메뉴 건너뛰기




Volumn 4, Issue 5, 2015, Pages 533-544

Novel therapies in small cell lung cancer

Author keywords

Immune therapy; Molecular targeted therapy; Notch inhibition; PARP1 inhibition; Small cell lung cancer (SCLC)

Indexed keywords


EID: 84960076428     PISSN: 22186751     EISSN: 22264477     Source Type: Journal    
DOI: 10.3978/j.issn.2218-6751.2015.07.20     Document Type: Review
Times cited : (61)

References (64)
  • 1
    • 33750603100 scopus 로고    scopus 로고
    • Changing epidemiology of small-cell lung cancer in the United States over the last 30 years: analysis of the surveillance, epidemiologic, and end results database
    • Govindan R, Page N, Morgensztern D, et al. Changing epidemiology of small-cell lung cancer in the United States over the last 30 years: analysis of the surveillance, epidemiologic, and end results database. J Clin Oncol 2006;24:4539-44.
    • (2006) J Clin Oncol , vol.24 , pp. 4539-4544
    • Govindan, R.1    Page, N.2    Morgensztern, D.3
  • 2
    • 0025215511 scopus 로고
    • Ten-year survival of patients with small-cell lung cancer treated with combination chemotherapy with or without irradiation
    • Johnson BE, Grayson J, Makuch RW, et al. Ten-year survival of patients with small-cell lung cancer treated with combination chemotherapy with or without irradiation. J Clin Oncol 1990;8:396-401.
    • (1990) J Clin Oncol , vol.8 , pp. 396-401
    • Johnson, B.E.1    Grayson, J.2    Makuch, R.W.3
  • 3
    • 74449085934 scopus 로고    scopus 로고
    • A small-cell lung cancer genome with complex signatures of tobacco exposure
    • Pleasance ED, Stephens PJ, O'Meara S, et al. A small-cell lung cancer genome with complex signatures of tobacco exposure. Nature 2010;463:184-90.
    • (2010) Nature , vol.463 , pp. 184-190
    • Pleasance, E.D.1    Stephens, P.J.2    O'Meara, S.3
  • 4
    • 0034910622 scopus 로고    scopus 로고
    • Molecular genetics of small cell lung carcinoma
    • Wistuba II, Gazdar AF, Minna JD. Molecular genetics of small cell lung carcinoma. Semin Oncol 2001;28:3-13.
    • (2001) Semin Oncol , vol.28 , pp. 3-13
    • Wistuba, I.I.1    Gazdar, A.F.2    Minna, J.D.3
  • 5
    • 0025223332 scopus 로고
    • Variable mutations of the RB gene in small-cell lung carcinoma
    • Mori N, Yokota J, Akiyama T, et al. Variable mutations of the RB gene in small-cell lung carcinoma. Oncogene 1990;5:1713-7.
    • (1990) Oncogene , vol.5 , pp. 1713-1717
    • Mori, N.1    Yokota, J.2    Akiyama, T.3
  • 6
    • 51649091690 scopus 로고    scopus 로고
    • Genetic changes in small cell lung carcinoma
    • Arriola E, Cañadas I, Arumí M, et al. Genetic changes in small cell lung carcinoma. Clin Transl Oncol 2008;10:189-97.
    • (2008) Clin Transl Oncol , vol.10 , pp. 189-197
    • Arriola, E.1    Cañadas, I.2    Arumí, M.3
  • 7
    • 0032581519 scopus 로고    scopus 로고
    • PTEN/MMAC1 mutations identified in small cell, but not in non-small cell lung cancers
    • Yokomizo A, Tindall DJ, Drabkin H, et al. PTEN/MMAC1 mutations identified in small cell, but not in non-small cell lung cancers. Oncogene 1998;17:475-9.
    • (1998) Oncogene , vol.17 , pp. 475-479
    • Yokomizo, A.1    Tindall, D.J.2    Drabkin, H.3
  • 8
    • 58149149814 scopus 로고    scopus 로고
    • Epidermal growth factor receptor mutations in small cell lung cancer
    • Tatematsu A, Shimizu J, Murakami Y, et al. Epidermal growth factor receptor mutations in small cell lung cancer. Clin Cancer Res 2008;14:6092-6.
