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Volumn 11, Issue , 2015, Pages 1391-1400

New advances in the treatment of generalized lipodystrophy: Role of metreleptin

Author keywords

Adipose tissue; Leptin; Lipodystrophy; Metreleptin; Pharmacology

Indexed keywords

HEMOGLOBIN A1C; LEPTIN; METRELEPTIN; TRIACYLGLYCEROL;

EID: 84941927691     PISSN: 11766336     EISSN: 1178203X     Source Type: Journal    
DOI: 10.2147/TCRM.S66521     Document Type: Review
Times cited : (21)

References (62)
  • 1
    • 79952185204 scopus 로고    scopus 로고
    • Lipodystrophy: Pathophysiology and advances in treatment
    • Fiorenza CG, Chou SH, Mantzoros CS. Lipodystrophy: pathophysiology and advances in treatment. Nat Rev Endocrinol. 2011;7(3):137-150.
    • (2011) Nat Rev Endocrinol , vol.7 , Issue.3 , pp. 137-150
    • Fiorenza, C.G.1    Chou, S.H.2    Mantzoros, C.S.3
  • 2
    • 80655145234 scopus 로고    scopus 로고
    • Clinical review: Lipodystrophies: Genetic and acquired body fat disorders
    • Garg A. Clinical review: lipodystrophies: genetic and acquired body fat disorders. J Clin Endocrinol Metab. 2011;96(11):3313-3325.
    • (2011) J Clin Endocrinol Metab , vol.96 , Issue.11 , pp. 3313-3325
    • Garg, A.1
  • 3
    • 84921953911 scopus 로고    scopus 로고
    • Leptin in congenital and HIV-associated lipodystrophy
    • Tsoukas MA, Farr OM, Mantzoros CS. Leptin in congenital and HIV-associated lipodystrophy. Metabolism. 2015;64(1):47-59.
    • (2015) Metabolism , vol.64 , Issue.1 , pp. 47-59
    • Tsoukas, M.A.1    Farr, O.M.2    Mantzoros, C.S.3
  • 4
    • 0031053535 scopus 로고    scopus 로고
    • Immunohistochemical localization of leptin and uncoupling protein in white and brown adipose tissue
    • Cinti S, Frederich RC, Zingaretti MC, De Matteis R, Flier JS, Lowell BB. Immunohistochemical localization of leptin and uncoupling protein in white and brown adipose tissue. Endocrinology. 1997;138(2):797-804.
    • (1997) Endocrinology , vol.138 , Issue.2 , pp. 797-804
    • Cinti, S.1    Frederich, R.C.2    Zingaretti, M.C.3    De Matteis, R.4    Flier, J.S.5    Lowell, B.B.6
  • 5
    • 84937970956 scopus 로고    scopus 로고
    • University of Washington Center for Mendelian G. Whole exome sequencing identifies de novo heterozygous CAV1 mutations associated with a novel neonatal onset lipodystrophy syndrome
    • Garg A, Kircher M, Del Campo M, Amato RS, Agarwal AK, University of Washington Center for Mendelian G. Whole exome sequencing identifies de novo heterozygous CAV1 mutations associated with a novel neonatal onset lipodystrophy syndrome. Am J Med Genet A. 2015;167(8):1796-1806.
    • (2015) Am J Med Genet A , vol.167 , Issue.8 , pp. 1796-1806
    • Garg, A.1    Kircher, M.2    Del Campo, M.3    Amato, R.S.4    Agarwal, A.K.5
  • 6
    • 79955907495 scopus 로고    scopus 로고
    • Molecular mechanisms of human lipodystrophies: From adipocyte lipid droplet to oxidative stress and lipotoxicity
    • Vigouroux C, Caron-Debarle M, Le Dour C, Magre J, Capeau J. Molecular mechanisms of human lipodystrophies: from adipocyte lipid droplet to oxidative stress and lipotoxicity. Int J Biochem Cell Biol. 2011;43(6):862-876.
    • (2011) Int J Biochem Cell Biol , vol.43 , Issue.6 , pp. 862-876
    • Vigouroux, C.1    Caron-Debarle, M.2    Le Dour, C.3    Magre, J.4    Capeau, J.5
  • 7
    • 77953939677 scopus 로고    scopus 로고
    • Clinical classification and treatment of congenital and acquired lipodystrophy
    • Chan JL, Oral EA. Clinical classification and treatment of congenital and acquired lipodystrophy. Endocr Pract. 2010;16(2):310-323.
