SCATTERING; ULTRASTRUCTURE; X RAY DIFFRACTION;

AMINO ACID SEQUENCE; ANIMALS; AXIN PROTEIN; CELL LINE; DROSOPHILA; DROSOPHILA PROTEINS; HEK293 CELLS; HUMANS; MICE; MODELS, MOLECULAR; MOLECULAR SEQUENCE DATA; MUTATION, MISSENSE; NEOPLASMS; POINT MUTATION; PROTEIN AGGREGATES; PROTEIN CONFORMATION; PROTEIN INTERACTION MAPS; SCATTERING, SMALL ANGLE; SEQUENCE ALIGNMENT; WNT SIGNALING PATHWAY; X-RAY DIFFRACTION;

EID: 84961226460     PISSN: 15459993     EISSN: 15459985     Source Type: Journal    
DOI: 10.1038/nsmb.3191     Document Type: Article

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