    • (2008) Clin Cancer Res , vol.14 , pp. 6092-6096
    • Tatematsu, A.1    Shimizu, J.2    Murakami, Y.3
  • 9
    • 69849115509 scopus 로고    scopus 로고
    • Oncogenic mutation of PIK3CA in small cell lung carcinoma: a potential therapeutic target pathway for chemotherapy-resistant lung cancer
    • Shibata T, Kokubu A, Tsuta K, et al. Oncogenic mutation of PIK3CA in small cell lung carcinoma: a potential therapeutic target pathway for chemotherapy-resistant lung cancer. Cancer Lett 2009;283:203-11.
    • (2009) Cancer Lett , vol.283 , pp. 203-211
    • Shibata, T.1    Kokubu, A.2    Tsuta, K.3
  • 10
    • 0033083898 scopus 로고    scopus 로고
    • Genetic changes in the spectrum of neuroendocrine lung tumors
    • Onuki N, Wistuba II, Travis WD, et al. Genetic changes in the spectrum of neuroendocrine lung tumors. Cancer 1999;85:600-7.
    • (1999) Cancer , vol.85 , pp. 600-607
    • Onuki, N.1    Wistuba, I.I.2    Travis, W.D.3
  • 12
    • 84866851740 scopus 로고    scopus 로고
    • Integrative genome analyses identify key somatic driver mutations of small-cell lung cancer
    • Peifer M, Fernández-Cuesta L, Sos ML, et al. Integrative genome analyses identify key somatic driver mutations of small-cell lung cancer. Nat Genet 2012;44:1104-10.
    • (2012) Nat Genet , vol.44 , pp. 1104-1110
    • Peifer, M.1    Fernández-Cuesta, L.2    Sos, M.L.3
  • 13
    • 77953406697 scopus 로고    scopus 로고
    • Targeting p53 for Novel Anticancer Therapy
    • Wang Z, Sun Y. Targeting p53 for Novel Anticancer Therapy. Transl Oncol 2010;3:1-12.
    • (2010) Transl Oncol , vol.3 , pp. 1-12
    • Wang, Z.1    Sun, Y.2
  • 14
    • 84877063307 scopus 로고    scopus 로고
    • Neuroendocrine and epithelial phenotypes in small-cell lung cancer: implications for metastasis and survival in patients
    • Stovold R, Meredith SL, Bryant JL, et al. Neuroendocrine and epithelial phenotypes in small-cell lung cancer: implications for metastasis and survival in patients. Br J Cancer 2013;108:1704-11.
    • (2013) Br J Cancer , vol.108 , pp. 1704-1711
    • Stovold, R.1    Meredith, S.L.2    Bryant, J.L.3
  • 15
    • 34147150440 scopus 로고    scopus 로고
    • Irinotecan (I), carboplatin (C), and radiotherapy (RT) followed by maintenance bevacizumab (B) in the treatment (tx) of limited-stage small cell lung cancer (LS-SCLC): Update of a phase II trial of the Minnie Pearl Cancer Research Network
    • Patton JF, Spigel DR, Greco FA, et al. Irinotecan (I), carboplatin (C), and radiotherapy (RT) followed by maintenance bevacizumab (B) in the treatment (tx) of limited-stage small cell lung cancer (LS-SCLC): Update of a phase II trial of the Minnie Pearl Cancer Research Network. J Clin Oncol 2006;24:abstr 7085.
    • (2006) J Clin Oncol , vol.24
    • Patton, J.F.1    Spigel, D.R.2    Greco, F.A.3
  • 16
    • 71649092006 scopus 로고    scopus 로고
    • Tracheoesophageal (TE) fistula development in a phase II trial of concurrent chemoradiation (CRT) and bevacizumab (B) in limited-stage small-cell lung cancer (LS-SCLC)
    • Spigel DR, Hainsworth JD, Farley C, et al. Tracheoesophageal (TE) fistula development in a phase II trial of concurrent chemoradiation (CRT) and bevacizumab (B) in limited-stage small-cell lung cancer (LS-SCLC). J Clin Oncol 2008;26:abstr 7554.
    • (2008) J Clin Oncol , vol.26
    • Spigel, D.R.1    Hainsworth, J.D.2    Farley, C.3
  • 17
    • 79957940921 scopus 로고    scopus 로고
    • Randomized phase II study of bevacizumab in combination with chemotherapy in previously untreated extensive-stage small-cell lung cancer: results from the SALUTE trial
    • Spigel DR, Townley PM, Waterhouse DM, et al. Randomized phase II study of bevacizumab in combination with chemotherapy in previously untreated extensive-stage small-cell lung cancer: results from the SALUTE trial. J Clin Oncol 2011;29:2215-22.