    • (2010) Endocr Pract , vol.16 , Issue.2 , pp. 310-323
    • Chan, J.L.1    Oral, E.A.2
  • 8
    • 84939466634 scopus 로고    scopus 로고
    • Lipodystrophies: Adipose tissue disorders with severe metabolic implications
    • Apr 2
    • Cortes VA, Fernandez-Galilea M. Lipodystrophies: adipose tissue disorders with severe metabolic implications. J Physiol Biochem. Epub 2015 Apr 2.
    • (2015) J Physiol Biochem. Epub
    • Cortes, V.A.1    Fernandez-Galilea, M.2
  • 10
    • 77955665707 scopus 로고    scopus 로고
    • Is there a human model for the ‘metabolic syndrome’ with a defined aetiology?
    • Gorden P, Lupsa BC, Chong AY, Lungu AO. Is there a human model for the ‘metabolic syndrome’ with a defined aetiology? Diabetologia. 2010;53(7):1534-1536.
    • (2010) Diabetologia , vol.53 , Issue.7 , pp. 1534-1536
    • Gorden, P.1    Lupsa, B.C.2    Chong, A.Y.3    Lungu, A.O.4
  • 11
    • 84923955669 scopus 로고    scopus 로고
    • Leptin treatment: Facts and expectations
    • Paz-Filho G, Mastronardi CA, Licinio J. Leptin treatment: facts and expectations. Metabolism. 2015;64(1):146-156.
    • (2015) Metabolism , vol.64 , Issue.1 , pp. 146-156
    • Paz-Filho, G.1    Mastronardi, C.A.2    Licinio, J.3
  • 12
    • 84879467338 scopus 로고    scopus 로고
    • Metreleptin: First global approval
    • Chou K, Perry CM. Metreleptin: first global approval. Drugs. 2013;73(9):989-997.
    • (2013) Drugs , vol.73 , Issue.9 , pp. 989-997
    • Chou, K.1    Perry, C.M.2
  • 13
    • 84921264634 scopus 로고    scopus 로고
    • Leptin therapy gains FDA approval
    • Sinha G. Leptin therapy gains FDA approval. Nat Biotechnol. 2014;32(4):300-302.
    • (2014) Nat Biotechnol , vol.32 , Issue.4 , pp. 300-302
    • Sinha, G.1
  • 14
    • 84879990867 scopus 로고    scopus 로고
    • Molecular pathways involved in the improvement of non-alcoholic fatty liver disease
    • Paz-Filho G, Mastronardi CA, Parker BJ, et al. Molecular pathways involved in the improvement of non-alcoholic fatty liver disease. J Mol Endocrinol. 2013;51(1):167-179.
    • (2013) J Mol Endocrinol , vol.51 , Issue.1 , pp. 167-179
    • Paz-Filho, G.1    Mastronardi, C.A.2    Parker, B.J.3
  • 15
    • 84919386898 scopus 로고    scopus 로고
    • Leptin replacement therapy for the treatment of non-HAART associated lipodystrophy syndromes: A meta-analysis into the effects of leptin on metabolic and hepatic endpoints
    • Rodriguez AJ, Neeman T, Giles AG, Mastronardi CA, Paz Filho G. Leptin replacement therapy for the treatment of non-HAART associated lipodystrophy syndromes: a meta-analysis into the effects of leptin on metabolic and hepatic endpoints. Arq Bras Endocrinol Metabol. 2014;58(8):783-797.
    • (2014) Arq Bras Endocrinol Metabol , vol.58 , Issue.8 , pp. 783-797
    • Rodriguez, A.J.1    Neeman, T.2    Giles, A.G.3    Mastronardi, C.A.4    Paz Filho, G.5
  • 16
    • 84929347106 scopus 로고    scopus 로고
    • Partial and generalized lipodystrophy: Comparison of baseline characteristics and response to metreleptin
    • Diker-Cohen T, Cochran E, Gorden P, Brown RJ. Partial and generalized lipodystrophy: comparison of baseline characteristics and response to metreleptin. J Clin Endocrinol Metab. 2015;100(5):1802-1810.
