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Volumn 10, Issue , 2011, Pages

The structural impact of cancer-associated missense mutations in oncogenes and tumor suppressors

Author keywords

[No Author keywords available]

Indexed keywords

ADENOSINE TRIPHOSPHATE; B RAF KINASE; GUANOSINE TRIPHOSPHATE; K RAS PROTEIN; PROTEIN KINASE B; PROTEIN KINASE LKB1; PROTEIN MLH1; PROTEIN MSH2; PROTEIN P53; PROTEIN TYROSINE PHOSPHATASE SHP 2; RAS ASSOCIATION DOMAIN FAMILY PROTEIN 1A; SCATTER FACTOR RECEPTOR; SMAD4 PROTEIN; VASCULOTROPIN; VON HIPPEL LINDAU PROTEIN; WT1 PROTEIN; ONCOPROTEIN; TUMOR SUPPRESSOR PROTEIN;

EID: 79955907500     PISSN: None     EISSN: 14764598     Source Type: Journal    
DOI: 10.1186/1476-4598-10-54     Document Type: Article
Times cited : (51)

References (44)
  • 7
    • 54549108740 scopus 로고    scopus 로고
    • Comprehensive genomic characterization defines human glioblastoma genes and core pathways
    • 10.1038/nature07385, 2671642, 18772890, CancerGenome Atlas Research Network
    • CancerGenome Atlas Research Network Comprehensive genomic characterization defines human glioblastoma genes and core pathways. Nature 2008, 455:1061-1068. 10.1038/nature07385, 2671642, 18772890, CancerGenome Atlas Research Network.
    • (2008) Nature , vol.455 , pp. 1061-1068
  • 8
    • 63749120567 scopus 로고    scopus 로고
    • The SAAPdb web resource: a large-scale structural analysis of mutant proteins
    • 10.1002/humu.20898, 19191322
    • Hurst JM, McMillan LE, Porter CT, Allen J, Fakorede A, Martin AC. The SAAPdb web resource: a large-scale structural analysis of mutant proteins. Hum Mutat 2009, 30:616-624. 10.1002/humu.20898, 19191322.
    • (2009) Hum Mutat , vol.30 , pp. 616-624
    • Hurst, J.M.1    McMillan, L.E.2    Porter, C.T.3    Allen, J.4    Fakorede, A.5    Martin, A.C.6
  • 9
    • 77949898545 scopus 로고    scopus 로고
    • The (non)malignancy of cancerous amino acidic substitutions
    • Talavera D, Taylor MS, Thornton JM. The (non)malignancy of cancerous amino acidic substitutions. Proteins 2010, 78:518-529.
    • (2010) Proteins , vol.78 , pp. 518-529
    • Talavera, D.1    Taylor, M.S.2    Thornton, J.M.3
  • 10
    • 44649115241 scopus 로고    scopus 로고
    • Functional classification analysis of somatically mutated genes in human breast and colorectal cancers
    • 10.1016/j.ygeno.2008.03.002, 2492759, 18434084
    • Chittenden TW, Howe EA, Culhane AC, Sultana R, Taylor JM, Holmes C, Quackenbush J. Functional classification analysis of somatically mutated genes in human breast and colorectal cancers. Genomics 2008, 91:508-511. 10.1016/j.ygeno.2008.03.002, 2492759, 18434084.
    • (2008) Genomics , vol.91 , pp. 508-511
    • Chittenden, T.W.1    Howe, E.A.2    Culhane, A.C.3    Sultana, R.4    Taylor, J.M.5    Holmes, C.6    Quackenbush, J.7
  • 11
    • 33750353461 scopus 로고    scopus 로고
    • Predicting the effects of amino acid substitutions on protein function
    • 10.1146/annurev.genom.7.080505.115630, 16824020
    • Ng PC, Henikoff S. Predicting the effects of amino acid substitutions on protein function. Annu Rev Genomics Hum Genet 2006, 7:61-80. 10.1146/annurev.genom.7.080505.115630, 16824020.
    • (2006) Annu Rev Genomics Hum Genet , vol.7 , pp. 61-80
    • Ng, P.C.1    Henikoff, S.2
  • 12
    • 0043122919 scopus 로고    scopus 로고
    • SIFT: Predicting amino acid changes that affect protein function
    • 10.1093/nar/gkg509, 168916, 12824425
    • Ng PC, Henikoff S. SIFT: Predicting amino acid changes that affect protein function. Nucleic acids research 2003, 31:3812-3814. 10.1093/nar/gkg509, 168916, 12824425.
    • (2003) Nucleic acids research , vol.31 , pp. 3812-3814
    • Ng, P.C.1    Henikoff, S.2
  • 13
    • 0036713510 scopus 로고    scopus 로고
    • Human non-synonymous SNPs: server and survey
    • 10.1093/nar/gkf493, 137415, 12202775