    • (2011) J Clin Oncol , vol.29 , pp. 2215-2222
    • Spigel, D.R.1    Townley, P.M.2    Waterhouse, D.M.3
  • 18
    • 78650483125 scopus 로고    scopus 로고
    • Paclitaxel plus bevacizumab in patients with chemosensitive relapsed small cell lung cancer: a safety, feasibility, and efficacy study from the Hoosier Oncology Group
    • Jalal S, Bedano P, Einhorn L, et al. Paclitaxel plus bevacizumab in patients with chemosensitive relapsed small cell lung cancer: a safety, feasibility, and efficacy study from the Hoosier Oncology Group. J Thorac Oncol 2010;5:2008-11.
    • (2010) J Thorac Oncol , vol.5 , pp. 2008-2011
    • Jalal, S.1    Bedano, P.2    Einhorn, L.3
  • 19
    • 84933521056 scopus 로고    scopus 로고
    • Chemotherapy With or Without Maintenance Sunitinib for Untreated Extensive-Stage Small-Cell Lung Cancer: A Randomized, Double-Blind, Placebo-Controlled Phase II Study-CALGB 30504 (Alliance)
    • Ready NE, Pang HH, Gu L, et al. Chemotherapy With or Without Maintenance Sunitinib for Untreated Extensive-Stage Small-Cell Lung Cancer: A Randomized, Double-Blind, Placebo-Controlled Phase II Study-CALGB 30504 (Alliance). J Clin Oncol 2015;33:1660-5.
    • (2015) J Clin Oncol , vol.33 , pp. 1660-1665
    • Ready, N.E.1    Pang, H.H.2    Gu, L.3
  • 20
    • 84905867667 scopus 로고    scopus 로고
    • Southwest Oncology Group S0802: a randomized, phase II trial of weekly topotecan with and without ziv-aflibercept in patients with platinum-treated small-cell lung cancer
    • Allen JW, Moon J, Redman M, et al. Southwest Oncology Group S0802: a randomized, phase II trial of weekly topotecan with and without ziv-aflibercept in patients with platinum-treated small-cell lung cancer. J Clin Oncol 2014;32:2463-70.
    • (2014) J Clin Oncol , vol.32 , pp. 2463-2470
    • Allen, J.W.1    Moon, J.2    Redman, M.3
  • 21
    • 33845490014 scopus 로고    scopus 로고
    • Paclitaxel-carboplatin alone or with bevacizumab for non-small-cell lung cancer
    • Sandler A, Gray R, Perry MC, et al. Paclitaxel-carboplatin alone or with bevacizumab for non-small-cell lung cancer. N Engl J Med 2006;355:2542-50.
    • (2006) N Engl J Med , vol.355 , pp. 2542-2550
    • Sandler, A.1    Gray, R.2    Perry, M.C.3
  • 22
    • 84866324536 scopus 로고    scopus 로고
    • Proteomic profiling identifies dysregulated pathways in small cell lung cancer and novel therapeutic targets including PARP1
    • Byers LA, Wang J, Nilsson MB, et al. Proteomic profiling identifies dysregulated pathways in small cell lung cancer and novel therapeutic targets including PARP1. Cancer Discov 2012;2:798-811.
    • (2012) Cancer Discov , vol.2 , pp. 798-811
    • Byers, L.A.1    Wang, J.2    Nilsson, M.B.3
  • 23
    • 84888096960 scopus 로고    scopus 로고
    • Proteomic markers of DNA repair and PI3K pathway activation predict response to the PARP inhibitor BMN 673 in small cell lung cancer
    • Cardnell RJ, Feng Y, Diao L, et al. Proteomic markers of DNA repair and PI3K pathway activation predict response to the PARP inhibitor BMN 673 in small cell lung cancer. Clin Cancer Res 2013;19:6322-8.
    • (2013) Clin Cancer Res , vol.19 , pp. 6322-6328
    • Cardnell, R.J.1    Feng, Y.2    Diao, L.3
  • 24
    • 84938064315 scopus 로고    scopus 로고
    • Safety and antitumor activity of the PARP inhibitor BMN673 in a phase 1 trial recruiting metastatic small-cell lung cancer (SCLC) and germline BRCA-mutation carrier cancer patients
    • Wainberg ZA, Rafii S, Ramanathan RK, et al. Safety and antitumor activity of the PARP inhibitor BMN673 in a phase 1 trial recruiting metastatic small-cell lung cancer (SCLC) and germline BRCA-mutation carrier cancer patients. J Clin Oncol 2014;32:abstr 7522.
