메뉴 건너뛰기




Volumn 21, Issue 1, 2016, Pages 133-142

Sphingosine-1-phosphate signaling: Unraveling its role as a drug target against infectious diseases

Author keywords

[No Author keywords available]

Indexed keywords

4 [[4 (4 CHLOROPHENYL) 2 THIAZOLYL]AMINO]PHENOL; 5 (4 PHENYL 5 TRIFLUOROMETHYL 2 THIENYL) 3 (3 TRIFLUOROMETHYLPHENYL) 1,2,4 OXADIAZOLE; AAL R; ACYLTRANSFERASE INHIBITOR; ANTIINFLAMMATORY AGENT; CYM 5442; DIMETHYLSPHINGOSINE; ENZYME ANTIBODY; FINGOLIMOD; IMMUNOSUPPRESSIVE AGENT; PHOSPHOLIPASE D; SPHINGOSINE 1 PHOSPHATE; SPHINGOSINE 1 PHOSPHATE RECEPTOR; UNCLASSIFIED DRUG; ANTIINFECTIVE AGENT; LYSOPHOSPHOLIPID; SPHINGOSINE; SPHINGOSINE 1-PHOSPHATE;

EID: 84960214021     PISSN: 13596446     EISSN: 18785832     Source Type: Journal    
DOI: 10.1016/j.drudis.2015.09.013     Document Type: Review
Times cited : (27)

References (84)
  • 1
    • 84923376044 scopus 로고    scopus 로고
    • A balance between membrane elasticity and polymerization energy sets the shape of spherical clathrin coats
    • M. Saleem, and et al. A balance between membrane elasticity and polymerization energy sets the shape of spherical clathrin coats Nat. Commun. 6 2015 6249
    • (2015) Nat. Commun. , vol.6 , pp. 6249
    • Saleem, M.1
  • 2
    • 84928471907 scopus 로고    scopus 로고
    • Orchestration of membrane receptor signaling by membrane lipids
    • M. Arish, and et al. Orchestration of membrane receptor signaling by membrane lipids Biochimie 113 2015 111 124
    • (2015) Biochimie , vol.113 , pp. 111-124
    • Arish, M.1
  • 3
    • 38549152194 scopus 로고    scopus 로고
    • Principles of bioactive lipid signalling: Lessons from sphingolipids
    • Y.A. Hannun, and L.M. Obeid Principles of bioactive lipid signalling: lessons from sphingolipids Nat. Rev. Mol. Cell Biol. 9 2008 139 150
    • (2008) Nat. Rev. Mol. Cell Biol. , vol.9 , pp. 139-150
    • Hannun, Y.A.1    Obeid, L.M.2
  • 4
    • 77953790503 scopus 로고    scopus 로고
    • An update on sphingosine-1-phosphate and other sphingolipid mediators
    • H. Fyrst, and J.D. Saba An update on sphingosine-1-phosphate and other sphingolipid mediators Nat. Chem. Biol. 6 2010 489 497
    • (2010) Nat. Chem. Biol. , vol.6 , pp. 489-497
    • Fyrst, H.1    Saba, J.D.2
  • 5
    • 84880519812 scopus 로고    scopus 로고
    • Bioactive lipids S1P and C1P are prometastatic factors in human rhabdomyosarcoma, and their tissue levels increase in response to radio/chemotherapy
    • G. Schneider, and et al. Bioactive lipids S1P and C1P are prometastatic factors in human rhabdomyosarcoma, and their tissue levels increase in response to radio/chemotherapy Mol. Cancer Res. 11 2013 793 807
    • (2013) Mol. Cancer Res. , vol.11 , pp. 793-807
    • Schneider, G.1
  • 6
    • 84887611445 scopus 로고    scopus 로고
    • Lipidomic profiling of bioactive lipids by mass spectrometry during microbial infections
    • V.C. Tam Lipidomic profiling of bioactive lipids by mass spectrometry during microbial infections Semin. Immunol. 25 2013 240 248
    • (2013) Semin. Immunol. , vol.25 , pp. 240-248
    • Tam, V.C.1
  • 7
    • 77956862615 scopus 로고    scopus 로고
    • Intracellular localization of sphingosine kinase 1 alters access to substrate pools but does not affect the degradative fate of sphingosine-1-phosphate
    • D.L. Siow, and et al. Intracellular localization of sphingosine kinase 1 alters access to substrate pools but does not affect the degradative fate of sphingosine-1-phosphate J. Lipid Res. 51 2010 2546 2559
    • (2010) J. Lipid Res. , vol.51 , pp. 2546-2559
    • Siow, D.L.1
  • 8
    • 27744547965 scopus 로고    scopus 로고
    • SphK1 and SphK2, sphingosine kinase isoenzymes with opposing functions in sphingolipid metabolism
    • M. Maceyka, and et al. SphK1 and SphK2, sphingosine kinase isoenzymes with opposing functions in sphingolipid metabolism J. Biol. Chem. 280 2005 37118 37129
    • (2005) J. Biol. Chem. , vol.280 , pp. 37118-37129
    • MacEyka, M.1
  • 9
    • 0037135572 scopus 로고    scopus 로고
    • Sphingosine 1-phosphate, a key cell signaling molecule
    • S. Spiegel, and S. Milstien Sphingosine 1-phosphate, a key cell signaling molecule J. Biol. Chem. 277 2002 25851 25854
    • (2002) J. Biol. Chem. , vol.277 , pp. 25851-25854
    • Spiegel, S.1    Milstien, S.2