    • (2015) J Clin Endocrinol Metab , vol.100 , Issue.5 , pp. 1802-1810
    • Diker-Cohen, T.1    Cochran, E.2    Gorden, P.3    Brown, R.J.4
  • 17
    • 32944460924 scopus 로고    scopus 로고
    • Genetic basis of lipodystrophies and management of metabolic complications
    • Agarwal AK, Garg A. Genetic basis of lipodystrophies and management of metabolic complications. Annu Rev Med. 2006;57:297-311.
    • (2006) Annu Rev Med , vol.57 , pp. 297-311
    • Agarwal, A.K.1    Garg, A.2
  • 18
    • 79954546193 scopus 로고    scopus 로고
    • Genetic and metabolic description of five patients with Berardinelli-Seip syndrome
    • Barra CB, Savoldelli RD, Manna TD, et al. Genetic and metabolic description of five patients with Berardinelli-Seip syndrome. Arq Bras Endocrinol Metabol. 2011;55(1):54-59.
    • (2011) Arq Bras Endocrinol Metabol , vol.55 , Issue.1 , pp. 54-59
    • Barra, C.B.1    Savoldelli, R.D.2    Manna, T.D.3
  • 19
    • 0036578783 scopus 로고    scopus 로고
    • AGPAT2 is mutated in congenital generalized lipodystrophy linked to chromosome 9q34
    • Agarwal AK, Arioglu E, De Almeida S, et al. AGPAT2 is mutated in congenital generalized lipodystrophy linked to chromosome 9q34. Nat Genet. 2002;31(1):21-23.
    • (2002) Nat Genet , vol.31 , Issue.1 , pp. 21-23
    • Agarwal, A.K.1    Arioglu, E.2    De Almeida, S.3
  • 20
    • 0034941121 scopus 로고    scopus 로고
    • Identification of the gene altered in Berardinelli-Seip congenital lipodystrophy on chromosome 11q13
    • Magre J, Delepine M, Khallouf E, et al. Identification of the gene altered in Berardinelli-Seip congenital lipodystrophy on chromosome 11q13. Nat Genet. 2001;28(4):365-370.
    • (2001) Nat Genet , vol.28 , Issue.4 , pp. 365-370
    • Magre, J.1    Delepine, M.2    Khallouf, E.3
  • 21
    • 41549146084 scopus 로고    scopus 로고
    • Association of a homozygous nonsense caveolin-1 mutation with Berardinelli-Seip congenital lipodystrophy
    • Kim CA, Delepine M, Boutet E, et al. Association of a homozygous nonsense caveolin-1 mutation with Berardinelli-Seip congenital lipodystrophy. J Clin Endocrinol Metab. 2008;93(4):1129-1134.
    • (2008) J Clin Endocrinol Metab , vol.93 , Issue.4 , pp. 1129-1134
    • Kim, C.A.1    Delepine, M.2    Boutet, E.3
  • 22
    • 70349195987 scopus 로고    scopus 로고
    • Human PTRF mutations cause secondary deficiency of caveolins resulting in muscular dystrophy with generalized lipodystrophy
    • Hayashi YK, Matsuda C, Ogawa M, et al. Human PTRF mutations cause secondary deficiency of caveolins resulting in muscular dystrophy with generalized lipodystrophy. J Clin Invest. 2009;119(9):2623-2633.
    • (2009) J Clin Invest , vol.119 , Issue.9 , pp. 2623-2633
    • Hayashi, Y.K.1    Matsuda, C.2    Ogawa, M.3
  • 23
    • 84893216910 scopus 로고    scopus 로고
    • Exploring the pathophysiology behind the more common genetic and acquired lipodystrophies
    • Nolis T. Exploring the pathophysiology behind the more common genetic and acquired lipodystrophies. J Hum Genet. 2014;59(1):16-23.
    • (2014) J Hum Genet , vol.59 , Issue.1 , pp. 16-23
    • Nolis, T.1
  • 24
    • 0023507413 scopus 로고
    • Lipoatrophic panniculitis: A possible autoimmune inflammatory disease of fat. Report of three cases
    • Billings JK, Milgraum SS, Gupta AK, Headington JT, Rasmussen JE. Lipoatrophic panniculitis: a possible autoimmune inflammatory disease of fat. Report of three cases. Arch Dermatol. 1987;123(12):1662-1666.