    • (2014) J Clin Oncol , vol.32
    • Wainberg, Z.A.1    Rafii, S.2    Ramanathan, R.K.3
  • 25
    • 84903816737 scopus 로고    scopus 로고
    • Phase 1B study of amuvatinib in combination with five standard cancer therapies in adults with advanced solid tumors
    • Mita M, Gordon M, Rosen L, et al. Phase 1B study of amuvatinib in combination with five standard cancer therapies in adults with advanced solid tumors. Cancer Chemother Pharmacol 2014;74:195-204.
    • (2014) Cancer Chemother Pharmacol , vol.74 , pp. 195-204
    • Mita, M.1    Gordon, M.2    Rosen, L.3
  • 26
    • 84894435688 scopus 로고    scopus 로고
    • A phase 2 study of Amuvatinib (MP-470), the first RAD51 inhibitor in combination with platinum-etoposide (PE) in refractory or relapsed small cell lung cancer (ESCAPE)
    • Byers L, Horn L, Gandhi J, et al. A phase 2 study of Amuvatinib (MP-470), the first RAD51 inhibitor in combination with platinum-etoposide (PE) in refractory or relapsed small cell lung cancer (ESCAPE). Cancer Res 2013;73:abstr 2095.
    • (2013) Cancer Res , vol.73
    • Byers, L.1    Horn, L.2    Gandhi, J.3
  • 27
    • 84894636613 scopus 로고    scopus 로고
    • Synergism of cyclin-dependent kinase inhibitors with camptothecin derivatives in small cell lung cancer cell lines
    • Hamilton G, Klameth L, Rath B, et al. Synergism of cyclin-dependent kinase inhibitors with camptothecin derivatives in small cell lung cancer cell lines. Molecules 2014;19:2077-88.
    • (2014) Molecules , vol.19 , pp. 2077-2088
    • Hamilton, G.1    Klameth, L.2    Rath, B.3
  • 28
    • 84907938536 scopus 로고    scopus 로고
    • ASCL1 is a lineage oncogene providing therapeutic targets for high-grade neuroendocrine lung cancers
    • Augustyn A, Borromeo M, Wang T, et al. ASCL1 is a lineage oncogene providing therapeutic targets for high-grade neuroendocrine lung cancers. Proc Natl Acad Sci U S A 2014;111:14788-93.
    • (2014) Proc Natl Acad Sci U S A , vol.111 , pp. 14788-14793
    • Augustyn, A.1    Borromeo, M.2    Wang, T.3
  • 29
    • 84961288878 scopus 로고    scopus 로고
    • Molecular pathways: novel approaches for improved therapeutic targeting of Hedgehog signaling in cancer stem cells
    • Justilien V, Fields AP. Molecular pathways: novel approaches for improved therapeutic targeting of Hedgehog signaling in cancer stem cells. Clin Cancer Res 2015;21:505-13.
    • (2015) Clin Cancer Res , vol.21 , pp. 505-513
    • Justilien, V.1    Fields, A.P.2
  • 30
    • 81255171373 scopus 로고    scopus 로고
    • A crucial requirement for Hedgehog signaling in small cell lung cancer
    • Park KS, Martelotto LG, Peifer M, et al. A crucial requirement for Hedgehog signaling in small cell lung cancer. Nat Med 2011;17:1504-8.
    • (2011) Nat Med , vol.17 , pp. 1504-1508
    • Park, K.S.1    Martelotto, L.G.2    Peifer, M.3
  • 31
    • 84898721363 scopus 로고    scopus 로고
    • A phase I, multicenter, open-label, first-in-human, dose-escalation study of the oral smoothened inhibitor Sonidegib (LDE225) in patients with advanced solid tumors
    • Rodon J, Tawbi HA, Thomas AL, et al. A phase I, multicenter, open-label, first-in-human, dose-escalation study of the oral smoothened inhibitor Sonidegib (LDE225) in patients with advanced solid tumors. Clin Cancer Res 2014;20:1900-9.
    • (2014) Clin Cancer Res , vol.20 , pp. 1900-1909
    • Rodon, J.1    Tawbi, H.A.2    Thomas, A.L.3
  • 32
    • 84894420979 scopus 로고    scopus 로고
    • Three-arm randomized phase II study of cisplatin and etoposide (CE) versus CE with either vismodegib (V) or cixutumumab (Cx) for patients with extensive stage-small cell lung cancer (ES-SCLC) (ECOG 1508)
    • Belani CP, Dahlberg SE, Rudin CM, et al. Three-arm randomized phase II study of cisplatin and etoposide (CE) versus CE with either vismodegib (V) or cixutumumab (Cx) for patients with extensive stage-small cell lung cancer (ES-SCLC) (ECOG 1508). J Clin Oncol 2013;31:abstr 7508.