  • 10
    • 0035023404 scopus 로고    scopus 로고
    • Sphingosine-1-phosphate phosphatases
    • S.M. Mandala Sphingosine-1-phosphate phosphatases Prostaglandins 64 2001 143 156
    • (2001) Prostaglandins , vol.64 , pp. 143-156
    • Mandala, S.M.1
  • 11
    • 77955508596 scopus 로고    scopus 로고
    • Structure and function of sphingosine-1-phosphate lyase, a key enzyme of sphingolipid metabolism
    • F. Bourquin, and et al. Structure and function of sphingosine-1-phosphate lyase, a key enzyme of sphingolipid metabolism Structure 18 2010 1054 1065
    • (2010) Structure , vol.18 , pp. 1054-1065
    • Bourquin, F.1
  • 12
    • 78751525273 scopus 로고    scopus 로고
    • The sphingosine 1-phosphate transporter, SPNS2, functions as a transporter of the phosphorylated form of the immunomodulating agent FTY720
    • Y. Hisano, and et al. The sphingosine 1-phosphate transporter, SPNS2, functions as a transporter of the phosphorylated form of the immunomodulating agent FTY720 J. Biol. Chem. 286 2011 1758 1766
    • (2011) J. Biol. Chem. , vol.286 , pp. 1758-1766
    • Hisano, Y.1
  • 13
    • 35648942122 scopus 로고    scopus 로고
    • A novel method to quantify sphingosine 1-phosphate by immobilized metal affinity chromatography (IMAC)
    • Y.M. Lee, and et al. A novel method to quantify sphingosine 1-phosphate by immobilized metal affinity chromatography (IMAC) Prostaglandins Other Lipid Mediat. 84 2007 154 162
    • (2007) Prostaglandins Other Lipid Mediat. , vol.84 , pp. 154-162
    • Lee, Y.M.1
  • 14
    • 78650881166 scopus 로고    scopus 로고
    • Sphingosine-1-phosphate and immune regulation: Trafficking and beyond
    • H. Chi Sphingosine-1-phosphate and immune regulation: trafficking and beyond Trends Pharmacol. Sci. 32 2011 16 24
    • (2011) Trends Pharmacol. Sci. , vol.32 , pp. 16-24
    • Chi, H.1
  • 15
    • 52949108813 scopus 로고    scopus 로고
    • The alliance of sphingosine-1-phosphate and its receptors in immunity
    • J. Rivera, and et al. The alliance of sphingosine-1-phosphate and its receptors in immunity Nat. Rev. Immunol. 8 2008 753 763
    • (2008) Nat. Rev. Immunol. , vol.8 , pp. 753-763
    • Rivera, J.1
  • 16
    • 0031473680 scopus 로고    scopus 로고
    • Functional roles of sphingosine, sphingosine 1-phosphate, and methylsphingosines: in regard to membrane sphingolipid signaling pathways
    • Y. Igarashi Functional roles of sphingosine, sphingosine 1-phosphate, and methylsphingosines: in regard to membrane sphingolipid signaling pathways J. Biochem. 122 1997 1080 1087
    • (1997) J. Biochem. , vol.122 , pp. 1080-1087
    • Igarashi, Y.1
  • 17
    • 12244310530 scopus 로고    scopus 로고
    • Activation of human monocytic cells by lysophosphatidic acid and sphingosine-1-phosphate
    • M. Fueller, and et al. Activation of human monocytic cells by lysophosphatidic acid and sphingosine-1-phosphate Cell Signal. 15 2003 367 375
    • (2003) Cell Signal. , vol.15 , pp. 367-375
    • Fueller, M.1
  • 18
    • 2442681332 scopus 로고    scopus 로고
    • Expression of the lysophospholipid receptor family and investigation of lysophospholipid-mediated responses in human macrophages
    • C.Q. Duong, and et al. Expression of the lysophospholipid receptor family and investigation of lysophospholipid-mediated responses in human macrophages Biochim. Biophys. Acta 1682 2004 112 119
    • (2004) Biochim. Biophys. Acta , vol.1682 , pp. 112-119
    • Duong, C.Q.1
  • 19
    • 77956568581 scopus 로고    scopus 로고
    • Sphingosine 1-phosphate receptor 1 and 3 are upregulated in multiple sclerosis lesions
    • R. Van Doorn, and et al. Sphingosine 1-phosphate receptor 1 and 3 are upregulated in multiple sclerosis lesions Glia 58 2010 1465 1476
    • (2010) Glia , vol.58 , pp. 1465-1476
    • Van Doorn, R.1
  • 20
    • 77749245824 scopus 로고    scopus 로고
    • S1P3 confers differential S1P-induced migration by autoreactive and non-autoreactive immature B cells and is required for normal B-cell development
    • E.E. Donovan, and et al. S1P3 confers differential S1P-induced migration by autoreactive and non-autoreactive immature B cells and is required for normal B-cell development Eur. J. Immunol. 40 2010 688 698
    • (2010) Eur. J. Immunol. , vol.40 , pp. 688-698
    • Donovan, E.E.1
  • 21