    • (1987) Arch Dermatol , vol.123 , Issue.12 , pp. 1662-1666
    • Billings, J.K.1    Milgraum, S.S.2    Gupta, A.K.3    Headington, J.T.4    Rasmussen, J.E.5
  • 25
    • 0031931291 scopus 로고    scopus 로고
    • Dysregulation of insulin-like growth factors in a case of generalized acquired lipoatrophic diabetes mellitus (Lawrence Syndrome) connected with autoantibodies against adipocyte membranes
    • Hubler A, Abendroth K, Keiner T, et al. Dysregulation of insulin-like growth factors in a case of generalized acquired lipoatrophic diabetes mellitus (Lawrence Syndrome) connected with autoantibodies against adipocyte membranes. Exp Clin Endocrinol Diabetes. 1998;106(1):79-84.
    • (1998) Exp Clin Endocrinol Diabetes , vol.106 , Issue.1 , pp. 79-84
    • Hubler, A.1    Abendroth, K.2    Keiner, T.3
  • 26
    • 84879130540 scopus 로고    scopus 로고
    • The liver diseases of lipodystrophy: The long-term effect of leptin treatment
    • Safar Zadeh E, Lungu AO, Cochran EK, et al. The liver diseases of lipodystrophy: the long-term effect of leptin treatment. J Hepatol. 2013;59(1):131-137.
    • (2013) J Hepatol , vol.59 , Issue.1 , pp. 131-137
    • Safar Zadeh, E.1    Lungu, A.O.2    Cochran, E.K.3
  • 27
    • 84931025156 scopus 로고    scopus 로고
    • Metreleptin and generalized lipodystrophy and evolving therapeutic perspectives
    • Tchang BG, Shukla AP, Aronne LJ. Metreleptin and generalized lipodystrophy and evolving therapeutic perspectives. Expert Opin Biol Ther. 2015;15(7):1061-1075.
    • (2015) Expert Opin Biol Ther , vol.15 , Issue.7 , pp. 1061-1075
    • Tchang, B.G.1    Shukla, A.P.2    Aronne, L.J.3
  • 29
    • 84941920064 scopus 로고    scopus 로고
    • Endocrinologic and Metabolic Drugs Advisory Committee Briefing Document 2013, Accessed July 8, 2015
    • Bristol-Myers Squibb Company. Endocrinologic and Metabolic Drugs Advisory Committee Briefing Document 2013; 2013. Available from: http://www.fda.gov/downloads/AdvisoryCommittees/CommitteesMeetingMaterials/Drugs/EndocrinologicandMetabolicDrugsAdvisoryCommittee/UCM377929.pdf. Accessed July 8, 2015
    • (2013)
  • 30
    • 0033051724 scopus 로고    scopus 로고
    • Effect of leptin on cytochrome P-450, conjugation, and antioxidant enzymes in the ob/ob mouse
    • Watson AM, Poloyac SM, Howard G, Blouin RA. Effect of leptin on cytochrome P-450, conjugation, and antioxidant enzymes in the ob/ob mouse. Drug Metab Dispos. 1999;27(6):695-700.
    • (1999) Drug Metab Dispos , vol.27 , Issue.6 , pp. 695-700
    • Watson, A.M.1    Poloyac, S.M.2    Howard, G.3    Blouin, R.A.4
  • 31
    • 77953527930 scopus 로고    scopus 로고
    • Neuroendocrine body weight regulation: Integration between fat tissue, gastrointestinal tract, and the brain
    • Boguszewski CL, Paz-Filho G, Velloso LA. Neuroendocrine body weight regulation: integration between fat tissue, gastrointestinal tract, and the brain. Endokrynol Pol. 2010;61(2):194-206.
    • (2010) Endokrynol Pol , vol.61 , Issue.2 , pp. 194-206
    • Boguszewski, C.L.1    Paz-Filho, G.2    Velloso, L.A.3
  • 32
    • 79955043136 scopus 로고    scopus 로고
    • Ten years of leptin replacement therapy
    • Paz-Filho G, Wong ML, Licinio J. Ten years of leptin replacement therapy. Obes Rev. 2011;12(5):e315-e323.
