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Volumn 22, Issue 2, 2016, Pages 88-98

Leptin regulation of immune responses

Author keywords

Acquired immune system; Innate; Leptin regulation

Indexed keywords

LEPTIN; LEPTIN RECEPTOR; MITOGEN ACTIVATED PROTEIN KINASE; RETINOID RELATED ORPHAN RECEPTOR GAMMA; RORC PROTEIN, HUMAN;

EID: 84960408672     PISSN: 14714914     EISSN: 1471499X     Source Type: Journal    
DOI: 10.1016/j.molmed.2015.12.001     Document Type: Review
Times cited : (196)

References (64)
  • 1
    • 75949118405 scopus 로고    scopus 로고
    • Fasting and postprandial relationships among plasma leptin, ghrelin, and insulin in prepubertal obese children
    • Gil-Campos M., et al. Fasting and postprandial relationships among plasma leptin, ghrelin, and insulin in prepubertal obese children. Clin. Nutr. 2010, 29:54-59.
    • (2010) Clin. Nutr. , vol.29 , pp. 54-59
    • Gil-Campos, M.1
  • 2
    • 33845642664 scopus 로고    scopus 로고
    • The role of leptin and ghrelin in the regulation of food intake and body weight in humans: a review
    • Klok M.D., et al. The role of leptin and ghrelin in the regulation of food intake and body weight in humans: a review. Obes. Rev. 2007, 8:21-34.
    • (2007) Obes. Rev. , vol.8 , pp. 21-34
    • Klok, M.D.1
  • 3
    • 0030738331 scopus 로고    scopus 로고
    • Leptin levels do not change acutely with food administration in normal or obese subjects, but are negatively correlated with pituitary-adrenal activity
    • Korbonits M., et al. Leptin levels do not change acutely with food administration in normal or obese subjects, but are negatively correlated with pituitary-adrenal activity. Clin. Endocrinol. 1997, 46:751-757.
    • (1997) Clin. Endocrinol. , vol.46 , pp. 751-757
    • Korbonits, M.1
  • 4
    • 0035195887 scopus 로고    scopus 로고
    • Leptin regulation of the immune response and the immunodeficiency of malnutrition
    • Faggioni R., et al. Leptin regulation of the immune response and the immunodeficiency of malnutrition. FASEB J. 2001, 15:2565-2571.
    • (2001) FASEB J. , vol.15 , pp. 2565-2571
    • Faggioni, R.1
  • 5
    • 0035431169 scopus 로고    scopus 로고
    • The effects of leptin administration in non-obese human subjects
    • Mackintosh R., Hirsch J. The effects of leptin administration in non-obese human subjects. Obes. Res. 2001, 9:462-469.
    • (2001) Obes. Res. , vol.9 , pp. 462-469
    • Mackintosh, R.1    Hirsch, J.2
  • 6
    • 0034235094 scopus 로고    scopus 로고
    • Serum leptin concentrations during severe protein-energy malnutrition: correlation with growth parameters and endocrine function
    • Soliman A.T., et al. Serum leptin concentrations during severe protein-energy malnutrition: correlation with growth parameters and endocrine function. Metabolism 2000, 49:819-825.
    • (2000) Metabolism , vol.49 , pp. 819-825
    • Soliman, A.T.1
  • 7
    • 0036319605 scopus 로고    scopus 로고
    • Leptin levels are associated with immune response in malnourished infants
    • Palacio A., et al. Leptin levels are associated with immune response in malnourished infants. J. Clin. Endocrinol. Metab. 2002, 87:3040-3046.
    • (2002) J. Clin. Endocrinol. Metab. , vol.87 , pp. 3040-3046
    • Palacio, A.1
  • 8
    • 22844435205 scopus 로고    scopus 로고
    • Assessment by flow cytometry of cytokine production in malnourished children assessment by flow cytometry of cytokine production in malnourished children
    • Rodríguez L., et al. Assessment by flow cytometry of cytokine production in malnourished children assessment by flow cytometry of cytokine production in malnourished children. Clin. Vaccine Immunol. 2005, 12:502-507.
