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Volumn 59, Issue 5, 2016, Pages 920-927

Renaissance of leptin for obesity therapy

Author keywords

Leptin; Leptin resistance; Leptin sensitivity; Obesity; Pharmacology; Polypharmacy; Review; Type 2 diabetes

Indexed keywords

AMYLIN; FIBROBLAST GROWTH FACTOR 21; GLUCAGON LIKE PEPTIDE 1; GLUCAGON LIKE PEPTIDE 1 RECEPTOR; GLUCAGON RECEPTOR; LEPTIN; METFORMIN;

EID: 84961216805     PISSN: 0012186X     EISSN: 14320428     Source Type: Journal    
DOI: 10.1007/s00125-016-3906-7     Document Type: Review
Times cited : (29)

References (65)
  • 1
    • 84925855354 scopus 로고    scopus 로고
    • The hunger genes: pathways to obesity
    • PID: 25815990
    • van der Klaauw AA, Farooqi IS (2015) The hunger genes: pathways to obesity. Cell 161:119–132
    • (2015) Cell , vol.161 , pp. 119-132
    • van der Klaauw, A.A.1    Farooqi, I.S.2
  • 2
    • 0028139089 scopus 로고
    • Positional cloning of the mouse obese gene and its human homologue
    • COI: 1:CAS:528:DyaK2MXisVGqsbs%3D, PID: 7984236
    • Zhang Y, Proenca R, Maffei M, Barone M, Leopold L, Friedman JM (1994) Positional cloning of the mouse obese gene and its human homologue. Nature 372:425–432
    • (1994) Nature , vol.372 , pp. 425-432
    • Zhang, Y.1    Proenca, R.2    Maffei, M.3    Barone, M.4    Leopold, L.5    Friedman, J.M.6
  • 3
    • 0032747280 scopus 로고    scopus 로고
    • Recombinant leptin for weight loss in obese and lean adults: a randomized, controlled, dose-escalation trial
    • COI: 1:CAS:528:DyaK1MXnsVSisbk%3D, PID: 10546697
    • Heymsfield SB, Greenberg AS, Fujioka K et al (1999) Recombinant leptin for weight loss in obese and lean adults: a randomized, controlled, dose-escalation trial. JAMA 282:1568–1575
    • (1999) JAMA , vol.282 , pp. 1568-1575
    • Heymsfield, S.B.1    Greenberg, A.S.2    Fujioka, K.3
  • 4
    • 78049311283 scopus 로고    scopus 로고
    • Obesity and leptin resistance: distinguishing cause from effect
    • COI: 1:CAS:528:DC%2BC3cXhtlKltL7L, PID: 20846876
    • Myers MG Jr, Leibel RL, Seeley RJ, Schwartz MW (2010) Obesity and leptin resistance: distinguishing cause from effect. Trends Endocrinol Metab 21:643–651
    • (2010) Trends Endocrinol Metab , vol.21 , pp. 643-651
    • Myers, M.G.1    Leibel, R.L.2    Seeley, R.J.3    Schwartz, M.W.4
  • 5
    • 0037148928 scopus 로고    scopus 로고
    • Leptin-replacement therapy for lipodystrophy
    • COI: 1:CAS:528:DC%2BD38XhsFKqu7c%3D, PID: 11856796
    • Oral EA, Simha V, Ruiz E et al (2002) Leptin-replacement therapy for lipodystrophy. N Engl J Med 346:570–578
    • (2002) N Engl J Med , vol.346 , pp. 570-578
    • Oral, E.A.1    Simha, V.2    Ruiz, E.3
  • 6
    • 0033575993 scopus 로고    scopus 로고
    • Effects of recombinant leptin therapy in a child with congenital leptin deficiency
    • COI: 1:STN:280:DyaK1MvgsVyrtA%3D%3D, PID: 10486419
    • Farooqi IS, Jebb SA, Langmack G et al (1999) Effects of recombinant leptin therapy in a child with congenital leptin deficiency. N Engl J Med 341:879–884
    • (1999) N Engl J Med , vol.341 , pp. 879-884
    • Farooqi, I.S.1    Jebb, S.A.2    Langmack, G.3
  • 7
    • 0036800760 scopus 로고    scopus 로고
    • Beneficial effects of leptin on obesity, T cell hyporesponsiveness, and neuroendocrine/metabolic dysfunction of human congenital leptin deficiency
    • COI: 1:CAS:528:DC%2BD38XotFGlurk%3D, PID: 12393845
    • Farooqi IS, Matarese G, Lord GM et al (2002) Beneficial effects of leptin on obesity, T cell hyporesponsiveness, and neuroendocrine/metabolic dysfunction of human congenital leptin deficiency. J Clin Invest 110:1093–1103
    • (2002) J Clin Invest , vol.110 , pp. 1093-1103
    • Farooqi, I.S.1    Matarese, G.2    Lord, G.M.3
  • 8
    • 84930199338 scopus 로고    scopus 로고
    • Treatment of obesity with celastrol
    • COI: 1:CAS:528:DC%2BC2MXpt1Sgtb0%3D, PID: 26000480
    • Liu J, Lee J, Salazar Hernandez MA, Mazitschek R, Ozcan U (2015) Treatment of obesity with celastrol. Cell 161:999–1011