    • (2013) J Clin Oncol , vol.31
    • Belani, C.P.1    Dahlberg, S.E.2    Rudin, C.M.3
  • 33
    • 77953700950 scopus 로고    scopus 로고
    • Targeting Notch to target cancer stem cells
    • Pannuti A, Foreman K, Rizzo P, et al. Targeting Notch to target cancer stem cells. Clin Cancer Res 2010;16:3141-52.
    • (2010) Clin Cancer Res , vol.16 , pp. 3141-3152
    • Pannuti, A.1    Foreman, K.2    Rizzo, P.3
  • 34
    • 84891840587 scopus 로고    scopus 로고
    • Targeting notch signaling pathway in cancer: clinical development advances and challenges
    • Takebe N, Nguyen D, Yang SX. Targeting notch signaling pathway in cancer: clinical development advances and challenges. Pharmacol Ther 2014;141:140-9.
    • (2014) Pharmacol Ther , vol.141 , pp. 140-149
    • Takebe, N.1    Nguyen, D.2    Yang, S.X.3
  • 35
    • 84947704341 scopus 로고    scopus 로고
    • Final results of phase Ib of tarextumab (TRXT, OMP-59R5, anti-Notch2/3) in combination with etoposide and platinum (EP) in patients (pts) with untreated extensive-stage small-cell lung cancer (ED-SCLC)
    • Pietanza MC. Final results of phase Ib of tarextumab (TRXT, OMP-59R5, anti-Notch2/3) in combination with etoposide and platinum (EP) in patients (pts) with untreated extensive-stage small-cell lung cancer (ED-SCLC). J Clin Oncol 2015;33:abstr 7508.
    • (2015) J Clin Oncol , vol.33
    • Pietanza, M.C.1
  • 36
    • 84866849548 scopus 로고    scopus 로고
    • Comprehensive genomic analysis identifies SOX2 as a frequently amplified gene in small-cell lung cancer
    • Rudin CM, Durinck S, Stawiski EW, et al. Comprehensive genomic analysis identifies SOX2 as a frequently amplified gene in small-cell lung cancer. Nat Genet 2012;44:1111-6.
    • (2012) Nat Genet , vol.44 , pp. 1111-1116
    • Rudin, C.M.1    Durinck, S.2    Stawiski, E.W.3
  • 37
    • 58149346173 scopus 로고    scopus 로고
    • The hepatocyte growth factor/c-Met signaling pathway as a therapeutic target to inhibit angiogenesis
    • You WK, McDonald DM. The hepatocyte growth factor/c-Met signaling pathway as a therapeutic target to inhibit angiogenesis. BMB Rep 2008;41:833-9.
    • (2008) BMB Rep , vol.41 , pp. 833-839
    • You, W.K.1    McDonald, D.M.2
  • 38
    • 34247855046 scopus 로고    scopus 로고
    • Bortezomib (PS-341) in relapsed or refractory extensive stage small cell lung cancer: a Southwest Oncology Group phase II trial (S0327)
    • Lara PN Jr, Chansky K, Davies AM, et al. Bortezomib (PS-341) in relapsed or refractory extensive stage small cell lung cancer: a Southwest Oncology Group phase II trial (S0327). J Thorac Oncol 2006;1:996-1001.
    • (2006) J Thorac Oncol , vol.1 , pp. 996-1001
    • Lara, P.N.1    Chansky, K.2    Davies, A.M.3
  • 39
    • 84925337149 scopus 로고    scopus 로고
    • Assessment of ABT-263 activity across a cancer cell line collection leads to a potent combination therapy for small-cell lung cancer
    • Faber AC, Farago AF, Costa C, et al. Assessment of ABT-263 activity across a cancer cell line collection leads to a potent combination therapy for small-cell lung cancer. Proc Natl Acad Sci U S A 2015;112:E1288-96.
    • (2015) Proc Natl Acad Sci U S A , vol.112 , pp. E1288-E1296
    • Faber, A.C.1    Farago, A.F.2    Costa, C.3
  • 40
    • 84920502676 scopus 로고    scopus 로고
    • Use of thoracic radiotherapy for extensive stage small-cell lung cancer: a phase 3 randomised controlled trial
    • Slotman BJ, van Tinteren H, Praag JO, et al. Use of thoracic radiotherapy for extensive stage small-cell lung cancer: a phase 3 randomised controlled trial. Lancet 2015;385:36-42.
