The role of leptin in the development of pulmonary neutrophilia in infection and acute lung injury

Critical Care Medicine

Volumn 42, Issue 2, 2014, Pages

  Ubags, Niki D ^a,b   Vernooy, Juanita H ^b   Burg, Elianne ^a   Hayes, Catherine ^a   Bement, Jenna ^a   Dilli, Estee ^a   Zabeau, Lennart ^c   Abraham, Edward ^d   Poch, Katie R ^d   Nick, Jerry A ^d   Dienz, Oliver ^a   Zuñiga, Joaquin ^e   Wargo, Matthew J ^a   Mizgerd, Joseph P ^f   Tavernier, Jan ^c   Rincón, Mercedes ^a   Poynter, Matthew E ^a   Wouters, Emiel F M ^b   Suratt, Benjamin T ^a  

^a UNIVERSITY OF VERMONT COLLEGE OF MEDICINE   (United States)

^b MAASTRICHT UNIVERSITY MEDICAL CENTER   (Netherlands)

^c GHENT UNIVERSITY   (Belgium)

^d DEPARTMENT OF MEDICINE   (United States)

^e INSTITUTO NACIONAL DE ENFERMEDADES RESPIRATORIAS   (Mexico)

^f BOSTON UNIVERSITY SCHOOL OF MEDICINE   (United States)

Author keywords

Chemotaxis; Cytokines; Immunity; Innate; Neutrophil; Pneumonia

Indexed keywords

LEPTIN;

ACUTE LUNG INJURY; ANIMAL; C57BL MOUSE; FEMALE; HUMAN; LEUKOCYTE DISORDERS; MOUSE; NEUTROPHIL; NEUTROPHIL CHEMOTAXIS; PHYSIOLOGY; PNEUMONIA, BACTERIAL; PNEUMONIA, VIRAL;

ACUTE LUNG INJURY; ANIMALS; FEMALE; HUMANS; LEPTIN; LEUKOCYTE DISORDERS; MICE; MICE, INBRED C57BL; NEUTROPHIL INFILTRATION; NEUTROPHILS; PNEUMONIA, BACTERIAL; PNEUMONIA, VIRAL;

EID: 84893236159     PISSN: 00903493     EISSN: 15300293     Source Type: Journal    
DOI: 10.1097/CCM.0000000000000048     Document Type: Article

References (50)

