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Volumn 5, Issue 1, 2016, Pages 2-15

Cellular and molecular biology of small cell lung cancer: An overview

Author keywords

Biomarkers; Immune system; Small cell lung cancer (SCLC); Targeted therapies

Indexed keywords


EID: 84960104601     PISSN: 22186751     EISSN: 22264477     Source Type: Journal    
DOI: 10.3978/j.issn.2218-6751.2016.01.02     Document Type: Review
Times cited : (74)

References (126)
  • 1
    • 20444424204 scopus 로고    scopus 로고
    • Stem cells for lung cancer?
    • Berns A. Stem cells for lung cancer? Cell 2005;121:811-3.
    • (2005) Cell , vol.121 , pp. 811-813
    • Berns, A.1
  • 3
    • 1542319868 scopus 로고    scopus 로고
    • Basal cells are a multipotent progenitor capable of renewing the bronchial epithelium
    • Hong KU, Reynolds SD, Watkins S, et al. Basal cells are a multipotent progenitor capable of renewing the bronchial epithelium. Am J Pathol 2004;164:577-88.
    • (2004) Am J Pathol , vol.164 , pp. 577-588
    • Hong, K.U.1    Reynolds, S.D.2    Watkins, S.3
  • 4
    • 0033875885 scopus 로고    scopus 로고
    • Neuroepithelial bodies of pulmonary airways serve as a reservoir of progenitor cells capable of epithelial regeneration
    • Reynolds SD, Giangreco A, Power JH, et al. Neuroepithelial bodies of pulmonary airways serve as a reservoir of progenitor cells capable of epithelial regeneration. Am J Pathol 2000;156:269-78.
    • (2000) Am J Pathol , vol.156 , pp. 269-278
    • Reynolds, S.D.1    Giangreco, A.2    Power, J.H.3
  • 5
    • 20444397431 scopus 로고    scopus 로고
    • Identification of bronchioalveolar stem cells in normal lung and lung cancer
    • Kim CF, Jackson EL, Woolfenden AE, et al. Identification of bronchioalveolar stem cells in normal lung and lung cancer. Cell 2005;121:823-35.
    • (2005) Cell , vol.121 , pp. 823-835
    • Kim, C.F.1    Jackson, E.L.2    Woolfenden, A.E.3
  • 6
    • 77956619564 scopus 로고    scopus 로고
    • Cell of origin of lung cancer
    • Sutherland KD, Berns A. Cell of origin of lung cancer. Mol Oncol 2010;4:397-403.
    • (2010) Mol Oncol , vol.4 , pp. 397-403
    • Sutherland, K.D.1    Berns, A.2
  • 7
    • 74449085934 scopus 로고    scopus 로고
    • A small-cell lung cancer genome with complex signatures of tobacco exposure
    • Pleasance ED, Stephens PJ, O'Meara S, et al. A small-cell lung cancer genome with complex signatures of tobacco exposure. Nature 2010;463:184-90.
    • (2010) Nature , vol.463 , pp. 184-190
    • Pleasance, E.D.1    Stephens, P.J.2    O'Meara, S.3
  • 8
    • 80051725013 scopus 로고    scopus 로고
    • Characterization of the cell of origin for small cell lung cancer
    • Park KS, Liang MC, Raiser DM, et al. Characterization of the cell of origin for small cell lung cancer. Cell Cycle 2011;10:2806-15.
    • (2011) Cell Cycle , vol.10 , pp. 2806-2815
    • Park, K.S.1    Liang, M.C.2    Raiser, D.M.3
  • 9
    • 84867912495 scopus 로고    scopus 로고
    • Functional characterization of pulmonary neuroendocrine cells in lung development, injury, and tumorigenesis
    • Song H, Yao E, Lin C, et al. Functional characterization of pulmonary neuroendocrine cells in lung development, injury, and tumorigenesis. Proc Natl Acad Sci U S A 2012;109:17531-6.
    • (2012) Proc Natl Acad Sci U S A , vol.109 , pp. 17531-17536
    • Song, H.1    Yao, E.2    Lin, C.3
  • 10
    • 79958761641 scopus 로고    scopus 로고
    • Cell of origin of small cell lung cancer: inactivation of Trp53 and Rb1 in distinct cell types of adult mouse lung
    • Sutherland KD, Proost N, Brouns I, et al. Cell of origin of small cell lung cancer: inactivation of Trp53 and Rb1 in distinct cell types of adult mouse lung. Cancer Cell 2011;19:754-64.
    • (2011) Cancer Cell , vol.19 , pp. 754-764
    • Sutherland, K.D.1    Proost, N.2    Brouns, I.3
  • 11
    • 0141523025 scopus 로고    scopus 로고
    • Induction of small cell lung cancer by somatic inactivation of both Trp53 and Rb1 in a conditional mouse model
    • Meuwissen R, Linn SC, Linnoila RI, et al. Induction of small cell lung cancer by somatic inactivation of both Trp53 and Rb1 in a conditional mouse model. Cancer Cell 2003;4:181-9.
    • (2003) Cancer Cell , vol.4 , pp. 181-189
    • Meuwissen, R.1    Linn, S.C.2    Linnoila, R.I.3
  • 12
    • 0030936265 scopus 로고    scopus 로고
    • An achaete-scute homologue essential for neuroendocrine differentiation in the lung
    • Borges M, Linnoila RI, van de Velde HJ, et al. An achaete-scute homologue essential for neuroendocrine differentiation in the lung. Nature 1997;386:852-5.
    • (1997) Nature , vol.386 , pp. 852-855
    • Borges, M.1    Linnoila, R.I.2    van de Velde, H.J.3
  • 13
    • 0033885165 scopus 로고    scopus 로고
    • Constitutive achaete-scute homologue-1 promotes airway dysplasia and lung neuroendocrine tumors in transgenic mice
    • Linnoila RI, Zhao B, DeMayo JL, et al. Constitutive achaete-scute homologue-1 promotes airway dysplasia and lung neuroendocrine tumors in transgenic mice. Cancer Res 2000;60:4005-9.
    • (2000) Cancer Res , vol.60 , pp. 4005-4009
    • Linnoila, R.I.1    Zhao, B.2    DeMayo, J.L.3
  • 14
    • 59149099364 scopus 로고    scopus 로고
    • Achaete-scute complex homologue 1 regulates tumor-initiating capacity in human small cell lung cancer
    • Jiang T, Collins BJ, Jin N, et al. Achaete-scute complex homologue 1 regulates tumor-initiating capacity in human small cell lung cancer. Cancer Res 2009;69:845-54.
    • (2009) Cancer Res , vol.69 , pp. 845-854
    • Jiang, T.1    Collins, B.J.2    Jin, N.3
  • 15
    • 84864755117 scopus 로고    scopus 로고
    • Achaetescute homologue-1 (ASH1) stimulates migration of lung cancer cells through Cdk5/p35 pathway
    • Demelash A, Rudrabhatla P, Pant HC, et al. Achaetescute homologue-1 (ASH1) stimulates migration of lung cancer cells through Cdk5/p35 pathway. Mol Biol Cell 2012;23:2856-66.
    • (2012) Mol Biol Cell , vol.23 , pp. 2856-2866
    • Demelash, A.1    Rudrabhatla, P.2    Pant, H.C.3
  • 16
    • 0842287503 scopus 로고    scopus 로고
    • Achaete-scute homolog-1 and Notch in lung neuroendocrine development and cancer
    • Ball DW. Achaete-scute homolog-1 and Notch in lung neuroendocrine development and cancer. Cancer Lett 2004;204:159-69.
    • (2004) Cancer Lett , vol.204 , pp. 159-169
    • Ball, D.W.1
  • 17
    • 0027420712 scopus 로고
    • Mammalian achaete-scute homolog 1 is required for the early development of olfactory and autonomic neurons
    • Guillemot F, Lo LC, Johnson JE, et al. Mammalian achaete-scute homolog 1 is required for the early development of olfactory and autonomic neurons. Cell 1993;75:463-76.
