-
1
-
-
0021227676
-
The role of protein kinase C in cell surface signal transduction and tumour promotion
-
Nishizuka, Y. (1984) The role of protein kinase C in cell surface signal transduction and tumour promotion. Nature 308, 693-698
-
(1984)
Nature
, vol.308
, pp. 693-698
-
-
Nishizuka, Y.1
-
2
-
-
0021750054
-
Inositol trisphosphate, a novel second messenger in cellular signal transduction
-
Berridge, M.J. and Irvine, R.F. (1984) Inositol trisphosphate, a novel second messenger in cellular signal transduction. Nature 312, 315-321
-
(1984)
Nature
, vol.312
, pp. 315-321
-
-
Berridge, M.J.1
Irvine, R.F.2
-
3
-
-
0030992837
-
Signalling through the lipid products of phosphoinositide-3-OH kinase
-
Toker, A. and Cantley, L.C. (1997) Signalling through the lipid products of phosphoinositide-3-OH kinase. Nature 387, 673-676
-
(1997)
Nature
, vol.387
, pp. 673-676
-
-
Toker, A.1
Cantley, L.C.2
-
4
-
-
0024795059
-
Sphingomyelin turnover induced by vitamin D3 in HL-60 cells: Role in cell differentiation
-
Okazaki, T., Bell, R.M., and Hannun, Y.A. (1989) Sphingomyelin turnover induced by vitamin D3 in HL-60 cells: Role in cell differentiation. J. Biol Chem. 264, 19076-19080
-
(1989)
J. Biol Chem.
, vol.264
, pp. 19076-19080
-
-
Okazaki, T.1
Bell, R.M.2
Hannun, Y.A.3
-
5
-
-
0028297068
-
The sphingomyelin pathway in tumor necrosis factor and interleukin-1 signaling
-
Kolesnick, R. and Golde, D.W. (1994) The sphingomyelin pathway in tumor necrosis factor and interleukin-1 signaling. Cell 77, 325-328
-
(1994)
Cell
, vol.77
, pp. 325-328
-
-
Kolesnick, R.1
Golde, D.W.2
-
6
-
-
0030448021
-
Functions of ceramide in coordinating cellular responses to stress
-
Hannun, Y.A. (1996) Functions of ceramide in coordinating cellular responses to stress. Science 274, 1855-1859
-
(1996)
Science
, vol.274
, pp. 1855-1859
-
-
Hannun, Y.A.1
-
7
-
-
0029862561
-
Sphingolipid metabolism and cell growth regulation
-
Spiegel, S. and Merrill, A.H., Jr. (1996) Sphingolipid metabolism and cell growth regulation. FASEB J. 10, 1388-1397
-
(1996)
FASEB J.
, vol.10
, pp. 1388-1397
-
-
Spiegel, S.1
Merrill Jr., A.H.2
-
8
-
-
0025077629
-
Bifunctional role of glycosphingolipids. Modulators for transmembrane signaling and mediators for cellular interactions
-
Hakomori, S. (1990) Bifunctional role of glycosphingolipids. Modulators for transmembrane signaling and mediators for cellular interactions. J. Biol. Chem. 265, 18713-18716
-
(1990)
J. Biol. Chem.
, vol.265
, pp. 18713-18716
-
-
Hakomori, S.1
-
9
-
-
0027429271
-
Gangliosides and glycosphingolipids as modulators of cell growth, adhesion, and transmembrane signaling
-
Hakomori, S. and Igarashi, Y. (1993) Gangliosides and glycosphingolipids as modulators of cell growth, adhesion, and transmembrane signaling. Adv. Lipid Res. 25, 147-162
-
(1993)
Adv. Lipid Res.
, vol.25
, pp. 147-162
-
-
Hakomori, S.1
Igarashi, Y.2
-
10
-
-
0029609895
-
Functional role of glycosphingolipids in cell recognition and signaling
-
Hakomori, S. and Igarashi, Y. (1995) Functional role of glycosphingolipids in cell recognition and signaling. J. Biochem. 118, 1091-1103
-
(1995)
J. Biochem.
, vol.118
, pp. 1091-1103
-
-
Hakomori, S.1
Igarashi, Y.2
-
11
-
-
0028986238
-
Secretory phospholipase A2 generates the novel lipid mediator lysophosphatidic acid in membrane microvesicles shed from activated cells
-
Fourcade, O., Simon, M.F., Viode, C., Rugani, N., Leballe, F., Ragab, A., Fournie, B., Sarda, L., and Chap, H. (1995) Secretory phospholipase A2 generates the novel lipid mediator lysophosphatidic acid in membrane microvesicles shed from activated cells. Cell 80, 919-927
-
(1995)
Cell
, vol.80
, pp. 919-927
-
-
Fourcade, O.1
Simon, M.F.2
Viode, C.3
Rugani, N.4
Leballe, F.5
Ragab, A.6
Fournie, B.7
Sarda, L.8
Chap, H.9
-
12
-
-
0029948396
-
Suppression of ceramide-mediated programmed cell death by sphingosine-1-phosphate
-
Cuvillier, O., Pirianov, G., Kleuser, B., Vanek, P.G., Coso, O.A., Gutkind, S., and Spiegel, S. (1996) Suppression of ceramide-mediated programmed cell death by sphingosine-1-phosphate. Nature 381, 800-803
-
(1996)
Nature
, vol.381
, pp. 800-803
-
-
Cuvillier, O.1
Pirianov, G.2
Kleuser, B.3
Vanek, P.G.4
Coso, O.A.5
Gutkind, S.6
Spiegel, S.7
-
13
-
-
0030893370
-
Expression of neutral sphingomyelinase identifies a distinct pool of sphingomyelin involved in apoptosis
-
Zhang, P., Liu, B., Jenkins, G.M., Hannun, Y.A., and Obeid, L.M. (1997) Expression of neutral sphingomyelinase identifies a distinct pool of sphingomyelin involved in apoptosis. J. Biol. Chem. 272, 9609-9612
-
(1997)