1. Rubenfeld GD, Caldwell E, Peabody E, et al: Incidence and outcomes of acute lung injury. N Engl J Med 2005; 353:1685-1693
2. Sheu CC, Gong MN, Zhai R, et al: The influence of infection sites on development and mortality of ARDS. Intensive Care Med 2010; 36:963-970
3. Steinberg KP, Milberg JA, Martin TR, et al: Evolution of bronchoalveolar cell populations in the adult respiratory distress syndrome. Am J Respir Crit Care Med 1994; 150:113-122
4. Vandivier RW, Henson PM, Douglas IS: Burying the dead: The impact of failed apoptotic cell removal (efferocytosis) on chronic inflammatory lung disease. Chest 2006; 129:1673-1682
5. Droemann D, Aries SP, Hansen F, et al: Decreased apoptosis and increased activation of alveolar neutrophils in bacterial pneumonia. Chest 2000; 117:1679-1684
6. Matute-Bello G, Liles WC, Radella F II, et al: Modulation of neutrophil apoptosis by granulocyte colony-stimulating factor and granulocyte/macrophage colony-stimulating factor during the course of acute respiratory distress syndrome. Crit Care Med 2000; 28:1-7
7. Matute-Bello G, Liles WC, Radella F II, et al: Neutrophil apoptosis in the acute respiratory distress syndrome. Am J Respir Crit Care Med 1997; 156:1969-1977
8. Matute-Bello G, Martin TR: Science review: Apoptosis in acute lung injury. Crit Care 2003; 7:355-358
9. Lee WL, Downey GP: Neutrophil activation and acute lung injury. Curr Opin Crit Care 2001; 7:1-7
10. Suratt BT, Parsons PE: Mechanisms of acute lung injury/acute respiratory distress syndrome. Clin Chest Med 2006; 27:579-589; abstract viii
11. Muoio DM, Lynis Dohm G: Peripheral metabolic actions of leptin. Best Pract Res Clin Endocrinol Metab 2002; 16:653-666
12. La Cava A, Matarese G: The weight of leptin in immunity. Nat Rev Immunol 2004; 4:371-379
13. Zarkesh-Esfahani H, Pockley G, Metcalfe RA, et al: High-dose leptin activates human leukocytes via receptor expression on monocytes. J Immunol 2001; 167:4593-4599
14. Dixit VD, Mielenz M, Taub DD, et al: Leptin induces growth hormone secretion from peripheral blood mononuclear cells via a protein kinase C-and nitric oxide-dependent mechanism. Endocrinology 2003; 144:5595-5603
15. Mancuso P, Gottschalk A, Phare SM, et al: Leptin-deficient mice exhibit impaired host defense in Gram-negative pneumonia. J Immunol 2002; 168:4018-4024
16. Hsu A, Aronoff DM, Phipps J, et al: Leptin improves pulmonary bacterial clearance and survival in ob/ob mice during pneumococcal pneumonia. Clin Exp Immunol 2007; 150:332-339
17. Caldefie-Chezet F, Poulin A, Vasson MP: Leptin regulates functional capacities of polymorphonuclear neutrophils. Free Radic Res 2003; 37:809-814
18. Bruno A, Conus S, Schmid I, et al: Apoptotic pathways are inhibited by leptin receptor activation in neutrophils. J Immunol 2005; 174:8090-8096
19. Vernooy JH, Bracke KR, Drummen NE, et al: Leptin modulates innate and adaptive immune cell recruitment after cigarette smoke exposure in mice. J Immunol 2010; 184:7169-7177
20. Vernooy JH, Drummen NE, Van Suylen RJ, et al: Enhanced pulmonary leptin expression in patients with severe COPD and asymptomatic smokers. Thorax 2009; 64:26-32
21. Jain M, Budinger GR, Lo A, et al: Leptin promotes fibroproliferative acute respiratory distress syndrome by inhibiting peroxisome proliferator-activated receptor-. Am J Respir Crit Care Med 2011; 183:1490-1498
22. Bellmeyer A, Martino JM, Chandel NS, et al: Leptin resistance protects mice from hyperoxia-induced acute lung injury. Am J Respir Crit Care Med 2007; 175:587-594
23. Nick JA, Coldren CD, Geraci MW, et al: Recombinant human activated protein C reduces human endotoxin-induced pulmonary inflammation via inhibition of neutrophil chemotaxis. Blood 2004; 104:3878-3885
24. Dienz O, Rud JG, Eaton SM, et al: Essential role of IL-6 in protection against H1N1 influenza virus by promoting neutrophil survival in the lung. Mucosal Immunol 2012; 5:258-266
25. Mizgerd JP, Lupa MM, Kogan MS, et al: Nuclear factor-kappaB p50 limits inflammation and prevents lung injury during Escherichia coli pneumonia. Am J Respir Crit Care Med 2003; 168:810-817