    • (1993) Cell , vol.75 , pp. 463-476
    • Guillemot, F.1    Lo, L.C.2    Johnson, J.E.3
  • 18
    • 84870508104 scopus 로고    scopus 로고
    • Multidirectional differentiation of Achaete-Scute homologue-1-defined progenitors in lung development and injury repair
    • Li Y, Linnoila RI. Multidirectional differentiation of Achaete-Scute homologue-1-defined progenitors in lung development and injury repair. Am J Respir Cell Mol Biol 2012;47:768-75.
    • (2012) Am J Respir Cell Mol Biol , vol.47 , pp. 768-775
    • Li, Y.1    Linnoila, R.I.2
  • 19
    • 84954403082 scopus 로고    scopus 로고
    • NOTCH, ASCL1, p53 and RB alterations define an alternative pathway driving neuroendocrine and small cell lung carcinomas
    • Meder L, König K, Ozretić L, et al. NOTCH, ASCL1, p53 and RB alterations define an alternative pathway driving neuroendocrine and small cell lung carcinomas. Int J Cancer 2016;138:927-38.
    • (2016) Int J Cancer , vol.138 , pp. 927-938
    • Meder, L.1    König, K.2    Ozretić, L.3
  • 20
    • 84907938536 scopus 로고    scopus 로고
    • ASCL1 is a lineage oncogene providing therapeutic targets for highgrade neuroendocrine lung cancers
    • Augustyn A, Borromeo M, Wang T, et al. ASCL1 is a lineage oncogene providing therapeutic targets for highgrade neuroendocrine lung cancers. Proc Natl Acad Sci U S A 2014;111:14788-93.
    • (2014) Proc Natl Acad Sci U S A , vol.111 , pp. 14788-14793
    • Augustyn, A.1    Borromeo, M.2    Wang, T.3
  • 21
    • 84883202463 scopus 로고    scopus 로고
    • NeuroD1 regulation of migration accompanies the differential sensitivity of neuroendocrine carcinomas to TrkB inhibition
    • Osborne JK, Larsen JE, Gonzales JX, et al. NeuroD1 regulation of migration accompanies the differential sensitivity of neuroendocrine carcinomas to TrkB inhibition. Oncogenesis 2013;2:e63.
    • (2013) Oncogenesis , vol.2 , pp. e63
    • Osborne, J.K.1    Larsen, J.E.2    Gonzales, J.X.3
  • 22
    • 84876205922 scopus 로고    scopus 로고
    • NeuroD1 regulates survival and migration of neuroendocrine lung carcinomas via signaling molecules TrkB and NCAM
    • Osborne JK, Larsen JE, Shields MD, et al. NeuroD1 regulates survival and migration of neuroendocrine lung carcinomas via signaling molecules TrkB and NCAM. Proc Natl Acad Sci U S A 2013;110:6524-9.
    • (2013) Proc Natl Acad Sci U S A , vol.110 , pp. 6524-6529
    • Osborne, J.K.1    Larsen, J.E.2    Shields, M.D.3
  • 23
    • 0023681795 scopus 로고
    • myc family DNA amplification in small cell lung cancer patients' tumors and corresponding cell lines
    • Johnson BE, Makuch RW, Simmons AD, et al. myc family DNA amplification in small cell lung cancer patients' tumors and corresponding cell lines. Cancer Res 1988;48:5163-6.
    • (1988) Cancer Res , vol.48 , pp. 5163-5166
    • Johnson, B.E.1    Makuch, R.W.2    Simmons, A.D.3
  • 24
    • 0022392771 scopus 로고
    • L-myc, a new mycrelated gene amplified and expressed in human small cell lung cancer
    • Nau MM, Brooks BJ, Battey J, et al. L-myc, a new mycrelated gene amplified and expressed in human small cell lung cancer. Nature 1985;318:69-73.
    • (1985) Nature , vol.318 , pp. 69-73
    • Nau, M.M.1    Brooks, B.J.2    Battey, J.3
  • 25
    • 84923358817 scopus 로고    scopus 로고
    • Cell-of-origin chromatin organization shapes the mutational landscape of cancer
    • Polak P, Karlić R, Koren A, et al. Cell-of-origin chromatin organization shapes the mutational landscape of cancer. Nature 2015;518:360-4.
    • (2015) Nature , vol.518 , pp. 360-364
    • Polak, P.1    Karlić, R.2    Koren, A.3
  • 26
    • 0037330728 scopus 로고    scopus 로고
    • The P16/ cyclin D1/Rb pathway in neuroendocrine tumors of the lung
    • Beasley MB, Lantuejoul S, Abbondanzo S, et al. The P16/ cyclin D1/Rb pathway in neuroendocrine tumors of the lung. Hum Pathol 2003;34:136-42.
    • (2003) Hum Pathol , vol.34 , pp. 136-142
    • Beasley, M.B.1    Lantuejoul, S.2    Abbondanzo, S.3
  • 27
    • 84896333670 scopus 로고    scopus 로고
    • Genetic and clonal dissection of murine small cell lung carcinoma progression by genome sequencing
    • McFadden DG, Papagiannakopoulos T, Taylor-Weiner A, et al. Genetic and clonal dissection of murine small cell lung carcinoma progression by genome sequencing. Cell 2014;156:1298-311.
    • (2014) Cell , vol.156 , pp. 1298-1311
    • McFadden, D.G.1    Papagiannakopoulos, T.2    Taylor-Weiner, A.3
  • 28
    • 79960463418 scopus 로고    scopus 로고
    • Nuclear factor I/B is an oncogene in small cell lung cancer
    • Dooley AL, Winslow MM, Chiang DY, et al. Nuclear factor I/B is an oncogene in small cell lung cancer. Genes Dev 2011;25:1470-5.
    • (2011) Genes Dev , vol.25 , pp. 1470-1475
    • Dooley, A.L.1    Winslow, M.M.2    Chiang, D.Y.3
  • 29
    • 84875813017 scopus 로고    scopus 로고
    • Mouse models for lung cancer
    • Kwon MC, Berns A. Mouse models for lung cancer. Mol Oncol 2013;7:165-77.
    • (2013) Mol Oncol , vol.7 , pp. 165-177
    • Kwon, M.C.1    Berns, A.2
  • 30
    • 0034964480 scopus 로고    scopus 로고
    • Heterogeneity of so-called neuroendocrine lung tumors
    • Yesner R. Heterogeneity of so-called neuroendocrine lung tumors. Exp Mol Pathol 2001;70:179-82.
    • (2001) Exp Mol Pathol , vol.70 , pp. 179-182
    • Yesner, R.1
  • 31
    • 78249262321 scopus 로고    scopus 로고
    • Neuroendocrine tumors of the lung: an update
    • Rekhtman N. Neuroendocrine tumors of the lung: an update. Arch Pathol Lab Med 2010;134:1628-38.
    • (2010) Arch Pathol Lab Med , vol.134 , pp. 1628-1638
    • Rekhtman, N.1
  • 32
    • 9844233708 scopus 로고    scopus 로고
    • Identification of MEN1 gene mutations in sporadic carcinoid tumors of the lung
    • Debelenko LV, Brambilla E, Agarwal SK, et al. Identification of MEN1 gene mutations in sporadic carcinoid tumors of the lung. Hum Mol Genet 1997;6:2285-90.
    • (1997) Hum Mol Genet , vol.6 , pp. 2285-2290
    • Debelenko, L.V.1    Brambilla, E.2    Agarwal, S.K.3
  • 33
    • 84902284546 scopus 로고    scopus 로고
    • Frequent mutations in chromatin-remodelling genes in pulmonary carcinoids
    • Fernandez-Cuesta L, Peifer M, Lu X, et al. Frequent mutations in chromatin-remodelling genes in pulmonary carcinoids. Nat Commun 2014;5:3518.