    • (2015) Cell , vol.161 , pp. 999-1011
    • Liu, J.1    Lee, J.2    Salazar Hernandez, M.A.3    Mazitschek, R.4    Ozcan, U.5
  • 9
    • 84923501805 scopus 로고    scopus 로고
    • Leptin resistance in diet-induced obesity: the role of hypothalamic inflammation
    • PID: 25589226
    • de Git KC, Adan RA (2015) Leptin resistance in diet-induced obesity: the role of hypothalamic inflammation. Obes Rev 16:207–224
    • (2015) Obes Rev , vol.16 , pp. 207-224
    • de Git, K.C.1    Adan, R.A.2
  • 10
    • 84906275240 scopus 로고    scopus 로고
    • Inactivation of SOCS3 in leptin receptor-expressing cells protects mice from diet-induced insulin resistance but does not prevent obesity
    • COI: 1:CAS:528:DC%2BC2cXhtVKhu7zP, PID: 25161884
    • Pedroso JA, Buonfiglio DC, Cardinali LI et al (2014) Inactivation of SOCS3 in leptin receptor-expressing cells protects mice from diet-induced insulin resistance but does not prevent obesity. Mol Metab 3:608–618
    • (2014) Mol Metab , vol.3 , pp. 608-618
    • Pedroso, J.A.1    Buonfiglio, D.C.2    Cardinali, L.I.3
  • 11
    • 77954175048 scopus 로고    scopus 로고
    • Modulation of hypothalamic PTP1B in the TNF-α-induced insulin and leptin resistance
    • COI: 1:CAS:528:DC%2BC3cXosVygsLk%3D, PID: 20576518
    • Picardi PK, Caricilli AM, de Abreu LL, Carvalheira JB, Velloso LA, Saad MJ (2010) Modulation of hypothalamic PTP1B in the TNF-α-induced insulin and leptin resistance. FEBS Lett 584:3179–3184
    • (2010) FEBS Lett , vol.584 , pp. 3179-3184
    • Picardi, P.K.1    Caricilli, A.M.2    de Abreu, L.L.3    Carvalheira, J.B.4    Velloso, L.A.5    Saad, M.J.6
  • 12
    • 77955052291 scopus 로고    scopus 로고
    • Inhibition of PTP1B by trodusquemine (MSI-1436) causes fat-specific weight loss in diet-induced obese mice
    • COI: 1:CAS:528:DC%2BC3cXptlymsbY%3D, PID: 20075852
    • Lantz KA, Hart SG, Planey SL et al (2010) Inhibition of PTP1B by trodusquemine (MSI-1436) causes fat-specific weight loss in diet-induced obese mice. Obesity 18:1516–1523
    • (2010) Obesity , vol.18 , pp. 1516-1523
    • Lantz, K.A.1    Hart, S.G.2    Planey, S.L.3
  • 13
    • 84903705433 scopus 로고    scopus 로고
    • Clusterin/ApoJ enhances central leptin signaling through Lrp2-mediated endocytosis
    • COI: 1:CAS:528:DC%2BC2cXht1ems7zO, PID: 24825475
    • Byun K, Gil SY, Namkoong C et al (2014) Clusterin/ApoJ enhances central leptin signaling through Lrp2-mediated endocytosis. EMBO Rep 15:801–808
    • (2014) EMBO Rep , vol.15 , pp. 801-808
    • Byun, K.1    Gil, S.Y.2    Namkoong, C.3
  • 14
    • 44449175729 scopus 로고    scopus 로고
    • Leptin responsiveness restored by amylin agonism in diet-induced obesity: evidence from nonclinical and clinical studies
    • COI: 1:CAS:528:DC%2BD1cXmsFCqsLw%3D, PID: 18458326
    • Roth JD, Roland BL, Cole RL et al (2008) Leptin responsiveness restored by amylin agonism in diet-induced obesity: evidence from nonclinical and clinical studies. Proc Natl Acad Sci U S A 105:7257–7262
    • (2008) Proc Natl Acad Sci U S A , vol.105 , pp. 7257-7262
    • Roth, J.D.1    Roland, B.L.2    Cole, R.L.3
  • 15
    • 85027936258 scopus 로고    scopus 로고
    • Restoration of leptin responsiveness in diet-induced obese mice using an optimized leptin analog in combination with exendin-4 or FGF21
    • PID: 22565812
    • Müller TD, Sullivan LM, Habegger K et al (2012) Restoration of leptin responsiveness in diet-induced obese mice using an optimized leptin analog in combination with exendin-4 or FGF21. J Pept Sci 18:383–393
    • (2012) J Pept Sci , vol.18 , pp. 383-393
    • Müller, T.D.1    Sullivan, L.M.2    Habegger, K.3
  • 16
    • 33644774745 scopus 로고    scopus 로고
    • Metformin restores leptin sensitivity in high-fat-fed obese rats with leptin resistance
    • COI: 1:CAS:528:DC%2BD28XisVWis7Y%3D, PID: 16505235
    • Kim YW, Kim JY, Park YH et al (2006) Metformin restores leptin sensitivity in high-fat-fed obese rats with leptin resistance. Diabetes 55:716–724