    • (2015) Lancet , vol.385 , pp. 36-42
    • Slotman, B.J.1    van Tinteren, H.2    Praag, J.O.3
  • 41
    • 0017704414 scopus 로고
    • Nephrectomy for renal cell carcinoma with metastases
    • Freed SZ. Nephrectomy for renal cell carcinoma with metastases. Urology 1977;9:613-6.
    • (1977) Urology , vol.9 , pp. 613-616
    • Freed, S.Z.1
  • 42
    • 0025041298 scopus 로고
    • Preparative cytoreductive surgery in patients with metastatic renal cell carcinoma treated with adoptive immunotherapy with interleukin-2 or interleukin-2 plus lymphokine activated killer cells
    • discussion 617-8
    • Robertson CN, Linehan WM, Pass HI, et al. Preparative cytoreductive surgery in patients with metastatic renal cell carcinoma treated with adoptive immunotherapy with interleukin-2 or interleukin-2 plus lymphokine activated killer cells. J Urol 1990;144:614-7; discussion 617-8.
    • (1990) J Urol , vol.144 , pp. 614-617
    • Robertson, C.N.1    Linehan, W.M.2    Pass, H.I.3
  • 43
    • 0142009530 scopus 로고    scopus 로고
    • Paraneoplastic syndromes involving the nervous system
    • Darnell RB, Posner JB. Paraneoplastic syndromes involving the nervous system. N Engl J Med 2003;349:1543-54.
    • (2003) N Engl J Med , vol.349 , pp. 1543-1554
    • Darnell, R.B.1    Posner, J.B.2
  • 44
    • 84892485531 scopus 로고    scopus 로고
    • Immune checkpoint inhibitors: making immunotherapy a reality for the treatment of lung cancer
    • Brahmer JR, Pardoll DM. Immune checkpoint inhibitors: making immunotherapy a reality for the treatment of lung cancer. Cancer Immunol Res 2013;1:85-91.
    • (2013) Cancer Immunol Res , vol.1 , pp. 85-91
    • Brahmer, J.R.1    Pardoll, D.M.2
  • 45
    • 68449095394 scopus 로고    scopus 로고
    • Patients with lung cancer and paraneoplastic Hu syndrome harbor HuD-specific type 2 CD8+ T cells
    • Roberts WK, Deluca IJ, Thomas A, et al. Patients with lung cancer and paraneoplastic Hu syndrome harbor HuD-specific type 2 CD8+ T cells. J Clin Invest 2009;119:2042-51.
    • (2009) J Clin Invest , vol.119 , pp. 2042-2051
    • Roberts, W.K.1    Deluca, I.J.2    Thomas, A.3
  • 46
    • 0034002647 scopus 로고    scopus 로고
    • Reactivity of monoclonal antibodies with ganglioside antigens in human small cell lung cancer tissues
    • Brezicka T, Bergman B, Olling S, et al. Reactivity of monoclonal antibodies with ganglioside antigens in human small cell lung cancer tissues. Lung Cancer 2000;28:29-36.
    • (2000) Lung Cancer , vol.28 , pp. 29-36
    • Brezicka, T.1    Bergman, B.2    Olling, S.3
  • 47
    • 0032979212 scopus 로고    scopus 로고
    • Long survival of patients with small cell lung cancer after adjuvant treatment with the anti-idiotypic antibody BEC2 plus Bacillus Calmette-Guérin
    • Grant SC, Kris MG, Houghton AN, et al. Long survival of patients with small cell lung cancer after adjuvant treatment with the anti-idiotypic antibody BEC2 plus Bacillus Calmette-Guérin. Clin Cancer Res 1999;5:1319-23.
    • (1999) Clin Cancer Res , vol.5 , pp. 1319-1323
    • Grant, S.C.1    Kris, M.G.2    Houghton, A.N.3
  • 48
    • 27244446896 scopus 로고    scopus 로고
    • Phase III study of adjuvant vaccination with Bec2/bacille Calmette-Guerin in responding patients with limited-disease small-cell lung cancer (European Organisation for Research and Treatment of Cancer 08971-08971B; Silva Study)
    • Giaccone G, Debruyne C, Felip E, et al. Phase III study of adjuvant vaccination with Bec2/bacille Calmette-Guerin in responding patients with limited-disease small-cell lung cancer (European Organisation for Research and Treatment of Cancer 08971-08971B; Silva Study). J Clin Oncol 2005;23:6854-64.
