Toward classification of BRCA1 missense variants using a biophysical approach

Journal of Biological Chemistry

Volumn 285, Issue 26, 2010, Pages 20080-20087

  Rowling, Pamela J E ^a   Cook, Rebecca ^a   Itzhaki, Laura S ^a  

^a HUTCHISON MRC RESEARCH CENTRE   (United Kingdom)

Author keywords

[No Author keywords available]

Indexed keywords

BREAST CANCER; COMPUTER ALGORITHM; FOLDED STATE; GERM LINE; MUTANT EFFECTS; OVARIAN CANCERS; PHOSPHORYLATED SUBSTRATES; SMALL MOLECULES; SUSCEPTIBILITY GENES; THERAPEUTIC STRATEGY;

ALGORITHMS; BINDING ENERGY; ESCHERICHIA COLI; PHOSPHORYLATION; PROTEINS; THERMODYNAMIC STABILITY;

MOLECULES;

BRCA1 PROTEIN;

AMINO ACID SUBSTITUTION; ARTICLE; BINDING AFFINITY; BINDING SITE; CLASSIFICATION ALGORITHM; ESCHERICHIA COLI; GENETIC ALGORITHM; GENETIC VARIABILITY; LOSS OF FUNCTION MUTATION; MISSENSE MUTATION; NONHUMAN; PRIORITY JOURNAL; PROTEIN DOMAIN; PROTEIN PHOSPHORYLATION; STRUCTURE ANALYSIS; THERMODYNAMICS; THERMOSTABILITY;

ALGORITHMS; BINDING SITES; BRCA1 PROTEIN; BREAST NEOPLASMS; ESCHERICHIA COLI; FEMALE; FLUORESCENCE POLARIZATION; GERM-LINE MUTATION; GUANIDINE; HUMANS; MODELS, MOLECULAR; MUTAGENESIS, SITE-DIRECTED; MUTANT PROTEINS; MUTATION, MISSENSE; OVARIAN NEOPLASMS; PHOSPHOPEPTIDES; PROTEIN FOLDING; PROTEIN STABILITY; PROTEIN STRUCTURE, TERTIARY; RECOMBINANT PROTEINS; TEMPERATURE; THERMODYNAMICS;

ESCHERICHIA COLI;

EID: 77953756428     PISSN: 00219258     EISSN: 1083351X     Source Type: Journal    
DOI: 10.1074/jbc.M109.088922     Document Type: Article

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