J. Biol. Chem.
, vol.272
, pp. 9609-9612
-
-
Zhang, P.1
Liu, B.2
Jenkins, G.M.3
Hannun, Y.A.4
Obeid, L.M.5
-
14
-
-
0015901914
-
Sphingosine kinase in blood platelets
-
Stoffel, W., Heimann, G., and Hellenbroich, B. (1973) Sphingosine kinase in blood platelets. Hoppe-Seyler's Z. Physiol. Chem. 354, 562-566
-
(1973)
Hoppe-Seyler's Z. Physiol. Chem.
, vol.354
, pp. 562-566
-
-
Stoffel, W.1
Heimann, G.2
Hellenbroich, B.3
-
15
-
-
0025351642
-
Intracellular calcium release mediated by sphingosine derivatives generated in cells
-
Ghosh, T.K., Bian, J., and Gill, D.L. (1990) Intracellular calcium release mediated by sphingosine derivatives generated in cells. Science 248, 1653-1656
-
(1990)
Science
, vol.248
, pp. 1653-1656
-
-
Ghosh, T.K.1
Bian, J.2
Gill, D.L.3
-
16
-
-
0026049696
-
Sphingosine-1-phosphate, a novel lipid, involved in cellular proliferation
-
Zhang, H., Desai, N.N., Olivera, A., Seki, T., Brooker, G., and Spiegel, S. (1991) Sphingosine-1-phosphate, a novel lipid, involved in cellular proliferation. J. Cell Biol. 114, 155-167
-
(1991)
J. Cell Biol.
, vol.114
, pp. 155-167
-
-
Zhang, H.1
Desai, N.N.2
Olivera, A.3
Seki, T.4
Brooker, G.5
Spiegel, S.6
-
17
-
-
0027371722
-
Sphingosine-1-phosphate as second messenger in cell proliferation induced by PDGF and FCS mitogens
-
Olivera, A. and Spiegel, S. (1993) Sphingosine-1-phosphate as second messenger in cell proliferation induced by PDGF and FCS mitogens. Nature 365, 557-560
-
(1993)
Nature
, vol.365
, pp. 557-560
-
-
Olivera, A.1
Spiegel, S.2
-
18
-
-
0029996127
-
Calcium mobilization via sphingosine kinase in signaling by the FcεRI antigen receptor
-
Choi, O.H., Kim, J.-H., and Kinet, J.-P. (1996) Calcium mobilization via sphingosine kinase in signaling by the FcεRI antigen receptor. Nature 380, 634-636
-
(1996)
Nature
, vol.380
, pp. 634-636
-
-
Choi, O.H.1
Kim, J.-H.2
Kinet, J.-P.3
-
19
-
-
0026440839
-
Chemical synthesis of D-erythro-sphingosine-1-phosphate, and its inhibitory effect on cell motility
-
Ruan, P., Hakomori, S., and Igarashi, Y. (1992) Chemical synthesis of D-erythro-sphingosine-1-phosphate, and its inhibitory effect on cell motility. Biomed. Chem. Lett. 2, 973-978
-
(1992)
Biomed. Chem. Lett.
, vol.2
, pp. 973-978
-
-
Ruan, P.1
Hakomori, S.2
Igarashi, Y.3
-
20
-
-
0026774525
-
Sphingosine-1-phosphate, a specific endogenous signaling molecule controlling cell motility and tumor cell invasiveness
-
Sadahira, Y., Ruan, F., Hakomori, S., and Igarashi, Y. (1992) Sphingosine-1-phosphate, a specific endogenous signaling molecule controlling cell motility and tumor cell invasiveness. Proc. Natl. Acad. Sci. USA 89, 9686-9690
-
(1992)
Proc. Natl. Acad. Sci. USA
, vol.89
, pp. 9686-9690
-
-
Sadahira, Y.1
Ruan, F.2
Hakomori, S.3
Igarashi, Y.4
-
21
-
-
0028268198
-
Sphingosine-1-phosphate inhibits extracellular matrix protein-induced haptotactic motility but not adhesion of B16 mouse melanoma cells
-
Sadahira, Y., Zheng, M., Ruan, F., Hakomori, S., and Igarashi, Y. (1994) Sphingosine-1-phosphate inhibits extracellular matrix protein-induced haptotactic motility but not adhesion of B16 mouse melanoma cells. FEBS Lett. 340, 99-103
-
(1994)
FEBS Lett.
