메뉴 건너뛰기




Volumn 13, Issue 3, 2016, Pages 699-709

Glycyrrhetinic Acid Mediated Drug Delivery Carriers for Hepatocellular Carcinoma Therapy

Author keywords

anti HCC; delivery systems; GA; liver targeting

Indexed keywords

DRUG CARRIER; GLYCYRRHETINIC ACID; LIPOSOME; NANOPARTICLE; ANTINEOPLASTIC AGENT;

EID: 84960104275     PISSN: 15438384     EISSN: 15438392     Source Type: Journal    
DOI: 10.1021/acs.molpharmaceut.5b00677     Document Type: Article
Times cited : (123)

References (77)
  • 1
    • 84937517958 scopus 로고    scopus 로고
    • Liver cancer: Approaching a personalized care
    • Bruix, J.; Han, K. H.; Gores, G.; Llovet, J. M.; Mazzaferro, V. Liver cancer: Approaching a personalized care J. Hepatol. 2015, 62, S144-S156 10.1016/j.jhep.2015.02.007
    • (2015) J. Hepatol. , vol.62 , pp. S144-S156
    • Bruix, J.1    Han, K.H.2    Gores, G.3    Llovet, J.M.4    Mazzaferro, V.5
  • 3
    • 84878059220 scopus 로고    scopus 로고
    • Transarterial chemoembolization of hepatocellular carcinoma - Agents and drugs: An overview. Part 2
    • Giunchedi, P.; Maestri, M.; Gavini, E.; Dionigi, P.; Rassu, G. Transarterial chemoembolization of hepatocellular carcinoma - agents and drugs: an overview. Part 2 Expert Opin. Drug Delivery 2013, 10, 799-810 10.1517/17425247.2013.796359
    • (2013) Expert Opin. Drug Delivery , vol.10 , pp. 799-810
    • Giunchedi, P.1    Maestri, M.2    Gavini, E.3    Dionigi, P.4    Rassu, G.5
  • 5
    • 84869475394 scopus 로고    scopus 로고
    • Recent progress in understanding, diagnosing, and treating hepatocellular carcinoma
    • Maluccio, M.; Covey, A. Recent progress in understanding, diagnosing, and treating hepatocellular carcinoma Ca-Cancer J. Clin. 2012, 62, 394-399 10.3322/caac.21161
    • (2012) Ca-Cancer J. Clin. , vol.62 , pp. 394-399
    • Maluccio, M.1    Covey, A.2
  • 6
    • 84928990257 scopus 로고    scopus 로고
    • Chemotherapy and target therapy for hepatocellular carcinoma: New advances and challenges
    • Deng, G. L.; Zeng, S.; Shen, H. Chemotherapy and target therapy for hepatocellular carcinoma: New advances and challenges World J. Hepatol. 2015, 7, 787-798 10.4254/wjh.v7.i5.787
    • (2015) World J. Hepatol. , vol.7 , pp. 787-798
    • Deng, G.L.1    Zeng, S.2    Shen, H.3
  • 7
    • 84942196257 scopus 로고    scopus 로고
    • Hepatocellular carcinoma: Where there is unmet need
    • Bupathi, M.; Kaseb, A.; Meric-Bernstam, F.; Naing, A. Hepatocellular carcinoma: Where there is unmet need Mol. Oncol. 2015, 9 (8) 1501-1509 10.1016/j.molonc.2015.06.005
    • (2015) Mol. Oncol. , vol.9 , Issue.8 , pp. 1501-1509
    • Bupathi, M.1    Kaseb, A.2    Meric-Bernstam, F.3    Naing, A.4
  • 9
    • 84928752915 scopus 로고    scopus 로고
    • Antioxidant and hepatoprotective effect of Penthorum chinense Pursh extract against t-BHP-induced liver damage in L02 cells