    • (2014) Nat Commun , vol.5 , pp. 3518
    • Fernandez-Cuesta, L.1    Peifer, M.2    Lu, X.3
  • 34
    • 1542375346 scopus 로고    scopus 로고
    • Two prognostically significant subtypes of high-grade lung neuroendocrine tumours independent of small-cell and large-cell neuroendocrine carcinomas identified by gene expression profiles
    • Jones MH, Virtanen C, Honjoh D, et al. Two prognostically significant subtypes of high-grade lung neuroendocrine tumours independent of small-cell and large-cell neuroendocrine carcinomas identified by gene expression profiles. Lancet 2004;363:775-81.
    • (2004) Lancet , vol.363 , pp. 775-781
    • Jones, M.H.1    Virtanen, C.2    Honjoh, D.3
  • 35
    • 84878430396 scopus 로고    scopus 로고
    • Multicentre phase II study of cisplatin-etoposide chemotherapy for advanced large-cell neuroendocrine lung carcinoma: the GFPC 0302 study
    • Le Treut J, Sault MC, Lena H, et al. Multicentre phase II study of cisplatin-etoposide chemotherapy for advanced large-cell neuroendocrine lung carcinoma: the GFPC 0302 study. Ann Oncol 2013;24:1548-52.
    • (2013) Ann Oncol , vol.24 , pp. 1548-1552
    • Le Treut, J.1    Sault, M.C.2    Lena, H.3
  • 36
    • 33644840322 scopus 로고    scopus 로고
    • Role of chemotherapy and the receptor tyrosine kinases KIT, PDGFRalpha, PDGFRbeta, and Met in large-cell neuroendocrine carcinoma of the lung
    • Rossi G, Cavazza A, Marchioni A, et al. Role of chemotherapy and the receptor tyrosine kinases KIT, PDGFRalpha, PDGFRbeta, and Met in large-cell neuroendocrine carcinoma of the lung. J Clin Oncol 2005;23:8774-85.
    • (2005) J Clin Oncol , vol.23 , pp. 8774-8785
    • Rossi, G.1    Cavazza, A.2    Marchioni, A.3
  • 37
    • 84890046280 scopus 로고    scopus 로고
    • A genomics-based classification of human lung tumors
    • 209ra153
    • Clinical Lung Cancer Genome Project (CLCGP); Network Genomic Medicine (NGM). A genomics-based classification of human lung tumors. Sci Transl Med 2013;5:209ra153.
    • (2013) Sci Transl Med , vol.5
  • 39
    • 77950996012 scopus 로고    scopus 로고
    • ERCC1 and Ki67 in small cell lung carcinoma and other neuroendocrine tumors of the lung: distribution and impact on survival
    • Skov BG, Holm B, Erreboe A, et al. ERCC1 and Ki67 in small cell lung carcinoma and other neuroendocrine tumors of the lung: distribution and impact on survival. J Thorac Oncol 2010;5:453-9.
    • (2010) J Thorac Oncol , vol.5 , pp. 453-459
    • Skov, B.G.1    Holm, B.2    Erreboe, A.3
  • 40
    • 73649161518 scopus 로고
    • Histological lung cancer types. A morphological and biological correlation
    • Kreyberg L. Histological lung cancer types. A morphological and biological correlation. Acta Pathol Microbiol Scand Suppl 1962;Suppl 157:1-92.
    • (1962) Acta Pathol Microbiol Scand Suppl , pp. 1-92
    • Kreyberg, L.1
  • 42
    • 0036724780 scopus 로고    scopus 로고
    • Small cell lung carcinoma (SCLC): a clinicopathologic study of 100 cases with surgical specimens
    • Nicholson SA, Beasley MB, Brambilla E, et al. Small cell lung carcinoma (SCLC): a clinicopathologic study of 100 cases with surgical specimens. Am J Surg Pathol 2002;26:1184-97.
    • (2002) Am J Surg Pathol , vol.26 , pp. 1184-1197
    • Nicholson, S.A.1    Beasley, M.B.2    Brambilla, E.3
  • 43
    • 78649390219 scopus 로고    scopus 로고
    • Advances in neuroendocrine lung tumors
    • Travis WD. Advances in neuroendocrine lung tumors. Ann Oncol 2010;21 Suppl 7:vii65-71.
    • (2010) Ann Oncol , vol.21 , pp. vii65-vii71
    • Travis, W.D.1
  • 44
    • 0000513167 scopus 로고
    • Oat-cell carcinoma of the bronchus
    • Azzopardi JG. Oat-cell carcinoma of the bronchus. J Pathol Bacteriol 1959;78:513-9.
    • (1959) J Pathol Bacteriol , vol.78 , pp. 513-519
    • Azzopardi, J.G.1
  • 45
    • 0033795923 scopus 로고    scopus 로고
    • Cytokeratin 7 and cytokeratin 20 expression in epithelial neoplasms: a survey of 435 cases
    • Chu P, Wu E, Weiss LM. Cytokeratin 7 and cytokeratin 20 expression in epithelial neoplasms: a survey of 435 cases. Mod Pathol 2000;13:962-72.
    • (2000) Mod Pathol , vol.13 , pp. 962-972
    • Chu, P.1    Wu, E.2    Weiss, L.M.3
  • 46
    • 84860589522 scopus 로고    scopus 로고
    • Update on small cell carcinoma and its differentiation from squamous cell carcinoma and other non-small cell carcinomas
    • Travis WD. Update on small cell carcinoma and its differentiation from squamous cell carcinoma and other non-small cell carcinomas. Mod Pathol 2012;25 Suppl 1:S18-30.
    • (2012) Mod Pathol , vol.25 , pp. S18-30
    • Travis, W.D.1
  • 47
    • 33748860926 scopus 로고    scopus 로고
    • Distinction of pulmonary large cell neuroendocrine carcinoma from small cell lung carcinoma: a morphological, immunohistochemical, and molecular analysis
    • Hiroshima K, Iyoda A, Shida T, et al. Distinction of pulmonary large cell neuroendocrine carcinoma from small cell lung carcinoma: a morphological, immunohistochemical, and molecular analysis. Mod Pathol 2006;19:1358-68.
    • (2006) Mod Pathol , vol.19 , pp. 1358-1368
    • Hiroshima, K.1    Iyoda, A.2    Shida, T.3
  • 48
    • 0028073366 scopus 로고
    • The spectrum of immunohistochemical staining of small-cell lung carcinoma in specimens from transbronchial and open-lung biopsies
    • Guinee DG Jr, Fishback NF, Koss MN, et al. The spectrum of immunohistochemical staining of small-cell lung carcinoma in specimens from transbronchial and open-lung biopsies. Am J Clin Pathol 1994;102:406-14.
    • (1994) Am J Clin Pathol , vol.102 , pp. 406-414
    • Guinee, D.G.1    Fishback, N.F.2    Koss, M.N.3
  • 49
    • 0034075111 scopus 로고    scopus 로고
    • Thyroid transcription factor-1 is expressed in extrapulmonary small cell carcinomas but not in other extrapulmonary neuroendocrine tumors
    • Agoff SN, Lamps LW, Philip AT, et al. Thyroid transcription factor-1 is expressed in extrapulmonary small cell carcinomas but not in other extrapulmonary neuroendocrine tumors. Mod Pathol 2000;13:238-42.
    • (2000) Mod Pathol , vol.13 , pp. 238-242
    • Agoff, S.N.1    Lamps, L.W.2    Philip, A.T.3
  • 50
    • 84924590266 scopus 로고    scopus 로고
    • RB loss in resistant EGFR mutant lung adenocarcinomas that transform to small-cell lung cancer
    • Niederst MJ, Sequist LV, Poirier JT, et al. RB loss in resistant EGFR mutant lung adenocarcinomas that transform to small-cell lung cancer. Nat Commun 2015;6:6377.
    • (2015) Nat Commun , vol.6 , pp. 6377
    • Niederst, M.J.1    Sequist, L.V.2    Poirier, J.T.3
  • 51
    • 79953118839 scopus 로고    scopus 로고
    • Genotypic and histological evolution of lung cancers acquiring resistance to EGFR inhibitors
    • 75ra26
    • Sequist LV, Waltman BA, Dias-Santagata D, et al. Genotypic and histological evolution of lung cancers acquiring resistance to EGFR inhibitors. Sci Transl Med 2011;3:75ra26.