, vol.340
, pp. 99-103
-
-
Sadahira, Y.1
Zheng, M.2
Ruan, F.3
Hakomori, S.4
Igarashi, Y.5
-
22
-
-
0029027589
-
Sphingosine-1-phosphate inhibits PDGF-induced chemotaxis of human arterial smooth muscle cells: Spatial and temporal modulation of PDGF chemotactic signal transduction
-
Bornfeldt, K.E., Graves, L.M., Raines, E.W., Igarashi, Y., Wayman, G., Yamamura, S., Yatomi, Y., Sidhu, J.S., Krebs, E. G., Hakomori, S., and Ross, R. (1995) Sphingosine-1-phosphate inhibits PDGF-induced chemotaxis of human arterial smooth muscle cells: spatial and temporal modulation of PDGF chemotactic signal transduction. J. Cell Biol. 130, 193-206
-
(1995)
J. Cell Biol.
, vol.130
, pp. 193-206
-
-
Bornfeldt, K.E.1
Graves, L.M.2
Raines, E.W.3
Igarashi, Y.4
Wayman, G.5
Yamamura, S.6
Yatomi, Y.7
Sidhu, J.S.8
Krebs, E.G.9
Hakomori, S.10
Ross, R.11
-
23
-
-
0029879269
-
Sphingosine-1-phosphate inhibits actin nucleation and pseudopodium formation to control cell motility of mouse melanoma cells
-
Yamamura, S., Sadahira, Y., Ruan, F., Hakomori, S., and Igarashi, Y. (1996) Sphingosine-1-phosphate inhibits actin nucleation and pseudopodium formation to control cell motility of mouse melanoma cells. FEBS Lett. 382, 193-197
-
(1996)
FEBS Lett.
, vol.382
, pp. 193-197
-
-
Yamamura, S.1
Sadahira, Y.2
Ruan, F.3
Hakomori, S.4
Igarashi, Y.5
-
24
-
-
0030868653
-
Sphingosine 1-phosphate regulates melanoma cell motility through a receptor-coupled extracellular action and in a pertussis toxin insensitive manner
-
Yamamura, S., Yatomi, Y., Ruan, F., Sweeney, E.A., Hakomori, S., and Igarashi, Y. (1997) Sphingosine 1-phosphate regulates melanoma cell motility through a receptor-coupled extracellular action and in a pertussis toxin insensitive manner. Biochemistry 36, 10751-10759
-
(1997)
Biochemistry
, vol.36
, pp. 10751-10759
-
-
Yamamura, S.1
Yatomi, Y.2
Ruan, F.3
Sweeney, E.A.4
Hakomori, S.5
Igarashi, Y.6
-
25
-
-
0029052921
-
Sphingosine-1-phosphate: A platelet-activating sphingolipid released from agonist-stimulated human platelets
-
Yatomi, Y., Ruan, F., Hakomori, S., and Igarashi, Y. (1995) Sphingosine-1-phosphate: a platelet-activating sphingolipid released from agonist-stimulated human platelets. Blood 86, 193-202
-
(1995)
Blood
, vol.86
, pp. 193-202
-
-
Yatomi, Y.1
Ruan, F.2
Hakomori, S.3
Igarashi, Y.4
-
26
-
-
0031040704
-
Sphingosine 1-phosphate induces platelet activation through an extracellular action and shares a platelet surface receptor with lysophosphatidic acid
-
Yatomi, Y., Yamamura, S., Ruan, F., and Igarashi, Y. (1997) Sphingosine 1-phosphate induces platelet activation through an extracellular action and shares a platelet surface receptor with lysophosphatidic acid. J. Biol. Chem. 272, 5291-5297
-
(1997)
J. Biol. Chem.
, vol.272
, pp. 5291-5297
-
-
Yatomi, Y.1
Yamamura, S.2
Ruan, F.3
Igarashi, Y.4
-
27
-
-
0030961305
-
Sphingosine 1-phosphate, a bioactive sphingolipid abundantly stored in platelets, is a normal constituent in plasma and serum
-
Yatomi, Y., Igarashi, Y., Yang, L., Hisano, N., Ruomei, Q., Asazuma, N., Satoh, K., Ozaki, Y., and Kume, S. (1997) Sphingosine 1-phosphate, a bioactive sphingolipid abundantly stored in platelets, is a normal constituent in plasma and serum. J. Biochem. 121, 969-973
-
(1997)
J. Biochem.
, vol.121
, pp. 969-973
-
-
Yatomi, Y.1
Igarashi, Y.2
Yang, L.3
Hisano, N.4
Ruomei, Q.5
Asazuma, N.6
Satoh, K.7
Ozaki, Y.8
Kume, S.9
-
28
-
-
0029128576
-
Quantitative measurement of sphingosine 1-phosphate in biological samples by acylation with radioactive acetic anhydride
-
Yatomi, Y., Ruan, F., Ohta, H., Welch, R.J., Hakomori, S., and Igarashi, Y. (1995) Quantitative measurement of sphingosine 1-phosphate in biological samples by acylation with radioactive acetic anhydride. Anal. Biochem. 230, 315-320
-
(1995)
Anal. Biochem.