    • (2011) Obes Rev , vol.12 , Issue.5 , pp. e315-e323
    • Paz-Filho, G.1    Wong, M.L.2    Licinio, J.3
  • 33
    • 0037148928 scopus 로고    scopus 로고
    • Leptin-replacement therapy for lipodystrophy
    • Oral EA, Simha V, Ruiz E, et al. Leptin-replacement therapy for lipodystrophy. N Engl J Med. 2002;346(8):570-578.
    • (2002) N Engl J Med , vol.346 , Issue.8 , pp. 570-578
    • Oral, E.A.1    Simha, V.2    Ruiz, E.3
  • 34
    • 49449092051 scopus 로고    scopus 로고
    • Berardinelli syndrome. A case report with fatal outcome
    • Daher E, Silva Junior G, Benevides V, et al. Berardinelli syndrome. A case report with fatal outcome. Invest Clin. 2008;49(2):251-255.
    • (2008) Invest Clin , vol.49 , Issue.2 , pp. 251-255
    • Daher, E.1    Silva Junior, G.2    Benevides, V.3
  • 35
    • 0029895842 scopus 로고    scopus 로고
    • Generalized lipodystrophy, congenital and acquired (Lipoatrophy)
    • Seip M, Trygstad O. Generalized lipodystrophy, congenital and acquired (lipoatrophy). Acta Paediatr Suppl. 1996;413:2-28.
    • (1996) Acta Paediatr Suppl , vol.413 , pp. 2-28
    • Seip, M.1    Trygstad, O.2
  • 36
    • 34547652977 scopus 로고    scopus 로고
    • Metabolic correction induced by leptin replacement treatment in young children with Berardinelli-Seip congenital lipoatrophy
    • Beltrand J, Beregszaszi M, Chevenne D, et al. Metabolic correction induced by leptin replacement treatment in young children with Berardinelli-Seip congenital lipoatrophy. Pediatrics. 2007;120(2):e291-e296.
    • (2007) Pediatrics , vol.120 , Issue.2 , pp. e291-e296
    • Beltrand, J.1    Beregszaszi, M.2    Chevenne, D.3
  • 37
    • 77952692495 scopus 로고    scopus 로고
    • Resistance to leptin-replacement therapy in Berardinelli-Seip congenital lipodystrophy: An immunological origin
    • Beltrand J, Lahlou N, Le Charpentier T, et al. Resistance to leptin-replacement therapy in Berardinelli-Seip congenital lipodystrophy: an immunological origin. Eur J Endocrinol. 2010;162(6):1083-1091.
    • (2010) Eur J Endocrinol , vol.162 , Issue.6 , pp. 1083-1091
    • Beltrand, J.1    Lahlou, N.2    Le Charpentier, T.3
  • 38
    • 84862951024 scopus 로고    scopus 로고
    • Clinical effects of long-term metreleptin treatment in patients with lipodystrophy
    • Chan JL, Lutz K, Cochran E, et al. Clinical effects of long-term metreleptin treatment in patients with lipodystrophy. Endocr Pract. 2011;17(6):922-932.
    • (2011) Endocr Pract , vol.17 , Issue.6 , pp. 922-932
    • Chan, J.L.1    Lutz, K.2    Cochran, E.3
  • 39
    • 72449185147 scopus 로고    scopus 로고
    • Efficacy of leptin therapy in the different forms of human lipodystrophy
    • Chong AY, Lupsa BC, Cochran EK, Gorden P. Efficacy of leptin therapy in the different forms of human lipodystrophy. Diabetologia. 2010;53(1):27-35.
    • (2010) Diabetologia , vol.53 , Issue.1 , pp. 27-35
    • Chong, A.Y.1    Lupsa, B.C.2    Cochran, E.K.3    Gorden, P.4
  • 40
    • 33846950833 scopus 로고    scopus 로고
    • Efficacy and safety of leptin-replacement therapy and possible mechanisms of leptin actions in patients with generalized lipodystrophy
    • Ebihara K, Kusakabe T, Hirata M, et al. Efficacy and safety of leptin-replacement therapy and possible mechanisms of leptin actions in patients with generalized lipodystrophy. J Clin Endocrinol Metab. 2007;92(2):532-541.