    • (2005) Clin. Vaccine Immunol. , vol.12 , pp. 502-507
    • Rodríguez, L.1
  • 9
    • 84902334434 scopus 로고    scopus 로고
    • Severe acute malnutrition in childhood: hormonal and metabolic status at presentation, response to treatment, and predictors of mortality
    • Bartz S., et al. Severe acute malnutrition in childhood: hormonal and metabolic status at presentation, response to treatment, and predictors of mortality. J. Clin. Endocrinol. Metab. 2014, 99:2128-2137.
    • (2014) J. Clin. Endocrinol. Metab. , vol.99 , pp. 2128-2137
    • Bartz, S.1
  • 10
    • 51349114095 scopus 로고    scopus 로고
    • Expression of cytokine mRNA in lymphocytes of malnourished children
    • González-Martínez H., et al. Expression of cytokine mRNA in lymphocytes of malnourished children. J. Clin. Immunol. 2008, 28:593-599.
    • (2008) J. Clin. Immunol. , vol.28 , pp. 593-599
    • González-Martínez, H.1
  • 11
    • 34247874513 scopus 로고    scopus 로고
    • Effect of leptin on activation and cytokine synthesis in peripheral blood lymphocytes of malnourished infected children
    • Rodríguez L., et al. Effect of leptin on activation and cytokine synthesis in peripheral blood lymphocytes of malnourished infected children. Clin. Exp. Immunol. 2007, 148:478-485.
    • (2007) Clin. Exp. Immunol. , vol.148 , pp. 478-485
    • Rodríguez, L.1
  • 12
    • 77951686557 scopus 로고    scopus 로고
    • Role of leptin in the activation of immune cells
    • Fernández-Riejos B., et al. Role of leptin in the activation of immune cells. Mediators Inflamm. 2011, 2010:568343.
    • (2011) Mediators Inflamm. , vol.2010 , pp. 568343
    • Fernández-Riejos, B.1
  • 13
    • 84655176433 scopus 로고    scopus 로고
    • Leptin as an immunomodulator
    • Procaccini C., et al. Leptin as an immunomodulator. Mol. Aspects Med. 2012, 33:35.
    • (2012) Mol. Aspects Med. , vol.33 , pp. 35
    • Procaccini, C.1
  • 14
    • 0036100751 scopus 로고    scopus 로고
    • Distribution of the long leptin receptor isoform in brush border, basolateral membrane, and cytoplasm of enterocytes
    • Barrenetxe J., et al. Distribution of the long leptin receptor isoform in brush border, basolateral membrane, and cytoplasm of enterocytes. Gut 2002, 50:797-802.
    • (2002) Gut , vol.50 , pp. 797-802
    • Barrenetxe, J.1
  • 15
    • 0036866913 scopus 로고    scopus 로고
    • Leptin: a review of its peripheral actions and interactions
    • Margetic S., et al. Leptin: a review of its peripheral actions and interactions. Int. J. Obes. Relat. Metab. Disord. 2002, 26:1407-1433.
    • (2002) Int. J. Obes. Relat. Metab. Disord. , vol.26 , pp. 1407-1433
    • Margetic, S.1
  • 16
    • 84866171025 scopus 로고    scopus 로고
    • Alterations of leptin in the course of inflammation and severe sepsis
    • Behnes M., et al. Alterations of leptin in the course of inflammation and severe sepsis. BMC Infect. Dis. 2012, 12:217.
    • (2012) BMC Infect. Dis. , vol.12 , pp. 217
    • Behnes, M.1
  • 17
    • 84965186219 scopus 로고    scopus 로고
    • Cytokine responses to Staphylococcus aureus bloodstream infection differ between patient cohorts that have different clinical courses of infection
    • McNicholas S., et al. Cytokine responses to Staphylococcus aureus bloodstream infection differ between patient cohorts that have different clinical courses of infection. BMC Infect. Dis. 2014, 14:580.