    • (2006) Diabetes , vol.55 , pp. 716-724
    • Kim, Y.W.1    Kim, J.Y.2    Park, Y.H.3
  • 17
    • 84933052892 scopus 로고    scopus 로고
    • Meta-chlorophenylpiperazine enhances leptin sensitivity in diet-induced obese mice
    • COI: 1:CAS:528:DC%2BC2MXhtVOhurrE, PID: 25817043
    • Yan C, Yang Y, Saito K et al (2015) Meta-chlorophenylpiperazine enhances leptin sensitivity in diet-induced obese mice. Br J Pharmacol 172:3510–3521
    • (2015) Br J Pharmacol , vol.172 , pp. 3510-3521
    • Yan, C.1    Yang, Y.2    Saito, K.3
  • 18
    • 0034714049 scopus 로고    scopus 로고
    • Synergistic interaction between CCK and leptin to regulate food intake
    • COI: 1:CAS:528:DC%2BD3cXntF2htLo%3D, PID: 11024569
    • Wang L, Barachina MD, Martinez V, Wei JY, Tache Y (2000) Synergistic interaction between CCK and leptin to regulate food intake. Regul Pept 92:79–85
    • (2000) Regul Pept , vol.92 , pp. 79-85
    • Wang, L.1    Barachina, M.D.2    Martinez, V.3    Wei, J.Y.4    Tache, Y.5
  • 19
    • 50649099514 scopus 로고    scopus 로고
    • Leptin extends the anorectic effects of chronic PYY(3-36) administration in ad libitum-fed rats
    • COI: 1:CAS:528:DC%2BD1cXoslynsL0%3D, PID: 18417649
    • Unniappan S, Kieffer TJ (2008) Leptin extends the anorectic effects of chronic PYY(3-36) administration in ad libitum-fed rats. Am J Physiol Regul Integr Comp Physiol 295:R51–R58
    • (2008) Am J Physiol Regul Integr Comp Physiol , vol.295 , pp. R51-R58
    • Unniappan, S.1    Kieffer, T.J.2
  • 20
    • 84907977576 scopus 로고    scopus 로고
    • A missing link in body weight homeostasis: the catabolic signal of the overfed state
    • COI: 1:CAS:528:DC%2BC2cXhsFyrtbrK, PID: 25295786
    • Ravussin Y, Leibel RL, Ferrante AW Jr (2014) A missing link in body weight homeostasis: the catabolic signal of the overfed state. Cell Metab 20:565–572
    • (2014) Cell Metab , vol.20 , pp. 565-572
    • Ravussin, Y.1    Leibel, R.L.2    Ferrante, A.W.3
  • 21
    • 84930574173 scopus 로고    scopus 로고
    • Diet-induced obese mice retain endogenous leptin action
    • COI: 1:CAS:528:DC%2BC2MXosVaqtro%3D, PID: 25980347
    • Ottaway N, Mahbod P, Rivero B et al (2015) Diet-induced obese mice retain endogenous leptin action. Cell Metab 21:877–882
    • (2015) Cell Metab , vol.21 , pp. 877-882
    • Ottaway, N.1    Mahbod, P.2    Rivero, B.3
  • 22
    • 57849115277 scopus 로고    scopus 로고
    • Endoplasmic reticulum stress plays a central role in development of leptin resistance
    • COI: 1:CAS:528:DC%2BD1MXptFWquw%3D%3D, PID: 19117545
    • Ozcan L, Ergin AS, Lu A et al (2009) Endoplasmic reticulum stress plays a central role in development of leptin resistance. Cell Metab 9:35–51
    • (2009) Cell Metab , vol.9 , pp. 35-51
    • Ozcan, L.1    Ergin, A.S.2    Lu, A.3
  • 23
    • 84879065487 scopus 로고    scopus 로고
    • Obesity induces hypothalamic endoplasmic reticulum stress and impairs proopiomelanocortin (POMC) post-translational processing
    • COI: 1:CAS:528:DC%2BC3sXpsFantbw%3D, PID: 23640886
    • Cakir I, Cyr NE, Perello M et al (2013) Obesity induces hypothalamic endoplasmic reticulum stress and impairs proopiomelanocortin (POMC) post-translational processing. J Biol Chem 288:17675–17688
    • (2013) J Biol Chem , vol.288 , pp. 17675-17688
    • Cakir, I.1    Cyr, N.E.2    Perello, M.3
  • 24
    • 52949096557 scopus 로고    scopus 로고
    • Hypothalamic IKKβ/NF-κB and ER stress link overnutrition to energy imbalance and obesity
    • COI: 1:CAS:528:DC%2BD1cXht1Gkt7nP, PID: 18854155
    • Zhang X, Zhang G, Zhang H, Karin M, Bai H, Cai D (2008) Hypothalamic IKKβ/NF-κB and ER stress link overnutrition to energy imbalance and obesity. Cell 135:61–73
    • (2008) Cell , vol.135 , pp. 61-73
    • Zhang, X.1    Zhang, G.2    Zhang, H.3    Karin, M.4    Bai, H.5    Cai, D.6
  • 25
    • 84901782701 scopus 로고    scopus 로고
    • Therapeutic potential of flurbiprofen against obesity in mice
    • COI: 1:CAS:528:DC%2BC2cXotlOru74%3D, PID: 24813992
