A critical role for the sphingosine analog AAL-R in dampening the cytokine response during influenza virus infection

Proceedings of the National Academy of Sciences of the United States of America

Volumn 106, Issue 5, 2009, Pages 1560-1565

  Marsolais, David ^a   Hahm, Bumsuk ^a,b   Walsh, Kevin B ^a   Edelmann, Kurt H ^a   McGavern, Dorian ^a   Hatta, Yasuko ^c   Kawaoka, Yoshihiro ^c,d   Rosen, Hugh ^a   Oldstone, Michael B A ^a  

^a SCRIPPS RESEARCH INSTITUTE   (United States)

^b University of Missouri   (United States)

^c UNIVERSITY OF WISCONSIN MADISON   (United States)

^d UNIVERSITY OF TOKYO   (Japan)

Author keywords

Cytokine storm; Dendritic cells; Immunopathology; T cells

Indexed keywords

CHEMOKINE; CYTOKINE; NEUTRALIZING ANTIBODY; SPHINGOSINE AAL R; SPHINGOSINE DERIVATIVE; UNCLASSIFIED DRUG; SPHINGOSINE; VIRUS ANTIBODY; VIRUS DNA;

ANIMAL EXPERIMENT; ARTICLE; CD8+ T LYMPHOCYTE; CELL DESTRUCTION; CELL EXPANSION; CELL MATURATION; CELL PROLIFERATION; CONTROLLED STUDY; CYTOKINE PRODUCTION; CYTOLYSIS; CYTOTOXIC T LYMPHOCYTE; DENDRITIC CELL; DRUG EFFECT; IMMUNE INJURY; IMMUNE RESPONSE; IMMUNOMODULATION; IMMUNOPATHOLOGY; IN VIVO STUDY; INFLUENZA; INFLUENZA VIRUS; INOCULATION; LYMPH NODE; MACROPHAGE; MOUSE; NEUTROPHIL; NEUTROPHIL CHEMOTAXIS; NONHUMAN; PRIORITY JOURNAL; RESPIRATORY SYSTEM; T LYMPHOCYTE ACTIVATION; TISSUE INJURY; AMINO ACID SEQUENCE; ANIMAL; ANTIGEN PRESENTING CELL; BIOSYNTHESIS; DISEASE MODEL; HUMAN; IMMUNOLOGY; LUNG; METABOLISM; MOLECULAR GENETICS; NUCLEOTIDE SEQUENCE; PATHOPHYSIOLOGY; SERODIAGNOSIS;

ORTHOMYXOVIRIDAE;

AMINO ACID SEQUENCE; ANIMALS; ANTIBODIES, VIRAL; ANTIGEN-PRESENTING CELLS; BASE SEQUENCE; CYTOKINES; DISEASE MODELS, ANIMAL; DNA, VIRAL; HUMANS; INFLUENZA, HUMAN; LUNG; MICE; MOLECULAR SEQUENCE DATA; NEUTRALIZATION TESTS; SPHINGOSINE; T-LYMPHOCYTES, CYTOTOXIC;

EID: 60849108052     PISSN: 00278424     EISSN: 10916490     Source Type: Journal    
DOI: 10.1073/pnas.0812689106     Document Type: Article

References (38)