    • (2011) Sci Transl Med , vol.3
    • Sequist, L.V.1    Waltman, B.A.2    Dias-Santagata, D.3
  • 52
    • 84866851740 scopus 로고    scopus 로고
    • Integrative genome analyses identify key somatic driver mutations of small-cell lung cancer
    • Peifer M, Fernández-Cuesta L, Sos ML, et al. Integrative genome analyses identify key somatic driver mutations of small-cell lung cancer. Nat Genet 2012;44:1104-10.
    • (2012) Nat Genet , vol.44 , pp. 1104-1110
    • Peifer, M.1    Fernández-Cuesta, L.2    Sos, M.L.3
  • 53
    • 84866849548 scopus 로고    scopus 로고
    • Comprehensive genomic analysis identifies SOX2 as a frequently amplified gene in small-cell lung cancer
    • Rudin CM, Durinck S, Stawiski EW, et al. Comprehensive genomic analysis identifies SOX2 as a frequently amplified gene in small-cell lung cancer. Nat Genet 2012;44:1111-6.
    • (2012) Nat Genet , vol.44 , pp. 1111-1116
    • Rudin, C.M.1    Durinck, S.2    Stawiski, E.W.3
  • 54
    • 84938132350 scopus 로고    scopus 로고
    • Comprehensive genomic profiles of small cell lung cancer
    • George J, Lim JS, Jang SJ, et al. Comprehensive genomic profiles of small cell lung cancer. Nature 2015;524:47-53.
    • (2015) Nature , vol.524 , pp. 47-53
    • George, J.1    Lim, J.S.2    Jang, S.J.3
  • 55
    • 0032581519 scopus 로고    scopus 로고
    • PTEN/ MMAC1 mutations identified in small cell, but not in nonsmall cell lung cancers
    • Yokomizo A, Tindall DJ, Drabkin H, et al. PTEN/ MMAC1 mutations identified in small cell, but not in nonsmall cell lung cancers. Oncogene 1998;17:475-9.
    • (1998) Oncogene , vol.17 , pp. 475-479
    • Yokomizo, A.1    Tindall, D.J.2    Drabkin, H.3
  • 56
    • 84879422834 scopus 로고    scopus 로고
    • Notch inhibitors for cancer treatment
    • Espinoza I, Miele L. Notch inhibitors for cancer treatment. Pharmacol Ther 2013;139:95-110.
    • (2013) Pharmacol Ther , vol.139 , pp. 95-110
    • Espinoza, I.1    Miele, L.2
  • 57
    • 34548452775 scopus 로고    scopus 로고
    • Tumor suppressor role of Notch-1 signaling in neuroendocrine tumors
    • Kunnimalaiyaan M, Chen H. Tumor suppressor role of Notch-1 signaling in neuroendocrine tumors. Oncologist 2007;12:535-42.
    • (2007) Oncologist , vol.12 , pp. 535-542
    • Kunnimalaiyaan, M.1    Chen, H.2
  • 58
    • 0033792527 scopus 로고    scopus 로고
    • Basic helix-loophelix transcription factors regulate the neuroendocrine differentiation of fetal mouse pulmonary epithelium
    • Ito T, Udaka N, Yazawa T, et al. Basic helix-loophelix transcription factors regulate the neuroendocrine differentiation of fetal mouse pulmonary epithelium. Development 2000;127:3913-21.
    • (2000) Development , vol.127 , pp. 3913-3921
    • Ito, T.1    Udaka, N.2    Yazawa, T.3
  • 59
    • 0035300448 scopus 로고    scopus 로고
    • Notch signaling induces cell cycle arrest in small cell lung cancer cells
    • Sriuranpong V, Borges MW, Ravi RK, et al. Notch signaling induces cell cycle arrest in small cell lung cancer cells. Cancer Res 2001;61:3200-5.
    • (2001) Cancer Res , vol.61 , pp. 3200-3205
    • Sriuranpong, V.1    Borges, M.W.2    Ravi, R.K.3
  • 60
    • 0036232405 scopus 로고    scopus 로고
    • Notch signaling induces rapid degradation of achaete-scute homolog 1
    • Sriuranpong V, Borges MW, Strock CL, et al. Notch signaling induces rapid degradation of achaete-scute homolog 1. Mol Cell Biol 2002;22:3129-39.
    • (2002) Mol Cell Biol , vol.22 , pp. 3129-3139
    • Sriuranpong, V.1    Borges, M.W.2    Strock, C.L.3
  • 61
    • 84896082963 scopus 로고    scopus 로고
    • From fly wings to targeted cancer therapies: a centennial for notch signaling
    • Ntziachristos P, Lim JS, Sage J, et al. From fly wings to targeted cancer therapies: a centennial for notch signaling. Cancer Cell 2014;25:318-34.
    • (2014) Cancer Cell , vol.25 , pp. 318-334
    • Ntziachristos, P.1    Lim, J.S.2    Sage, J.3
  • 62
    • 79551601837 scopus 로고    scopus 로고
    • Notch inhibition by the ligand DELTA-LIKE 3 defines the mechanism of abnormal vertebral segmentation in spondylocostal dysostosis
    • Chapman G, Sparrow DB, Kremmer E, et al. Notch inhibition by the ligand DELTA-LIKE 3 defines the mechanism of abnormal vertebral segmentation in spondylocostal dysostosis. Hum Mol Genet 2011;20:905-16.
    • (2011) Hum Mol Genet , vol.20 , pp. 905-916
    • Chapman, G.1    Sparrow, D.B.2    Kremmer, E.3
  • 63
    • 34547566893 scopus 로고    scopus 로고
    • Divergent functions and distinct localization of the Notch ligands DLL1 and DLL3 in vivo
    • Geffers I, Serth K, Chapman G, et al. Divergent functions and distinct localization of the Notch ligands DLL1 and DLL3 in vivo. J Cell Biol 2007;178:465-76.
    • (2007) J Cell Biol , vol.178 , pp. 465-476
    • Geffers, I.1    Serth, K.2    Chapman, G.3
  • 64
    • 84927668768 scopus 로고    scopus 로고
    • O-fucosylation of DLL3 is required for its function during somitogenesis
    • Serth K, Schuster-Gossler K, Kremmer E, et al. O-fucosylation of DLL3 is required for its function during somitogenesis. PLoS One 2015;10:e0123776.
    • (2015) PLoS One , vol.10 , pp. e0123776
    • Serth, K.1    Schuster-Gossler, K.2    Kremmer, E.3
  • 65
    • 63349094403 scopus 로고    scopus 로고
    • Ascl1 and Neurog2 form novel complexes and regulate Deltalike3 (Dll3) expression in the neural tube
    • Henke RM, Meredith DM, Borromeo MD, et al. Ascl1 and Neurog2 form novel complexes and regulate Deltalike3 (Dll3) expression in the neural tube. Dev Biol 2009;328:529-40.
    • (2009) Dev Biol , vol.328 , pp. 529-540
    • Henke, R.M.1    Meredith, D.M.2    Borromeo, M.D.3
  • 66
    • 84940403711 scopus 로고    scopus 로고
    • A DLL3-targeted antibody-drug conjugate eradicates highgrade pulmonary neuroendocrine tumor-initiating cells in vivo
    • 302ra136
    • Saunders LR, Bankovich AJ, Anderson WC, et al. A DLL3-targeted antibody-drug conjugate eradicates highgrade pulmonary neuroendocrine tumor-initiating cells in vivo. Sci Transl Med 2015;7:302ra136.
    • (2015) Sci Transl Med , vol.7
    • Saunders, L.R.1    Bankovich, A.J.2    Anderson, W.C.3
  • 67
    • 84960175641 scopus 로고    scopus 로고
    • Safety, activity, and response durability assessment of single agent rovalpituzumab tesirine, a delta-like protein3 (DLL3)-targeted anibody drug conjugate (ADC), in small cell lung cancer (SCLC) [abstract LBA 7]
    • European Cancer Congress, Vienna, Austria
    • Pietanza MC, Spigel D, Bauer TM, et al. Safety, activity, and response durability assessment of single agent rovalpituzumab tesirine, a delta-like protein3 (DLL3)-targeted anibody drug conjugate (ADC), in small cell lung cancer (SCLC) [abstract LBA 7]. European Cancer Congress, Vienna, Austria, 2015.