    • Hosoi T, Baba S, Ozawa K (2014) Therapeutic potential of flurbiprofen against obesity in mice. Biochem Biophys Res Commun 449:132–134
    • (2014) Biochem Biophys Res Commun , vol.449 , pp. 132-134
    • Hosoi, T.1    Baba, S.2    Ozawa, K.3
  • 26
    • 84895742693 scopus 로고    scopus 로고
    • Flurbiprofen ameliorated obesity by attenuating leptin resistance induced by endoplasmic reticulum stress
    • COI: 1:CAS:528:DC%2BC2cXjvVyjtLg%3D, PID: 24421337
    • Hosoi T, Yamaguchi R, Noji K et al (2014) Flurbiprofen ameliorated obesity by attenuating leptin resistance induced by endoplasmic reticulum stress. EMBO Mol Med 6:335–346
    • (2014) EMBO Mol Med , vol.6 , pp. 335-346
    • Hosoi, T.1    Yamaguchi, R.2    Noji, K.3
  • 27
    • 84908204729 scopus 로고    scopus 로고
    • Chaperoning to the metabolic party: the emerging therapeutic role of heat-shock proteins in obesity and type 2 diabetes
    • COI: 1:CAS:528:DC%2BC2cXhsFWlur3K, PID: 25379403
    • Henstridge DC, Whitham M, Febbraio MA (2014) Chaperoning to the metabolic party: the emerging therapeutic role of heat-shock proteins in obesity and type 2 diabetes. Mol Metab 3:781–793
    • (2014) Mol Metab , vol.3 , pp. 781-793
    • Henstridge, D.C.1    Whitham, M.2    Febbraio, M.A.3
  • 28
    • 77955411159 scopus 로고    scopus 로고
    • Tauroursodeoxycholic acid may improve liver and muscle but not adipose tissue insulin sensitivity in obese men and women
    • COI: 1:CAS:528:DC%2BC3cXhtVOlsbrF, PID: 20522594
    • Kars M, Yang L, Gregor MF et al (2010) Tauroursodeoxycholic acid may improve liver and muscle but not adipose tissue insulin sensitivity in obese men and women. Diabetes 59:1899–1905
    • (2010) Diabetes , vol.59 , pp. 1899-1905
    • Kars, M.1    Yang, L.2    Gregor, M.F.3
  • 29
    • 84881478531 scopus 로고    scopus 로고
    • Potential for therapeutic manipulation of the UPR in disease
    • COI: 1:CAS:528:DC%2BC3sXntVWqtrc%3D, PID: 23572207
    • Park SW, Ozcan U (2013) Potential for therapeutic manipulation of the UPR in disease. Semin Immunopathol 35:351–373
    • (2013) Semin Immunopathol , vol.35 , pp. 351-373
    • Park, S.W.1    Ozcan, U.2
  • 30
    • 84943455845 scopus 로고    scopus 로고
    • Celastrol protects against obesity and metabolic dysfunction through activation of a HSF1-PGC1α transcriptional axis
    • COI: 1:CAS:528:DC%2BC2MXhsVGnsb3K, PID: 26344102
    • Ma X, Xu L, Alberobello AT et al (2015) Celastrol protects against obesity and metabolic dysfunction through activation of a HSF1-PGC1α transcriptional axis. Cell Metab 22:695–708
    • (2015) Cell Metab , vol.22 , pp. 695-708
    • Ma, X.1    Xu, L.2    Alberobello, A.T.3
  • 31
    • 79953046341 scopus 로고    scopus 로고
    • Inflammatory mechanisms in obesity
    • COI: 1:CAS:528:DC%2BC3MXltlKnsL8%3D, PID: 21219177
    • Gregor MF, Hotamisligil GS (2011) Inflammatory mechanisms in obesity. Annu Rev Immunol 29:415–445
    • (2011) Annu Rev Immunol , vol.29 , pp. 415-445
    • Gregor, M.F.1    Hotamisligil, G.S.2
  • 32
    • 84922802034 scopus 로고    scopus 로고
    • Hypothalamic inflammation in the control of metabolic function
    • COI: 1:CAS:528:DC%2BC2MXls1Ckurg%3D, PID: 25668019
    • Valdearcos M, Xu AW, Koliwad SK (2015) Hypothalamic inflammation in the control of metabolic function. Annu Rev Physiol 77:131–160
    • (2015) Annu Rev Physiol , vol.77 , pp. 131-160
    • Valdearcos, M.1    Xu, A.W.2    Koliwad, S.K.3
  • 33
    • 84855459760 scopus 로고    scopus 로고
    • Obesity is associated with hypothalamic injury in rodents and humans
    • COI: 1:CAS:528:DC%2BC38XkvFCltw%3D%3D, PID: 22201683
    • Thaler JP, Yi CX, Schur EA et al (2012) Obesity is associated with hypothalamic injury in rodents and humans. J Clin Invest 122:153–162
    • (2012) J Clin Invest , vol.122 , pp. 153-162
    • Thaler, J.P.1    Yi, C.X.2    Schur, E.A.3
  • 34
    • 70349484212 scopus 로고    scopus 로고
    • MyD88 signaling in the CNS is required for development of fatty acid-induced leptin resistance and diet-induced obesity