, vol.230
, pp. 315-320
-
-
Yatomi, Y.1
Ruan, F.2
Ohta, H.3
Welch, R.J.4
Hakomori, S.5
Igarashi, Y.6
-
30
-
-
2642614668
-
Sphingosine-phosphate content in platelet plasma samples correlates with poor platelet increments after transfusion and occurrences of platelet transfusion reactions in patients
-
in press
-
Igarashi, Y., Yatomi, Y., and Kickler, T.H. (1997) Sphingosine-phosphate content in platelet plasma samples correlates with poor platelet increments after transfusion and occurrences of platelet transfusion reactions in patients. Am. J. Hematol. in press
-
(1997)
Am. J. Hematol.
-
-
Igarashi, Y.1
Yatomi, Y.2
Kickler, T.H.3
-
31
-
-
0029879915
-
Sphingosine-1-phosphate rapidly induces Rho-dependent neurite retraction: Action through a specific cell surface receptor
-
Postma, F.R., Jalink, K., Hengeveld, T., and Moolenaar, W.H. (1996) Sphingosine-1-phosphate rapidly induces Rho-dependent neurite retraction: action through a specific cell surface receptor. EMBO J. 15, 2388-2395
-
(1996)
EMBO J.
, vol.15
, pp. 2388-2395
-
-
Postma, F.R.1
Jalink, K.2
Hengeveld, T.3
Moolenaar, W.H.4
-
32
-
-
0027074149
-
Biosynthesis of sphingolipids: Dihydroceramide and not sphinganine is desaturated by cultured cells
-
Rother, J., van Echten, G., Schwarzmann, G., and Sandhoff, K. (1992) Biosynthesis of sphingolipids: dihydroceramide and not sphinganine is desaturated by cultured cells. Biochem. Biophys. Res. Commun. 189, 14-20
-
(1992)
Biochem. Biophys. Res. Commun.
, vol.189
, pp. 14-20
-
-
Rother, J.1
Van Echten, G.2
Schwarzmann, G.3
Sandhoff, K.4
-
33
-
-
0024541436
-
Functions of sphingolipids and sphingolipid breakdown products in cellular regulation
-
Hannun, Y.A. and Bell, R.M. (1989) Functions of sphingolipids and sphingolipid breakdown products in cellular regulation. Science 243, 500-507
-
(1989)
Science
, vol.243
, pp. 500-507
-
-
Hannun, Y.A.1
Bell, R.M.2
-
34
-
-
0030971056
-
Selective involvement of ceramide in cytokine-induced apoptosis. Ceramide inhibits phorbol ester activation of nuclear factor kappa B
-
Gamard, C.J., Dbaibo, G.S., Liu, B., Obeid, L.M., and Hannun, Y.A. (1997) Selective involvement of ceramide in cytokine-induced apoptosis. Ceramide inhibits phorbol ester activation of nuclear factor kappa B. J. Biol. Chem. 272, 16474-16481
-
(1997)
J. Biol. Chem.
, vol.272
, pp. 16474-16481
-
-
Gamard, C.J.1
Dbaibo, G.S.2
Liu, B.3
Obeid, L.M.4
Hannun, Y.A.5
-
35
-
-
0027973628
-
A possible role of sphingosine in induction of apoptosis by tumor necrosis factor-α in human neutrophils
-
Ohta, H., Yatomi, Y., Sweeney, E.A., Hakomori, S., and Igarashi, Y. (1994) A possible role of sphingosine in induction of apoptosis by tumor necrosis factor-α in human neutrophils FEBS Lett. 355, 267-270
-
(1994)
FEBS Lett.
, vol.355
, pp. 267-270
-
-
Ohta, H.1
Yatomi, Y.2
Sweeney, E.A.3
Hakomori, S.4
Igarashi, Y.5
-
36
-
-
0028900748
-
Induction of apoptosis by sphingosine in human leukemic HL-60 cells: A possible endogenous modulator of apoptotic DNA fragmentation occurring during phorbol ester-induced differentiation
-
Ohta, H., Sweeney, E.A., Masamune, A., Yatomi, Y., Hakomori, S., and Igarashi, Y. (1995) Induction of apoptosis by sphingosine in human leukemic HL-60 cells: A possible endogenous modulator of apoptotic DNA fragmentation occurring during phorbol ester-induced differentiation. Cancer Res. 55, 691-697
-
(1995)
Cancer Res.
