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Volumn 32, Issue 1, 2011, Pages 16-24

Sphingosine-1-phosphate and immune regulation: Trafficking and beyond

Author keywords

[No Author keywords available]

Indexed keywords

2 AMINO 2 [2 [4 (3 BENZYLOXYPHENYLTHIO) 2 CHLOROPHENYL]ETHYL] 1,3 PROPANEDIOL; 5 (4 PHENYL 5 TRIFLUOROMETHYL 2 THIENYL) 3 (3 TRIFLUOROMETHYLPHENYL) 1,2,4 OXADIAZOLE; BETA1A INTERFERON; CD45RA ANTIGEN; CHEMOKINE RECEPTOR CCR7; FC RECEPTOR; FINGOLIMOD; IMMUNOGLOBULIN ENHANCER BINDING PROTEIN; IMMUNOMODULATING AGENT; LYASE; MAMMALIAN TARGET OF RAPAMYCIN; MONOCLONAL ANTIBODY; N,N DIMETHYLSPHINGOSINE; PLACEBO; PROTEIN KINASE C GAMMA; PROTEINASE ACTIVATED RECEPTOR 1; RAPAMYCIN; SPHINGOSINE 1 PHOSPHATE; SPHINGOSINE 1 PHOSPHATE ANTIBODY; SPHINGOSINE 1 PHOSPHATE LYASE; SPHINGOSINE 1 PHOSPHATE RECEPTOR; SPHINGOSINE KINASE 1; SPHINGOSINE KINASE 2; SPHINGOSINE KINASE INHIBITOR; TOLL LIKE RECEPTOR; TRANSCRIPTION FACTOR FOXP3; TRANSFORMING GROWTH FACTOR BETA; TUMOR NECROSIS FACTOR RECEPTOR; TUMOR NECROSIS FACTOR RECEPTOR ASSOCIATED FACTOR 2; UNCLASSIFIED DRUG; UNINDEXED DRUG;

EID: 78650881166     PISSN: 01656147     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.tips.2010.11.002     Document Type: Review
Times cited : (158)

References (81)
  • 1
    • 67650762826 scopus 로고    scopus 로고
    • Sphingosine 1-phosphate receptor signaling
    • H. Rosen Sphingosine 1-phosphate receptor signaling Annu. Rev. Biochem. 78 2009 743 768
    • (2009) Annu. Rev. Biochem. , vol.78 , pp. 743-768
    • Rosen, H.1
  • 2
    • 52949108813 scopus 로고    scopus 로고
    • The alliance of sphingosine-1-phosphate and its receptors in immunity
    • J. Rivera The alliance of sphingosine-1-phosphate and its receptors in immunity Nat. Rev. Immunol. 8 2008 753 763
    • (2008) Nat. Rev. Immunol. , vol.8 , pp. 753-763
    • Rivera, J.1
  • 3
    • 34247379074 scopus 로고    scopus 로고
    • Promotion of lymphocyte egress into blood and lymph by distinct sources of sphingosine-1-phosphate
    • R. Pappu Promotion of lymphocyte egress into blood and lymph by distinct sources of sphingosine-1-phosphate Science 316 2007 295 298
    • (2007) Science , vol.316 , pp. 295-298
    • Pappu, R.1
  • 4
    • 41449112571 scopus 로고    scopus 로고
    • Vascular endothelium as a contributor of plasma sphingosine 1-phosphate
    • K. Venkataraman Vascular endothelium as a contributor of plasma sphingosine 1-phosphate Circ. Res. 102 2008 669 676
    • (2008) Circ. Res. , vol.102 , pp. 669-676
    • Venkataraman, K.1
  • 5
    • 77952961847 scopus 로고    scopus 로고
    • Neural crest-derived pericytes promote egress of mature thymocytes at the corticomedullary junction
    • M.A. Zachariah, and J.G. Cyster Neural crest-derived pericytes promote egress of mature thymocytes at the corticomedullary junction Science 328 2010 1129 1135
    • (2010) Science , vol.328 , pp. 1129-1135
    • Zachariah, M.A.1    Cyster, J.G.2
  • 6
    • 76149126108 scopus 로고    scopus 로고
    • Lymphatic endothelial cell sphingosine kinase activity is required for lymphocyte egress and lymphatic patterning
    • T.H. Pham Lymphatic endothelial cell sphingosine kinase activity is required for lymphocyte egress and lymphatic patterning J. Exp. Med. 207 2010 17 27
    • (2010) J. Exp. Med. , vol.207 , pp. 17-27
    • Pham, T.H.1
  • 7
    • 24644469502 scopus 로고    scopus 로고
    • Lymphocyte sequestration through S1P lyase inhibition and disruption of S1P gradients
    • S.R. Schwab Lymphocyte sequestration through S1P lyase inhibition and disruption of S1P gradients Science 309 2005 1735 1739
    • (2005) Science , vol.309 , pp. 1735-1739
    • Schwab, S.R.1
  • 8
    • 36248956701 scopus 로고    scopus 로고
    • Finding a way out: Lymphocyte egress from lymphoid organs
    • S.R. Schwab, and J.G. Cyster Finding a way out: lymphocyte egress from lymphoid organs Nat. Immunol. 8 2007 1295 1301
    • (2007) Nat. Immunol. , vol.8 , pp. 1295-1301
    • Schwab, S.R.1    Cyster, J.G.2