    • (2005) J Clin Oncol , vol.23 , pp. 6854-6864
    • Giaccone, G.1    Debruyne, C.2    Felip, E.3
  • 49
    • 77952135152 scopus 로고    scopus 로고
    • INGN-225: a dendritic cell-based p53 vaccine (Ad.p53-DC) in small cell lung cancer: observed association between immune response and enhanced chemotherapy effect
    • Chiappori AA, Soliman H, Janssen WE, et al. INGN-225: a dendritic cell-based p53 vaccine (Ad.p53-DC) in small cell lung cancer: observed association between immune response and enhanced chemotherapy effect. Expert Opin Biol Ther 2010;10:983-91.
    • (2010) Expert Opin Biol Ther , vol.10 , pp. 983-991
    • Chiappori, A.A.1    Soliman, H.2    Janssen, W.E.3
  • 50
    • 84876412243 scopus 로고    scopus 로고
    • Rationale for chemotherapy, immunotherapy, and checkpoint blockade in SCLC: beyond traditional treatment approaches
    • Spigel DR, Socinski MA. Rationale for chemotherapy, immunotherapy, and checkpoint blockade in SCLC: beyond traditional treatment approaches. J Thorac Oncol 2013;8:587-98.
    • (2013) J Thorac Oncol , vol.8 , pp. 587-598
    • Spigel, D.R.1    Socinski, M.A.2
  • 51
    • 0031045897 scopus 로고    scopus 로고
    • Interferon maintenance therapy for small cell lung cancer: improvement in long-term survival
    • Mattson K, Niiranen A, Ruotsalainen T, et al. Interferon maintenance therapy for small cell lung cancer: improvement in long-term survival. J Interferon Cytokine Res 1997;17:103-5.
    • (1997) J Interferon Cytokine Res , vol.17 , pp. 103-105
    • Mattson, K.1    Niiranen, A.2    Ruotsalainen, T.3
  • 52
    • 0034070142 scopus 로고    scopus 로고
    • Interferon-alpha and 13-cis-retinoic acid as maintenance therapy after high-dose combination chemotherapy with growth factor support for small cell lung cancer--a feasibility study
    • Ruotsalainen T, Halme M, Isokangas OP, et al. Interferon-alpha and 13-cis-retinoic acid as maintenance therapy after high-dose combination chemotherapy with growth factor support for small cell lung cancer--a feasibility study. Anticancer Drugs 2000;11:101-8.
    • (2000) Anticancer Drugs , vol.11 , pp. 101-108
    • Ruotsalainen, T.1    Halme, M.2    Isokangas, O.P.3
  • 53
    • 77957020019 scopus 로고    scopus 로고
    • Maintenance or consolidation therapy in small-cell lung cancer: a systematic review and meta-analysis
    • Rossi A, Garassino MC, Cinquini M, et al. Maintenance or consolidation therapy in small-cell lung cancer: a systematic review and meta-analysis. Lung Cancer 2010;70:119-28.
    • (2010) Lung Cancer , vol.70 , pp. 119-128
    • Rossi, A.1    Garassino, M.C.2    Cinquini, M.3
  • 54
    • 79952840120 scopus 로고    scopus 로고
    • Synergistic activity of ixabepilone plus other anticancer agents: preclinical and clinical evidence
    • Lee F, Jure-Kunkel MN, Salvati ME. Synergistic activity of ixabepilone plus other anticancer agents: preclinical and clinical evidence. Ther Adv Med Oncol 2011;3:11-25.
    • (2011) Ther Adv Med Oncol , vol.3 , pp. 11-25
    • Lee, F.1    Jure-Kunkel, M.N.2    Salvati, M.E.3
  • 55
    • 84918828514 scopus 로고    scopus 로고
    • Genetic basis for clinical response to CTLA-4 blockade in melanoma
    • Snyder A, Makarov V, Merghoub T, et al. Genetic basis for clinical response to CTLA-4 blockade in melanoma. N Engl J Med 2014;371:2189-99.
    • (2014) N Engl J Med , vol.371 , pp. 2189-2199
    • Snyder, A.1    Makarov, V.2    Merghoub, T.3
  • 56
    • 84939518267 scopus 로고    scopus 로고
    • Phase I/II study of nivolumab with or without ipilimumab for treatment of recurrent small cell lung cancer (SCLC): CA209-032
    • Antonia SJ. Phase I/II study of nivolumab with or without ipilimumab for treatment of recurrent small cell lung cancer (SCLC): CA209-032. J Clin Oncol 2015;33:abstr 7503.
