Disruption of leptin receptor-STAT3 signaling enhances leukotriene production and pulmonary host defense against pneumococcal pneumonia

Journal of Immunology

Volumn 186, Issue 2, 2011, Pages 1081-1090

  Mancuso, Peter ^a   Peters Golden, Marc ^b   Goel, Deepti ^a   Goldberg, Jared ^a   Brock, Thomas G ^b   Greenwald Yarnell, Megan ^b   Myers Jr , Martin G ^b  

^a UNIVERSITY OF MICHIGAN   (United States)

^b UNIVERSITY OF MICHIGAN MEDICAL SCHOOL   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

ARACHIDONIC ACID; CYTOSOLIC PHOSPHOLIPASE A2; CYTOSOLIC PHOSPHOLIPASE A2 ALPHA; LEPTIN RECEPTOR; LEUKOTRIENE; MITOGEN ACTIVATED PROTEIN KINASE 1; MITOGEN ACTIVATED PROTEIN KINASE 3; PEPTIDOLEUKOTRIENE; STAT3 PROTEIN; UNCLASSIFIED DRUG;

ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ANTIBACTERIAL ACTIVITY; ARTICLE; BACTERIAL CLEARANCE; BACTERICIDAL ACTIVITY; CONTROLLED STUDY; HOST RESISTANCE; IN VITRO STUDY; IN VIVO STUDY; INNATE IMMUNITY; LUNG ALVEOLUS MACROPHAGE; MOUSE; MUTANT; NONHUMAN; PHAGOCYTOSIS; PRIORITY JOURNAL; PROSTAGLANDIN SYNTHESIS; SIGNAL TRANSDUCTION; STREPTOCOCCUS PNEUMONIA; STREPTOCOCCUS PNEUMONIAE; SURVIVAL; WILD TYPE;

ANIMALS; CELLS, CULTURED; DISEASE MODELS, ANIMAL; FEMALE; GENE KNOCK-IN TECHNIQUES; IMMUNITY, INNATE; LEUKOTRIENES; MALE; MICE; MICE, OBESE; MICE, TRANSGENIC; PNEUMONIA, PNEUMOCOCCAL; PROTEIN ISOFORMS; RECEPTORS, LEPTIN; SIGNAL TRANSDUCTION; STAT3 TRANSCRIPTION FACTOR; STREPTOCOCCUS PNEUMONIAE; UP-REGULATION;

EID: 79251560944     PISSN: 00221767     EISSN: 15506606     Source Type: Journal    
DOI: 10.4049/jimmunol.1001470     Document Type: Article

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