Cutting edge: Mycobacterium tuberculosis blocks Ca2+ signaling and phagosome maturation in human macrophages via specific inhibition of sphingosine kinase

Journal of Immunology

Volumn 170, Issue 6, 2003, Pages 2811-2815

  Malik, Zulfiqar A ^a,c   Thompson, Christopher R ^a   Hashimi, Samad ^b   Porter, Brandon ^a   Iyer, Shankar S ^a,b   Kusner, David J ^a,b  

^a UNIVERSITY OF IOWA   (United States)

^b UNIVERSITY OF IOWA   (United States)

^c UNIVERSITY OF TEXAS SOUTHWESTERN MEDICAL CENTER   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

CALCIUM ION; SPHINGOSINE KINASE;

ARTICLE; CALCIUM SIGNALING; CELL VIABILITY; CONTROLLED STUDY; ENZYME INHIBITION; HUMAN; HUMAN CELL; LYSOSOME; MACROPHAGE; MYCOBACTERIUM TUBERCULOSIS; PATHOGENESIS; PHAGOCYTOSIS; PHAGOSOME; PRIORITY JOURNAL; TUBERCULOSIS;

EID: 0037443426     PISSN: 00221767     EISSN: None     Source Type: Journal    
DOI: 10.4049/jimmunol.170.6.2811     Document Type: Article

References (18)

1. Dye, C., B. G. Williams, M. A. Espinal, and M. C. Raviglione. 2002. Erasing the world's slow stain: strategies to beat multidrug-resistant tuberculosis. Science 295:2042.
2. Russell, D. G. 2001. Mycobacterium tuberculosis: here today, and here tomorrow. Nat. Rev. Mol. Cell Biol. 2:569.
3. Xu, S., A. Cooper, S. Sturgill-Koszycki, T. van Heyningen, D. Chatterjee, I. Orme, P. Allen, and D. G. Russell. 1994. Intracellular trafficking in Mycobacterium tuberculosis and Mycobacterium avium-infected macrophages. J. Immunol. 153:2568.
4. Via, L. E., D. Deretic, R. J. Ulmer, N. S. Hibler, L. A. Huber, and V. Deretic. 1997. Arrest of mycobacterial phagosome maturation is caused by a block in vesicle fusion between stages controlled by rab5 and rab7. J. Biol. Chem. 272:13326.
5. Fratti, R. A., J. M. Backer, J. Gruenberg, S. Corvera, and V. Deretic. 2001. Role of phosphatidylinositol 3-kinase and Rab5 effectors in phagosomal biogenesis and mycobacterial phagosome maturation arrest. J. Cell Biol. 154:631.
6. Fratti, R. A., J. Chua, and V. Deretic. 2002. Cellubrevin alterations and Mycobacterium tuberculosis phagosome maturation arrest. J. Biol. Chem. 277:17320.
7. 2+ signaling by Mycobacterium tuberculosis is associated with decreased phagosome-lysosome fusion and increased survival within human macrophages. J. Exp. Med. 191:287.
8. Malik, Z. A., S. S. Iyer, and D. J. Kusner. 2001. Mycobacterium tuberculosis phagosomes exhibit altered calmodulin-dependent signal transduction: contribution to inhibition of phagosome-lysosome fusion and intracellular survival in human macrophages. J. Immunol. 166:3392.
9. Fallman, M., D. P. Lew, O. Stendahl, and T. Andersson. 1989. Receptor-mediated phagocytosis in human neutrophils is associated with increased formation of inositol phosphates and diacylglycerol. J. Clin. Invest. 84:886
10. Melendez, A. J., R. A. Floto, D. J. Gillooly, M. M. Harnett, and J. M. Allen. 1998. FcγRI coupling to phospholipase D initiates sphingosine kinase-mediated calcium mobilization and vesicular trafficking. J. Biol. Chem. 273:9393.
11. Buehrer, B. M., and R. M. Bell. 1992. Inhibition of sphingosine kinase in vitro and in platelets. J. Biol. Chem. 267:3154.
12. Johnson, K. R., K. P. Becker, M. M. Facchinetti, Y. A. Hannun, and L. M. Obeid. 2002. PKC dependent activation of sphingosine kinase 1 and translocation to the plasma membrane. J. Biol. Chem. 277:35257.
13. Schlesinger, L. S. 1993. Macrophage phagocytosis of virulent but not attenuated strains of Mycobacterium tuberculosis is mediated by mannose receptors in addition to complement receptors. J. Immunol. 150:2920.
14. Ernst, J. D. 1998. Macrophage receptors for Mycobacterium tuberculosis. Infect. Immun. 66:1277.
15. 2 integrin on neutrophils. Biochem. J. 317:403.
16. β3 phosphorylation in the desensitization of cellular responses to platelet-activating factor. J. Biol. Chem. 272:11706
17. Spiegel, S., and S. Milstien. 2002. Sphingosine 1-phosphate, a key cell signaling molecule. J. Biol. Chem. 277:25851.
18. Levitz, S. M., A. Tabuni, T. R. Kozel, R. S. MacGill, R. R. Ingalls, and D. T. Golenbock. 1997. Binding of Cryptococcus neoformans to heterologously expressed human complement receptors. Infect. Immun. 65:931.