  • 9
    • 64049113731 scopus 로고    scopus 로고
    • Chemical modulators of sphingosine-1-phosphate receptors as barrier-oriented therapeutic molecules
    • D. Marsolais, and H. Rosen Chemical modulators of sphingosine-1-phosphate receptors as barrier-oriented therapeutic molecules Nat. Rev. Drug Discov. 8 2009 297 307
    • (2009) Nat. Rev. Drug Discov. , vol.8 , pp. 297-307
    • Marsolais, D.1    Rosen, H.2
  • 10
    • 0037066466 scopus 로고    scopus 로고
    • Alteration of lymphocyte trafficking by sphingosine-1-phosphate receptor agonists
    • S. Mandala Alteration of lymphocyte trafficking by sphingosine-1- phosphate receptor agonists Science 296 2002 346 349
    • (2002) Science , vol.296 , pp. 346-349
    • Mandala, S.1
  • 11
    • 0037077308 scopus 로고    scopus 로고
    • The immune modulator FTY720 targets sphingosine 1-phosphate receptors
    • V. Brinkmann The immune modulator FTY720 targets sphingosine 1-phosphate receptors J. Biol. Chem. 277 2002 21453 21457
    • (2002) J. Biol. Chem. , vol.277 , pp. 21453-21457
    • Brinkmann, V.1
  • 12
    • 1642580757 scopus 로고    scopus 로고
    • Lymphocyte egress from thymus and peripheral lymphoid organs is dependent on S1P receptor 1
    • M. Matloubian Lymphocyte egress from thymus and peripheral lymphoid organs is dependent on S1P receptor 1 Nature 427 2004 355 360
    • (2004) Nature , vol.427 , pp. 355-360
    • Matloubian, M.1
  • 13
    • 2442561611 scopus 로고    scopus 로고
    • Expression of the sphingosine 1-phosphate receptor. S1P1, on T-cells controls thymic emigration
    • M.L. Allende Expression of the sphingosine 1-phosphate receptor. S1P1, on T-cells controls thymic emigration J. Biol. Chem. 279 2004 15396 15401
    • (2004) J. Biol. Chem. , vol.279 , pp. 15396-15401
    • Allende, M.L.1
  • 14
    • 14044258490 scopus 로고    scopus 로고
    • Cutting edge: Regulation of T cell trafficking and primary immune responses by sphingosine 1-phosphate receptor 1
    • H. Chi, and R.A. Flavell Cutting edge: regulation of T cell trafficking and primary immune responses by sphingosine 1-phosphate receptor 1 J. Immunol. 174 2005 2485 2488
    • (2005) J. Immunol. , vol.174 , pp. 2485-2488
    • Chi, H.1    Flavell, R.A.2
  • 15
    • 13544270248 scopus 로고    scopus 로고
    • Immunological effects of transgenic constitutive expression of the type 1 sphingosine 1-phosphate receptor by mouse lymphocytes
    • M.H. Graler Immunological effects of transgenic constitutive expression of the type 1 sphingosine 1-phosphate receptor by mouse lymphocytes J. Immunol. 174 2005 1997 2003
    • (2005) J. Immunol. , vol.174 , pp. 1997-2003
    • Graler, M.H.1
  • 16
    • 37349069359 scopus 로고    scopus 로고
    • The sphingosine 1-phosphate receptor 1 causes tissue retention by inhibiting the entry of peripheral tissue T lymphocytes into afferent lymphatics
    • L.G. Ledgerwood The sphingosine 1-phosphate receptor 1 causes tissue retention by inhibiting the entry of peripheral tissue T lymphocytes into afferent lymphatics Nat. Immunol. 9 2008 42 53
    • (2008) Nat. Immunol. , vol.9 , pp. 42-53
    • Ledgerwood, L.G.1
  • 17
    • 70449700288 scopus 로고    scopus 로고
    • Discontinued postnatal thymocyte development in sphingosine 1-phosphate-lyase-deficient mice
    • C. Weber Discontinued postnatal thymocyte development in sphingosine 1-phosphate-lyase-deficient mice J. Immunol. 183 2009 4292 4301
    • (2009) J. Immunol. , vol.183 , pp. 4292-4301
    • Weber, C.1
  • 18
    • 58149474166 scopus 로고    scopus 로고
    • Incomplete inhibition of sphingosine 1-phosphate lyase modulates immune system function yet prevents early lethality and non-lymphoid lesions
    • P. Vogel Incomplete inhibition of sphingosine 1-phosphate lyase modulates immune system function yet prevents early lethality and non-lymphoid lesions PLoS ONE 4 2009 e4112
    • (2009) PLoS ONE , vol.4 , pp. 4112
    • Vogel, P.1
  • 19
    • 77954421069 scopus 로고    scopus 로고