    • Hu, Y.; Wang, S.; Wang, A.; Lin, L.; Chen, M.; Wang, Y. Antioxidant and hepatoprotective effect of Penthorum chinense Pursh extract against t-BHP-induced liver damage in L02 cells Molecules 2015, 20, 6443-6453 10.3390/molecules20046443
    • (2015) Molecules , vol.20 , pp. 6443-6453
    • Hu, Y.1    Wang, S.2    Wang, A.3    Lin, L.4    Chen, M.5    Wang, Y.6
  • 11
    • 34250778943 scopus 로고    scopus 로고
    • Structure-dependent activity of glycyrrhetinic acid derivatives as peroxisome proliferator-activated receptor {gamma} agonists in colon cancer cells
    • Chintharlapalli, S.; Papineni, S.; Jutooru, I.; McAlees, A.; Safe, S. Structure-dependent activity of glycyrrhetinic acid derivatives as peroxisome proliferator-activated receptor {gamma} agonists in colon cancer cells Mol. Cancer Ther. 2007, 6, 1588-1598 10.1158/1535-7163.MCT-07-0022
    • (2007) Mol. Cancer Ther. , vol.6 , pp. 1588-1598
    • Chintharlapalli, S.1    Papineni, S.2    Jutooru, I.3    McAlees, A.4    Safe, S.5
  • 12
    • 84863718527 scopus 로고    scopus 로고
    • Glycyrrhizin in patients who failed previous interferon alpha-based therapies: Biochemical and histological effects after 52 weeks
    • Manns, M. P.; Wedemeyer, H.; Singer, A.; Khomutjanskaja, N.; Dienes, H. P.; Roskams, T.; Goldin, R.; Hehnke, U.; Inoue, H. Glycyrrhizin in patients who failed previous interferon alpha-based therapies: biochemical and histological effects after 52 weeks J. Viral Hepat. 2012, 19, 537-546 10.1111/j.1365-2893.2011.01579.x
    • (2012) J. Viral Hepat. , vol.19 , pp. 537-546
    • Manns, M.P.1    Wedemeyer, H.2    Singer, A.3    Khomutjanskaja, N.4    Dienes, H.P.5    Roskams, T.6    Goldin, R.7    Hehnke, U.8    Inoue, H.9
  • 13
    • 27944489889 scopus 로고    scopus 로고
    • Glycyrrhetinic acid and related compounds induce G1 arrest and apoptosis in human hepatocellular carcinoma HepG2
    • Satomi, Y.; Nishino, H.; Shibata, S. Glycyrrhetinic acid and related compounds induce G1 arrest and apoptosis in human hepatocellular carcinoma HepG2 Anticancer Res. 2005, 25, 4043-4047
    • (2005) Anticancer Res. , vol.25 , pp. 4043-4047
    • Satomi, Y.1    Nishino, H.2    Shibata, S.3
  • 14
    • 84916618605 scopus 로고    scopus 로고
    • Glycyrrhetinic Acid triggers a protective autophagy by activation of extracellular regulated protein kinases in hepatocellular carcinoma cells
    • Tang, Z. H.; Li, T.; Chang, L. L.; Zhu, H.; Tong, Y. G.; Chen, X. P.; Wang, Y. T.; Lu, J. J. Glycyrrhetinic Acid triggers a protective autophagy by activation of extracellular regulated protein kinases in hepatocellular carcinoma cells J. Agric. Food Chem. 2014, 62, 11910-11916 10.1021/jf503968k
    • (2014) J. Agric. Food Chem. , vol.62 , pp. 11910-11916
    • Tang, Z.H.1    Li, T.2    Chang, L.L.3    Zhu, H.4    Tong, Y.G.5    Chen, X.P.6    Wang, Y.T.7    Lu, J.J.8
  • 15
    • 33644866837 scopus 로고    scopus 로고
    • Glycyrrhetic acid (a metabolic substance and aglycon of glycyrrhizin) induces apoptosis in human hepatoma, promyelotic leukemia and stomach cancer cells