, vol.55
, pp. 691-697
-
-
Ohta, H.1
Sweeney, E.A.2
Masamune, A.3
Yatomi, Y.4
Hakomori, S.5
Igarashi, Y.6
-
37
-
-
0030453430
-
Tumor necrosis factor alpha-induced apoptosis in cardiac myocytes. Involvement of the sphingolipid signaling cascade in cardiac cell death
-
Krown, K.A., Page, M.T., Nguyen, C., Zechner, D., Gutierrez, V., Comstock, K.L., Glembotski, C.C., Quintana, P.J., and Sabbadini, R.A. (1996) Tumor necrosis factor alpha-induced apoptosis in cardiac myocytes. Involvement of the sphingolipid signaling cascade in cardiac cell death. J. Clin. Invest. 98, 2854-2865
-
(1996)
J. Clin. Invest.
, vol.98
, pp. 2854-2865
-
-
Krown, K.A.1
Page, M.T.2
Nguyen, C.3
Zechner, D.4
Gutierrez, V.5
Comstock, K.L.6
Glembotski, C.C.7
Quintana, P.J.8
Sabbadini, R.A.9
-
38
-
-
0031040328
-
Sphingosine mediates the immediate negative inotropic effects of tumor necrosis factor-alpha in the adult mammalian cardiac myocyte
-
Oral, H., Dorn, G.W. 2nd, and Mann, D.L. (1997) Sphingosine mediates the immediate negative inotropic effects of tumor necrosis factor-alpha in the adult mammalian cardiac myocyte. J. Biol. Chem. 272, 4836-4842
-
(1997)
J. Biol. Chem.
, vol.272
, pp. 4836-4842
-
-
Oral, H.1
Dorn II, G.W.2
Mann, D.L.3
-
39
-
-
0030004270
-
Sphingosine and N,N-dimethylsphingosine induce apoptosis in a variety of human cancer cell lines
-
Sweeney, E.A., Sakakura, C., Shirahama, T., Masamune, A., Ohta, H., Hakomori, S., and Igarashi, Y. (1996) Sphingosine and N,N-dimethylsphingosine induce apoptosis in a variety of human cancer cell lines. Int. J. Cancer 66, 358-366
-
(1996)
Int. J. Cancer
, vol.66
, pp. 358-366
-
-
Sweeney, E.A.1
Sakakura, C.2
Shirahama, T.3
Masamune, A.4
Ohta, H.5
Hakomori, S.6
Igarashi, Y.7
-
40
-
-
0030854629
-
Inhibition of MAPKinase by sphingosine and its methylated derivative N,N-dimethylsphingosine; a correlation with induction of apoptosis in solid tumor cells
-
Sakakura, C., Sweeney, E.A., Shirahama, T., Solca, F., Kohno, M., Hakomori, S., Fischer, E.H., and Igarashi, Y. (1997) Inhibition of MAPKinase by sphingosine and its methylated derivative N,N-dimethylsphingosine; a correlation with induction of apoptosis in solid tumor cells. Int. J. Oncol. 11, 31-39
-
(1997)
Int. J. Oncol.
, vol.11
, pp. 31-39
-
-
Sakakura, C.1
Sweeney, E.A.2
Shirahama, T.3
Solca, F.4
Kohno, M.5
Hakomori, S.6
Fischer, E.H.7
Igarashi, Y.8
-
41
-
-
0030071041
-
Suppression of Bcl-2 gene expression by sphingosine in the apoptosis of human leukemic HL-60 cells during phorbol ester-induced terminal differentiation
-
Sakakura, C., Sweeney, E.A., Shirahama, T., Hakomori, S., and Igarashi, Y. (1996) Suppression of Bcl-2 gene expression by sphingosine in the apoptosis of human leukemic HL-60 cells during phorbol ester-induced terminal differentiation. FEBS Lett. 379, 177-180
-
(1996)
FEBS Lett.
, vol.379
, pp. 177-180
-
-
Sakakura, C.1
Sweeney, E.A.2
Shirahama, T.3
Hakomori, S.4
Igarashi, Y.5
-
42
-
-
17344383499
-
L gene expression
-
L gene expression. FEBS Lett. 407, 97-100
-
(1997)
FEBS Lett.
, vol.407
, pp. 97-100
-
-
Shirahama, T.1
Sakakura, C.2
Sweeney, E.A.3
Takemoto, M.4
Ozawa, M.5
Ohi, Y.6
Igarashi, Y.7
-
43
-
-
9344222195
-
Bcl-2 interrupts the ceramide-mediated pathway of cell death
-
Zhang, J., Alter, N., Reed, J.C., Borner, C., Obeid, L.M., and Hannun, Y.A. (1996) Bcl-2 interrupts the ceramide-mediated pathway of cell death. Proc. Natl. Acad. Sci. USA 93, 5325-5328
-
(1996)
Proc. Natl. Acad. Sci. USA
, vol.93
, pp. 5325-5328
-
-
Zhang, J.1
Alter, N.2
Reed, J.C.3
Borner, C.4
Obeid, L.M.5
Hannun, Y.A.6
-
44
-
-
0028838536
-
The signal modulator protein 14-3-3 is a target of sphingosine- Or N,N-dimethylsphingosine-dependent kinase in 3T3(A31) cells
-
Megidish, T., White, T., Takio, K., Titani, K., Igarashi, Y., and Hakomori, S. (1995) The signal modulator protein 14-3-3 is a target of sphingosine-or N,N-dimethylsphingosine-dependent kinase in 3T3(A31) cells. Biochem. Biophys. Res. Commun. 216, 739-747
-
(1995)
Biochem. Biophys. Res. Commun.