    • Cell-surface residence of sphingosine 1-phosphate receptor 1 on lymphocytes determines lymphocyte egress kinetics
    • S. Thangada Cell-surface residence of sphingosine 1-phosphate receptor 1 on lymphocytes determines lymphocyte egress kinetics J. Exp. Med. 207 2010 1475 1483
    • (2010) J. Exp. Med. , vol.207 , pp. 1475-1483
    • Thangada, S.1
  • 20
    • 33645289121 scopus 로고    scopus 로고
    • CD69 acts downstream of interferon-alpha/beta to inhibit S1P1 and lymphocyte egress from lymphoid organs
    • L.R. Shiow CD69 acts downstream of interferon-alpha/beta to inhibit S1P1 and lymphocyte egress from lymphoid organs Nature 440 2006 540 544
    • (2006) Nature , vol.440 , pp. 540-544
    • Shiow, L.R.1
  • 21
    • 33746334804 scopus 로고    scopus 로고
    • Kruppel-like factor 2 regulates thymocyte and T-cell migration
    • C.M. Carlson Kruppel-like factor 2 regulates thymocyte and T-cell migration Nature 442 2006 299 302
    • (2006) Nature , vol.442 , pp. 299-302
    • Carlson, C.M.1
  • 22
    • 30044441314 scopus 로고    scopus 로고
    • Sphingosine 1-phosphate type 1 receptor agonism inhibits transendothelial migration of medullary T cells to lymphatic sinuses
    • S.H. Wei Sphingosine 1-phosphate type 1 receptor agonism inhibits transendothelial migration of medullary T cells to lymphatic sinuses Nat. Immunol. 6 2005 1228 1235
    • (2005) Nat. Immunol. , vol.6 , pp. 1228-1235
    • Wei, S.H.1
  • 23
    • 65949105042 scopus 로고    scopus 로고
    • Persistent signaling induced by FTY720-phosphate is mediated by internalized S1P1 receptors
    • F. Mullershausen Persistent signaling induced by FTY720-phosphate is mediated by internalized S1P1 receptors Nat. Chem. Biol. 5 2009 428 434
    • (2009) Nat. Chem. Biol. , vol.5 , pp. 428-434
    • Mullershausen, F.1
  • 24
    • 33846864904 scopus 로고    scopus 로고
    • The immunosuppressant drug FTY720 inhibits cytosolic phospholipase A2 independently of sphingosine-1-phosphate receptors
    • S.G. Payne The immunosuppressant drug FTY720 inhibits cytosolic phospholipase A2 independently of sphingosine-1-phosphate receptors Blood 109 2007 1077 1085
    • (2007) Blood , vol.109 , pp. 1077-1085
    • Payne, S.G.1
  • 25
    • 77952309720 scopus 로고    scopus 로고
    • S1P1 receptor directs the release of immature B cells from bone marrow into blood
    • M.L. Allende S1P1 receptor directs the release of immature B cells from bone marrow into blood J. Exp. Med. 207 2010 1113 1124
    • (2010) J. Exp. Med. , vol.207 , pp. 1113-1124
    • Allende, M.L.1
  • 26
    • 77949521813 scopus 로고    scopus 로고
    • A role for S1P and S1P1 in immature B cell egress from mouse bone marrow
    • J.P. Pereira A role for S1P and S1P1 in immature B cell egress from mouse bone marrow PLoS ONE 5 2010 e9277
    • (2010) PLoS ONE , vol.5 , pp. 9277
    • Pereira, J.P.1
  • 27
    • 37349013401 scopus 로고    scopus 로고
    • Follicular shuttling of marginal zone B cells facilitates antigen transport
    • G. Cinamon Follicular shuttling of marginal zone B cells facilitates antigen transport Nat. Immunol. 9 2008 54 62
    • (2008) Nat. Immunol. , vol.9 , pp. 54-62
    • Cinamon, G.1
  • 28
    • 63649143900 scopus 로고    scopus 로고
    • Sphingosine-1-phosphate mobilizes osteoclast precursors and regulates bone homeostasis
    • M. Ishii Sphingosine-1-phosphate mobilizes osteoclast precursors and regulates bone homeostasis Nature 458 2009 524 528
    • (2009) Nature , vol.458 , pp. 524-528
    • Ishii, M.1
  • 29
    • 36248966560 scopus 로고    scopus 로고
    • Natural killer cell trafficking in vivo requires a dedicated sphingosine 1-phosphate receptor
    • T. Walzer Natural killer cell trafficking in vivo requires a dedicated sphingosine 1-phosphate receptor Nat. Immunol. 8 2007 1337 1344
    • (2007) Nat. Immunol. , vol.8 , pp. 1337-1344
    • Walzer, T.1
  • 30
    • 70449732610 scopus 로고    scopus 로고
    • T-bet-dependent S1P5 expression in NK cells promotes egress from lymph nodes and bone marrow
