Effect of leptin on activation and cytokine synthesis in peripheral blood lymphocytes of malnourished infected children

Clinical and Experimental Immunology

Volumn 148, Issue 3, 2007, Pages 478-485

  Rodriguez L ^a   Graniel, J ^b   Ortiz, R ^a  

^a DEPARTAMENTO DE QUÍMICA   (Mexico)

^b Hospital Pediatrico Iztapalapa   (Mexico)

Author keywords

Activation; Cytokines; Infections; Leptin; Malnutrition

Indexed keywords

GAMMA INTERFERON; INTERLEUKIN 2; LEPTIN;

ANTIGEN EXPRESSION; ARTICLE; CD4+ T LYMPHOCYTE; CD8+ T LYMPHOCYTE; CLINICAL ARTICLE; CONTROLLED STUDY; CYTOKINE PRODUCTION; FEMALE; HUMAN; HUMAN CELL; INFANT; INFECTION; LYMPHOCYTE ACTIVATION; MALE; MALNUTRITION; PERIPHERAL LYMPHOCYTE; PRESCHOOL CHILD; PRIORITY JOURNAL; T LYMPHOCYTE;

CD4-POSITIVE T-LYMPHOCYTES; CD8-POSITIVE T-LYMPHOCYTES; CELLS, CULTURED; CHILD, PRESCHOOL; CYTOKINES; FEMALE; HUMANS; INFANT; INTERFERON TYPE II; INTERLEUKINS; LEPTIN; LYMPHOCYTE ACTIVATION; MALE; MALNUTRITION; OPPORTUNISTIC INFECTIONS;

EID: 34247874513     PISSN: 00099104     EISSN: 13652249     Source Type: Journal    
DOI: 10.1111/j.1365-2249.2007.03361.x     Document Type: Article

References (30)

1. Faggioni R, Moser A, Feingold K, Grunfeld C. Reduced leptin levels in starvation increase susceptibility to endotoxic shock. Am J Pathol 2000 156:1781 7.
2. Matarese G. Leptin and the immune system: how nutritional status influences the immune response. Eur Cytokine Netw 2000 11:7 14.
3. Ozata M, Ozdemir I, Licinio J. Human leptin deficiency caused by a missense mutation: multiple endocrine defects, decreased sympathetic tone, and immune system dysfunction indicate new targets for leptin action, greater central than peripheral resistance to the effects of leptin, and spontaneous correction of leptin-mediated defects. J Clin Endocrinol Metab 1999 84:3686 95.
4. Faggioni R, Kenneth R, Feingold K, Grunfeld C. Leptin regulation of the immune response and the immunodeficiency of malnutrition. FASEB J 2001 15:2565 71.
5. Zhang F, Chen Y, Heiman M, Dimarchi R. Leptin: structure, function and biology. Vitam Horm 2005 71:345 72.
6. Zhang F, Basinski MB, Beals JM et al. Crystal structure of the obese protein leptin-E100. Nature 1997 387:206 9.
7. Tartaglia A. The leptin receptor. J Biol Chem 1997 272:6093 6.
8. Ahima RS, Osei SY. Leptin signaling. Physiol Behav 2004 81:223 41.
9. Fantuzzi G, Faggioni R. Leptin in the regulation of immunity, inflammation, and hematopoiesis. J Leukoc Biol 2000 68:437 46.
10. Lord GM, Matarese G, Howard J, Baker R, Bloom S, Lechler R. Leptin modulates the T-cell immune response and reverses starvation-induced immunosuppression. Nature 1998 394:897 901.
11. Howard J, Lord G, Matarese G. Leptin protects mice from starvation-induced lymphoid atrophy and increases thymic cellularity in ob/ob mice. J Clin Invest 1999 104:1051 59.
12. Zarkesh-Esfahani H, Pockley G, Metcalfe R et al. High-dose leptin activates human leukocytes via receptor expression on monocytes. J Immunol 2001 167:4593 99.
13. Gabay C, Dreyer M, Pellegrinelli N, Chicheportiche R, Meier C. Leptin directly induces the secretion of interleukin 1 receptor antagonist in human monocytes. J Clin Endocrinol Metab 2001 86:783 91.
14. Moore SE, Morgan G, Collison A, Swain J, O'Connell M, Prentice A. Leptin, malnutrition, and immune response in rural Gambian children. Arch Dis Child 2002 87:192 7.
15. Rodríguez L, González C, Flores L, Jiménez-Zamudio L, Granel J, Ortiz R. Assessment by flow cytometry of cytokine production in malnourished children. Clin Diagn Lab Immunol 2005 12:502 7.
16. Ramos-Galván R. Pediatric somatometry. Arch Inv Med (México) 1975 6 (Suppl. 1 83 396.
17. Infante-Duarte C, Kamradt T. Th1/Th2 balance in infection. Springer Semin Immunopathol 1999 21:317 38.
18. Hunter CA, Reiner SL. Cytokines and T cells in host defense. Curr Opin Immunol 2000 12:413 18.
19. Sánchez-Margalet V, Martín-Romero C, Santos-Alvarez J, Goberna R, Najib S, Gonzalez-Yanes C. Role of leptin as an immunomodulator of blood mononuclear cells: mechanisms of action. Clin Exp Immunol 2003 133:11 19.
20. Mancuso P, Gottschalk A, Phare S, Peters-Golden M, Lukacs N, Huffnagle G. Leptin-deficient mice exhibit impaired host defense in Gram-negative pneumonia. J Immunol 2002 168:4018 24.
21. González C, Rodríguez L, Bonilla E et al. Electrophoretic analysis of plasmatic and lymphocytes secreted proteins in malnourished children. Med Sci Res 1997 25:643 6.
22. Loffreda S, Yang S, Lin H et al. Leptin regulates proinflammatory immune responses. FASEB J 1998 12:57 65.
23. Soliman AEI, Zalabany M, Salama M, Ansari B. Serum leptin concentrations during severe protein-energy malnutrition: correlation with growth parameters and endocrine function. Metabolism 2000 49:819 25.
24. Palacio A, López M, Pérez-Bravo F, Monkeberg F, Schlesinger L. Leptin levels are associated with immune response in malnourished infants. J Clin Endocrinol Metab 2002 87:3040 46.
25. Walker D, Jason J, Wallace K et al. Spontaneous cytokine production and its effect on induced production. Clin Diagn Lab Immunol 2002 9:1049 56.
26. Nájera O, González C, Toledo G et al. Early activation of T, B and NK lymphocytes in infected malnourished and infected well-nourished children. J Nutr Immunol 2001 5:85 97.
27. Marzio R, Mauel J, Betz-Corradin S. CD69 and regulation of the immune function. Immunopharmacol Immunotoxicol 1999 21:565 82.
28. Sancho D, Gomez M, Sanchez-Madrid F. CD69 is an immunoregulatory molecule induced following activation. Trends Immunol 2005 26:136 40.
29. Martin-Romero C, Santos-Alvarez J, Goberna R, Sanchez-Margalet V. Human leptin enhances activation and proliferation of human circulating T lymphocytes. Cell Immunol 2000 199:15 24.
30. Lord GM, Matarese G, Bloom S, Lechler R. Leptin inhibits the anti-CD3-driven proliferation of peripheral blood T cells but enhances the production of proinflammatory cytokines. J Leukoc Biol 2002 72:330 38.