    • (2015) J Clin Oncol , vol.33
    • Antonia, S.J.1
  • 57
    • 84863911486 scopus 로고    scopus 로고
    • Ipilimumab in combination with paclitaxel and carboplatin as first-line treatment in stage IIIB/IV non-small-cell lung cancer: results from a randomized, double-blind, multicenter phase II study
    • Lynch TJ, Bondarenko I, Luft A, et al. Ipilimumab in combination with paclitaxel and carboplatin as first-line treatment in stage IIIB/IV non-small-cell lung cancer: results from a randomized, double-blind, multicenter phase II study. J Clin Oncol 2012;30:2046-54.
    • (2012) J Clin Oncol , vol.30 , pp. 2046-2054
    • Lynch, T.J.1    Bondarenko, I.2    Luft, A.3
  • 58
    • 84871532643 scopus 로고    scopus 로고
    • Ipilimumab in combination with paclitaxel and carboplatin as first-line therapy in extensive-disease-small-cell lung cancer: results from a randomized, double-blind, multicenter phase 2 trial
    • Reck M, Bondarenko I, Luft A, et al. Ipilimumab in combination with paclitaxel and carboplatin as first-line therapy in extensive-disease-small-cell lung cancer: results from a randomized, double-blind, multicenter phase 2 trial. Ann Oncol 2013;24:75-83.
    • (2013) Ann Oncol , vol.24 , pp. 75-83
    • Reck, M.1    Bondarenko, I.2    Luft, A.3
  • 59
    • 84939518267 scopus 로고    scopus 로고
    • Phase I/II study of nivolumab with or without ipilimumab for treatment of recurrent small cell lung cancer (SCLC): CA209-032
    • Antonia SJ, Bendell JC, Taylor MH, et al. Phase I/II study of nivolumab with or without ipilimumab for treatment of recurrent small cell lung cancer (SCLC): CA209-032. J Clin Oncol 2015;33:abstr 7503.
    • (2015) J Clin Oncol , vol.33
    • Antonia, S.J.1    Bendell, J.C.2    Taylor, M.H.3
  • 60
    • 84939548996 scopus 로고    scopus 로고
    • Pembrolizumab (MK-3475) in patients (pts) with extensive-stage small cell lung cancer (SCLC): Preliminary safety and efficacy results from KEYNOTE-028
    • Ott PA, Fernandez ME, Hiret S, et al. Pembrolizumab (MK-3475) in patients (pts) with extensive-stage small cell lung cancer (SCLC): Preliminary safety and efficacy results from KEYNOTE-028. J Clin Oncol 2015;33:abstr 7502.
    • (2015) J Clin Oncol , vol.33
    • Ott, P.A.1    Fernandez, M.E.2    Hiret, S.3
  • 61
    • 84960088654 scopus 로고    scopus 로고
    • Cited 2015 07/03/2015, Available online
    • Antibody-drug conjugate SC16LD6.5. Cited 2015 07/03/2015. Available online: http://www.cancer.gov/publications/dictionaries/cancer-drug?cdrid=751419
    • Antibody-drug conjugate SC16LD6.5
  • 62
    • 0023890167 scopus 로고
    • Production of immunoreactive insulin-like growth factor I and response to exogenous IGF-I in small cell lung cancer cell lines
    • Jaques G, Rotsch M, Wegmann C, et al. Production of immunoreactive insulin-like growth factor I and response to exogenous IGF-I in small cell lung cancer cell lines. Exp Cell Res 1988;176:336-43.
    • (1988) Exp Cell Res , vol.176 , pp. 336-343
    • Jaques, G.1    Rotsch, M.2    Wegmann, C.3
  • 63
    • 0023714574 scopus 로고
    • Insulin-like growth factor-I can mediate autocrine proliferation of human small cell lung cancer cell lines in vitro
    • Nakanishi Y, Mulshine JL, Kasprzyk PG, et al. Insulin-like growth factor-I can mediate autocrine proliferation of human small cell lung cancer cell lines in vitro. J Clin Invest 1988;82:354-9.
    • (1988) J Clin Invest , vol.82 , pp. 354-359
    • Nakanishi, Y.1    Mulshine, J.L.2    Kasprzyk, P.G.3
  • 64
    • 84960177888 scopus 로고    scopus 로고
    • Results from a randomized study of carboplatin and etoposide (CE) with or without palifosfamide (Pa) in extensive stage small cell lung cancer (ES-SCLC): The MATISSE study
    • Jalal SI. Results from a randomized study of carboplatin and etoposide (CE) with or without palifosfamide (Pa) in extensive stage small cell lung cancer (ES-SCLC): The MATISSE study. J Clin Oncol 2015;33:abstr 7504.
    • (2015) J Clin Oncol , vol.33
    • Jalal, S.I.1


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.