, vol.216
, pp. 739-747
-
-
Megidish, T.1
White, T.2
Takio, K.3
Titani, K.4
Igarashi, Y.5
Hakomori, S.6
-
45
-
-
0030993241
-
Inhibition of DNA primase by sphingosine and its analogues parallels with their growth suppression of cultured human leukemic cells
-
Tamiya-Koizumi, K., Murate, T., Suzuki, M., Simbulan, C.M., Nakagawa, M., Takemura, M., Furuta, K., Izuta, S., and Yoshida, S. (1997) Inhibition of DNA primase by sphingosine and its analogues parallels with their growth suppression of cultured human leukemic cells. Biochem. Mol. Biol. Int. 41, 1179-1189
-
(1997)
Biochem. Mol. Biol. Int.
, vol.41
, pp. 1179-1189
-
-
Tamiya-Koizumi, K.1
Murate, T.2
Suzuki, M.3
Simbulan, C.M.4
Nakagawa, M.5
Takemura, M.6
Furuta, K.7
Izuta, S.8
Yoshida, S.9
-
46
-
-
0029922118
-
Induction of apoptosis and potentiation of ceramide-mediated cytotoxicity by sphingoid bases in human myeloid leukemia cells
-
Jarvis, W.D., Fornari, F.A., Traylor, R.S., Martin, H.A., Kramer, L.B., Erukulla, R.K., Bittman, R., and Grant, S. (1996) Induction of apoptosis and potentiation of ceramide-mediated cytotoxicity by sphingoid bases in human myeloid leukemia cells. J. Biol. Chem. 271, 8275-8284
-
(1996)
J. Biol. Chem.
, vol.271
, pp. 8275-8284
-
-
Jarvis, W.D.1
Fornari, F.A.2
Traylor, R.S.3
Martin, H.A.4
Kramer, L.B.5
Erukulla, R.K.6
Bittman, R.7
Grant, S.8
-
47
-
-
0028848344
-
Differential regulation of sphingomyelinase and ceramidase activities by growth factors and cytokines. Implications for cellular proliferation and differentiation
-
Coroneos, E., Martinez, M., McKenna, S., and Kester, M. (1995) Differential regulation of sphingomyelinase and ceramidase activities by growth factors and cytokines. Implications for cellular proliferation and differentiation. J. Biol. Chem. 270, 23305-23309
-
(1995)
J. Biol. Chem.
, vol.270
, pp. 23305-23309
-
-
Coroneos, E.1
Martinez, M.2
McKenna, S.3
Kester, M.4
-
48
-
-
0024436946
-
Enzymatic synthesis of N, N-dimethylsphingosine: Demonstration of the sphingosine; N-methyltransferase in mouse brain
-
Igarashi, Y. and Hakomori, S. (1989) Enzymatic synthesis of N, N-dimethylsphingosine: Demonstration of the sphingosine; N-methyltransferase in mouse brain. Biochem. Biophys. Res. Commun. 164, 1411-1416
-
(1989)
Biochem. Biophys. Res. Commun.
, vol.164
, pp. 1411-1416
-
-
Igarashi, Y.1
Hakomori, S.2
-
49
-
-
0025253532
-
A specific enhancing effect of N,N-dimethylsphingosine on epidermal growth factor receptor autophosphorylation: Demonstration of its endogenous occurrence (and its virtual absence of unsubstituted sphingosine) in human epidermoid carcinoma A431 cells
-
Igarashi, Y., Kitamura, K., Toyokuni, T., Dean, B., Fenderson, B., Ogawa, T., and Hakomori, S. (1990) A specific enhancing effect of N,N-dimethylsphingosine on epidermal growth factor receptor autophosphorylation: Demonstration of its endogenous occurrence (and its virtual absence of unsubstituted sphingosine) in human epidermoid carcinoma A431 cells. J. Biol. Chem. 265, 5385-5389
-
(1990)
J. Biol. Chem.
, vol.265
, pp. 5385-5389
-
-
Igarashi, Y.1
Kitamura, K.2
Toyokuni, T.3
Dean, B.4
Fenderson, B.5
Ogawa, T.6
Hakomori, S.7
-
50
-
-
0025365763
-
A ceramide analogue inhibits T cell proliferative response through inhibition of glycosphingolipid synthesis and enhancement of N,N-dimethylsphingosine synthesis
-
Felding-Habermann, B., Igarashi, Y., Fenderson, B.A., Park, L. S., Radin, N.S., Inokuchi, J., Strassmann, G., Handa, K., and Hakomori, S. (1990) A ceramide analogue inhibits T cell proliferative response through inhibition of glycosphingolipid synthesis and enhancement of N,N-dimethylsphingosine synthesis. Biochemistry 29, 6314-6322
-
(1990)
Biochemistry
, vol.29
, pp. 6314-6322
-
-
Felding-Habermann, B.1
Igarashi, Y.2
Fenderson, B.A.3
Park, L.S.4
Radin, N.S.5
Inokuchi, J.6
Strassmann, G.7
Handa, K.8
Hakomori, S.9
-
51
-
-
0026661563
-
Plasmalopsychosine: A novel plasmal (fatty aldehyde) conjugate of psychosine with cyclic acetal linkage: Isolation and characterization from human brain white matter
-
Nudelman, E.D., Levery, S.B., Igarashi, Y., and Hakomori, S. (1992) Plasmalopsychosine: A novel plasmal (fatty aldehyde) conjugate of psychosine with cyclic acetal linkage: Isolation and characterization from human brain white matter. J. Biol. Chem. 267, 11007-11016
-
(1992)