    • Ramensky V, Bork P, Sunyaev S. Human non-synonymous SNPs: server and survey. Nucleic acids research 2002, 30:3894-3900. 10.1093/nar/gkf493, 137415, 12202775.
    • (2002) Nucleic acids research , vol.30 , pp. 3894-3900
    • Ramensky, V.1    Bork, P.2    Sunyaev, S.3
  • 14
    • 0035065485 scopus 로고    scopus 로고
    • SNPs, protein structure, and disease
    • 10.1002/humu.22, 11295823
    • Wang Z, Moult J. SNPs, protein structure, and disease. Human Mutation 2001, 17:263-270. 10.1002/humu.22, 11295823.
    • (2001) Human Mutation , vol.17 , pp. 263-270
    • Wang, Z.1    Moult, J.2
  • 15
    • 60749104999 scopus 로고    scopus 로고
    • Next generation tools for the annotation of human SNPs
    • 2638621, 19181721
    • Karchin R. Next generation tools for the annotation of human SNPs. Brief Bioinform 2009, 10:35-52. 2638621, 19181721.
    • (2009) Brief Bioinform , vol.10 , pp. 35-52
    • Karchin, R.1
  • 18
    • 0345059376 scopus 로고    scopus 로고
    • Announcing the worldwide Protein Data Bank
    • 10.1038/nsb1203-980, 14634627
    • Berman H, Henrick K, Nakamura H. Announcing the worldwide Protein Data Bank. Nat Struct Biol 2003, 10:980. 10.1038/nsb1203-980, 14634627.
    • (2003) Nat Struct Biol , vol.10 , pp. 980
    • Berman, H.1    Henrick, K.2    Nakamura, H.3
  • 19
    • 0030801002 scopus 로고    scopus 로고
    • Gapped BLAST and PSI-BLAST: a new generation of protein database search programs
    • 10.1093/nar/25.17.3389, 146917, 9254694
    • Altschul SF, Madden TL, Schaffer AA, Zhang J, Zhang Z, Miller W, Lipman DJ. Gapped BLAST and PSI-BLAST: a new generation of protein database search programs. Nucleic Acids Res 1997, 25:3389-3402. 10.1093/nar/25.17.3389, 146917, 9254694.
    • (1997) Nucleic Acids Res , vol.25 , pp. 3389-3402
    • Altschul, S.F.1    Madden, T.L.2    Schaffer, A.A.3    Zhang, J.4    Zhang, Z.5    Miller, W.6    Lipman, D.J.7
  • 20
    • 33646255012 scopus 로고
    • NACCESS, Computer Program, Department of Biochemistry and Molecular Biology, University College London
    • Hubbard SJ, Thornton JM. NACCESS, Computer Program, Department of Biochemistry and Molecular Biology, University College London. 1993,
    • (1993)
    • Hubbard, S.J.1    Thornton, J.M.2
  • 21
    • 0036291145 scopus 로고    scopus 로고
    • Predicting changes in the stability of proteins and protein complexes: a study of more than 1000 mutations
    • 10.1016/S0022-2836(02)00442-4, 12079393
    • Guerois R, Nielsen JE, Serrano L. Predicting changes in the stability of proteins and protein complexes: a study of more than 1000 mutations. J Mol Biol 2002, 320:369-387. 10.1016/S0022-2836(02)00442-4, 12079393.
    • (2002) J Mol Biol , vol.320 , pp. 369-387
    • Guerois, R.1    Nielsen, J.E.2    Serrano, L.3
  • 22
    • 0025370815 scopus 로고
    • Dominant forces in protein folding
    • 10.1021/bi00483a001, 2207096
    • Dill KA. Dominant forces in protein folding. Biochemistry 1990, 29:7133-7155. 10.1021/bi00483a001, 2207096.
    • (1990) Biochemistry , vol.29 , pp. 7133-7155
    • Dill, K.A.1
  • 23
    • 75849153303 scopus 로고    scopus 로고
    • The Universal Protein Resource (UniProt) in 2010
    • 2808944, 19843607, TheUniProt Consortium
    • TheUniProt Consortium The Universal Protein Resource (UniProt) in 2010. Nucl Acids Res 2010, 38:D142-148. 2808944, 19843607, TheUniProt Consortium.
    • (2010) Nucl Acids Res , vol.38
  • 24
    • 0345864027 scopus 로고    scopus 로고
    • The Catalytic Site Atlas: a resource of catalytic sites and residues identified in enzymes using structural data
    • 10.1093/nar/gkh028, 308762, 14681376
    • Porter CT, Bartlett GJ, Thornton JM. The Catalytic Site Atlas: a resource of catalytic sites and residues identified in enzymes using structural data. Nucleic Acids Res 2004, 32:D129-133. 10.1093/nar/gkh028, 308762, 14681376.