    • (2015)
    • Pietanza, M.C.1    Spigel, D.2    Bauer, T.M.3
  • 68
    • 33947632458 scopus 로고    scopus 로고
    • Fast, hungry and unstable: finding the Achilles' heel of small-cell lung cancer
    • Hann CL, Rudin CM. Fast, hungry and unstable: finding the Achilles' heel of small-cell lung cancer. Trends Mol Med 2007;13:150-7.
    • (2007) Trends Mol Med , vol.13 , pp. 150-157
    • Hann, C.L.1    Rudin, C.M.2
  • 69
    • 84880559818 scopus 로고    scopus 로고
    • Selective tropism of Seneca Valley virus for variant subtype small cell lung cancer
    • Poirier JT, Dobromilskaya I, Moriarty WF, et al. Selective tropism of Seneca Valley virus for variant subtype small cell lung cancer. J Natl Cancer Inst 2013;105:1059-65.
    • (2013) J Natl Cancer Inst , vol.105 , pp. 1059-1065
    • Poirier, J.T.1    Dobromilskaya, I.2    Moriarty, W.F.3
  • 70
    • 84948570001 scopus 로고    scopus 로고
    • DNA methylation in small cell lung cancer defines distinct disease subtypes and correlates with high expression of EZH2
    • Poirier JT, Gardner EE, Connis N, et al. DNA methylation in small cell lung cancer defines distinct disease subtypes and correlates with high expression of EZH2. Oncogene 2015;34:5869-78.
    • (2015) Oncogene , vol.34 , pp. 5869-5878
    • Poirier, J.T.1    Gardner, E.E.2    Connis, N.3
  • 71
    • 84880893647 scopus 로고    scopus 로고
    • EZH2 promotes E2F-driven SCLC tumorigenesis through modulation of apoptosis and cell-cycle regulation
    • Hubaux R, Thu KL, Coe BP, et al. EZH2 promotes E2F-driven SCLC tumorigenesis through modulation of apoptosis and cell-cycle regulation. J Thorac Oncol 2013;8:1102-6.
    • (2013) J Thorac Oncol , vol.8 , pp. 1102-1106
    • Hubaux, R.1    Thu, K.L.2    Coe, B.P.3
  • 72
    • 84884532954 scopus 로고    scopus 로고
    • Targeted disruption of the EZH2-EED complex inhibits EZH2-dependent cancer
    • Kim W, Bird GH, Neff T, et al. Targeted disruption of the EZH2-EED complex inhibits EZH2-dependent cancer. Nat Chem Biol 2013;9:643-50.
    • (2013) Nat Chem Biol , vol.9 , pp. 643-650
    • Kim, W.1    Bird, G.H.2    Neff, T.3
  • 73
    • 84904055873 scopus 로고    scopus 로고
    • EZH2-mediated inactivation of IFN-γ-JAK-STAT1 signaling is an effective therapeutic target in MYC-driven prostate cancer
    • Wee ZN, Li Z, Lee PL, et al. EZH2-mediated inactivation of IFN-γ-JAK-STAT1 signaling is an effective therapeutic target in MYC-driven prostate cancer. Cell Rep 2014;8:204-16.
    • (2014) Cell Rep , vol.8 , pp. 204-216
    • Wee, Z.N.1    Li, Z.2    Lee, P.L.3
  • 74
    • 84866324536 scopus 로고    scopus 로고
    • Proteomic profiling identifies dysregulated pathways in small cell lung cancer and novel therapeutic targets including PARP1
    • Byers LA, Wang J, Nilsson MB, et al. Proteomic profiling identifies dysregulated pathways in small cell lung cancer and novel therapeutic targets including PARP1. Cancer Discov 2012;2:798-811.
    • (2012) Cancer Discov , vol.2 , pp. 798-811
    • Byers, L.A.1    Wang, J.2    Nilsson, M.B.3
  • 75
    • 84888096960 scopus 로고    scopus 로고
    • Proteomic markers of DNA repair and PI3K pathway activation predict response to the PARP inhibitor BMN 673 in small cell lung cancer
    • Cardnell RJ, Feng Y, Diao L, et al. Proteomic markers of DNA repair and PI3K pathway activation predict response to the PARP inhibitor BMN 673 in small cell lung cancer. Clin Cancer Res 2013;19:6322-8.
    • (2013) Clin Cancer Res , vol.19 , pp. 6322-6328
    • Cardnell, R.J.1    Feng, Y.2    Diao, L.3
  • 77
    • 84866343458 scopus 로고    scopus 로고
    • A genetic snapshot of small cell lung cancer
    • Rosell R, Wannesson L. A genetic snapshot of small cell lung cancer. Cancer Discov 2012;2:769-71.
    • (2012) Cancer Discov , vol.2 , pp. 769-771
    • Rosell, R.1    Wannesson, L.2
  • 78
    • 84884157809 scopus 로고    scopus 로고
    • Predictive value of BRCA1, ERCC1, ATP7B, PKM2, TOPOI, TOPΟ-IIA, TOPOIIB and C-MYC genes in patients with small cell lung cancer (SCLC) who received first line therapy with cisplatin and etoposide
    • Karachaliou N, Papadaki C, Lagoudaki E, et al. Predictive value of BRCA1, ERCC1, ATP7B, PKM2, TOPOI, TOPΟ-IIA, TOPOIIB and C-MYC genes in patients with small cell lung cancer (SCLC) who received first line therapy with cisplatin and etoposide. PLoS One 2013;8:e74611.
    • (2013) PLoS One , vol.8 , pp. e74611
    • Karachaliou, N.1    Papadaki, C.2    Lagoudaki, E.3
  • 79
    • 84990944566 scopus 로고    scopus 로고
    • Poly (ADP) ribose polymerase enzyme inhibitor, veliparib, potentiates chemotherapy and radiation in vitro and in vivo in small cell lung cancer
    • Owonikoko TK, Zhang G, Deng X, et al. Poly (ADP) ribose polymerase enzyme inhibitor, veliparib, potentiates chemotherapy and radiation in vitro and in vivo in small cell lung cancer. Cancer Med 2014;3:1579-94.
    • (2014) Cancer Med , vol.3 , pp. 1579-1594
    • Owonikoko, T.K.1    Zhang, G.2    Deng, X.3
  • 80
    • 84931578364 scopus 로고    scopus 로고
    • A phase 1 safety study of veliparib combined with cisplatin and etoposide in extensive stage small cell lung cancer: A trial of the ECOG-ACRIN Cancer Research Group (E2511)
    • Owonikoko TK, Dahlberg SE, Khan SA, et al. A phase 1 safety study of veliparib combined with cisplatin and etoposide in extensive stage small cell lung cancer: A trial of the ECOG-ACRIN Cancer Research Group (E2511). Lung Cancer 2015;89:66-70.
    • (2015) Lung Cancer , vol.89 , pp. 66-70
    • Owonikoko, T.K.1    Dahlberg, S.E.2    Khan, S.A.3
  • 81
    • 84857073822 scopus 로고    scopus 로고
    • Phase II trial of temozolomide in patients with relapsed sensitive or refractory small cell lung cancer, with assessment of methylguanine-DNA methyltransferase as a potential biomarker
    • Pietanza MC, Kadota K, Huberman K, et al. Phase II trial of temozolomide in patients with relapsed sensitive or refractory small cell lung cancer, with assessment of methylguanine-DNA methyltransferase as a potential biomarker. Clin Cancer Res 2012;18:1138-45.