    • C.N. Jenne T-bet-dependent S1P5 expression in NK cells promotes egress from lymph nodes and bone marrow J. Exp. Med. 206 2009 2469 2481
    • (2009) J. Exp. Med. , vol.206 , pp. 2469-2481
    • Jenne, C.N.1
  • 31
    • 33947236062 scopus 로고    scopus 로고
    • Migration of CD4 T cells and dendritic cells toward sphingosine 1-phosphate (S1P) is mediated by different receptor subtypes: S1P regulates the functions of murine mature dendritic cells via S1P receptor type 3
    • Y. Maeda Migration of CD4 T cells and dendritic cells toward sphingosine 1-phosphate (S1P) is mediated by different receptor subtypes: S1P regulates the functions of murine mature dendritic cells via S1P receptor type 3 J. Immunol. 178 2007 3437 3446
    • (2007) J. Immunol. , vol.178 , pp. 3437-3446
    • Maeda, Y.1
  • 32
    • 77949332336 scopus 로고    scopus 로고
    • Inhibitory role of sphingosine 1-phosphate receptor 2 in macrophage recruitment during inflammation
    • J. Michaud Inhibitory role of sphingosine 1-phosphate receptor 2 in macrophage recruitment during inflammation J. Immunol. 184 2010 1475 1483
    • (2010) J. Immunol. , vol.184 , pp. 1475-1483
    • Michaud, J.1
  • 33
    • 77953255522 scopus 로고    scopus 로고
    • SphK1 regulates proinflammatory responses associated with endotoxin and polymicrobial sepsis
    • P. Puneet SphK1 regulates proinflammatory responses associated with endotoxin and polymicrobial sepsis Science 328 2010 1290 1294
    • (2010) Science , vol.328 , pp. 1290-1294
    • Puneet, P.1
  • 34
    • 61849157254 scopus 로고    scopus 로고
    • TNFR signaling: Ubiquitin-conjugated TRAFfic signals control stop-and-go for MAPK signaling complexes
    • M. Karin, and E. Gallagher TNFR signaling: ubiquitin-conjugated TRAFfic signals control stop-and-go for MAPK signaling complexes Immunol. Rev. 228 2009 225 240
    • (2009) Immunol. Rev. , vol.228 , pp. 225-240
    • Karin, M.1    Gallagher, E.2
  • 35
    • 70350028721 scopus 로고    scopus 로고
    • Regulation of JNK and p38 MAPK in the immune system: Signal integration, propagation and termination
    • G. Huang Regulation of JNK and p38 MAPK in the immune system: signal integration, propagation and termination Cytokine 48 2009 161 169
    • (2009) Cytokine , vol.48 , pp. 161-169
    • Huang, G.1
  • 36
    • 63649116570 scopus 로고    scopus 로고
    • Ubiquitylation in innate and adaptive immunity
    • V.G. Bhoj, and Z.J. Chen Ubiquitylation in innate and adaptive immunity Nature 458 2009 430 437
    • (2009) Nature , vol.458 , pp. 430-437
    • Bhoj, V.G.1    Chen, Z.J.2
  • 37
    • 77953923379 scopus 로고    scopus 로고
    • Sphingosine-1-phosphate is a missing cofactor for the E3 ubiquitin ligase TRAF2
    • S.E. Alvarez Sphingosine-1-phosphate is a missing cofactor for the E3 ubiquitin ligase TRAF2 Nature 465 2010 1084 1088
    • (2010) Nature , vol.465 , pp. 1084-1088
    • Alvarez, S.E.1
  • 38
    • 41649094810 scopus 로고    scopus 로고
    • Dendritic cell PAR1-S1P3 signalling couples coagulation and inflammation
    • F. Niessen Dendritic cell PAR1-S1P3 signalling couples coagulation and inflammation Nature 452 2008 654 658
    • (2008) Nature , vol.452 , pp. 654-658
    • Niessen, F.1
  • 39
    • 46949104885 scopus 로고    scopus 로고
    • Inside-out" signaling of sphingosine-1-phosphate: Therapeutic targets
    • K. Takabe Inside-out" signaling of sphingosine-1-phosphate: therapeutic targets Pharmacol. Rev. 60 2008 181 195
    • (2008) Pharmacol. Rev. , vol.60 , pp. 181-195
    • Takabe, K.1
  • 40
    • 33947147299 scopus 로고    scopus 로고
    • The sphingosine kinase-sphingosine-1-phosphate axis is a determinant of mast cell function and anaphylaxis
    • A. Olivera The sphingosine kinase-sphingosine-1-phosphate axis is a determinant of mast cell function and anaphylaxis Immunity 26 2007 287 297
    • (2007) Immunity , vol.26 , pp. 287-297
    • Olivera, A.1
  • 41
    • 68949119768 scopus 로고    scopus 로고
    • Sphingosine kinase 1 is pivotal for Fc epsilon RI-mediated mast cell signaling and functional responses in vitro and in vivo