    • 80051991367 scopus 로고    scopus 로고
    • Sphingosine kinase 1 and sphingosine 1-phosphate receptor 3 are functionally upregulated on astrocytes under pro-inflammatory conditions
    • I. Fischer, and et al. Sphingosine kinase 1 and sphingosine 1-phosphate receptor 3 are functionally upregulated on astrocytes under pro-inflammatory conditions PLoS ONE 6 2011 e23905
    • (2011) PLoS ONE , vol.6 , pp. e23905
    • Fischer, I.1
  • 22
    • 84862327950 scopus 로고    scopus 로고
    • Sphingosine 1-phosphate receptor 5 mediates the immune quiescence of the human brain endothelial barrier
    • R. van Doorn, and et al. Sphingosine 1-phosphate receptor 5 mediates the immune quiescence of the human brain endothelial barrier J. Neuroinflamm. 9 2012 133
    • (2012) J. Neuroinflamm. , vol.9 , pp. 133
    • Van Doorn, R.1
  • 23
    • 36248966560 scopus 로고    scopus 로고
    • Natural killer cell trafficking in vivo requires a dedicated sphingosine 1-phosphate receptor
    • T. Walzer, and et al. Natural killer cell trafficking in vivo requires a dedicated sphingosine 1-phosphate receptor Nat. Immunol. 8 2007 1337 1344
    • (2007) Nat. Immunol. , vol.8 , pp. 1337-1344
    • Walzer, T.1
  • 24
    • 38449105053 scopus 로고    scopus 로고
    • Sphingosine-1 phosphate signaling regulates positioning of dendritic cells within the spleen
    • N. Czeloth, and et al. Sphingosine-1 phosphate signaling regulates positioning of dendritic cells within the spleen J. Immunol. 179 2007 5855 5863
    • (2007) J. Immunol. , vol.179 , pp. 5855-5863
    • Czeloth, N.1
  • 25
    • 84868576048 scopus 로고    scopus 로고
    • Lysophospholipid receptor activation of RhoA and lipid signaling pathways
    • S.Y. Xiang, and et al. Lysophospholipid receptor activation of RhoA and lipid signaling pathways Biochim. Biophys. Acta 1831 2013 213 222
    • (2013) Biochim. Biophys. Acta , vol.1831 , pp. 213-222
    • Xiang, S.Y.1
  • 26
    • 84855303523 scopus 로고    scopus 로고
    • Sphingosine-1-phosphate signaling and its role in disease
    • M. Maceyka, and et al. Sphingosine-1-phosphate signaling and its role in disease Trends Cell Biol. 22 2012 50 60
    • (2012) Trends Cell Biol. , vol.22 , pp. 50-60
    • MacEyka, M.1
  • 27
    • 84856248243 scopus 로고    scopus 로고
    • Sphingosine 1-phosphate signalling in cancer
    • N.J. Pyne, and et al. Sphingosine 1-phosphate signalling in cancer Biochem. Soc. Trans. 40 2012 94 100
    • (2012) Biochem. Soc. Trans. , vol.40 , pp. 94-100
    • Pyne, N.J.1
  • 28
    • 84901936622 scopus 로고    scopus 로고
    • Sphingolipid metabolites in inflammatory disease
    • M. Maceyka, and S. Spiegel Sphingolipid metabolites in inflammatory disease Nature 510 2014 58 67
    • (2014) Nature , vol.510 , pp. 58-67
    • MacEyka, M.1    Spiegel, S.2
  • 29
    • 84879429159 scopus 로고    scopus 로고
    • Impaired T-cell responses to sphingosine-1-phosphate in HIV-1 infected lymph nodes
    • J.C. Mudd, and et al. Impaired T-cell responses to sphingosine-1-phosphate in HIV-1 infected lymph nodes Blood 121 2013 2914 2922
    • (2013) Blood , vol.121 , pp. 2914-2922
    • Mudd, J.C.1
  • 30
    • 84907976581 scopus 로고    scopus 로고
    • S1P-dependent trafficking of intracellular Yersinia pestis through lymph nodes establishes buboes and systemic infection
    • A.L. St John, and et al. S1P-dependent trafficking of intracellular Yersinia pestis through lymph nodes establishes buboes and systemic infection Immunity 41 2014 440 450
    • (2014) Immunity , vol.41 , pp. 440-450
    • St John, A.L.1
  • 31
    • 84859004243 scopus 로고    scopus 로고
    • Re-circulation of lymphocytes mediated by sphingosine-1-phosphate receptor-1 contributes to resistance against experimental infection with the protozoan parasite Trypanosoma cruzi
    • M.R. Dominguez, and et al. Re-circulation of lymphocytes mediated by sphingosine-1-phosphate receptor-1 contributes to resistance against experimental infection with the protozoan parasite Trypanosoma cruzi Vaccine 30 2012 2882 2891
    • (2012) Vaccine , vol.30 , pp. 2882-2891
    • Dominguez, M.R.1
  • 32
    • 0242298258 scopus 로고    scopus 로고
    • Differences in membrane association and sub-cellular distribution between NS2-3 and NS3 of bovine viral diarrhoea virus