    • Hibasami, H.; Iwase, H.; Yoshioka, K.; Takahashi, H. Glycyrrhetic acid (a metabolic substance and aglycon of glycyrrhizin) induces apoptosis in human hepatoma, promyelotic leukemia and stomach cancer cells Int. J. Mol. Med. 2006, 17, 215-219 10.3892/ijmm.17.2.215
    • (2006) Int. J. Mol. Med. , vol.17 , pp. 215-219
    • Hibasami, H.1    Iwase, H.2    Yoshioka, K.3    Takahashi, H.4
  • 16
    • 84873985718 scopus 로고    scopus 로고
    • 18beta-glycyrrhetinic acid inhibits hepatocellular carcinoma development by reversing hepatic stellate cell-mediated immunosuppression in mice
    • Kuang, P.; Zhao, W.; Su, W.; Zhang, Z.; Zhang, L.; Liu, J.; Ren, G.; Yin, Z.; Wang, X. 18beta-glycyrrhetinic acid inhibits hepatocellular carcinoma development by reversing hepatic stellate cell-mediated immunosuppression in mice Int. J. Cancer 2013, 132, 1831-1841 10.1002/ijc.27852
    • (2013) Int. J. Cancer , vol.132 , pp. 1831-1841
    • Kuang, P.1    Zhao, W.2    Su, W.3    Zhang, Z.4    Zhang, L.5    Liu, J.6    Ren, G.7    Yin, Z.8    Wang, X.9
  • 17
    • 84899814901 scopus 로고    scopus 로고
    • Recent advances in active hepatic targeting drug delivery system
    • Wang, Y.; Du, H.; Zhai, G. Recent advances in active hepatic targeting drug delivery system Curr. Drug Targets 2014, 15, 573-599 10.2174/1389450115666140309232100
    • (2014) Curr. Drug Targets , vol.15 , pp. 573-599
    • Wang, Y.1    Du, H.2    Zhai, G.3
  • 18
    • 84870356290 scopus 로고    scopus 로고
    • Lactosylated liposomes for targeted delivery of doxorubicin to hepatocellular carcinoma
    • Zhou, X.; Zhang, M.; Yung, B.; Li, H.; Zhou, C.; Lee, L. J.; Lee, R. J. Lactosylated liposomes for targeted delivery of doxorubicin to hepatocellular carcinoma Int. J. Nanomed. 2012, 7, 5465-5474 10.2147/IJN.S33965
    • (2012) Int. J. Nanomed. , vol.7 , pp. 5465-5474
    • Zhou, X.1    Zhang, M.2    Yung, B.3    Li, H.4    Zhou, C.5    Lee, L.J.6    Lee, R.J.7
  • 21
    • 84863242810 scopus 로고    scopus 로고
    • Folate-functionalized polymeric micelles based on biodegradable PEG-PDLLA as a hepatic carcinoma-targeting delivery system
    • Niu, C.; Sun, Q.; Zhou, J.; Cheng, D.; Hong, G. Folate-functionalized polymeric micelles based on biodegradable PEG-PDLLA as a hepatic carcinoma-targeting delivery system Asian Pac. J. Cancer Prev. 2011, 12, 1995-1999
    • (2011) Asian Pac. J. Cancer Prev. , vol.12 , pp. 1995-1999
    • Niu, C.1    Sun, Q.2    Zhou, J.3    Cheng, D.4    Hong, G.5
  • 22
    • 14644392093 scopus 로고    scopus 로고
    • Folate receptor expression in carcinomas and normal tissues determined by a quantitative radioligand binding assay
    • Parker, N.; Turk, M. J.; Westrick, E.; Lewis, J. D.; Low, P. S.; Leamon, C. P. Folate receptor expression in carcinomas and normal tissues determined by a quantitative radioligand binding assay Anal. Biochem. 2005, 338, 284-293 10.1016/j.ab.2004.12.026
    • (2005) Anal. Biochem. , vol.338 , pp. 284-293