J. Biol. Chem.
, vol.267
, pp. 11007-11016
-
-
Nudelman, E.D.1
Levery, S.B.2
Igarashi, Y.3
Hakomori, S.4
-
52
-
-
0031568264
-
Simultaneous quantitative determination method for sphingolipid metabolites by liquid chromatography/ionspray ionization tandem mass spectrometry
-
Mano, N., Oda, Y., Yamada, K., Asakawa, N., and Katayama, K. (1997) Simultaneous quantitative determination method for sphingolipid metabolites by liquid chromatography/ionspray ionization tandem mass spectrometry. Anal. Biochem. 244, 291-300
-
(1997)
Anal. Biochem.
, vol.244
, pp. 291-300
-
-
Mano, N.1
Oda, Y.2
Yamada, K.3
Asakawa, N.4
Katayama, K.5
-
53
-
-
0031584862
-
N,N-Dimethylsphingosine phosphorylation in human platelets
-
Yatomi, Y., Ozaki, Y., Satoh, K., Kume, S., Ruan, F., and Igarashi, Y. (1997) N,N-Dimethylsphingosine phosphorylation in human platelets. Biochem. Biophys. Res. Commun. 231, 848-851
-
(1997)
Biochem. Biophys. Res. Commun.
, vol.231
, pp. 848-851
-
-
Yatomi, Y.1
Ozaki, Y.2
Satoh, K.3
Kume, S.4
Ruan, F.5
Igarashi, Y.6
-
54
-
-
0024439904
-
Effect of chemically well-defined sphingosine and its N-methyl derivatives on protein kinase C and src kinase activities
-
Igarashi, Y., Hakomori, S., Toyokuni, T., Dean, B., Fujita, S., Sugimoto, M., Ogawa, T., El-Ghendy, K., and Racker, E. (1989) Effect of chemically well-defined sphingosine and its N-methyl derivatives on protein kinase C and src kinase activities. Biochemistry 28, 6796-6800
-
(1989)
Biochemistry
, vol.28
, pp. 6796-6800
-
-
Igarashi, Y.1
Hakomori, S.2
Toyokuni, T.3
Dean, B.4
Fujita, S.5
Sugimoto, M.6
Ogawa, T.7
El-Ghendy, K.8
Racker, E.9
-
55
-
-
0026319890
-
Cell membrane signaling as target in cancer therapy II: Inhibitory effect of N,N,N-trimethylsphingosine on metastatic potential of murine B16 melanoma cell line through blocking of tumor cell-dependent platelet aggregation
-
Okoshi, H., Hakomori, S., Nisar, M., Zhou, Q., Kimura, S., Tashiro, K., and Igarashi, Y. (1991) Cell membrane signaling as target in cancer therapy II: Inhibitory effect of N,N,N-trimethylsphingosine on metastatic potential of murine B16 melanoma cell line through blocking of tumor cell-dependent platelet aggregation. Cancer Res. 51, 6019-6024
-
(1991)
Cancer Res.
, vol.51
, pp. 6019-6024
-
-
Okoshi, H.1
Hakomori, S.2
Nisar, M.3
Zhou, Q.4
Kimura, S.5
Tashiro, K.6
Igarashi, Y.7
-
56
-
-
0025756765
-
Cell membrane signaling as target in cancer therapy: Inhibitory effect of N,N-dimethyl and N,N,N-trimethylsphingosine derivatives on in vivo and in vitro growth of human tumor cells in nude mice
-
Endo, K., Igarashi, Y., Nisar, M., Zhou, Q., and Hakomori, S. (1991) Cell membrane signaling as target in cancer therapy: Inhibitory effect of N,N-dimethyl and N,N,N-trimethylsphingosine derivatives on in vivo and in vitro growth of human tumor cells in nude mice. Cancer Res. 51, 1613-1618
-
(1991)
Cancer Res.