    • (2014) BMC Infect. Dis. , vol.14 , pp. 580
    • McNicholas, S.1
  • 18
    • 84891090989 scopus 로고    scopus 로고
    • Leptin metabolically licenses T cells for activation to link nutrition and immunity
    • Saucillo D.C., et al. Leptin metabolically licenses T cells for activation to link nutrition and immunity. J. Immunol. 2014, 192:136-144.
    • (2014) J. Immunol. , vol.192 , pp. 136-144
    • Saucillo, D.C.1
  • 20
    • 84870475160 scopus 로고    scopus 로고
    • T cell-derived leptin contributes to increased frequency of T helper type 17 cells in female patients with Hashimoto's thyroiditis
    • Wang S., et al. T cell-derived leptin contributes to increased frequency of T helper type 17 cells in female patients with Hashimoto's thyroiditis. Clin. Exp. Immunol. 2013, 171:63-68.
    • (2013) Clin. Exp. Immunol. , vol.171 , pp. 63-68
    • Wang, S.1
  • 21
    • 84868129089 scopus 로고    scopus 로고
    • h17 cell response
    • h17 cell response. Arthritis Rheum. 2012, 64:3564-3573.
    • (2012) Arthritis Rheum. , vol.64 , pp. 3564-3573
    • Deng, J.1
  • 22
    • 84929649679 scopus 로고    scopus 로고
    • h17 differentiation
    • h17 differentiation. J. Immunol. 2015, 194:5253-5260.
    • (2015) J. Immunol. , vol.194 , pp. 5253-5260
    • Reis, B.S.1
  • 23
    • 84875464349 scopus 로고    scopus 로고
    • h17 responses in systemic lupus erythematosus
    • h17 responses in systemic lupus erythematosus. J. Immunol. 2013, 190:3054-3058.
    • (2013) J. Immunol. , vol.190 , pp. 3054-3058
    • Yu, Y.1
  • 24
    • 84876461373 scopus 로고    scopus 로고
    • Circulating regulatory T cells are reduced in obesity and may identify subjects at increased metabolic and cardiovascular risk
    • Wagner N-M., et al. Circulating regulatory T cells are reduced in obesity and may identify subjects at increased metabolic and cardiovascular risk. Obesity 2013, 21:461-468.
    • (2013) Obesity , vol.21 , pp. 461-468
    • Wagner, N.-M.1
  • 25
    • 84863135746 scopus 로고    scopus 로고
    • Cutting Edge: fasting-induced hypoleptinemia expands functional regulatory T cells in systemic lupus erythematosus
    • Liu Y., et al. Cutting Edge: fasting-induced hypoleptinemia expands functional regulatory T cells in systemic lupus erythematosus. J. Immunol. 2012, 188:2070-2073.
    • (2012) J. Immunol. , vol.188 , pp. 2070-2073
    • Liu, Y.1
  • 26
    • 84863624001 scopus 로고    scopus 로고
    • Ablation of leptin receptor mediated extracellular regulated kinase activation impairs host defense against Gram-negative pneumonia
    • Mancuso P., et al. Ablation of leptin receptor mediated extracellular regulated kinase activation impairs host defense against Gram-negative pneumonia. J. Immunol. 2012, 189:867-875.
    • (2012) J. Immunol. , vol.189 , pp. 867-875
    • Mancuso, P.1
  • 27
    • 84875670302 scopus 로고    scopus 로고
    • Leptin up-regulates TLR2 in human monocytes
    • Jaedicke K.M., et al. Leptin up-regulates TLR2 in human monocytes. J. Leukoc. Biol. 2013, 93:561-571.
    • (2013) J. Leukoc. Biol. , vol.93 , pp. 561-571
    • Jaedicke, K.M.1
  • 28
    • 84861913952 scopus 로고    scopus 로고
    • Lipid droplets and cellular lipid metabolism
    • Walther T.C., Farese R.V. Lipid droplets and cellular lipid metabolism. Annu. Rev. Biochem. 2012, 81:687-714.