1. Whitton JL, Oldstone MB (2001) in Fields virology, 4th ed., eds Knipe DM, Howley PM, Griffin DE, Lamb RE, Martin MA, Rolzman B, Straus SE (Lippincott Williams & Wilkins, Philadelphia), pp 285-320.
2. La Gruta NL, Kedzierska K, Stambas J, Doherty PC (2007) A question of self-preservation: immunopathology in influenza virus infection. Immunol Cell Biol 85:85-92.
3. Graham MB, Braciale TJ (1997) Resistance to and recovery from lethal influenza virus infection in B lymphocyte-deficient mice. J Exp Med 186:2063-2068.
4. Zinkernagel RM, Althage A (1977) Antiviral protection by virus-immune cytotoxic T cells: infected target cells are lysed before infectious virus progeny is assembled. J Exp Med 145:644-651.
5. Moskophidis D, Kioussis D (1998) Contribution of virus-specific CD8+ cytotoxic T cells to virus clearance or pathologic manifestations of influenza virus infection in a T cell receptor transgenic mouse model. J Exp Med 188:223-232.
6. Goulding J, et al. (2007) Respiratory infections: do we ever recover? Proc Am Thorac Soc 4:618-625.
7. Gerhard W (2001) The role of the antibody response in influenza virus infection. Curr Top Microbiol Immunol 260:171-190.
8. Biron CA, Sen GC (2007) in Fields Virology, 5th ed., eds Knipe DM, Howley PM, Griffin DE, Lamb RE, Martin MA, Rolzman B, Straus SE (Lippincott Williams & Wilkins, Philadelphia), pp 249-278.
9. Braciale TJ, Hahn YS, Burton DR (2007) in Fields Virology, 5th ed., eds Knipe DM, Howley PM, Griffin DE, Lamb RE, Martin MA, Rolzman B, Straus SE (Lippincott Williams & Wilkins, Philadelphia), pp 279-326.
10. Kash JC, et al. (2006) Genomic analysis of increased host immune and cell death responses induced by 1918 influenza virus. Nature 443:578-581.
11. Kobasa D, et al. (2007) Aberrant innate immune response in lethal infection of macaques with the 1918 influenza virus. Nature 445:319-323.
12. Cheung CY, et al. (2002) Induction of proinflammatory cytokines in human macrophages by influenza A (H5N1) viruses: a mechanism for the unusual severity of human disease? Lancet 360:1831-1837.
13. Tumpey TM, et al. (2005) Characterization of the reconstructed 1918 Spanish influenza pandemic virus. Science 310:77-80.
14. Beigel JH, et al. (2005) Avian influenza A (H5N1) infection in humans. N Engl J Med 353:1374-1385.
15. Uiprasertkul M, et al. (2007) Apoptosis and Pathogenesis of Avian Influenza A (H5N1) Virus in Humans. Emerg Infect Dis 13:708-712.
16. de Jong MD, et al. (2006) Fatal outcome of human influenza A (H5N1) is associated with high viral load and hypercytokinemia. Nat Med 12:1203-1207.
17. To KF, et al. (2001) Pathology of fatal human infection associated with avian influenza A H5N1 virus. J Med Virol 63:242-246.
18. Peiris JS, et al. (2004) Re-emergence of fatal human influenza A subtype H5N1 disease. Lancet 363:617-619.
19. Pearson H (2006) Controlling immune response may cut bird flu death rate. Nat Med 12:1105.
20. Hilleman MR (2002) Realities and enigmas of human viral influenza: pathogenesis, epidemiologyand control. Vaccine 20:3068-3087.
21. Eccles R (2005) Understanding the symptoms of the common cold and influenza. Lancet Infect Dis5:718-725.
22. Marsolais D, et al.(2008)Local not systemic modulation of dendritic cell S1Preceptorsin lung blunts virus-specific immune responses to influenza. Mol Pharmacol 74:896-903.
23. Neumann G, et al. (1999) Generation of influenza A viruses entirely from cloned cDNAs. Proc Natl Acad Sci USA 96:9345-9350.
24. Christen U, et al.(2004)Aviral epitope that mimics a self antigen canaccelerate but not initiate autoimmune diabetes. J Clin Invest 114:1290-1298.
25. McGavern DB, Christen U, Oldstone MB (2002) Molecular anatomy of antigen-specific CD8(+) T cell engagement and synapse formation in vivo. Nat Immunol 3:918-925.
26. Belz GT, et al. (2004) Distinct migrating and nonmigrating dendritic cell populations are involved in MHC class I-restricted antigen presentation after lung infection with virus. Proc Natl Acad Sci USA101:8670-8675.
27. Baumgarth N, KelsoA(1996)Functionally distinct T cells in three compartments of the respiratory tract after influenza virus infection. Eur J Immunol 26:2189-2197.
28. Steinman RM,Hemmi H (2006)Dendriticcells: translating innate to adaptive immunity. Curr Top Microbiol Immunol 311:17-58.
29. Allan RS, et al. (2006) Migratory dendritic cells transfer antigen to a lymph node- resident dendritic cell population for efficient CTL priming. Immunity 25:153-162.
30. Budde K, et al. (2006) FTY720 (fingolimod) in renal transplantation. Clin Transplant 20 Suppl 17:17-24.
31. Mandala S, et al. (2002) Alteration of lymphocyte trafficking by sphingosine-1- phosphate receptor agonists. Science 296:346-349.
32. Sanna MG, et al. (2004) Sphingosine 1-phosphate (S1P) receptor subtypes S1P1 and S1P3, respectively, regulate lymphocyte recirculation and heart rate. J Biol Chem 279:13839-13848.
33. Pinschewer DD, et al. (2000) FTY720 immunosuppression impairs effector T cell peripheral homing without affecting induction, expansion, and memory. J Immunol 164:5761-5770.
34. Lan YY, et al. (2005)The sphingosine-1-phosphate receptor agonist FTY720 modulates dendritic cell trafficking in vivo. Am J Transplant 5:2649-2659.
35. Maeda Y, et al. (2007) Migration of CD4 T cells and dendritic cells toward sphingosine 1-phosphate(S1P) is mediatedby differentreceptorsubtypes: S1Pregulatesthefunctions ofmurine mature dendriticcellsvia S1P receptor type 3. JImmunol178:3437-3446.
36. Moyron-Quiroz JE, et al. (2006) Persistence and responsiveness of immunologic memory in the absence of secondary lymphoid organs. Immunity25:643-654.
37. Han S, et al. (2004)FTY720suppresseshumoral immunity by inhibiting germinal center reaction. Blood104:4129-4133.
38. GeurtsvanKessel CH, et al. (2008) Clearance of influenza virus from the lung depends on migrator y langerin+CD11b- but not plasmacytoid dendritic cells. J Exp Med 205:1621-1634.