    • (2012) Clin Cancer Res , vol.18 , pp. 1138-1145
    • Pietanza, M.C.1    Kadota, K.2    Huberman, K.3
  • 82
    • 81255171373 scopus 로고    scopus 로고
    • A crucial requirement for Hedgehog signaling in small cell lung cancer
    • Park KS, Martelotto LG, Peifer M, et al. A crucial requirement for Hedgehog signaling in small cell lung cancer. Nat Med 2011;17:1504-8.
    • (2011) Nat Med , vol.17 , pp. 1504-1508
    • Park, K.S.1    Martelotto, L.G.2    Peifer, M.3
  • 83
    • 58149144784 scopus 로고    scopus 로고
    • Immunohistochemical expression of basic fibroblast growth factor and fibroblast growth factor receptors 1 and 2 in the pathogenesis of lung cancer
    • Behrens C, Lin HY, Lee JJ, et al. Immunohistochemical expression of basic fibroblast growth factor and fibroblast growth factor receptors 1 and 2 in the pathogenesis of lung cancer. Clin Cancer Res 2008;14:6014-22.
    • (2008) Clin Cancer Res , vol.14 , pp. 6014-6022
    • Behrens, C.1    Lin, H.Y.2    Lee, J.J.3
  • 84
    • 58849122812 scopus 로고    scopus 로고
    • Fibroblast growth factor (FGF) and FGF receptor-mediated autocrine signaling in non-small-cell lung cancer cells
    • Marek L, Ware KE, Fritzsche A, et al. Fibroblast growth factor (FGF) and FGF receptor-mediated autocrine signaling in non-small-cell lung cancer cells. Mol Pharmacol 2009;75:196-207.
    • (2009) Mol Pharmacol , vol.75 , pp. 196-207
    • Marek, L.1    Ware, K.E.2    Fritzsche, A.3
  • 85
    • 84893717646 scopus 로고    scopus 로고
    • Fibroblast growth factor receptor 1 (FGFR1) amplification is a potential therapeutic target in small-cell lung cancer
    • Schultheis AM, Bos M, Schmitz K, et al. Fibroblast growth factor receptor 1 (FGFR1) amplification is a potential therapeutic target in small-cell lung cancer. Mod Pathol 2014;27:214-21.
    • (2014) Mod Pathol , vol.27 , pp. 214-221
    • Schultheis, A.M.1    Bos, M.2    Schmitz, K.3
  • 86
    • 33746306130 scopus 로고    scopus 로고
    • FGF-2 protects small cell lung cancer cells from apoptosis through a complex involving PKCepsilon, B-Raf and S6K2
    • Pardo OE, Wellbrock C, Khanzada UK, et al. FGF-2 protects small cell lung cancer cells from apoptosis through a complex involving PKCepsilon, B-Raf and S6K2. EMBO J 2006;25:3078-88.
    • (2006) EMBO J , vol.25 , pp. 3078-3088
    • Pardo, O.E.1    Wellbrock, C.2    Khanzada, U.K.3
  • 87
    • 84942917739 scopus 로고    scopus 로고
    • Fibroblast Growth Factor Receptor 1 and Related Ligands in Small-Cell Lung Cancer
    • Zhang L, Yu H, Badzio A, et al. Fibroblast Growth Factor Receptor 1 and Related Ligands in Small-Cell Lung Cancer. J Thorac Oncol 2015;10:1083-90.
    • (2015) J Thorac Oncol , vol.10 , pp. 1083-1090
    • Zhang, L.1    Yu, H.2    Badzio, A.3
  • 88
    • 0024351090 scopus 로고
    • Human ret protooncogene mapped to chromosome 10q11.2
    • Ishizaka Y, Itoh F, Tahira T, et al. Human ret protooncogene mapped to chromosome 10q11.2. Oncogene 1989;4:1519-21.
    • (1989) Oncogene , vol.4 , pp. 1519-1521
    • Ishizaka, Y.1    Itoh, F.2    Tahira, T.3
  • 89
    • 13844252032 scopus 로고    scopus 로고
    • Direct interactions among Ret, GDNF and GFRalpha1 molecules reveal new insights into the assembly of a functional threeprotein complex
    • Amoresano A, Incoronato M, Monti G, et al. Direct interactions among Ret, GDNF and GFRalpha1 molecules reveal new insights into the assembly of a functional threeprotein complex. Cell Signal 2005;17:717-27.
    • (2005) Cell Signal , vol.17 , pp. 717-727
    • Amoresano, A.1    Incoronato, M.2    Monti, G.3
  • 90
    • 84906238714 scopus 로고    scopus 로고
    • RET mutations in neuroendocrine tumors: including small-cell lung cancer
    • Rudin CM, Drilon A, Poirier JT. RET mutations in neuroendocrine tumors: including small-cell lung cancer. J Thorac Oncol 2014;9:1240-2.
    • (2014) J Thorac Oncol , vol.9 , pp. 1240-1242
    • Rudin, C.M.1    Drilon, A.2    Poirier, J.T.3
  • 91
    • 84896517688 scopus 로고    scopus 로고
    • CD133+ cancer stem-like cells in small cell lung cancer are highly tumorigenic and chemoresistant but sensitive to a novel neuropeptide antagonist
    • Sarvi S, Mackinnon AC, Avlonitis N, et al. CD133+ cancer stem-like cells in small cell lung cancer are highly tumorigenic and chemoresistant but sensitive to a novel neuropeptide antagonist. Cancer Res 2014;74:1554-65.
    • (2014) Cancer Res , vol.74 , pp. 1554-1565
    • Sarvi, S.1    Mackinnon, A.C.2    Avlonitis, N.3
  • 92
    • 84960175642 scopus 로고    scopus 로고
    • FAK and PI3K/mTOR Inhibitors Target Cancer Stem Cells: Implications for SCLC Treatment Strategies
    • Kolev VN, Xu Q, Padval M, et al. FAK and PI3K/mTOR Inhibitors Target Cancer Stem Cells: Implications for SCLC Treatment Strategies. Cancer Res 2015;75:1525.
    • (2015) Cancer Res , vol.75 , pp. 1525
    • Kolev, V.N.1    Xu, Q.2    Padval, M.3
  • 93
    • 84906231103 scopus 로고    scopus 로고
    • Therapeutic priority of the PI3K/AKT/mTOR pathway in small cell lung cancers as revealed by a comprehensive genomic analysis
    • Umemura S, Mimaki S, Makinoshima H, et al. Therapeutic priority of the PI3K/AKT/mTOR pathway in small cell lung cancers as revealed by a comprehensive genomic analysis. J Thorac Oncol 2014;9:1324-31.
    • (2014) J Thorac Oncol , vol.9 , pp. 1324-1331
    • Umemura, S.1    Mimaki, S.2    Makinoshima, H.3
  • 94
    • 0027943632 scopus 로고
    • Small cell carcinomas of the lung express the Bcl-2 protein
    • Ben-Ezra JM, Kornstein MJ, Grimes MM, et al. Small cell carcinomas of the lung express the Bcl-2 protein. Am J Pathol 1994;145:1036-40.
    • (1994) Am J Pathol , vol.145 , pp. 1036-1040
    • Ben-Ezra, J.M.1    Kornstein, M.J.2    Grimes, M.M.3
  • 95
    • 0028081924 scopus 로고
    • Expression of bcl-2 in small cell lung carcinoma cells
    • Ikegaki N, Katsumata M, Minna J, et al. Expression of bcl-2 in small cell lung carcinoma cells. Cancer Res 1994;54:6-8.
    • (1994) Cancer Res , vol.54 , pp. 6-8
    • Ikegaki, N.1    Katsumata, M.2    Minna, J.3
  • 96
    • 0028857747 scopus 로고
    • Expression of bcl-2 oncogene protein is prevalent in small cell lung carcinomas
    • Jiang SX, Sato Y, Kuwao S, et al. Expression of bcl-2 oncogene protein is prevalent in small cell lung carcinomas. J Pathol 1995;177:135-8.