    • Parker, N.1    Turk, M.J.2    Westrick, E.3    Lewis, J.D.4    Low, P.S.5    Leamon, C.P.6
  • 23
    • 84925464727 scopus 로고    scopus 로고
    • Active radar guides missile to its target: Receptor-based targeted treatment of hepatocellular carcinoma by nanoparticulate systems
    • Yan, J. J.; Liao, J. Z.; Lin, J. S.; He, X. X. Active radar guides missile to its target: receptor-based targeted treatment of hepatocellular carcinoma by nanoparticulate systems Tumor Biol. 2015, 36, 55-67 10.1007/s13277-014-2855-3
    • (2015) Tumor Biol. , vol.36 , pp. 55-67
    • Yan, J.J.1    Liao, J.Z.2    Lin, J.S.3    He, X.X.4
  • 24
    • 0025805614 scopus 로고
    • Specific binding of glycyrrhetinic acid to the rat liver membrane
    • Negishi, M.; Irie, A.; Nagata, N.; Ichikawa, A. Specific binding of glycyrrhetinic acid to the rat liver membrane Biochim. Biophys. Acta, Biomembr. 1991, 1066, 77-82 10.1016/0005-2736(91)90253-5
    • (1991) Biochim. Biophys. Acta, Biomembr. , vol.1066 , pp. 77-82
    • Negishi, M.1    Irie, A.2    Nagata, N.3    Ichikawa, A.4
  • 25
    • 84864109937 scopus 로고    scopus 로고
    • Self-assembly and liver targeting of sulfated chitosan nanoparticles functionalized with glycyrrhetinic acid
    • Tian, Q.; Wang, X. H.; Wang, W.; Zhang, C. N.; Wang, P.; Yuan, Z. Self-assembly and liver targeting of sulfated chitosan nanoparticles functionalized with glycyrrhetinic acid Nanomedicine 2012, 8, 870-879 10.1016/j.nano.2011.11.002
    • (2012) Nanomedicine , vol.8 , pp. 870-879
    • Tian, Q.1    Wang, X.H.2    Wang, W.3    Zhang, C.N.4    Wang, P.5    Yuan, Z.6
  • 26
    • 84929191259 scopus 로고    scopus 로고
    • A novel glycyrrhetinic acid-modified oxaliplatin liposome for liver-targeting and in vitro/vivo evaluation
    • Chen, J.; Jiang, H.; Wu, Y.; Li, Y.; Gao, Y. A novel glycyrrhetinic acid-modified oxaliplatin liposome for liver-targeting and in vitro/vivo evaluation Drug Des., Dev. Ther. 2015, 9, 2265-2275 10.2147/DDDT.S81722
    • (2015) Drug Des., Dev. Ther. , vol.9 , pp. 2265-2275
    • Chen, J.1    Jiang, H.2    Wu, Y.3    Li, Y.4    Gao, Y.5
  • 27
    • 84964374836 scopus 로고    scopus 로고
    • Preparation and evaluation of liver-targeting micelles loaded with oxaliplatin
    • Yan, G.; Chen, Q.; Xu, L.; Wei, H.; Ma, C.; Sun, Y. Preparation and evaluation of liver-targeting micelles loaded with oxaliplatin Artif. Cells, Nanomed., Biotechnol. 2014, 1-6 10.3109/21691401.2014.962747
    • (2014) Artif. Cells, Nanomed., Biotechnol. , pp. 1-6
    • Yan, G.1    Chen, Q.2    Xu, L.3    Wei, H.4    Ma, C.5    Sun, Y.6
  • 28
    • 84885077408 scopus 로고    scopus 로고
    • Synthesis of Glycyrrhetinic Acid-Modified Chitosan 5-Fluorouracil Nanoparticles and Its Inhibition of Liver Cancer Characteristics in Vitro and in Vivo
    • Cheng, M.; Gao, X.; Wang, Y.; Chen, H.; He, B.; Xu, H.; Li, Y.; Han, J.; Zhang, Z. Synthesis of Glycyrrhetinic Acid-Modified Chitosan 5-Fluorouracil Nanoparticles and Its Inhibition of Liver Cancer Characteristics in Vitro and in Vivo Mar. Drugs 2013, 11, 3517-3536 10.3390/md11093517