    • (2007) J Clin Endocrinol Metab , vol.92 , Issue.2 , pp. 532-541
    • Ebihara, K.1    Kusakabe, T.2    Hirata, M.3
  • 41
    • 21344447493 scopus 로고    scopus 로고
    • Long-term efficacy of leptin replacement in patients with generalized lipodystrophy
    • Javor ED, Cochran EK, Musso C, Young JR, Depaoli AM, Gorden P. Long-term efficacy of leptin replacement in patients with generalized lipodystrophy. Diabetes. 2005;54(7):1994-2002.
    • (2005) Diabetes , vol.54 , Issue.7 , pp. 1994-2002
    • Javor, E.D.1    Cochran, E.K.2    Musso, C.3    Young, J.R.4    Depaoli, A.M.5    Gorden, P.6
  • 42
    • 16244363679 scopus 로고    scopus 로고
    • Leptin reverses nonalcoholic steatohepatitis in patients with severe lipodystrophy
    • Javor ED, Ghany MG, Cochran EK, et al. Leptin reverses nonalcoholic steatohepatitis in patients with severe lipodystrophy. Hepatology. 2005;41(4):753-760.
    • (2005) Hepatology , vol.41 , Issue.4 , pp. 753-760
    • Javor, E.D.1    Ghany, M.G.2    Cochran, E.K.3
  • 43
    • 12144288571 scopus 로고    scopus 로고
    • Changes in body composition in patients with severe lipodystrophy after leptin replacement therapy
    • Moran SA, Patten N, Young JR, et al. Changes in body composition in patients with severe lipodystrophy after leptin replacement therapy. Metabolism. 2004;53(4):513-519.
    • (2004) Metabolism , vol.53 , Issue.4 , pp. 513-519
    • Moran, S.A.1    Patten, N.2    Young, J.R.3
  • 44
    • 0036317022 scopus 로고    scopus 로고
    • Effect of leptin replacement on pituitary hormone regulation in patients with severe lipodystrophy
    • Oral EA, Ruiz E, Andewelt A, et al. Effect of leptin replacement on pituitary hormone regulation in patients with severe lipodystrophy. J Clin Endocrinol Metab. 2002;87(7):3110-3117.
    • (2002) J Clin Endocrinol Metab , vol.87 , Issue.7 , pp. 3110-3117
    • Oral, E.A.1    Ruiz, E.2    Ewelt, A.3
  • 45
    • 33947283865 scopus 로고    scopus 로고
    • Long-term efficacy of leptin replacement in patients with Dunnigan-type familial partial lipodystrophy
    • Park JY, Javor ED, Cochran EK, DePaoli AM, Gorden P. Long-term efficacy of leptin replacement in patients with Dunnigan-type familial partial lipodystrophy. Metabolism. 2007;56(4):508-516.
    • (2007) Metabolism , vol.56 , Issue.4 , pp. 508-516
    • Park, J.Y.1    Javor, E.D.2    Cochran, E.K.3    Depaoli, A.M.4    Gorden, P.5
  • 46
    • 0036114844 scopus 로고    scopus 로고
    • Leptin reverses insulin resistance and hepatic steatosis in patients with severe lipodystrophy
    • Petersen KF, Oral EA, Dufour S, et al. Leptin reverses insulin resistance and hepatic steatosis in patients with severe lipodystrophy. J Clin Invest. 2002;109(10):1345-1350.
    • (2002) J Clin Invest , vol.109 , Issue.10 , pp. 1345-1350
    • Petersen, K.F.1    Oral, E.A.2    Dufour, S.3
  • 47
    • 84858027751 scopus 로고    scopus 로고
    • Comparison of efficacy and safety of leptin replacement therapy in moderately and severely hypoleptinemic patients with familial partial lipodystrophy of the Dunnigan variety
    • Simha V, Subramanyam L, Szczepaniak L, et al. Comparison of efficacy and safety of leptin replacement therapy in moderately and severely hypoleptinemic patients with familial partial lipodystrophy of the Dunnigan variety. J Clin Endocrinol Metab. 2012;97(3):785-792.