    • (2012) Annu. Rev. Biochem. , vol.81 , pp. 687-714
    • Walther, T.C.1    Farese, R.V.2
  • 29
    • 48349107532 scopus 로고    scopus 로고
    • Lipid bodies in innate immune response to bacterial and parasite infections
    • D'Avila H., et al. Lipid bodies in innate immune response to bacterial and parasite infections. Int. Immunopharmacol. 2008, 8:1308-1315.
    • (2008) Int. Immunopharmacol. , vol.8 , pp. 1308-1315
    • D'Avila, H.1
  • 30
    • 84874585039 scopus 로고    scopus 로고
    • High insulin and leptin increase resistin and inflammatory cytokine production from human mononuclear cells
    • Tsiotra P.C., et al. High insulin and leptin increase resistin and inflammatory cytokine production from human mononuclear cells. Biomed. Res. Int. 2013, 2013:487081.
    • (2013) Biomed. Res. Int. , vol.2013 , pp. 487081
    • Tsiotra, P.C.1
  • 31
    • 84951823798 scopus 로고    scopus 로고
    • Leptin deficiency shifts mast cells toward anti-inflammatory actions and protects mice from obesity and diabetes by polarizing m2 macrophages
    • Zhou Y., et al. Leptin deficiency shifts mast cells toward anti-inflammatory actions and protects mice from obesity and diabetes by polarizing m2 macrophages. Cell Metab. 2015, 22:1-14.
    • (2015) Cell Metab. , vol.22 , pp. 1-14
    • Zhou, Y.1
  • 33
    • 84879350349 scopus 로고    scopus 로고
    • A mechanistic role for leptin in human dendritic cell migration: differences between ileum and colon in health and Crohn's disease
    • Al-Hassi H.O., et al. A mechanistic role for leptin in human dendritic cell migration: differences between ileum and colon in health and Crohn's disease. Mucosal Immunol. 2013, 6:751-761.
    • (2013) Mucosal Immunol. , vol.6 , pp. 751-761
    • Al-Hassi, H.O.1
  • 34
    • 1642525689 scopus 로고    scopus 로고
    • Leptin indirectly activates human neutrophils via induction of TNF-alpha
    • Zarkesh-Esfahani H., et al. Leptin indirectly activates human neutrophils via induction of TNF-alpha. J. Immunol. 2004, 172:1809-1814.
    • (2004) J. Immunol. , vol.172 , pp. 1809-1814
    • Zarkesh-Esfahani, H.1
  • 35
    • 84863807826 scopus 로고    scopus 로고
    • Obesity is associated with neutrophil dysfunction and attenuation of murine acute lung injury
    • Kordonowy L.L., et al. Obesity is associated with neutrophil dysfunction and attenuation of murine acute lung injury. Am. J. Respir. Cell Mol. Biol. 2012, 47:120-127.
    • (2012) Am. J. Respir. Cell Mol. Biol. , vol.47 , pp. 120-127
    • Kordonowy, L.L.1
  • 36
    • 84890821186 scopus 로고    scopus 로고
    • Role of leptin-mediated colonic inflammation in defense against Clostridium difficile colitis
    • Madan R., et al. Role of leptin-mediated colonic inflammation in defense against Clostridium difficile colitis. Infect. Immun. 2014, 82:341-349.
    • (2014) Infect. Immun. , vol.82 , pp. 341-349
    • Madan, R.1
  • 37
    • 79952209777 scopus 로고    scopus 로고
    • A mutation in the leptin receptor is associated with Entamoeba histolytica infection in children
    • Duggal P., et al. A mutation in the leptin receptor is associated with Entamoeba histolytica infection in children. J. Clin. Invest. 2011, 121:1191-1198.
    • (2011) J. Clin. Invest. , vol.121 , pp. 1191-1198
    • Duggal, P.1
  • 38
    • 84861146534 scopus 로고    scopus 로고
    • Leptin protects host cells from Entamoeba histolytica cytotoxicity by a STAT3-dependent mechanism
    • Marie C.S., et al. Leptin protects host cells from Entamoeba histolytica cytotoxicity by a STAT3-dependent mechanism. Infect. Immun. 2012, 80:1934-1943.