    • G. Zhang, and et al. Differences in membrane association and sub-cellular distribution between NS2-3 and NS3 of bovine viral diarrhoea virus Virus Res. 97 2003 89 102
    • (2003) Virus Res. , vol.97 , pp. 89-102
    • Zhang, G.1
  • 33
    • 67649389850 scopus 로고    scopus 로고
    • Inhibition of sphingosine kinase by bovine viral diarrhea virus NS3 is crucial for efficient viral replication and cytopathogenesis
    • D. Yamane, and et al. Inhibition of sphingosine kinase by bovine viral diarrhea virus NS3 is crucial for efficient viral replication and cytopathogenesis J. Biol. Chem. 284 2009 13648 13659
    • (2009) J. Biol. Chem. , vol.284 , pp. 13648-13659
    • Yamane, D.1
  • 34
    • 79955764352 scopus 로고    scopus 로고
    • Tumour necrosis factor alpha (TNF-alpha) stimulation of cells with established dengue virus type 2 infection induces cell death that is accompanied by a reduced ability of TNF-alpha to activate nuclear factor kappaB and reduced sphingosine kinase-1 activity
    • S. Wati, and et al. Tumour necrosis factor alpha (TNF-alpha) stimulation of cells with established dengue virus type 2 infection induces cell death that is accompanied by a reduced ability of TNF-alpha to activate nuclear factor kappaB and reduced sphingosine kinase-1 activity J. Gen. Virol. 92 2011 807 818
    • (2011) J. Gen. Virol. , vol.92 , pp. 807-818
    • Wati, S.1
  • 35
    • 77953923379 scopus 로고    scopus 로고
    • Sphingosine-1-phosphate is a missing cofactor for the E3 ubiquitin ligase TRAF2
    • S.E. Alvarez, and et al. Sphingosine-1-phosphate is a missing cofactor for the E3 ubiquitin ligase TRAF2 Nature 465 2010 1084 1088
    • (2010) Nature , vol.465 , pp. 1084-1088
    • Alvarez, S.E.1
  • 36
    • 84885664703 scopus 로고    scopus 로고
    • Reduced sphingosine kinase 1 activity in dengue virus type-2 infected cells can be mediated by the 3′ untranslated region of dengue virus type-2 RNA
    • J.M. Carr, and et al. Reduced sphingosine kinase 1 activity in dengue virus type-2 infected cells can be mediated by the 3′ untranslated region of dengue virus type-2 RNA J. Gen. Virol. 94 2013 2437 2448
    • (2013) J. Gen. Virol. , vol.94 , pp. 2437-2448
    • Carr, J.M.1
  • 37
    • 54449086337 scopus 로고    scopus 로고
    • Human cytomegalovirus regulates bioactive sphingolipids
    • N.J. Machesky, and et al. Human cytomegalovirus regulates bioactive sphingolipids J. Biol. Chem. 283 2008 26148 26160
    • (2008) J. Biol. Chem. , vol.283 , pp. 26148-26160
    • MacHesky, N.J.1
  • 38
    • 84883313477 scopus 로고    scopus 로고
    • Sphingosine kinase 1 serves as a pro-viral factor by regulating viral RNA synthesis and nuclear export of viral ribonucleoprotein complex upon influenza virus infection
    • Y.J. Seo, and et al. Sphingosine kinase 1 serves as a pro-viral factor by regulating viral RNA synthesis and nuclear export of viral ribonucleoprotein complex upon influenza virus infection PLOS ONE 8 2013 e75005
    • (2013) PLOS ONE , vol.8 , pp. e75005
    • Seo, Y.J.1
  • 39
    • 84890850726 scopus 로고    scopus 로고
    • Sphingosine kinase 1 regulates measles virus replication
    • M. Vijayan, and et al. Sphingosine kinase 1 regulates measles virus replication Virology 450-451 2014 55 63
    • (2014) Virology , vol.450-451 , pp. 55-63
    • Vijayan, M.1
  • 40
    • 2942521188 scopus 로고    scopus 로고
    • Sphingosine kinase mediates activation of extracellular signal-related kinase and Akt by respiratory syncytial virus
    • M.M. Monick, and et al. Sphingosine kinase mediates activation of extracellular signal-related kinase and Akt by respiratory syncytial virus Am. J. Respir. Cell Mol. Biol. 30 2004 844 852
    • (2004) Am. J. Respir. Cell Mol. Biol. , vol.30 , pp. 844-852
    • Monick, M.M.1
  • 41
    • 77954967774 scopus 로고    scopus 로고
    • Sphingosine 1-phosphate-metabolizing enzymes control influenza virus propagation and viral cytopathogenicity
    • Y.J. Seo, and et al. Sphingosine 1-phosphate-metabolizing enzymes control influenza virus propagation and viral cytopathogenicity J. Virol. 84 2010 8124 8131
    • (2010) J. Virol. , vol.84 , pp. 8124-8131
    • Seo, Y.J.1
  • 42
    • 84885028138 scopus 로고    scopus 로고
    • H9N2 avian influenza infection altered expression pattern of Sphiogosine-1-phosphate Receptor 1 in BALB/c mice