, vol.51
, pp. 1613-1618
-
-
Endo, K.1
Igarashi, Y.2
Nisar, M.3
Zhou, Q.4
Hakomori, S.5
-
57
-
-
0026355736
-
Down-regulation of GMP-140 expression on platelets by N,N-dimethyl and N,N,N-trimethyl derivatives of sphingosine
-
Handa, K., Igarashi, Y., Nisar, M., and Hakomori, S. (1991) Down-regulation of GMP-140 expression on platelets by N,N-dimethyl and N,N,N-trimethyl derivatives of sphingosine. Biochemistry 30, 11682-11686
-
(1991)
Biochemistry
, vol.30
, pp. 11682-11686
-
-
Handa, K.1
Igarashi, Y.2
Nisar, M.3
Hakomori, S.4
-
58
-
-
0030054341
-
N,N-Dimethylsphingosine inhibition of sphingosine kinase and sphingosine 1-phosphate activity in human platelets
-
Yatomi, Y., Ruan, F., Megidish, T., Toyokuni, T., Hakomori, S., and Igarashi, Y. (1996) N,N-Dimethylsphingosine inhibition of sphingosine kinase and sphingosine 1-phosphate activity in human platelets. Biochemistry 35, 626-633
-
(1996)
Biochemistry
, vol.35
, pp. 626-633
-
-
Yatomi, Y.1
Ruan, F.2
Megidish, T.3
Toyokuni, T.4
Hakomori, S.5
Igarashi, Y.6
-
59
-
-
0031035476
-
In vitro and in vivo induction of apoptosis by sphingosine and N,N-dimethylsphingosine in human epidermal carcinoma KB-3-1 and its multidrug resistant cells
-
Shirahama, T., Sweeney, E.A., Sakakura, C., Nishiyama, K., Akiyama, S., Hakomori, S., and Igarashi, Y. (1997) In vitro and in vivo induction of apoptosis by sphingosine and N,N-dimethylsphingosine in human epidermal carcinoma KB-3-1 and its multidrug resistant cells. Clin. Cancer Res. 3, 257-264
-
(1997)
Clin. Cancer Res.
, vol.3
, pp. 257-264
-
-
Shirahama, T.1
Sweeney, E.A.2
Sakakura, C.3
Nishiyama, K.4
Akiyama, S.5
Hakomori, S.6
Igarashi, Y.7
-
60
-
-
0029060591
-
N,N,N-Trimethylsphingosine inhibits interleukin-1-induced NF-κB activation and consequent E-selectin expression in human umbilical vein endothelial cells
-
Masamune, A., Hakomori, S., and Igarashi, Y. (1995) N,N,N-Trimethylsphingosine inhibits interleukin-1-induced NF-κB activation and consequent E-selectin expression in human umbilical vein endothelial cells. FEBS Lett. 367, 205-209
-
(1995)
FEBS Lett.
, vol.367
, pp. 205-209
-
-
Masamune, A.1
Hakomori, S.2
Igarashi, Y.3
-
61
-
-
0029132954
-
Myocardial and endothelial protection by N,N,N-trimethylsphingosine in feline myocardial ischemia and reperfusion injury
-
Heart Circul. Physiol.
-
Murohara, T., Buerke, M., Margiotta, J., Ruan, F., Igarashi Y., Hakomori, S., and Lefer, A.M. (1995) Myocardial and endothelial protection by N,N,N-trimethylsphingosine in feline myocardial ischemia and reperfusion injury. Am. J. Physiol. 269 (Heart Circul. Physiol.) 38, H504-514
-
(1995)
Am. J. Physiol.
, vol.38-269
-
-
Murohara, T.1
Buerke, M.2
Margiotta, J.3
Ruan, F.4
Igarashi, Y.5
Hakomori, S.6
Lefer, A.M.7
-
62
-
-
0029920489
-
Myocardial protection by N,N,N-trimethylsphingosine in ischemia reperfusion injury is mediated by inhibition of p-selectin
-
Scalia, R., Murohara, T., Delyani, J.A., Nossuli, O., and Lefer, A.M. (1996) Myocardial protection by N,N,N-trimethylsphingosine in ischemia reperfusion injury is mediated by inhibition of p-selectin. J. Leukoc. Biol. 59, 317-324
-
(1996)
J. Leukoc. Biol.
, vol.59
, pp. 317-324
-
-
Scalia, R.1
Murohara, T.2
Delyani, J.A.3
Nossuli, O.4
Lefer, A.M.5
-
63
-
-
2642609583
-
Trimethylsphingosine blocks transmembrane signaling in neutrophils/endothelial cells/platelets and inhibits subsequent neutrophil-mediated reperfusion injury and inflammatory response
-
Vedder, N.B., Han, K.T., Igarashi, Y., Singhai, A.K., Hakomori, S., and Winn, R.K. (1994) Trimethylsphingosine blocks transmembrane signaling in neutrophils/endothelial cells/platelets and inhibits subsequent neutrophil-mediated reperfusion injury and inflammatory response. 39th Annual Meeting of Plastic Surgery Research Council 16-19
-
(1994)
39th Annual Meeting of Plastic Surgery Research Council
, pp. 16-19
-
-
Vedder, N.B.1
Han, K.T.2
Igarashi, Y.3
Singhai, A.K.4
Hakomori, S.5
Winn, R.K.6
-
64
-
-
0031015007
-
2+ system in FRTL-5 thyroid cells: Possible involvement of guanosine triphosphate-binding proteins in the lipid signaling
-
2+ system in FRTL-5 thyroid cells: possible involvement of guanosine triphosphate-binding proteins in the lipid signaling. Endocrinology 138, 220-229
-
(1997)
Endocrinology
, vol.138
, pp. 220-229
-
-
Okajima, F.1
Tomura, H.2
Sho, K.3
Kimura, T.4
Sato, K.5
Im, D.S.6
Akbar, M.7
Kondo, Y.8
|