    • (2012) Infect. Immun. , vol.80 , pp. 1934-1943
    • Marie, C.S.1
  • 39
    • 80053172375 scopus 로고    scopus 로고
    • Leptin and leptin receptor polymorphisms are associated with poor outcome (death) in patients with non-appendicular secondary peritonitis
    • Bracho-Riquelme R.L., et al. Leptin and leptin receptor polymorphisms are associated with poor outcome (death) in patients with non-appendicular secondary peritonitis. Crit. Care 2011, 15:R227.
    • (2011) Crit. Care , vol.15 , pp. R227
    • Bracho-Riquelme, R.L.1
  • 40
    • 84877835708 scopus 로고    scopus 로고
    • Effect of the leptin receptor Q223R polymorphism on the host transcriptome following infection with Entamoeba histolytica
    • Mackey-Lawrence N.M., et al. Effect of the leptin receptor Q223R polymorphism on the host transcriptome following infection with Entamoeba histolytica. Infect. Immun. 2013, 81:1460-1470.
    • (2013) Infect. Immun. , vol.81 , pp. 1460-1470
    • Mackey-Lawrence, N.M.1
  • 41
    • 84920969940 scopus 로고    scopus 로고
    • Leptin receptor mutation results in defective neutrophil recruitment to the colon during Entamoeba histolytica infection
    • Naylor C., et al. Leptin receptor mutation results in defective neutrophil recruitment to the colon during Entamoeba histolytica infection. MBio 2014, 5:e02046-e2114.
    • (2014) MBio , vol.5 , pp. e02046-e2114
    • Naylor, C.1
  • 42
    • 84893236159 scopus 로고    scopus 로고
    • The role of leptin in the development of pulmonary neutrophilia in infection and acute lung injury
    • Ubags N.D., et al. The role of leptin in the development of pulmonary neutrophilia in infection and acute lung injury. Crit. Care Med. 2014, 42:e143-e151.
    • (2014) Crit. Care Med. , vol.42 , pp. e143-e151
    • Ubags, N.D.1
  • 43
    • 84884180175 scopus 로고    scopus 로고
    • Physiological concentrations of leptin do not affect human neutrophils
    • Kamp V.M., et al. Physiological concentrations of leptin do not affect human neutrophils. PLoS ONE 2013, 8:e73170.
    • (2013) PLoS ONE , vol.8 , pp. e73170
    • Kamp, V.M.1
  • 44
    • 84880449036 scopus 로고    scopus 로고
    • A high-fat diet increases interleukin-3 and granulocyte colony-stimulating factor production by bone marrow cells and triggers bone marrow hyperplasia and neutrophilia in Wistar rats
    • do Carmo L.S., et al. A high-fat diet increases interleukin-3 and granulocyte colony-stimulating factor production by bone marrow cells and triggers bone marrow hyperplasia and neutrophilia in Wistar rats. Exp. Biol. Med. 2013, 238:375-384.
    • (2013) Exp. Biol. Med. , vol.238 , pp. 375-384
    • do Carmo, L.S.1
  • 45
    • 84930413869 scopus 로고    scopus 로고
    • Neutrophil functions in morbidly obese subjects
    • Brotfain E., et al. Neutrophil functions in morbidly obese subjects. Clin. Exp. Immunol. 2015, 181:156-163.
    • (2015) Clin. Exp. Immunol. , vol.181 , pp. 156-163
    • Brotfain, E.1
  • 46
    • 79951852559 scopus 로고    scopus 로고
    • Leptin has a priming effect on eotaxin-induced human eosinophil chemotaxis
    • Kato H., et al. Leptin has a priming effect on eotaxin-induced human eosinophil chemotaxis. Int. Arch. Allergy Immunol. 2011, 155:335-344.
    • (2011) Int. Arch. Allergy Immunol. , vol.155 , pp. 335-344
    • Kato, H.1
  • 47
    • 79955526579 scopus 로고    scopus 로고
    • Leptin enhances survival and induces migration, degranulation, and cytokine synthesis of human basophils
    • Suzukawa M., et al. Leptin enhances survival and induces migration, degranulation, and cytokine synthesis of human basophils. J. Immunol. 2015, 186:5254-5260.