    • (2012) J Clin Endocrinol Metab , vol.97 , Issue.3 , pp. 785-792
    • Simha, V.1    Subramanyam, L.2    Szczepaniak, L.3
  • 48
    • 84897886068 scopus 로고    scopus 로고
    • Effects of leptin replacement therapy on pancreatic beta-cell function in patients with lipodystrophy
    • Muniyappa R, Brown RJ, Mari A, et al. Effects of leptin replacement therapy on pancreatic beta-cell function in patients with lipodystrophy. Diabetes Care. 2014;37(4):1101-1107.
    • (2014) Diabetes Care , vol.37 , Issue.4 , pp. 1101-1107
    • Muniyappa, R.1    Brown, R.J.2    Mari, A.3
  • 49
    • 84905833730 scopus 로고    scopus 로고
    • Bone mineral content in patients with congenital generalized lipodystrophy is unaffected by metreleptin replacement therapy
    • Christensen JD, Lungu AO, Cochran E, et al. Bone mineral content in patients with congenital generalized lipodystrophy is unaffected by metreleptin replacement therapy. J Clin Endocrinol Metab. 2014;99(8):E1493-E1500.
    • (2014) J Clin Endocrinol Metab , vol.99 , Issue.8 , pp. E1493-E1500
    • Christensen, J.D.1    Lungu, A.O.2    Cochran, E.3
  • 50
    • 84941919834 scopus 로고    scopus 로고
    • Lymphoma in acquired generalized lipodystrophy. Leuk Lymphoma
    • Brown RJ, Chan JL, Jaffe ES, et al. Lymphoma in acquired generalized lipodystrophy. Leuk Lymphoma. Epub 2015 Feb 13.
    • (2015) Epub , pp. 13
    • Brown, R.J.1    Chan, J.L.2    Jaffe, E.S.3
  • 51
    • 84932194685 scopus 로고    scopus 로고
    • Acquired generalized lipodystrophy associated with peripheral T cell lymphoma with cutaneous infiltration
    • Aslam A, Savage DB, Coulson IH. Acquired generalized lipodystrophy associated with peripheral T cell lymphoma with cutaneous infiltration. Int J Dermatol. 2015;54(7):827-829.
    • (2015) Int J Dermatol , vol.54 , Issue.7 , pp. 827-829
    • Aslam, A.1    Savage, D.B.2    Coulson, I.H.3
  • 52
    • 33845321919 scopus 로고    scopus 로고
    • Peripheral T-cell lymphoma presenting as lipoatrophy and nodules
    • Yiannias JA, DiCaudo DJ, Maskin E. Peripheral T-cell lymphoma presenting as lipoatrophy and nodules. Int J Dermatol. 2006;45(12):1415-1419.
    • (2006) Int J Dermatol , vol.45 , Issue.12 , pp. 1415-1419
    • Yiannias, J.A.1    Dicaudo, D.J.2    Maskin, E.3
  • 53
    • 80051800457 scopus 로고    scopus 로고
    • Long-term metreleptin treatment increases bone mineral density and content at the lumbar spine of lean hypoleptinemic women
    • Sienkiewicz E, Magkos F, Aronis KN, et al. Long-term metreleptin treatment increases bone mineral density and content at the lumbar spine of lean hypoleptinemic women. Metabolism. 2011;60(9):1211-1221.
    • (2011) Metabolism , vol.60 , Issue.9 , pp. 1211-1221
    • Sienkiewicz, E.1    Magkos, F.2    Aronis, K.N.3
  • 54
    • 84884395655 scopus 로고    scopus 로고
    • Selective leptin resistance revisited
    • Mark AL. Selective leptin resistance revisited. Am J Physiol Regul Integr Comp Physiol. 2013;305(6):R566-R581.
    • (2013) Am J Physiol Regul Integr Comp Physiol , vol.305 , Issue.6 , pp. R566-R581
    • Mark, A.L.1
  • 55
    • 27744596187 scopus 로고    scopus 로고
    • Effect of three treatment schedules of recombinant methionyl human leptin on body weight in obese adults: A randomized, placebo-controlled trial
    • Zelissen PM, Stenlof K, Lean ME, et al. Effect of three treatment schedules of recombinant methionyl human leptin on body weight in obese adults: a randomized, placebo-controlled trial. Diabetes Obes Metab. 2005;7(6):755-761.