    • (1995) J Pathol , vol.177 , pp. 135-138
    • Jiang, S.X.1    Sato, Y.2    Kuwao, S.3
  • 97
    • 79952291173 scopus 로고    scopus 로고
    • Phase I study of Navitoclax (ABT-263), a novel Bcl-2 family inhibitor, in patients with small-cell lung cancer and other solid tumors
    • Gandhi L, Camidge DR, Ribeiro de Oliveira M, et al. Phase I study of Navitoclax (ABT-263), a novel Bcl-2 family inhibitor, in patients with small-cell lung cancer and other solid tumors. J Clin Oncol 2011;29:909-16.
    • (2011) J Clin Oncol , vol.29 , pp. 909-916
    • Gandhi, L.1    Camidge, D.R.2    Ribeiro de Oliveira, M.3
  • 98
    • 84861482216 scopus 로고    scopus 로고
    • Phase II study of single-agent navitoclax (ABT-263) and biomarker correlates in patients with relapsed small cell lung cancer
    • Rudin CM, Hann CL, Garon EB, et al. Phase II study of single-agent navitoclax (ABT-263) and biomarker correlates in patients with relapsed small cell lung cancer. Clin Cancer Res 2012;18:3163-9.
    • (2012) Clin Cancer Res , vol.18 , pp. 3163-3169
    • Rudin, C.M.1    Hann, C.L.2    Garon, E.B.3
  • 99
    • 84925337149 scopus 로고    scopus 로고
    • Assessment of ABT-263 activity across a cancer cell line collection leads to a potent combination therapy for small-cell lung cancer
    • Faber AC, Farago AF, Costa C, et al. Assessment of ABT-263 activity across a cancer cell line collection leads to a potent combination therapy for small-cell lung cancer. Proc Natl Acad Sci U S A 2015;112:E1288-96.
    • (2015) Proc Natl Acad Sci U S A , vol.112 , pp. E1288-E1296
    • Faber, A.C.1    Farago, A.F.2    Costa, C.3
  • 100
    • 84919495606 scopus 로고    scopus 로고
    • Targeting transcriptional addictions in small cell lung cancer with a covalent CDK7 inhibitor
    • Christensen CL, Kwiatkowski N, Abraham BJ, et al. Targeting transcriptional addictions in small cell lung cancer with a covalent CDK7 inhibitor. Cancer Cell 2014;26:909-22.
    • (2014) Cancer Cell , vol.26 , pp. 909-922
    • Christensen, C.L.1    Kwiatkowski, N.2    Abraham, B.J.3
  • 101
    • 84928774156 scopus 로고    scopus 로고
    • The future of immune checkpoint therapy
    • Sharma P, Allison JP. The future of immune checkpoint therapy. Science 2015;348:56-61.
    • (2015) Science , vol.348 , pp. 56-61
    • Sharma, P.1    Allison, J.P.2
  • 102
    • 32944468708 scopus 로고    scopus 로고
    • Combination of p53 cancer vaccine with chemotherapy in patients with extensive stage small cell lung cancer
    • Antonia SJ, Mirza N, Fricke I, et al. Combination of p53 cancer vaccine with chemotherapy in patients with extensive stage small cell lung cancer. Clin Cancer Res 2006;12:878-87.
    • (2006) Clin Cancer Res , vol.12 , pp. 878-887
    • Antonia, S.J.1    Mirza, N.2    Fricke, I.3
  • 103
    • 0032979212 scopus 로고    scopus 로고
    • Long survival of patients with small cell lung cancer after adjuvant treatment with the anti-idiotypic antibody BEC2 plus Bacillus Calmette-Guérin
    • Grant SC, Kris MG, Houghton AN, et al. Long survival of patients with small cell lung cancer after adjuvant treatment with the anti-idiotypic antibody BEC2 plus Bacillus Calmette-Guérin. Clin Cancer Res 1999;5:1319-23.
    • (1999) Clin Cancer Res , vol.5 , pp. 1319-1323
    • Grant, S.C.1    Kris, M.G.2    Houghton, A.N.3
  • 104
    • 0142009530 scopus 로고    scopus 로고
    • Paraneoplastic syndromes involving the nervous system
    • Darnell RB, Posner JB. Paraneoplastic syndromes involving the nervous system. N Engl J Med 2003;349:1543-54.
    • (2003) N Engl J Med , vol.349 , pp. 1543-1554
    • Darnell, R.B.1    Posner, J.B.2
  • 105
    • 0026547716 scopus 로고
    • Anti-Hu--associated paraneoplastic encephalomyelitis/sensory neuronopathy. A clinical study of 71 patients
    • Dalmau J, Graus F, Rosenblum MK, et al. Anti-Hu--associated paraneoplastic encephalomyelitis/sensory neuronopathy. A clinical study of 71 patients. Medicine (Baltimore) 1992;71:59-72.
    • (1992) Medicine (Baltimore) , vol.71 , pp. 59-72
    • Dalmau, J.1    Graus, F.2    Rosenblum, M.K.3
  • 106
    • 68449095394 scopus 로고    scopus 로고
    • Patients with lung cancer and paraneoplastic Hu syndrome harbor HuD-specific type 2 CD8+ T cells
    • Roberts WK, Deluca IJ, Thomas A, et al. Patients with lung cancer and paraneoplastic Hu syndrome harbor HuD-specific type 2 CD8+ T cells. J Clin Invest 2009;119:2042-51.
    • (2009) J Clin Invest , vol.119 , pp. 2042-2051
    • Roberts, W.K.1    Deluca, I.J.2    Thomas, A.3
  • 107
    • 58149234402 scopus 로고    scopus 로고
    • Reciprocal CD4+ T-cell balance of effector CD62Llow CD4+ and CD62LhighCD25+ CD4+ regulatory T cells in small cell lung cancer reflects disease stage
    • Koyama K, Kagamu H, Miura S, et al. Reciprocal CD4+ T-cell balance of effector CD62Llow CD4+ and CD62LhighCD25+ CD4+ regulatory T cells in small cell lung cancer reflects disease stage. Clin Cancer Res 2008;14:6770-9.
    • (2008) Clin Cancer Res , vol.14 , pp. 6770-6779
    • Koyama, K.1    Kagamu, H.2    Miura, S.3
  • 108
    • 84922502823 scopus 로고    scopus 로고
    • PD-L1 expression in small cell neuroendocrine carcinomas
    • Schultheis AM, Scheel AH, Ozretić L, et al. PD-L1 expression in small cell neuroendocrine carcinomas. Eur J Cancer 2015;51:421-6.
    • (2015) Eur J Cancer , vol.51 , pp. 421-426
    • Schultheis, A.M.1    Scheel, A.H.2    Ozretić, L.3
  • 109
    • 84918828514 scopus 로고    scopus 로고
    • Genetic basis for clinical response to CTLA-4 blockade in melanoma
    • Snyder A, Makarov V, Merghoub T, et al. Genetic basis for clinical response to CTLA-4 blockade in melanoma. N Engl J Med 2014;371:2189-99.
    • (2014) N Engl J Med , vol.371 , pp. 2189-2199
    • Snyder, A.1    Makarov, V.2    Merghoub, T.3
  • 110
    • 84937108473 scopus 로고    scopus 로고
    • 1229PD: Smoking history and response to nivolumab in patients with advanced NSCLCS
    • Hellmann MD, Creelan BC, Woo K, et al. 1229PD: Smoking history and response to nivolumab in patients with advanced NSCLCS. Ann Oncol 2014;25:iv429.
    • (2014) Ann Oncol , vol.25 , pp. iv429
    • Hellmann, M.D.1    Creelan, B.C.2    Woo, K.3
  • 111
    • 84929481480 scopus 로고    scopus 로고
    • Pembrolizumab for the treatment of non-small-cell lung cancer
    • Garon EB, Rizvi NA, Hui R, et al. Pembrolizumab for the treatment of non-small-cell lung cancer. N Engl J Med 2015;372:2018-28.
    • (2015) N Engl J Med , vol.372 , pp. 2018-2028
    • Garon, E.B.1    Rizvi, N.A.2    Hui, R.3
  • 112
    • 84928761118 scopus 로고    scopus 로고
    • Cancer immunology. Mutational landscape determines sensitivity to PD-1 blockade in non-small cell lung cancer
    • Rizvi NA, Hellmann MD, Snyder A, et al. Cancer immunology. Mutational landscape determines sensitivity to PD-1 blockade in non-small cell lung cancer. Science 2015;348:124-8.