    • COI: 1:CAS:528:DC%2BD1MXhsFKltL3K, PID: 19808018
    • Kleinridders A, Schenten D, Konner AC et al (2009) MyD88 signaling in the CNS is required for development of fatty acid-induced leptin resistance and diet-induced obesity. Cell Metab 10:249–259
    • (2009) Cell Metab , vol.10 , pp. 249-259
    • Kleinridders, A.1    Schenten, D.2    Konner, A.C.3
  • 35
    • 58849149821 scopus 로고    scopus 로고
    • Saturated fatty acids produce an inflammatory response predominantly through the activation of TLR4 signaling in hypothalamus: implications for the pathogenesis of obesity
    • COI: 1:CAS:528:DC%2BD1MXhtVKrurw%3D, PID: 19144836
    • Milanski M, Degasperi G, Coope A et al (2009) Saturated fatty acids produce an inflammatory response predominantly through the activation of TLR4 signaling in hypothalamus: implications for the pathogenesis of obesity. J Neurosci 29:359–370
    • (2009) J Neurosci , vol.29 , pp. 359-370
    • Milanski, M.1    Degasperi, G.2    Coope, A.3
  • 36
    • 84888134187 scopus 로고    scopus 로고
    • Hormones and diet, but not body weight, control hypothalamic microglial activity
    • PID: 24166765
    • Gao Y, Ottaway N, Schriever SC et al (2014) Hormones and diet, but not body weight, control hypothalamic microglial activity. Glia 62:17–25
    • (2014) Glia , vol.62 , pp. 17-25
    • Gao, Y.1    Ottaway, N.2    Schriever, S.C.3
  • 37
    • 24944438230 scopus 로고    scopus 로고
    • Consumption of a fat-rich diet activates a proinflammatory response and induces insulin resistance in the hypothalamus
    • PID: 16002529
    • De Souza CT, Araujo EP, Bordin S et al (2005) Consumption of a fat-rich diet activates a proinflammatory response and induces insulin resistance in the hypothalamus. Endocrinology 146:4192–4199
    • (2005) Endocrinology , vol.146 , pp. 4192-4199
    • De Souza, C.T.1    Araujo, E.P.2    Bordin, S.3
  • 38
    • 47249148827 scopus 로고    scopus 로고
    • Protein-tyrosine phosphatase 1B expression is induced by inflammation in vivo
    • COI: 1:CAS:528:DC%2BD1cXlvFOqu7o%3D, PID: 18281274
    • Zabolotny JM, Kim YB, Welsh LA, Kershaw EE, Neel BG, Kahn BB (2008) Protein-tyrosine phosphatase 1B expression is induced by inflammation in vivo. J Biol Chem 283:14230–14241
    • (2008) J Biol Chem , vol.283 , pp. 14230-14241
    • Zabolotny, J.M.1    Kim, Y.B.2    Welsh, L.A.3    Kershaw, E.E.4    Neel, B.G.5    Kahn, B.B.6
  • 39
    • 84891719310 scopus 로고    scopus 로고
    • Hypothalamic inflammation: marker or mechanism of obesity pathogenesis?
    • COI: 1:CAS:528:DC%2BC3sXht1Snu73L, PID: 23881189
    • Thaler JP, Guyenet SJ, Dorfman MD, Wisse BE, Schwartz MW (2013) Hypothalamic inflammation: marker or mechanism of obesity pathogenesis? Diabetes 62:2629–2634
    • (2013) Diabetes , vol.62 , pp. 2629-2634
    • Thaler, J.P.1    Guyenet, S.J.2    Dorfman, M.D.3    Wisse, B.E.4    Schwartz, M.W.5
  • 40
    • 84903382613 scopus 로고    scopus 로고
    • Leptin signaling in astrocytes regulates hypothalamic neuronal circuits and feeding
    • COI: 1:CAS:528:DC%2BC2cXovFCgt7k%3D, PID: 24880214
    • Kim JG, Suyama S, Koch M et al (2014) Leptin signaling in astrocytes regulates hypothalamic neuronal circuits and feeding. Nat Neurosci 17:908–910
    • (2014) Nat Neurosci , vol.17 , pp. 908-910
    • Kim, J.G.1    Suyama, S.2    Koch, M.3
  • 41
    • 84883196625 scopus 로고    scopus 로고
    • Teasaponin reduces inflammation and central leptin resistance in diet-induced obese male mice
    • COI: 1:CAS:528:DC%2BC3sXhsVegsL7M, PID: 23751875
    • Yu Y, Wu Y, Szabo A et al (2013) Teasaponin reduces inflammation and central leptin resistance in diet-induced obese male mice. Endocrinology 154:3130–3140
    • (2013) Endocrinology , vol.154 , pp. 3130-3140
    • Yu, Y.1    Wu, Y.2    Szabo, A.3
  • 42
    • 66149118129 scopus 로고    scopus 로고
    • Hypothalamic proinflammatory lipid accumulation, inflammation, and insulin resistance in rats fed a high-fat diet