    • (2005) Diabetes Obes Metab , vol.7 , Issue.6 , pp. 755-761
    • Zelissen, P.M.1    Stenlof, K.2    Lean, M.E.3
  • 56
    • 0032747280 scopus 로고    scopus 로고
    • Recombinant leptin for weight loss in obese and lean adults: A randomized, controlled, dose-escalation trial
    • Heymsfield SB, Greenberg AS, Fujioka K, et al. Recombinant leptin for weight loss in obese and lean adults: a randomized, controlled, dose-escalation trial. J Am Med Assoc. 1999;282(16):1568-1575.
    • (1999) J am Med Assoc , vol.282 , Issue.16 , pp. 1568-1575
    • Heymsfield, S.B.1    Greenberg, A.S.2    Fujioka, K.3
  • 57
    • 79959409408 scopus 로고    scopus 로고
    • Efficacy of metreleptin in obese patients with type 2 diabetes: Cellular and molecular pathways underlying leptin tolerance
    • Moon HS, Matarese G, Brennan AM, et al. Efficacy of metreleptin in obese patients with type 2 diabetes: cellular and molecular pathways underlying leptin tolerance. Diabetes. 2011;60(6):1647-1656.
    • (2011) Diabetes , vol.60 , Issue.6 , pp. 1647-1656
    • Moon, H.S.1    Matarese, G.2    Brennan, A.M.3
  • 58
    • 69749086148 scopus 로고    scopus 로고
    • Enhanced weight loss with pramlintide/metreleptin: An integrated neurohormonal approach to obesity pharmacotherapy
    • Ravussin E, Smith SR, Mitchell JA, et al. Enhanced weight loss with pramlintide/metreleptin: an integrated neurohormonal approach to obesity pharmacotherapy. Obesity (Silver Spring). 2009;17(9):1736-1743.
    • (2009) Obesity (Silver Spring) , vol.17 , Issue.9 , pp. 1736-1743
    • Ravussin, E.1    Smith, S.R.2    Mitchell, J.A.3
  • 59
    • 80555135931 scopus 로고    scopus 로고
    • Novel strategy for the use of leptin for obesity therapy
    • Tam CS, Lecoultre V, Ravussin E. Novel strategy for the use of leptin for obesity therapy. Expert Opin Biol Ther. 2011;11(12):1677-1685.
    • (2011) Expert Opin Biol Ther , vol.11 , Issue.12 , pp. 1677-1685
    • Tam, C.S.1    Lecoultre, V.2    Ravussin, E.3
  • 60
    • 79959431773 scopus 로고    scopus 로고
    • Recombinant human leptin treatment does not improve insulin action in obese subjects with type 2 diabetes
    • Mittendorfer B, Horowitz JF, DePaoli AM, McCamish MA, Patterson BW, Klein S. Recombinant human leptin treatment does not improve insulin action in obese subjects with type 2 diabetes. Diabetes. 2011;60(5):1474-1477.
    • (2011) Diabetes , vol.60 , Issue.5 , pp. 1474-1477
    • Mittendorfer, B.1    Horowitz, J.F.2    Depaoli, A.M.3    McCamish, M.A.4    Patterson, B.W.5    Klein, S.6
  • 61
    • 84924041624 scopus 로고    scopus 로고
    • Leptin and the brain: Influences on brain development, cognitive functioning and psychiatric disorders
    • Farr OM, Tsoukas MA, Mantzoros CS. Leptin and the brain: influences on brain development, cognitive functioning and psychiatric disorders. Metabolism. 2015;64(1):114-130.
    • (2015) Metabolism , vol.64 , Issue.1 , pp. 114-130
    • Farr, O.M.1    Tsoukas, M.A.2    Mantzoros, C.S.3
  • 62
    • 84941909089 scopus 로고    scopus 로고
    • Clinical perspectives: Leptin replacement therapy for the treatment of lipodystrophy-associated non-alcoholic fatty liver disease
    • Rodríguez AJ, Mastronardi CA, Paz-Filho G. Clinical perspectives: leptin replacement therapy for the treatment of lipodystrophy-associated non-alcoholic fatty liver disease. Transl Gastrointest Cancer. 2014;4(1):98-107.
    • (2014) Transl Gastrointest Cancer , vol.4 , Issue.1 , pp. 98-107
    • Rodríguez, A.J.1    Mastronardi, C.A.2    Paz-Filho, G.3


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