    • S. Tong, and et al. H9N2 avian influenza infection altered expression pattern of Sphiogosine-1-phosphate Receptor 1 in BALB/c mice Virol. J. 10 2013 296
    • (2013) Virol. J. , vol.10 , pp. 296
    • Tong, S.1
  • 43
    • 80052940381 scopus 로고    scopus 로고
    • Endothelial cells are central orchestrators of cytokine amplification during influenza virus infection
    • J.R. Teijaro, and et al. Endothelial cells are central orchestrators of cytokine amplification during influenza virus infection Cell 146 2011 980 991
    • (2011) Cell , vol.146 , pp. 980-991
    • Teijaro, J.R.1
  • 44
    • 60849108052 scopus 로고    scopus 로고
    • A critical role for the sphingosine analog AAL-R in dampening the cytokine response during influenza virus infection
    • D. Marsolais, and et al. A critical role for the sphingosine analog AAL-R in dampening the cytokine response during influenza virus infection Proc. Natl. Acad. Sci. U. S. A. 106 2009 1560 1565
    • (2009) Proc. Natl. Acad. Sci. U. S. A. , vol.106 , pp. 1560-1565
    • Marsolais, D.1
  • 45
    • 50449085535 scopus 로고    scopus 로고
    • Local not systemic modulation of dendritic cell S1P receptors in lung blunts virus-specific immune responses to influenza
    • D. Marsolais, and et al. Local not systemic modulation of dendritic cell S1P receptors in lung blunts virus-specific immune responses to influenza Mol. Pharmacol. 74 2008 896 903
    • (2008) Mol. Pharmacol. , vol.74 , pp. 896-903
    • Marsolais, D.1
  • 46
    • 84855415476 scopus 로고    scopus 로고
    • Skin mast cells protect mice against vaccinia virus by triggering mast cell receptor S1PR2 and releasing antimicrobial peptides
    • Z. Wang, and et al. Skin mast cells protect mice against vaccinia virus by triggering mast cell receptor S1PR2 and releasing antimicrobial peptides J. Immunol. 188 2012 345 357
    • (2012) J. Immunol. , vol.188 , pp. 345-357
    • Wang, Z.1
  • 47
    • 2542431022 scopus 로고    scopus 로고
    • Sphingosine 1-phosphate induces antimicrobial activity both in vitro and in vivo
    • S.K. Garg, and et al. Sphingosine 1-phosphate induces antimicrobial activity both in vitro and in vivo J. Infect. Dis. 189 2004 2129 2138
    • (2004) J. Infect. Dis. , vol.189 , pp. 2129-2138
    • Garg, S.K.1
  • 48
    • 33750959027 scopus 로고    scopus 로고
    • Does sphingosine 1-phosphate play a protective role in the course of pulmonary tuberculosis?
    • S.K. Garg, and et al. Does sphingosine 1-phosphate play a protective role in the course of pulmonary tuberculosis? Clin. Immunol. 121 2006 260 264
    • (2006) Clin. Immunol. , vol.121 , pp. 260-264
    • Garg, S.K.1
  • 49
    • 34547769299 scopus 로고    scopus 로고
    • + T cells in Mycobacterium tuberculosis-infected monocytes
    • + T cells in Mycobacterium tuberculosis-infected monocytes Biochem. Biophys. Res. Commun. 361 2007 687 693
    • (2007) Biochem. Biophys. Res. Commun. , vol.361 , pp. 687-693
    • Santucci, M.B.1
  • 50
    • 38949111009 scopus 로고    scopus 로고
    • Sphingosine kinase, phosphatidylinositol 3-kinase, Akt, NF-kappaB, and p300 are required for CCL5 production in Mycobacterium bovis Bacillus Calmette-Guerin (BCG)-infected epithelial cells
    • P. Mendez-Samperio, and et al. Sphingosine kinase, phosphatidylinositol 3-kinase, Akt, NF-kappaB, and p300 are required for CCL5 production in Mycobacterium bovis Bacillus Calmette-Guerin (BCG)-infected epithelial cells Cell. Immunol. 249 2007 94 100
    • (2007) Cell. Immunol. , vol.249 , pp. 94-100
    • Mendez-Samperio, P.1
  • 51
    • 77953999839 scopus 로고    scopus 로고
    • CCL5 participates in early protection against Mycobacterium tuberculosis
    • B. Vesosky, and et al. CCL5 participates in early protection against Mycobacterium tuberculosis J. Leukoc. Biol. 87 2010 1153 1165
    • (2010) J. Leukoc. Biol. , vol.87 , pp. 1153-1165
    • Vesosky, B.1
  • 52
    • 0037443426 scopus 로고    scopus 로고
    • 2+ signaling and phagosome maturation in human macrophages via specific inhibition of sphingosine kinase
    • 2+ signaling and phagosome maturation in human macrophages via specific inhibition of sphingosine kinase J. Immunol. 170 2003 2811 2815
    • (2003) J. Immunol. , vol.170 , pp. 2811-2815
    • Malik, Z.A.1
  • 53
    • 84871166164 scopus 로고    scopus 로고