    • COI: 1:CAS:528:DC%2BD1MXlvFags7w%3D, PID: 19116375
    • Posey KA, Clegg DJ, Printz RL et al (2009) Hypothalamic proinflammatory lipid accumulation, inflammation, and insulin resistance in rats fed a high-fat diet. Am J Physiol Endocrinol Metab 296:E1003–E1012
    • (2009) Am J Physiol Endocrinol Metab , vol.296 , pp. E1003-E1012
    • Posey, K.A.1    Clegg, D.J.2    Printz, R.L.3
  • 43
    • 77951210900 scopus 로고    scopus 로고
    • NF-κB activation in hypothalamic pro-opiomelanocortin neurons is essential in illness- and leptin-induced anorexia
    • COI: 1:CAS:528:DC%2BC3cXjsFeht7c%3D, PID: 20097762
    • Jang PG, Namkoong C, Kang GM et al (2010) NF-κB activation in hypothalamic pro-opiomelanocortin neurons is essential in illness- and leptin-induced anorexia. J Biol Chem 285:9706–9715
    • (2010) J Biol Chem , vol.285 , pp. 9706-9715
    • Jang, P.G.1    Namkoong, C.2    Kang, G.M.3
  • 44
    • 77953390519 scopus 로고    scopus 로고
    • Central administration of interleukin-4 exacerbates hypothalamic inflammation and weight gain during high-fat feeding
    • Oh IS, Thaler JP, Ogimoto K, Wisse BE, Morton GJ, Schwartz MW (2010) Central administration of interleukin-4 exacerbates hypothalamic inflammation and weight gain during high-fat feeding. Am J Physiol Endocrinol Metab 299:E47–E53
    • (2010) Am J Physiol Endocrinol Metab , vol.299 , pp. E47-E53
    • Oh, I.S.1    Thaler, J.P.2    Ogimoto, K.3    Wisse, B.E.4    Morton, G.J.5    Schwartz, M.W.6
  • 45
    • 84940107968 scopus 로고    scopus 로고
    • Central inhibition of IKKβ/NF-κB signaling attenuates high-fat diet-induced obesity and glucose intolerance
    • COI: 1:CAS:528:DC%2BC2MXhtVSrur%2FE, PID: 25626735
    • Benzler J, Ganjam GK, Pretz D et al (2015) Central inhibition of IKKβ/NF-κB signaling attenuates high-fat diet-induced obesity and glucose intolerance. Diabetes 64:2015–2027
    • (2015) Diabetes , vol.64 , pp. 2015-2027
    • Benzler, J.1    Ganjam, G.K.2    Pretz, D.3
  • 46
    • 0035655494 scopus 로고    scopus 로고
    • Beneficial effects of metformin in normoglycemic morbidly obese adolescents
    • COI: 1:CAS:528:DC%2BD3MXptVGhtLs%3D, PID: 11735093
    • Kay JP, Alemzadeh R, Langley G, D’Angelo L, Smith P, Holshouser S (2001) Beneficial effects of metformin in normoglycemic morbidly obese adolescents. Metab Clin Exp 50:1457–1461
    • (2001) Metab Clin Exp , vol.50 , pp. 1457-1461
    • Kay, J.P.1    Alemzadeh, R.2    Langley, G.3    D’Angelo, L.4    Smith, P.5    Holshouser, S.6
  • 47
    • 0034914193 scopus 로고    scopus 로고
    • Metformin reduces weight, centripetal obesity, insulin, leptin, and low-density lipoprotein cholesterol in nondiabetic, morbidly obese subjects with body mass index greater than 30
    • COI: 1:CAS:528:DC%2BD3MXlt1Krsr4%3D, PID: 11436194
    • Glueck CJ, Fontaine RN, Wang P et al (2001) Metformin reduces weight, centripetal obesity, insulin, leptin, and low-density lipoprotein cholesterol in nondiabetic, morbidly obese subjects with body mass index greater than 30. Metab Clin Exp 50:856–861
    • (2001) Metab Clin Exp , vol.50 , pp. 856-861
    • Glueck, C.J.1    Fontaine, R.N.2    Wang, P.3
  • 48
    • 0036113811 scopus 로고    scopus 로고
    • Short-term treatment with metformin decreases serum leptin concentration without affecting body weight and body fat content in normal-weight healthy men
    • COI: 1:CAS:528:DC%2BD38Xisl2ksr4%3D, PID: 11912566
    • Fruehwald-Schultes B, Oltmanns KM, Toschek B et al (2002) Short-term treatment with metformin decreases serum leptin concentration without affecting body weight and body fat content in normal-weight healthy men. Metab Clin Exp 51:531–536
    • (2002) Metab Clin Exp , vol.51 , pp. 531-536
    • Fruehwald-Schultes, B.1    Oltmanns, K.M.2    Toschek, B.3
  • 49
    • 79951783938 scopus 로고    scopus 로고
    • The anorexigenic effects of metformin involve increases in hypothalamic leptin receptor expression
    • COI: 1:CAS:528:DC%2BC3MXit1Gruro%3D, PID: 20303124