    • P.N. Pushparaj Sphingosine kinase 1 is pivotal for Fc epsilon RI-mediated mast cell signaling and functional responses in vitro and in vivo J. Immunol. 183 2009 221 227
    • (2009) J. Immunol. , vol.183 , pp. 221-227
    • Pushparaj, P.N.1
  • 42
    • 43049171400 scopus 로고    scopus 로고
    • Distinct roles of sphingosine kinases 1 and 2 in human mast-cell functions
    • C.A. Oskeritzian Distinct roles of sphingosine kinases 1 and 2 in human mast-cell functions Blood 111 2008 4193 4200
    • (2008) Blood , vol.111 , pp. 4193-4200
    • Oskeritzian, C.A.1
  • 43
    • 77949518621 scopus 로고    scopus 로고
    • Essential roles of sphingosine-1-phosphate receptor 2 in human mast cell activation, anaphylaxis, and pulmonary edema
    • C.A. Oskeritzian Essential roles of sphingosine-1-phosphate receptor 2 in human mast cell activation, anaphylaxis, and pulmonary edema J. Exp. Med. 207 2010 465 474
    • (2010) J. Exp. Med. , vol.207 , pp. 465-474
    • Oskeritzian, C.A.1
  • 44
    • 77951817430 scopus 로고    scopus 로고
    • Sphingosine kinase 1 and sphingosine-1-phosphate receptor 2 are vital to recovery from anaphylactic shock in mice
    • A. Olivera Sphingosine kinase 1 and sphingosine-1-phosphate receptor 2 are vital to recovery from anaphylactic shock in mice J. Clin. Invest. 120 2010 1429 1440
    • (2010) J. Clin. Invest. , vol.120 , pp. 1429-1440
    • Olivera, A.1
  • 45
    • 51749096383 scopus 로고    scopus 로고
    • The vascular S1P gradient - Cellular sources and biological significance
    • T. Hla The vascular S1P gradient - cellular sources and biological significance Biochim. Biophys. Acta 1781 2008 477 482
    • (2008) Biochim. Biophys. Acta , vol.1781 , pp. 477-482
    • Hla, T.1
  • 46
    • 68849122050 scopus 로고    scopus 로고
    • Sphingosine-1-phosphate in the plasma compartment regulates basal and inflammation-induced vascular leak in mice
    • E. Camerer Sphingosine-1-phosphate in the plasma compartment regulates basal and inflammation-induced vascular leak in mice J. Clin. Invest. 119 2009 1871 1879
    • (2009) J. Clin. Invest. , vol.119 , pp. 1871-1879
    • Camerer, E.1
  • 47
    • 77956894066 scopus 로고    scopus 로고
    • Genetic sphingosine kinase 1 deficiency significantly decreases synovial inflammation and joint erosions in murine TNF-alpha-induced arthritis
    • D.A. Baker Genetic sphingosine kinase 1 deficiency significantly decreases synovial inflammation and joint erosions in murine TNF-alpha-induced arthritis J. Immunol. 185 2010 2570 2579
    • (2010) J. Immunol. , vol.185 , pp. 2570-2579
    • Baker, D.A.1
  • 48
    • 71849087397 scopus 로고    scopus 로고
    • Anti-inflammatory effects of sphingosine kinase modulation in inflammatory arthritis
    • W.Q. Lai Anti-inflammatory effects of sphingosine kinase modulation in inflammatory arthritis J. Immunol. 181 2008 8010 8017
    • (2008) J. Immunol. , vol.181 , pp. 8010-8017
    • Lai, W.Q.1
  • 49
    • 58249117646 scopus 로고    scopus 로고
    • A role for sphingosine kinase 1 in dextran sulfate sodium-induced colitis
    • A.J. Snider A role for sphingosine kinase 1 in dextran sulfate sodium-induced colitis FASEB J. 23 2009 143 152
    • (2009) FASEB J. , vol.23 , pp. 143-152
    • Snider, A.J.1
  • 50
    • 44849137343 scopus 로고    scopus 로고
    • The role of sphingosine kinase in a murine model of allergic asthma
    • W.Q. Lai The role of sphingosine kinase in a murine model of allergic asthma J. Immunol. 180 2008 4323 4329
    • (2008) J. Immunol. , vol.180 , pp. 4323-4329
    • Lai, W.Q.1
  • 51
    • 77952313777 scopus 로고    scopus 로고
    • Differentiation of effector CD4 T cell populations
    • J. Zhu Differentiation of effector CD4 T cell populations Annu. Rev. Immunol. 28 2010 445 489
    • (2010) Annu. Rev. Immunol. , vol.28 , pp. 445-489
    • Zhu, J.1
  • 52
    • 65549123867 scopus 로고    scopus 로고
    • + regulatory T cells: More of the same or a division of labor?