    • Mannose-capped lipoarabinomannan from Mycobacterium tuberculosis preferentially inhibits sphingosine-1-phosphate-induced migration of Th1 cells
    • J.M. Richmond, and et al. Mannose-capped lipoarabinomannan from Mycobacterium tuberculosis preferentially inhibits sphingosine-1-phosphate-induced migration of Th1 cells J. Immunol. 189 2012 5886 5895
    • (2012) J. Immunol. , vol.189 , pp. 5886-5895
    • Richmond, J.M.1
  • 54
    • 77956295892 scopus 로고    scopus 로고
    • Sphingosine kinase-1 (SphK-1) regulates Mycobacterium smegmatis infection in macrophages
    • H. Prakash, and et al. Sphingosine kinase-1 (SphK-1) regulates Mycobacterium smegmatis infection in macrophages PLoS ONE 5 2010 e10657
    • (2010) PLoS ONE , vol.5 , pp. e10657
    • Prakash, H.1
  • 55
    • 33646012613 scopus 로고    scopus 로고
    • Macrophage's proinflammatory response to a mycobacterial infection is dependent on sphingosine kinase-mediated activation of phosphatidylinositol phospholipase C, protein kinase C, ERK1/2, and phosphatidylinositol 3-kinase
    • M. Yadav, and et al. Macrophage's proinflammatory response to a mycobacterial infection is dependent on sphingosine kinase-mediated activation of phosphatidylinositol phospholipase C, protein kinase C, ERK1/2, and phosphatidylinositol 3-kinase J. Immunol. 176 2006 5494 5503
    • (2006) J. Immunol. , vol.176 , pp. 5494-5503
    • Yadav, M.1
  • 56
    • 1842425716 scopus 로고    scopus 로고
    • Clostridium perfringens alpha-toxin activates the sphingomyelin metabolism system in sheep erythrocytes
    • S. Ochi, and et al. Clostridium perfringens alpha-toxin activates the sphingomyelin metabolism system in sheep erythrocytes J. Biol. Chem. 279 2004 12181 12189
    • (2004) J. Biol. Chem. , vol.279 , pp. 12181-12189
    • Ochi, S.1
  • 57
    • 84896077471 scopus 로고    scopus 로고
    • Pseudomonas-derived ceramidase induces production of inflammatory mediators from human keratinocytes via sphingosine-1-phosphate
    • A. Oizumi, and et al. Pseudomonas-derived ceramidase induces production of inflammatory mediators from human keratinocytes via sphingosine-1-phosphate PLOS ONE 9 2014 e89402
    • (2014) PLOS ONE , vol.9 , pp. e89402
    • Oizumi, A.1
  • 58
    • 60749115540 scopus 로고    scopus 로고
    • Cholesterol depletion associated with Leishmania major infection alters macrophage CD40 signalosome composition and effector function
    • A. Rub, and et al. Cholesterol depletion associated with Leishmania major infection alters macrophage CD40 signalosome composition and effector function Nat. Immunol. 10 2009 273 280
    • (2009) Nat. Immunol. , vol.10 , pp. 273-280
    • Rub, A.1
  • 59
    • 84860380163 scopus 로고    scopus 로고
    • Leishmania-induced biphasic ceramide generation in macrophages is crucial for uptake and survival of the parasite
    • S. Majumder, and et al. Leishmania-induced biphasic ceramide generation in macrophages is crucial for uptake and survival of the parasite J. Infect. Dis. 205 2012 1607 1616
    • (2012) J. Infect. Dis. , vol.205 , pp. 1607-1616
    • Majumder, S.1
  • 60
    • 84884148888 scopus 로고    scopus 로고
    • Host-lipidome as a potential target of protozoan parasites
    • A. Rub, and et al. Host-lipidome as a potential target of protozoan parasites Microbes Infect. 15 2013 649 660
    • (2013) Microbes Infect. , vol.15 , pp. 649-660
    • Rub, A.1
  • 61
    • 84920540325 scopus 로고    scopus 로고
    • Early double-negative thymocyte export in Trypanosoma cruzi infection is restricted by sphingosine receptors and associated with human Chagas disease
    • A. Lepletier, and et al. Early double-negative thymocyte export in Trypanosoma cruzi infection is restricted by sphingosine receptors and associated with human Chagas disease PLoS Negl. Trop. Dis. 8 2014 e3203
    • (2014) PLoS Negl. Trop. Dis. , vol.8 , pp. e3203
    • Lepletier, A.1
  • 62
    • 79960731365 scopus 로고    scopus 로고
    • S1P is associated with protection in human and experimental cerebral malaria
    • C.A. Finney, and et al. S1P is associated with protection in human and experimental cerebral malaria Mol. Med. 17 2011 717 725
    • (2011) Mol. Med. , vol.17 , pp. 717-725
    • Finney, C.A.1
  • 63
    • 84887037125 scopus 로고    scopus 로고