    • Aubert G, Mansuy V, Voirol MJ, Pellerin L, Pralong FP (2011) The anorexigenic effects of metformin involve increases in hypothalamic leptin receptor expression. Metab Clin Exp 60:327–334
    • (2011) Metab Clin Exp , vol.60 , pp. 327-334
    • Aubert, G.1    Mansuy, V.2    Voirol, M.J.3    Pellerin, L.4    Pralong, F.P.5
  • 50
    • 0034302911 scopus 로고    scopus 로고
    • Effects of metformin and vanadium on leptin secretion from cultured rat adipocytes
    • COI: 1:CAS:528:DC%2BD3cXnslCntrk%3D, PID: 11068959
    • Mueller WM, Stanhope KL, Gregoire F, Evans JL, Havel PJ (2000) Effects of metformin and vanadium on leptin secretion from cultured rat adipocytes. Obes Res 8:530–539
    • (2000) Obes Res , vol.8 , pp. 530-539
    • Mueller, W.M.1    Stanhope, K.L.2    Gregoire, F.3    Evans, J.L.4    Havel, P.J.5
  • 51
    • 34547739135 scopus 로고    scopus 로고
    • Progressive reduction in body weight after treatment with the amylin analog pramlintide in obese subjects: a phase 2, randomized, placebo-controlled, dose-escalation study
    • COI: 1:CAS:528:DC%2BD2sXptl2hs7c%3D, PID: 17504894
    • Aronne L, Fujioka K, Aroda V et al (2007) Progressive reduction in body weight after treatment with the amylin analog pramlintide in obese subjects: a phase 2, randomized, placebo-controlled, dose-escalation study. J Clin Endocrinol Metab 92:2977–2983
    • (2007) J Clin Endocrinol Metab , vol.92 , pp. 2977-2983
    • Aronne, L.1    Fujioka, K.2    Aroda, V.3
  • 52
    • 69749086148 scopus 로고    scopus 로고
    • Enhanced weight loss with pramlintide/metreleptin: an integrated neurohormonal approach to obesity pharmacotherapy
    • COI: 1:CAS:528:DC%2BD1MXhtVKkurnF, PID: 19521351
    • Ravussin E, Smith SR, Mitchell JA et al (2009) Enhanced weight loss with pramlintide/metreleptin: an integrated neurohormonal approach to obesity pharmacotherapy. Obesity 17:1736–1743
    • (2009) Obesity , vol.17 , pp. 1736-1743
    • Ravussin, E.1    Smith, S.R.2    Mitchell, J.A.3
  • 53
    • 84931081506 scopus 로고    scopus 로고
    • Cooperative interaction between leptin and amylin signaling in the ventral tegmental area for the control of food intake
    • PID: 25898952
    • Mietlicki-Baase EG, Olivos DR, Jeffrey BA, Hayes MR (2015) Cooperative interaction between leptin and amylin signaling in the ventral tegmental area for the control of food intake. Am J Physiol Endocrinol Metab 308:E1116–E1122
    • (2015) Am J Physiol Endocrinol Metab , vol.308 , pp. E1116-E1122
    • Mietlicki-Baase, E.G.1    Olivos, D.R.2    Jeffrey, B.A.3    Hayes, M.R.4
  • 54
    • 73649137524 scopus 로고    scopus 로고
    • Mechanisms of amylin/leptin synergy in rodent models
    • COI: 1:CAS:528:DC%2BC3cXls1Cqsw%3D%3D, PID: 19875640
    • Turek VF, Trevaskis JL, Levin BE et al (2010) Mechanisms of amylin/leptin synergy in rodent models. Endocrinology 151:143–152
    • (2010) Endocrinology , vol.151 , pp. 143-152
    • Turek, V.F.1    Trevaskis, J.L.2    Levin, B.E.3
  • 55
    • 84921264634 scopus 로고    scopus 로고
    • Leptin therapy gains FDA approval
    • COI: 1:CAS:528:DC%2BC2cXmtlWns70%3D, PID: 24714458
    • Sinha G (2014) Leptin therapy gains FDA approval. Nat Biotechnol 32:300–302
    • (2014) Nat Biotechnol , vol.32 , pp. 300-302
    • Sinha, G.1
  • 56
    • 84949110073 scopus 로고    scopus 로고
    • Metreleptin for injection to treat the complications of leptin deficiency in patients with congenital or acquired generalized lipodystrophy
    • COI: 1:CAS:528:DC%2BC2MXhvFanurrI, PID: 26465174
    • Meehan CA, Cochran E, Kassai A, Brown RJ, Gorden P (2016) Metreleptin for injection to treat the complications of leptin deficiency in patients with congenital or acquired generalized lipodystrophy. Expert Rev Clin Pharmacol 9:59–68
    • (2016) Expert Rev Clin Pharmacol , vol.9 , pp. 59-68
    • Meehan, C.A.1    Cochran, E.2    Kassai, A.3    Brown, R.J.4    Gorden, P.5
  • 57
    • 84941927691 scopus 로고    scopus 로고
    • New advances in the treatment of generalized lipodystrophy: role of metreleptin