    • (2004) Nucleic Acids Res , vol.32
    • Porter, C.T.1    Bartlett, G.J.2    Thornton, J.M.3
  • 25
    • 2942598149 scopus 로고    scopus 로고
    • PhosphoSite: A bioinformatics resource dedicated to physiological protein phosphorylation
    • 10.1002/pmic.200300772, 15174125
    • Hornbeck PV, Chabra I, Kornhauser JM, Skrzypek E, Zhang B. PhosphoSite: A bioinformatics resource dedicated to physiological protein phosphorylation. Proteomics 2004, 4:1551-1561. 10.1002/pmic.200300772, 15174125.
    • (2004) Proteomics , vol.4 , pp. 1551-1561
    • Hornbeck, P.V.1    Chabra, I.2    Kornhauser, J.M.3    Skrzypek, E.4    Zhang, B.5
  • 26
    • 0034491038 scopus 로고    scopus 로고
    • Protein domain decomposition using a graph-theoretic approach
    • 10.1093/bioinformatics/16.12.1091, 11159328
    • Xu Y, Xu D, Gabow HN. Protein domain decomposition using a graph-theoretic approach. Bioinformatics 2000, 16:1091-1104. 10.1093/bioinformatics/16.12.1091, 11159328.
    • (2000) Bioinformatics , vol.16 , pp. 1091-1104
    • Xu, Y.1    Xu, D.2    Gabow, H.N.3
  • 27
    • 0000764772 scopus 로고
    • The Use of Multiple Measurements in Taxonomic Problems
    • Fisher RA. The Use of Multiple Measurements in Taxonomic Problems. Annals of Eugenics 1936, 7:179-188.
    • (1936) Annals of Eugenics , vol.7 , pp. 179-188
    • Fisher, R.A.1
  • 28
    • 0027401607 scopus 로고
    • The multistep nature of cancer
    • 10.1016/0168-9525(93)90209-Z, 8516849
    • Vogelstein B, Kinzler KW. The multistep nature of cancer. Trends Genet 1993, 9:138-141. 10.1016/0168-9525(93)90209-Z, 8516849.
    • (1993) Trends Genet , vol.9 , pp. 138-141
    • Vogelstein, B.1    Kinzler, K.W.2
  • 30
    • 74549207309 scopus 로고    scopus 로고
    • Assessing computational methods for predicting protein stability upon mutation: good on average but not in the details
    • 10.1093/protein/gzp030, 19561092
    • Potapov V, Cohen M, Schreiber G. Assessing computational methods for predicting protein stability upon mutation: good on average but not in the details. Protein Eng Des Sel 2009, 22:553-560. 10.1093/protein/gzp030, 19561092.
    • (2009) Protein Eng Des Sel , vol.22 , pp. 553-560
    • Potapov, V.1    Cohen, M.2    Schreiber, G.3
  • 31
    • 77957567368 scopus 로고    scopus 로고
    • Multiple tumor-suppressor genes on chromosome 3p contribute to head and neck squamous cell carcinoma tumorigenesis
    • Lee DJ, Schonleben F, Banuchi VE, Qiu W, Close LG, Assaad AM, Su GH. Multiple tumor-suppressor genes on chromosome 3p contribute to head and neck squamous cell carcinoma tumorigenesis. Cancer Biol Ther 2010, 10.
    • (2010) Cancer Biol Ther , vol.10
    • Lee, D.J.1    Schonleben, F.2    Banuchi, V.E.3    Qiu, W.4    Close, L.G.5    Assaad, A.M.6    Su, G.H.7
  • 32
    • 77949465285 scopus 로고    scopus 로고
    • Structural and functional restraints on the occurrence of single amino acid variations in human proteins
    • 10.1371/journal.pone.0009186, 2820541, 20169194
    • Gong S, Blundell TL. Structural and functional restraints on the occurrence of single amino acid variations in human proteins. PLoS One 2010, 5:e9186. 10.1371/journal.pone.0009186, 2820541, 20169194.
    • (2010) PLoS One , vol.5
    • Gong, S.1    Blundell, T.L.2
  • 34
    • 0025602908 scopus 로고
    • Tissue-specific transformation by epidermal growth factor receptor: a single point mutation within the ATP-binding pocket of the erbB product increases its intrinsic kinase activity and activates its sarcomagenic potential
    • 10.1073/pnas.87.23.9103, 55112, 1979168
    • Shu HK, Pelley RJ, Kung HJ. Tissue-specific transformation by epidermal growth factor receptor: a single point mutation within the ATP-binding pocket of the erbB product increases its intrinsic kinase activity and activates its sarcomagenic potential. Proc Natl Acad Sci USA 1990, 87:9103-9107. 10.1073/pnas.87.23.9103, 55112, 1979168.