    • (2015) J. Immunol. , vol.186 , pp. 5254-5260
    • Suzukawa, M.1
  • 48
    • 84879032476 scopus 로고    scopus 로고
    • Obesity increases eosinophil activity in asthmatic children and adolescents
    • Grotta M.B., et al. Obesity increases eosinophil activity in asthmatic children and adolescents. BMC Pulm. Med. 2013, 13:39.
    • (2013) BMC Pulm. Med. , vol.13 , pp. 39
    • Grotta, M.B.1
  • 49
    • 83455198332 scopus 로고    scopus 로고
    • Short-term and long-term leptin exposure differentially affect human natural killer cell immune functions
    • Wrann C.D., et al. Short-term and long-term leptin exposure differentially affect human natural killer cell immune functions. Am. J. Physiol. Endocrinol. Metab. 2012, 302:E108-E116.
    • (2012) Am. J. Physiol. Endocrinol. Metab. , vol.302 , pp. E108-E116
    • Wrann, C.D.1
  • 50
    • 84974578446 scopus 로고    scopus 로고
    • Altered NK cell function in obese healthy humans
    • Laue T., et al. Altered NK cell function in obese healthy humans. BMC Obes. 2015, 2:1.
    • (2015) BMC Obes. , vol.2 , pp. 1
    • Laue, T.1
  • 51
    • 84946492239 scopus 로고    scopus 로고
    • Decreased NK cell functions in obesity can be reactivated by fat mass reduction
    • Jahn J., et al. Decreased NK cell functions in obesity can be reactivated by fat mass reduction. Obesity 2015, 23:2233-2241.
    • (2015) Obesity , vol.23 , pp. 2233-2241
    • Jahn, J.1
  • 52
    • 84874220772 scopus 로고    scopus 로고
    • Leptin modulates dose-dependently the metabolic and cytolytic activities of NK-92 cells
    • Lamas B., et al. Leptin modulates dose-dependently the metabolic and cytolytic activities of NK-92 cells. J. Cell Physiol. 2013, 228:1202-1209.
    • (2013) J. Cell Physiol. , vol.228 , pp. 1202-1209
    • Lamas, B.1
  • 53
    • 79957459549 scopus 로고    scopus 로고
    • Charting the host adaptation of influenza viruses
    • dos Reis M., et al. Charting the host adaptation of influenza viruses. Mol. Biol. Evol. 2011, 28:1755-1767.
    • (2011) Mol. Biol. Evol. , vol.28 , pp. 1755-1767
    • dos Reis, M.1
  • 54
    • 78650188983 scopus 로고    scopus 로고
    • An oscillatory switch in mTOR kinase activity sets regulatory T cell responsiveness
    • Procaccini C., et al. An oscillatory switch in mTOR kinase activity sets regulatory T cell responsiveness. Immunity 2010, 33:929-941.
    • (2010) Immunity , vol.33 , pp. 929-941
    • Procaccini, C.1
  • 55
    • 36049051889 scopus 로고    scopus 로고
    • Leptin requires canonical migratory signaling pathways for induction of monocyte and macrophage chemotaxis
    • Gruen M.L., et al. Leptin requires canonical migratory signaling pathways for induction of monocyte and macrophage chemotaxis. Am. J. Physiol. Cell Physiol. 2007, 293:C1481-C1488.
    • (2007) Am. J. Physiol. Cell Physiol. , vol.293 , pp. C1481-C1488
    • Gruen, M.L.1
  • 56
    • 20444403798 scopus 로고    scopus 로고
    • Apoptotic pathways are inhibited by leptin receptor activation in neutrophils
    • Bruno A., et al. Apoptotic pathways are inhibited by leptin receptor activation in neutrophils. J. Immunol. 2005, 174:8090-8096.