    • Sphingosine kinase A is a pleiotropic and essential enzyme for Leishmania survival and virulence
    • O. Zhang, and et al. Sphingosine kinase A is a pleiotropic and essential enzyme for Leishmania survival and virulence Mol. Microbiol. 90 2013 489 501
    • (2013) Mol. Microbiol. , vol.90 , pp. 489-501
    • Zhang, O.1
  • 64
    • 77951216949 scopus 로고    scopus 로고
    • Role of host sphingosine kinase 1 in the lung response against Cryptococcosis
    • T. McQuiston, and et al. Role of host sphingosine kinase 1 in the lung response against Cryptococcosis Infect. Immun. 78 2010 2342 2352
    • (2010) Infect. Immun. , vol.78 , pp. 2342-2352
    • McQuiston, T.1
  • 65
    • 79955781310 scopus 로고    scopus 로고
    • Role of sphingosine-1-phosphate (S1P) and S1P receptor 2 in the phagocytosis of Cryptococcus neoformans by alveolar macrophages
    • T. McQuiston, and et al. Role of sphingosine-1-phosphate (S1P) and S1P receptor 2 in the phagocytosis of Cryptococcus neoformans by alveolar macrophages Microbiology 157 2011 1416 1427
    • (2011) Microbiology , vol.157 , pp. 1416-1427
    • McQuiston, T.1
  • 66
    • 0037077308 scopus 로고    scopus 로고
    • The immune modulator FTY720 targets sphingosine 1-phosphate receptors
    • V. Brinkmann, and et al. The immune modulator FTY720 targets sphingosine 1-phosphate receptors J. Biol. Chem. 277 2002 21453 21457
    • (2002) J. Biol. Chem. , vol.277 , pp. 21453-21457
    • Brinkmann, V.1
  • 67
    • 31544447428 scopus 로고    scopus 로고
    • Antagonism of sphingosine-1-phosphate receptors by FTY720 inhibits angiogenesis and tumor vascularization
    • K. LaMontagne, and et al. Antagonism of sphingosine-1-phosphate receptors by FTY720 inhibits angiogenesis and tumor vascularization Cancer Res. 66 2006 221 231
    • (2006) Cancer Res. , vol.66 , pp. 221-231
    • LaMontagne, K.1
  • 68
    • 84894483889 scopus 로고    scopus 로고
    • FTY720 (s)-phosphonate preserves sphingosine 1-phosphate receptor 1 expression and exhibits superior barrier protection to FTY720 in acute lung injury
    • L. Wang, and et al. FTY720 (s)-phosphonate preserves sphingosine 1-phosphate receptor 1 expression and exhibits superior barrier protection to FTY720 in acute lung injury Crit. Care Med. 42 2014 e189 e199
    • (2014) Crit. Care Med. , vol.42 , pp. e189-e199
    • Wang, L.1
  • 69
    • 34247874512 scopus 로고    scopus 로고
    • Immunosuppressive and anti-angiogenic sphingosine 1-phosphate receptor-1 agonists induce ubiquitinylation and proteasomal degradation of the receptor
    • M.L. Oo, and et al. Immunosuppressive and anti-angiogenic sphingosine 1-phosphate receptor-1 agonists induce ubiquitinylation and proteasomal degradation of the receptor J. Biol. Chem. 282 2007 9082 9089
    • (2007) J. Biol. Chem. , vol.282 , pp. 9082-9089
    • Oo, M.L.1
  • 70
    • 0034120178 scopus 로고    scopus 로고
    • FTY720 immunosuppression impairs effector T cell peripheral homing without affecting induction, expansion, and memory
    • D.D. Pinschewer, and et al. FTY720 immunosuppression impairs effector T cell peripheral homing without affecting induction, expansion, and memory J. Immunol. 164 2000 5761 5770
    • (2000) J. Immunol. , vol.164 , pp. 5761-5770
    • Pinschewer, D.D.1
  • 72
    • 84939885951 scopus 로고    scopus 로고
    • The role of sphingosine 1-phosphate in immunity and sepsis
    • M.H. Graler The role of sphingosine 1-phosphate in immunity and sepsis Am. J. Clin. Exp. Immunol. 1 2012 90 100
    • (2012) Am. J. Clin. Exp. Immunol. , vol.1 , pp. 90-100
    • Graler, M.H.1
  • 73
    • 84878826618 scopus 로고    scopus 로고
    • Treatment with the sphingosine-1-phosphate analogue FTY 720 reduces loss of plasma volume during experimental sepsis in the rat
    • C. Lundblad, and et al. Treatment with the sphingosine-1-phosphate analogue FTY 720 reduces loss of plasma volume during experimental sepsis in the rat Acta Anaesthesiol. Scand. 57 2013 713 718
    • (2013) Acta Anaesthesiol. Scand. , vol.57 , pp. 713-718
    • Lundblad, C.1
  • 74
    • 84916929004 scopus 로고    scopus 로고
    • Sphingoid long chain bases prevent lung infection by Pseudomonas aeruginosa
    • Y. Pewzner-Jung, and et al. Sphingoid long chain bases prevent lung infection by Pseudomonas aeruginosa EMBO Mol. Med. 6 2014 1205 1214