    • (1990) Proc Natl Acad Sci USA , vol.87 , pp. 9103-9107
    • Shu, H.K.1    Pelley, R.J.2    Kung, H.J.3
  • 36
    • 40949161558 scopus 로고    scopus 로고
    • Prediction of cancer driver mutations in protein kinases
    • 10.1158/0008-5472.CAN-07-5283, 18339846
    • Torkamani A, Schork NJ. Prediction of cancer driver mutations in protein kinases. Cancer Res 2008, 68:1675-1682. 10.1158/0008-5472.CAN-07-5283, 18339846.
    • (2008) Cancer Res , vol.68 , pp. 1675-1682
    • Torkamani, A.1    Schork, N.J.2
  • 37
    • 0037805547 scopus 로고    scopus 로고
    • RAS oncogenes: the first 30 years
    • 10.1038/nrc1097, 12778136
    • Malumbres M, Barbacid M. RAS oncogenes: the first 30 years. Nat Rev Cancer 2003, 3:459-465. 10.1038/nrc1097, 12778136.
    • (2003) Nat Rev Cancer , vol.3 , pp. 459-465
    • Malumbres, M.1    Barbacid, M.2
  • 38
    • 0024463212 scopus 로고
    • Structure of the guanine-nucleotide-binding domain of the Ha-ras oncogene product p21 in the triphosphate conformation
    • 10.1038/341209a0, 2476675
    • Pai EF, Kabsch W, Krengel U, Holmes KC, John J, Wittinghofer A. Structure of the guanine-nucleotide-binding domain of the Ha-ras oncogene product p21 in the triphosphate conformation. Nature 1989, 341:209-214. 10.1038/341209a0, 2476675.
    • (1989) Nature , vol.341 , pp. 209-214
    • Pai, E.F.1    Kabsch, W.2    Krengel, U.3    Holmes, K.C.4    John, J.5    Wittinghofer, A.6
  • 39
    • 77149124860 scopus 로고    scopus 로고
    • Inferring the functional effects of mutation through clusters of mutations in homologous proteins
    • 10.1002/humu.21194, 20052764
    • Yue P, Forrest WF, Kaminker JS, Lohr S, Zhang Z, Cavet G. Inferring the functional effects of mutation through clusters of mutations in homologous proteins. Hum Mutat 2010, 31:264-271. 10.1002/humu.21194, 20052764.
    • (2010) Hum Mutat , vol.31 , pp. 264-271
    • Yue, P.1    Forrest, W.F.2    Kaminker, J.S.3    Lohr, S.4    Zhang, Z.5    Cavet, G.6
  • 40
    • 76949086002 scopus 로고    scopus 로고
    • Statistical method on nonrandom clustering with application to somatic mutations in cancer
    • 10.1186/1471-2105-11-11, 2822753, 20053295
    • Ye J, Pavlicek A, Lunney EA, Rejto PA, Teng CH. Statistical method on nonrandom clustering with application to somatic mutations in cancer. BMC Bioinformatics 2010, 11:11. 10.1186/1471-2105-11-11, 2822753, 20053295.
    • (2010) BMC Bioinformatics , vol.11 , pp. 11
    • Ye, J.1    Pavlicek, A.2    Lunney, E.A.3    Rejto, P.A.4    Teng, C.H.5
  • 41
    • 69249115697 scopus 로고    scopus 로고
    • Cancer-specific high-throughput annotation of somatic mutations: computational prediction of driver missense mutations
    • 10.1158/0008-5472.CAN-09-1133, 2763410, 19654296
    • Carter H, Chen S, Isik L, Tyekucheva S, Velculescu VE, Kinzler KW, Vogelstein B, Karchin R. Cancer-specific high-throughput annotation of somatic mutations: computational prediction of driver missense mutations. Cancer Research 2009, 69:6660-6667. 10.1158/0008-5472.CAN-09-1133, 2763410, 19654296.
    • (2009) Cancer Research , vol.69 , pp. 6660-6667
    • Carter, H.1    Chen, S.2    Isik, L.3    Tyekucheva, S.4    Velculescu, V.E.5    Kinzler, K.W.6    Vogelstein, B.7    Karchin, R.8
  • 43
    • 44349170604 scopus 로고    scopus 로고
    • Insights into the oncogenic effects of PIK3CA mutations from the structure of p110alpha/p85alpha
    • 10.4161/cc.7.9.5817, 18418043
    • Huang CH, Mandelker D, Gabelli SB, Amzel LM. Insights into the oncogenic effects of PIK3CA mutations from the structure of p110alpha/p85alpha. Cell Cycle 2008, 7:1151-1156. 10.4161/cc.7.9.5817, 18418043.
    • (2008) Cell Cycle , vol.7 , pp. 1151-1156
    • Huang, C.H.1    Mandelker, D.2    Gabelli, S.B.3    Amzel, L.M.4


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