    • + regulatory T cells: more of the same or a division of labor? Immunity 30 2009 626 635
    • (2009) Immunity , vol.30 , pp. 626-635
    • Curotto De Lafaille, M.A.1    Lafaille, J.J.2
  • 53
    • 67649185215 scopus 로고    scopus 로고
    • The receptor S1P1 overrides regulatory T cell-mediated immune suppression through Akt-mTOR
    • G. Liu The receptor S1P1 overrides regulatory T cell-mediated immune suppression through Akt-mTOR Nat. Immunol. 10 2009 769 777
    • (2009) Nat. Immunol. , vol.10 , pp. 769-777
    • Liu, G.1
  • 54
    • 29144514700 scopus 로고    scopus 로고
    • + T-regulatory cells and enhances their functional activity
    • + T-regulatory cells and enhances their functional activity J. Immunol. 175 2005 7973 7980
    • (2005) J. Immunol. , vol.175 , pp. 7973-7980
    • Sawicka, E.1
  • 55
    • 33846908988 scopus 로고    scopus 로고
    • + regulatory T cells
    • + regulatory T cells J. Immunol. 178 2007 2458 2468
    • (2007) J. Immunol. , vol.178 , pp. 2458-2468
    • Daniel, C.1
  • 56
    • 77958151145 scopus 로고    scopus 로고
    • reg cells
    • reg cells Nat. Immunol. 11 2010 1047 1056
    • (2010) Nat. Immunol. , vol.11 , pp. 1047-1056
    • Liu, G.1
  • 58
    • 40749142071 scopus 로고    scopus 로고
    • Role of sphingosine 1-phosphate in the pathogenesis of Sjogren's syndrome
    • M. Sekiguchi Role of sphingosine 1-phosphate in the pathogenesis of Sjogren's syndrome J. Immunol. 180 2008 1921 1928
    • (2008) J. Immunol. , vol.180 , pp. 1921-1928
    • Sekiguchi, M.1
  • 59
    • 34247167227 scopus 로고    scopus 로고
    • Type 1 sphingosine 1-phosphate G protein-coupled receptor (S1P1) mediation of enhanced IL-4 generation by CD4 T cells from S1P1 transgenic mice
    • W. Wang Type 1 sphingosine 1-phosphate G protein-coupled receptor (S1P1) mediation of enhanced IL-4 generation by CD4 T cells from S1P1 transgenic mice J. Immunol. 178 2007 4885 4890
    • (2007) J. Immunol. , vol.178 , pp. 4885-4890
    • Wang, W.1
  • 60
    • 34247585411 scopus 로고    scopus 로고
    • Th17 augmentation in OTII TCR plus T cell-selective type 1 sphingosine 1-phosphate receptor double transgenic mice
    • M.C. Huang Th17 augmentation in OTII TCR plus T cell-selective type 1 sphingosine 1-phosphate receptor double transgenic mice J. Immunol. 178 2007 6806 6813
    • (2007) J. Immunol. , vol.178 , pp. 6806-6813
    • Huang, M.C.1
  • 61
    • 26444606350 scopus 로고    scopus 로고
    • Type 4 sphingosine 1-phosphate G protein-coupled receptor (S1P4) transduces S1P effects on T cell proliferation and cytokine secretion without signaling migration
    • W. Wang Type 4 sphingosine 1-phosphate G protein-coupled receptor (S1P4) transduces S1P effects on T cell proliferation and cytokine secretion without signaling migration FASEB J. 19 2005 1731 1733
    • (2005) FASEB J. , vol.19 , pp. 1731-1733
    • Wang, W.1
  • 62
    • 11144353922 scopus 로고    scopus 로고
    • Sphingosine 1-phosphate (S1P) receptor subtypes S1P1 and S1P3, respectively, regulate lymphocyte recirculation and heart rate
    • M.G. Sanna Sphingosine 1-phosphate (S1P) receptor subtypes S1P1 and S1P3, respectively, regulate lymphocyte recirculation and heart rate J. Biol. Chem. 279 2004 13839 13848
    • (2004) J. Biol. Chem. , vol.279 , pp. 13839-13848
    • Sanna, M.G.1
  • 63
    • 70849086174 scopus 로고    scopus 로고
    • FTY720 (fingolimod) in multiple sclerosis: Therapeutic effects in the immune and the central nervous system