    • (2015) Science , vol.348 , pp. 124-128
    • Rizvi, N.A.1    Hellmann, M.D.2    Snyder, A.3
  • 113
    • 84871532643 scopus 로고    scopus 로고
    • Ipilimumab in combination with paclitaxel and carboplatin as first-line therapy in extensive-disease-small-cell lung cancer: results from a randomized, double-blind, multicenter phase 2 trial
    • Reck M, Bondarenko I, Luft A, et al. Ipilimumab in combination with paclitaxel and carboplatin as first-line therapy in extensive-disease-small-cell lung cancer: results from a randomized, double-blind, multicenter phase 2 trial. Ann Oncol 2013;24:75-83.
    • (2013) Ann Oncol , vol.24 , pp. 75-83
    • Reck, M.1    Bondarenko, I.2    Luft, A.3
  • 114
    • 84926421308 scopus 로고    scopus 로고
    • Significance of programmed cell death-ligand 1 expression and its association with survival in patients with small cell lung cancer
    • Ishii H, Azuma K, Kawahara A, et al. Significance of programmed cell death-ligand 1 expression and its association with survival in patients with small cell lung cancer. J Thorac Oncol 2015;10:426-30.
    • (2015) J Thorac Oncol , vol.10 , pp. 426-430
    • Ishii, H.1    Azuma, K.2    Kawahara, A.3
  • 115
    • 0024576950 scopus 로고
    • Immunohistological detection of fucosyl-GM1 ganglioside in human lung cancer and normal tissues with monoclonal antibodies
    • Brezicka FT, Olling S, Nilsson O, et al. Immunohistological detection of fucosyl-GM1 ganglioside in human lung cancer and normal tissues with monoclonal antibodies. Cancer Res 1989;49:1300-5.
    • (1989) Cancer Res , vol.49 , pp. 1300-1305
    • Brezicka, F.T.1    Olling, S.2    Nilsson, O.3
  • 116
    • 0030741046 scopus 로고    scopus 로고
    • Ganglioside expression in lung cancer cell lines
    • Fuentes R, Allman R, Mason MD. Ganglioside expression in lung cancer cell lines. Lung Cancer 1997;18:21-33.
    • (1997) Lung Cancer , vol.18 , pp. 21-33
    • Fuentes, R.1    Allman, R.2    Mason, M.D.3
  • 117
    • 0029865646 scopus 로고    scopus 로고
    • Immunization of melanoma patients with BEC2 anti-idiotypic monoclonal antibody that mimics GD3 ganglioside: enhanced immunogenicity when combined with adjuvant
    • McCaffery M, Yao TJ, Williams L, et al. Immunization of melanoma patients with BEC2 anti-idiotypic monoclonal antibody that mimics GD3 ganglioside: enhanced immunogenicity when combined with adjuvant. Clin Cancer Res 1996;2:679-86.
    • (1996) Clin Cancer Res , vol.2 , pp. 679-686
    • McCaffery, M.1    Yao, T.J.2    Williams, L.3
  • 118
    • 27244446896 scopus 로고    scopus 로고
    • Phase III study of adjuvant vaccination with Bec2/bacille Calmette-Guerin in responding patients with limited-disease smallcell lung cancer (European Organisation for Research and Treatment of Cancer 08971-08971B; Silva Study)
    • Giaccone G, Debruyne C, Felip E, et al. Phase III study of adjuvant vaccination with Bec2/bacille Calmette-Guerin in responding patients with limited-disease smallcell lung cancer (European Organisation for Research and Treatment of Cancer 08971-08971B; Silva Study). J Clin Oncol 2005;23:6854-64.
    • (2005) J Clin Oncol , vol.23 , pp. 6854-6864
    • Giaccone, G.1    Debruyne, C.2    Felip, E.3
  • 119
    • 4644245711 scopus 로고    scopus 로고
    • Vaccination of patients with small-cell lung cancer with synthetic fucosyl GM-1 conjugated to keyhole limpet hemocyanin
    • Krug LM, Ragupathi G, Hood C, et al. Vaccination of patients with small-cell lung cancer with synthetic fucosyl GM-1 conjugated to keyhole limpet hemocyanin. Clin Cancer Res 2004;10:6094-100.
    • (2004) Clin Cancer Res , vol.10 , pp. 6094-6100
    • Krug, L.M.1    Ragupathi, G.2    Hood, C.3
  • 120
    • 0030855856 scopus 로고    scopus 로고
    • Decrease of interleukin-2 secretion is a new independent prognostic factor associated with poor survival in patients with smallcell lung cancer
    • Fischer JR, Schindel M, Bülzebruck H, et al. Decrease of interleukin-2 secretion is a new independent prognostic factor associated with poor survival in patients with smallcell lung cancer. Ann Oncol 1997;8:457-61.
    • (1997) Ann Oncol , vol.8 , pp. 457-461
    • Fischer, J.R.1    Schindel, M.2    Bülzebruck, H.3
  • 121
    • 84924690325 scopus 로고    scopus 로고
    • Performance-enhancing drugs: design and production of redirected chimeric antigen receptor (CAR) T cells
    • Levine BL. Performance-enhancing drugs: design and production of redirected chimeric antigen receptor (CAR) T cells. Cancer Gene Ther 2015;22:79-84.
    • (2015) Cancer Gene Ther , vol.22 , pp. 79-84
    • Levine, B.L.1
  • 122
    • 84928759208 scopus 로고    scopus 로고
    • Adoptive cell transfer as personalized immunotherapy for human cancer
    • Rosenberg SA, Restifo NP. Adoptive cell transfer as personalized immunotherapy for human cancer. Science 2015;348:62-8.
    • (2015) Science , vol.348 , pp. 62-68
    • Rosenberg, S.A.1    Restifo, N.P.2
  • 123
    • 35348931537 scopus 로고    scopus 로고
    • Targeting the neural cell adhesion molecule in cancer
    • Jensen M, Berthold F. Targeting the neural cell adhesion molecule in cancer. Cancer Lett 2007;258:9-21.
    • (2007) Cancer Lett , vol.258 , pp. 9-21
    • Jensen, M.1    Berthold, F.2
  • 124
    • 67650646082 scopus 로고    scopus 로고
    • CD47 is upregulated on circulating hematopoietic stem cells and leukemia cells to avoid phagocytosis
    • Jaiswal S, Jamieson CH, Pang WW, et al. CD47 is upregulated on circulating hematopoietic stem cells and leukemia cells to avoid phagocytosis. Cell 2009;138:271-85.
    • (2009) Cell , vol.138 , pp. 271-285
    • Jaiswal, S.1    Jamieson, C.H.2    Pang, W.W.3
  • 125
    • 67650632683 scopus 로고    scopus 로고
    • CD47 is an adverse prognostic factor and therapeutic antibody target on human acute myeloid leukemia stem cells
    • Majeti R, Chao MP, Alizadeh AA, et al. CD47 is an adverse prognostic factor and therapeutic antibody target on human acute myeloid leukemia stem cells. Cell 2009;138:286-99.
    • (2009) Cell , vol.138 , pp. 286-299
    • Majeti, R.1    Chao, M.P.2    Alizadeh, A.A.3
  • 126
    • 84860174226 scopus 로고    scopus 로고
    • The CD47-signal regulatory protein alpha (SIRPa) interaction is a therapeutic target for human solid tumors
    • Willingham SB, Volkmer JP, Gentles AJ, et al. The CD47-signal regulatory protein alpha (SIRPa) interaction is a therapeutic target for human solid tumors. Proc Natl Acad Sci U S A 2012;109:6662-7.
    • (2012) Proc Natl Acad Sci U S A , vol.109 , pp. 6662-6667
    • Willingham, S.B.1    Volkmer, J.P.2    Gentles, A.J.3


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.