26. Wargo MJ, Gross MJ, Rajamani S, et al: Hemolytic phospholipase C inhibition protects lung function during Pseudomonas aeruginosa infection. Am J Respir Crit Care Med 2011; 184:345-354
27. Kordonowy LL, Burg E, Lenox CC, et al: Obesity is associated with neutrophil dysfunction and attenuation of murine acute lung injury. Am J Respir Cell Mol Biol 2012; 47:120-127
28. Haslett C, Guthrie LA, Kopaniak MM, et al: Modulation of multiple neutrophil functions by preparative methods or trace concentrations of bacterial lipopolysaccharide. Am J Pathol 1985; 119:101-110
29. Suratt BT, Petty JM, Young SK, et al: Role of the CXCR4/SDF-1 chemokine axis in circulating neutrophil homeostasis. Blood 2004; 104:565-571
30. Suratt BT, Young SK, Lieber J, et al: Neutrophil maturation and activation determine anatomic site of clearance from circulation. Am J Physiol Lung Cell Mol Physiol 2001; 281:L913-L921
31. Petty JM, Sueblinvong V, Lenox CC, et al: Pulmonary stromal-derived factor-1 expression and effect on neutrophil recruitment during acute lung injury. J Immunol 2007; 178:8148-8157
32. Standiford TJ, Kunkel SL, Greenberger MJ, et al: Expression and regulation of chemokines in bacterial pneumonia. J Leukoc Biol 1996; 59:24-28
33. Sordi R, Menezes-de-Lima O, Della-Justina AM, et al: Pneumoniainduced sepsis in mice: Temporal study of inflammatory and cardiovascular parameters. Int J Exp Pathol 2013 Feb 27. [Epub ahead of print]
34. Bjørbaek C, Uotani S, da Silva B, et al: Divergent signaling capacities of the long and short isoforms of the leptin receptor. J Biol Chem 1997; 272:32686-32695
35. Claycombe K, King LE, Fraker PJ: A role for leptin in sustaining lymphopoiesis and myelopoiesis. Proc Natl Acad Sci USA 2008; 105:2017-2021
36. Aldawood A, Arabi Y, Dabbagh O: Association of obesity with increased mortality in the critically ill patient. Anaesth Intensive Care 2006; 34:629-633
37. Koç E, Ustünda G, Aliefendiolu D, et al: Serum leptin levels and their relationship to tumor necrosis factor-alpha and interleukin-6 in neonatal sepsis. J Pediatr Endocrinol Metab 2003; 16:1283-1287
38. Bruno A, Pace E, Chanez P, et al: Leptin and leptin receptor expression in asthma. J Allergy Clin Immunol 2009; 124:230-237, 237. e1-237.e4
39. Barazzone-Argiroffo C, Muzzin P, Donati YR, et al: Hyperoxia increases leptin production: A mechanism mediated through endogenous elevation of corticosterone. Am J Physiol Lung Cell Mol Physiol 2001; 281:L1150-L1156
40. Shore SA, Schwartzman IN, Mellema MS, et al: Effect of leptin on allergic airway responses in mice. J Allergy Clin Immunol 2005; 115:103-109
41. Montecucco F, Bianchi G, Gnerre P, et al: Induction of neutrophil chemotaxis by leptin: Crucial role for p38 and Src kinases. Ann N Y Acad Sci 2006; 1069:463-471
42. Ottonello L, Gnerre P, Bertolotto M, et al: Leptin as a uremic toxin interferes with neutrophil chemotaxis. J Am Soc Nephrol 2004; 15:2366-2372
43. Zarkesh-Esfahani H, Pockley AG, Wu Z, et al: Leptin indirectly activates human neutrophils via induction of TNF-alpha. J Immunol 2004; 172:1809-1814
44. Lakatos HF, Burgess HA, Thatcher TH, et al: Oropharyngeal aspiration of a silica suspension produces a superior model of silicosis in the mouse when compared to intratracheal instillation. Exp Lung Res 2006; 32:181-199
45. Mancuso P: Obesity and lung inflammation. J Appl Physiol (1985) 2010; 108:722-728
46. Baik I, Curhan GC, Rimm EB, et al: A prospective study of age and lifestyle factors in relation to community-acquired pneumonia in US men and women. Arch Intern Med 2000; 160:3082-3088
47. Mancuso P: Obesity and respiratory infections: Does excess adiposity weigh down host defense Pulm Pharmacol Ther 2013; 26:412-419
48. OBrien JM Jr, Phillips GS, Ali NA, et al: Body mass index is independently associated with hospital mortality in mechanically ventilated adults with acute lung injury. Crit Care Med 2006; 34:738-744
49. Martino JL, Stapleton RD, Wang M, et al: Extreme obesity and outcomes in critically ill patients. Chest 2011; 140:1198-1206
50. Stapleton RD, Dixon AE, Parsons PE, et al; NHLBI Acute Respiratory Distress Syndrome Network: The association between BMI and plasma cytokine levels in patients with acute lung injury. Chest 2010; 138:568-577