    • PID: 26396524
    • Rodriguez AJ, Mastronardi CA, Paz-Filho GJ (2015) New advances in the treatment of generalized lipodystrophy: role of metreleptin. Ther Clin Risk Manag 11:1391–1400
    • (2015) Ther Clin Risk Manag , vol.11 , pp. 1391-1400
    • Rodriguez, A.J.1    Mastronardi, C.A.2    Paz-Filho, G.J.3
  • 58
    • 84947020463 scopus 로고    scopus 로고
    • Emerging opportunities for the treatment of metabolic diseases: Glucagon-like peptide-1 based multi-agonists
    • Finan B, Clemmensen C, Muller TD (2015) Emerging opportunities for the treatment of metabolic diseases: Glucagon-like peptide-1 based multi-agonists. Mol Cell Endocrinol 418P1:42–54
    • (2015) Mol Cell Endocrinol , vol.418P1 , pp. 42-54
    • Finan, B.1    Clemmensen, C.2    Muller, T.D.3
  • 59
    • 70349308687 scopus 로고    scopus 로고
    • A new glucagon and GLP-1 co-agonist eliminates obesity in rodents
    • COI: 1:CAS:528:DC%2BD1MXosFWhsLk%3D, PID: 19597507
    • Day JW, Ottaway N, Patterson JT et al (2009) A new glucagon and GLP-1 co-agonist eliminates obesity in rodents. Nat Chem Biol 5:749–757
    • (2009) Nat Chem Biol , vol.5 , pp. 749-757
    • Day, J.W.1    Ottaway, N.2    Patterson, J.T.3
  • 60
    • 84897909191 scopus 로고    scopus 로고
    • GLP-1/glucagon coagonism restores leptin responsiveness in obese mice chronically maintained on an obesogenic diet
    • COI: 1:CAS:528:DC%2BC2cXls1Oit74%3D, PID: 24379349
    • Clemmensen C, Chabenne J, Finan B et al (2014) GLP-1/glucagon coagonism restores leptin responsiveness in obese mice chronically maintained on an obesogenic diet. Diabetes 63:1422–1427
    • (2014) Diabetes , vol.63 , pp. 1422-1427
    • Clemmensen, C.1    Chabenne, J.2    Finan, B.3
  • 61
    • 84908632199 scopus 로고    scopus 로고
    • Coinfusion of low-dose GLP-1 and glucagon in man results in a reduction in food intake
    • COI: 1:CAS:528:DC%2BC2cXhvVyhu7nK, PID: 24939425
    • Cegla J, Troke RC, Jones B et al (2014) Coinfusion of low-dose GLP-1 and glucagon in man results in a reduction in food intake. Diabetes 63:3711–3720
    • (2014) Diabetes , vol.63 , pp. 3711-3720
    • Cegla, J.1    Troke, R.C.2    Jones, B.3
  • 62
    • 84875409178 scopus 로고    scopus 로고
    • Coadministration of glucagon-like peptide-1 during glucagon infusion in humans results in increased energy expenditure and amelioration of hyperglycemia
    • COI: 1:CAS:528:DC%2BC3sXpvFCkur4%3D, PID: 23248172
    • Tan TM, Field BC, McCullough KA et al (2013) Coadministration of glucagon-like peptide-1 during glucagon infusion in humans results in increased energy expenditure and amelioration of hyperglycemia. Diabetes 62:1131–1138
    • (2013) Diabetes , vol.62 , pp. 1131-1138
    • Tan, T.M.1    Field, B.C.2    McCullough, K.A.3
  • 63
    • 84870902173 scopus 로고    scopus 로고
    • Targeted estrogen delivery reverses the metabolic syndrome
    • COI: 1:CAS:528:DC%2BC38Xhs1CktL7F, PID: 23142820
    • Finan B, Yang B, Ottaway N et al (2012) Targeted estrogen delivery reverses the metabolic syndrome. Nat Med 18:1847–1856
    • (2012) Nat Med , vol.18 , pp. 1847-1856
    • Finan, B.1    Yang, B.2    Ottaway, N.3
  • 64
    • 84873163621 scopus 로고    scopus 로고
    • Hypertension in obesity: is leptin the culprit?
    • COI: 1:CAS:528:DC%2BC3sXht1Oqsrk%3D, PID: 23333346
    • Simonds SE, Cowley MA (2013) Hypertension in obesity: is leptin the culprit? Trends Neurosci 36:121–132
    • (2013) Trends Neurosci , vol.36 , pp. 121-132
    • Simonds, S.E.1    Cowley, M.A.2
  • 65
    • 84973863192 scopus 로고    scopus 로고
    • Immunogenicity associated with metreleptin treatment in patients with obesity or lipodystrophy
    • Chan JL, Koda J, Heilig JS et al (2015) Immunogenicity associated with metreleptin treatment in patients with obesity or lipodystrophy. Clin Endocrinol. doi:10.1111/cen.12980
    • (2015) Clin Endocrinol
    • Chan, J.L.1    Koda, J.2    Heilig, J.S.3


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