    • V. Brinkmann FTY720 (fingolimod) in multiple sclerosis: therapeutic effects in the immune and the central nervous system Br. J. Pharmacol. 158 2009 1173 1182
    • (2009) Br. J. Pharmacol. , vol.158 , pp. 1173-1182
    • Brinkmann, V.1
  • 64
    • 76149093586 scopus 로고    scopus 로고
    • A placebo-controlled trial of oral fingolimod in relapsing multiple sclerosis
    • L. Kappos A placebo-controlled trial of oral fingolimod in relapsing multiple sclerosis N. Engl. J. Med. 362 2010 387 401
    • (2010) N. Engl. J. Med. , vol.362 , pp. 387-401
    • Kappos, L.1
  • 65
    • 76149140914 scopus 로고    scopus 로고
    • Oral fingolimod or intramuscular interferon for relapsing multiple sclerosis
    • J.A. Cohen Oral fingolimod or intramuscular interferon for relapsing multiple sclerosis N. Engl. J. Med. 362 2010 402 415
    • (2010) N. Engl. J. Med. , vol.362 , pp. 402-415
    • Cohen, J.A.1
  • 66
    • 24944535833 scopus 로고    scopus 로고
    • S1P1-selective in vivo-active agonists from high-throughput screening: Off-the-shelf chemical probes of receptor interactions, signaling, and fate
    • E. Jo S1P1-selective in vivo-active agonists from high-throughput screening: off-the-shelf chemical probes of receptor interactions, signaling, and fate Chem. Biol. 12 2005 703 715
    • (2005) Chem. Biol. , vol.12 , pp. 703-715
    • Jo, E.1
  • 67
    • 19944432761 scopus 로고    scopus 로고
    • KRP-203, a novel synthetic immunosuppressant, prolongs graft survival and attenuates chronic rejection in rat skin and heart allografts
    • H. Shimizu KRP-203, a novel synthetic immunosuppressant, prolongs graft survival and attenuates chronic rejection in rat skin and heart allografts Circulation 111 2005 222 229
    • (2005) Circulation , vol.111 , pp. 222-229
    • Shimizu, H.1
  • 68
    • 55249113624 scopus 로고    scopus 로고
    • Increased survival and reduced renal injury in MRL/lpr mice treated with a novel sphingosine-1-phosphate receptor agonist
    • S.E. Wenderfer Increased survival and reduced renal injury in MRL/lpr mice treated with a novel sphingosine-1-phosphate receptor agonist Kidney Int. 74 2008 1319 1326
    • (2008) Kidney Int. , vol.74 , pp. 1319-1326
    • Wenderfer, S.E.1
  • 69
    • 33746365908 scopus 로고    scopus 로고
    • Enhancement of capillary leakage and restoration of lymphocyte egress by a chiral S1P1 antagonist in vivo
    • M.G. Sanna Enhancement of capillary leakage and restoration of lymphocyte egress by a chiral S1P1 antagonist in vivo Nat. Chem. Biol. 2 2006 434 441
    • (2006) Nat. Chem. Biol. , vol.2 , pp. 434-441
    • Sanna, M.G.1
  • 70
    • 15444373345 scopus 로고    scopus 로고
    • Sphingosine 1-phosphate analogs as receptor antagonists
    • M.D. Davis Sphingosine 1-phosphate analogs as receptor antagonists J. Biol. Chem. 280 2005 9833 9841
    • (2005) J. Biol. Chem. , vol.280 , pp. 9833-9841
    • Davis, M.D.1
  • 71
    • 0037401276 scopus 로고    scopus 로고
    • Sphingosine 1-phosphate induces contraction of coronary artery smooth muscle cells via S1P2
    • T. Ohmori Sphingosine 1-phosphate induces contraction of coronary artery smooth muscle cells via S1P2 Cardiovasc. Res. 58 2003 170 177
    • (2003) Cardiovasc. Res. , vol.58 , pp. 170-177
    • Ohmori, T.1
  • 72
    • 77953966511 scopus 로고    scopus 로고
    • Sphingosine 1-phosphate and cancer
    • N.J. Pyne, and S. Pyne Sphingosine 1-phosphate and cancer Nat. Rev. Cancer 10 2010 489 503
    • (2010) Nat. Rev. Cancer , vol.10 , pp. 489-503