    • (2005) J. Immunol. , vol.174 , pp. 8090-8096
    • Bruno, A.1
  • 57
    • 33745624549 scopus 로고    scopus 로고
    • Induction of neutrophil chemotaxis by leptin: crucial role for p38 and Src kinases
    • Montecucco F., et al. Induction of neutrophil chemotaxis by leptin: crucial role for p38 and Src kinases. Ann. N.Y. Acad. Sci. 2006, 1069:463-471.
    • (2006) Ann. N.Y. Acad. Sci. , vol.1069 , pp. 463-471
    • Montecucco, F.1
  • 58
    • 38349174747 scopus 로고    scopus 로고
    • Leptin induces macrophage lipid body formation by a phosphatidylinositol 3-kinase- and mammalian target of rapamycin-dependent mechanism
    • Maya-Monteiro C.M., et al. Leptin induces macrophage lipid body formation by a phosphatidylinositol 3-kinase- and mammalian target of rapamycin-dependent mechanism. J. Biol. Chem. 2008, 283:2203-2210.
    • (2008) J. Biol. Chem. , vol.283 , pp. 2203-2210
    • Maya-Monteiro, C.M.1
  • 59
    • 84943809084 scopus 로고    scopus 로고
    • Leptin activation of mTOR pathway in intestinal epithelial cell triggers lipid droplet formation, cytokine production and increased cell proliferation
    • Fazolini N.P., et al. Leptin activation of mTOR pathway in intestinal epithelial cell triggers lipid droplet formation, cytokine production and increased cell proliferation. Cell Cycle 2015, 14:2667-2676.
    • (2015) Cell Cycle , vol.14 , pp. 2667-2676
    • Fazolini, N.P.1
  • 60
    • 84859746151 scopus 로고    scopus 로고
    • Leptin regulates proliferation and apoptosis of colorectal carcinoma through PI3K/Akt/mTOR signalling pathway
    • Wang D., et al. Leptin regulates proliferation and apoptosis of colorectal carcinoma through PI3K/Akt/mTOR signalling pathway. J. Biosci. 2011, 37:91-101.
    • (2011) J. Biosci. , vol.37 , pp. 91-101
    • Wang, D.1
  • 61
    • 15444366416 scopus 로고    scopus 로고
    • Feedback inhibition of leptin receptor/Jak2 signaling via Tyr1138 of the leptin receptor and suppressor of cytokine signaling 3
    • Dunn S.L., et al. Feedback inhibition of leptin receptor/Jak2 signaling via Tyr1138 of the leptin receptor and suppressor of cytokine signaling 3. Mol. Endocrinol. 2005, 19:925-938.
    • (2005) Mol. Endocrinol. , vol.19 , pp. 925-938
    • Dunn, S.L.1
  • 62
    • 79251560944 scopus 로고    scopus 로고
    • Disruption of leptin receptor STAT3 signaling enhances leukotriene production and pulmonary host defense against pneumococcal pneumonia
    • Mancuso P., et al. Disruption of leptin receptor STAT3 signaling enhances leukotriene production and pulmonary host defense against pneumococcal pneumonia. J. Immunol. 2011, 186:1081-1090.
    • (2011) J. Immunol. , vol.186 , pp. 1081-1090
    • Mancuso, P.1
  • 63
    • 84907867610 scopus 로고    scopus 로고
    • 20 years of leptin: connecting leptin signaling to biological function
    • Allison M.B., Myers M.G. 20 years of leptin: connecting leptin signaling to biological function. J. Endocrinol. 2014, 223:T25-T35.
    • (2014) J. Endocrinol. , vol.223 , pp. T25-T35
    • Allison, M.B.1    Myers, M.G.2
  • 64
    • 84902850370 scopus 로고    scopus 로고
    • Obesity-induced hyperleptinemia improves survival and immune response in a murine model of sepsis
    • Siegl D., et al. Obesity-induced hyperleptinemia improves survival and immune response in a murine model of sepsis. Anesthesiology 2014, 1-17.
    • (2014) Anesthesiology , pp. 1-17
    • Siegl, D.1


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.