    • (2014) EMBO Mol. Med. , vol.6 , pp. 1205-1214
    • Pewzner-Jung, Y.1
  • 75
    • 76449088823 scopus 로고    scopus 로고
    • The sphingosine kinase inhibitor N,N-dimethylsphingosine inhibits neointimal hyperplasia
    • R.A. McDonald, and et al. The sphingosine kinase inhibitor N,N-dimethylsphingosine inhibits neointimal hyperplasia Br. J. Pharmacol. 159 2010 543 553
    • (2010) Br. J. Pharmacol. , vol.159 , pp. 543-553
    • McDonald, R.A.1
  • 76
    • 84861152862 scopus 로고    scopus 로고
    • Sphingosine analogue AAL-R increases TLR7-mediated dendritic cell responses via p38 and type I IFN signaling pathways
    • Y.J. Seo, and et al. Sphingosine analogue AAL-R increases TLR7-mediated dendritic cell responses via p38 and type I IFN signaling pathways J. Immunol. 188 2012 4759 4768
    • (2012) J. Immunol. , vol.188 , pp. 4759-4768
    • Seo, Y.J.1
  • 77
    • 84875284312 scopus 로고    scopus 로고
    • Three phases of CD8T cell response in the lung following H1N1 influenza infection and sphingosine 1 phosphate agonist therapy
    • M.P. Matheu, and et al. Three phases of CD8T cell response in the lung following H1N1 influenza infection and sphingosine 1 phosphate agonist therapy PLOS ONE 8 2013 e58033
    • (2013) PLOS ONE , vol.8 , pp. e58033
    • Matheu, M.P.1
  • 78
    • 84870710094 scopus 로고    scopus 로고
    • Dissecting influenza virus pathogenesis uncovers a novel chemical approach to combat the infection
    • M.B. Oldstone, and et al. Dissecting influenza virus pathogenesis uncovers a novel chemical approach to combat the infection Virology 435 2013 92 101
    • (2013) Virology , vol.435 , pp. 92-101
    • Oldstone, M.B.1
  • 79
    • 84896793622 scopus 로고    scopus 로고
    • Sphingosine analog AAL-R promotes activation of LCMV-infected dendritic cells
    • Y.J. Seo, and B. Hahm Sphingosine analog AAL-R promotes activation of LCMV-infected dendritic cells Viral Immunol. 27 2014 82 86
    • (2014) Viral Immunol. , vol.27 , pp. 82-86
    • Seo, Y.J.1    Hahm, B.2
  • 80
    • 84930339698 scopus 로고    scopus 로고
    • Sphingosine-1-phosphate receptor agonism reduces Bordetella pertussis-mediated lung pathology
    • C. Skerry, and et al. Sphingosine-1-phosphate receptor agonism reduces Bordetella pertussis-mediated lung pathology J. Infect. Dis. 211 2014 1883 1886
    • (2014) J. Infect. Dis. , vol.211 , pp. 1883-1886
    • Skerry, C.1
  • 81
    • 84937765177 scopus 로고    scopus 로고
    • SphK1 inhibitor II (SKI-II) inhibits acute myelogenous leukemia cell growth in vitro and in vivo
    • L. Yang, and et al. SphK1 inhibitor II (SKI-II) inhibits acute myelogenous leukemia cell growth in vitro and in vivo Biochem. Biophys. Res. Commun. 460 2015 903 908
    • (2015) Biochem. Biophys. Res. Commun. , vol.460 , pp. 903-908
    • Yang, L.1
  • 82
    • 79951981180 scopus 로고    scopus 로고
    • Sphingosine-1-phosphate antibodies as potential agents in the treatment of cancer and age-related macular degeneration
    • R.A. Sabbadini Sphingosine-1-phosphate antibodies as potential agents in the treatment of cancer and age-related macular degeneration Br. J. Pharmacol. 162 2011 1225 1238
    • (2011) Br. J. Pharmacol. , vol.162 , pp. 1225-1238
    • Sabbadini, R.A.1
  • 83
    • 33644830810 scopus 로고    scopus 로고
    • Validation of an anti-sphingosine-1-phosphate antibody as a potential therapeutic in reducing growth, invasion, and angiogenesis in multiple tumor lineages
    • B. Visentin, and et al. Validation of an anti-sphingosine-1-phosphate antibody as a potential therapeutic in reducing growth, invasion, and angiogenesis in multiple tumor lineages Cancer Cell 9 2006 225 238
    • (2006) Cancer Cell , vol.9 , pp. 225-238
    • Visentin, B.1
  • 84
    • 84954526940 scopus 로고    scopus 로고
    • A tug-of-war between the host and the pathogen generates strategic hotspots for the development of novel therapeutic interventions against infectious diseases
    • A. Rana, and et al. A tug-of-war between the host and the pathogen generates strategic hotspots for the development of novel therapeutic interventions against infectious diseases Virulence 6 2015 566 580
    • (2015) Virulence , vol.6 , pp. 566-580
    • Rana, A.1


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.