    • Pyne, N.J.1    Pyne, S.2
  • 73
    • 68149124148 scopus 로고    scopus 로고
    • Distinct roles of sphingosine kinase 1 and 2 in murine collagen-induced arthritis
    • W.Q. Lai Distinct roles of sphingosine kinase 1 and 2 in murine collagen-induced arthritis J. Immunol. 183 2009 2097 2103
    • (2009) J. Immunol. , vol.183 , pp. 2097-2103
    • Lai, W.Q.1
  • 74
    • 51649122574 scopus 로고    scopus 로고
    • A selective sphingosine kinase 1 inhibitor integrates multiple molecular therapeutic targets in human leukemia
    • S.W. Paugh A selective sphingosine kinase 1 inhibitor integrates multiple molecular therapeutic targets in human leukemia Blood 112 2008 1382 1391
    • (2008) Blood , vol.112 , pp. 1382-1391
    • Paugh, S.W.1
  • 75
    • 70149120314 scopus 로고    scopus 로고
    • Targeting sphingosine kinase 1 inhibits Akt signaling, induces apoptosis, and suppresses growth of human glioblastoma cells and xenografts
    • D. Kapitonov Targeting sphingosine kinase 1 inhibits Akt signaling, induces apoptosis, and suppresses growth of human glioblastoma cells and xenografts Cancer Res. 69 2009 6915 6923
    • (2009) Cancer Res. , vol.69 , pp. 6915-6923
    • Kapitonov, D.1
  • 76
    • 67549106796 scopus 로고    scopus 로고
    • Synthesis and evaluation of sphingosine analogues as inhibitors of sphingosine kinases
    • L. Wong Synthesis and evaluation of sphingosine analogues as inhibitors of sphingosine kinases J. Med. Chem. 52 2009 3618 3626
    • (2009) J. Med. Chem. , vol.52 , pp. 3618-3626
    • Wong, L.1
  • 77
    • 77949748845 scopus 로고    scopus 로고
    • Pharmacology and antitumor activity of ABC294640, a selective inhibitor of sphingosine kinase-2
    • K.J. French Pharmacology and antitumor activity of ABC294640, a selective inhibitor of sphingosine kinase-2 J. Pharmacol. Exp. Ther. 333 2010 129 139
    • (2010) J. Pharmacol. Exp. Ther. , vol.333 , pp. 129-139
    • French, K.J.1
  • 78
    • 77951085269 scopus 로고    scopus 로고
    • A novel sphingosine kinase inhibitor induces autophagy in tumor cells
    • V. Beljanski A novel sphingosine kinase inhibitor induces autophagy in tumor cells J. Pharmacol. Exp. Ther. 333 2010 454 464
    • (2010) J. Pharmacol. Exp. Ther. , vol.333 , pp. 454-464
    • Beljanski, V.1
  • 79
    • 33644830810 scopus 로고    scopus 로고
    • Validation of an anti-sphingosine-1-phosphate antibody as a potential therapeutic in reducing growth, invasion, and angiogenesis in multiple tumor lineages
    • B. Visentin Validation of an anti-sphingosine-1-phosphate antibody as a potential therapeutic in reducing growth, invasion, and angiogenesis in multiple tumor lineages Cancer Cell 9 2006 225 238
    • (2006) Cancer Cell , vol.9 , pp. 225-238
    • Visentin, B.1
  • 80
    • 70350399322 scopus 로고    scopus 로고
    • Production and characterization of monoclonal anti-sphingosine-1- phosphate antibodies
    • N. O'Brien Production and characterization of monoclonal anti-sphingosine-1-phosphate antibodies J. Lipid Res. 50 2009 2245 2257
    • (2009) J. Lipid Res. , vol.50 , pp. 2245-2257
    • O'Brien, N.1
  • 81
    • 77953790503 scopus 로고    scopus 로고
    • An update on sphingosine-1-phosphate and other sphingolipid mediators
    • H. Fyrst, and J.D. Saba An update on sphingosine-1-phosphate and other sphingolipid mediators Nat. Chem. Biol. 6 2010 489 497
    • (2010) Nat. Chem. Biol. , vol.6 , pp. 489-497
    • Fyrst, H.1    Saba, J.D.2


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.