    • (2013) Mar. Drugs , vol.11 , pp. 3517-3536
    • Cheng, M.1    Gao, X.2    Wang, Y.3    Chen, H.4    He, B.5    Xu, H.6    Li, Y.7    Han, J.8    Zhang, Z.9
  • 29
    • 46849110600 scopus 로고    scopus 로고
    • Review of pharmacological effects of Glycyrrhiza sp. and its bioactive compounds
    • Asl, M. N.; Hosseinzadeh, H. Review of pharmacological effects of Glycyrrhiza sp. and its bioactive compounds Phytother. Res. 2008, 22, 709-724 10.1002/ptr.2362
    • (2008) Phytother. Res. , vol.22 , pp. 709-724
    • Asl, M.N.1    Hosseinzadeh, H.2
  • 30
    • 0033974827 scopus 로고    scopus 로고
    • Beta-glucuronidase inhibitory activity and hepatoprotective effect of 18 beta-glycyrrhetinic acid from the rhizomes of Glycyrrhiza uralensis
    • Shim, S. B.; Kim, N. J.; Kim, D. H. Beta-glucuronidase inhibitory activity and hepatoprotective effect of 18 beta-glycyrrhetinic acid from the rhizomes of Glycyrrhiza uralensis Planta Med. 2000, 66, 40-43 10.1055/s-2000-11109
    • (2000) Planta Med. , vol.66 , pp. 40-43
    • Shim, S.B.1    Kim, N.J.2    Kim, D.H.3
  • 31
    • 0036809836 scopus 로고    scopus 로고
    • Retinoic acid modulates gap junctional intercellular communication in hepatocytes and hepatoma cells
    • Ara, C.; Massimi, M.; Conti Devirgiliis, L. Retinoic acid modulates gap junctional intercellular communication in hepatocytes and hepatoma cells Cell. Mol. Life Sci. 2002, 59, 1758-1765 10.1007/PL00012503
    • (2002) Cell. Mol. Life Sci. , vol.59 , pp. 1758-1765
    • Ara, C.1    Massimi, M.2    Conti Devirgiliis, L.3
  • 33
    • 70349466804 scopus 로고    scopus 로고
    • Tramadol and flurbiprofen depress the cytotoxicity of cisplatin via their effects on gap junctions
    • He, B.; Tong, X.; Wang, L.; Wang, Q.; Ye, H.; Liu, B.; Hong, X.; Tao, L.; Harris, A. L. Tramadol and flurbiprofen depress the cytotoxicity of cisplatin via their effects on gap junctions Clin. Cancer Res. 2009, 15 (18) 5803-5810 10.1158/1078-0432.CCR-09-0811
    • (2009) Clin. Cancer Res. , vol.15 , Issue.18 , pp. 5803-5810
    • He, B.1    Tong, X.2    Wang, L.3    Wang, Q.4    Ye, H.5    Liu, B.6    Hong, X.7    Tao, L.8    Harris, A.L.9
  • 34
    • 84938223359 scopus 로고    scopus 로고
    • Anti-angiogenesis therapy and gap junction inhibition reduce MDA-MB-231 breast cancer cell invasion and metastasis in vitro and in vivo
    • Zibara, K.; Awada, Z.; Dib, L.; El-Saghir, J.; Al-Ghadban, S.; Ibrik, A.; El-Zein, N.; El-Sabban, M. Anti-angiogenesis therapy and gap junction inhibition reduce MDA-MB-231 breast cancer cell invasion and metastasis in vitro and in vivo Sci. Rep. 2015, 5, 12598 10.1038/srep12598
    • (2015) Sci. Rep. , vol.5 , pp. 12598
    • Zibara, K.1    Awada, Z.2    Dib, L.3    El-Saghir, J.4    Al-Ghadban, S.5    Ibrik, A.6    El-Zein, N.7    El-Sabban, M.8
  • 35
    • 15444365508 scopus 로고    scopus 로고
    • Licorice compounds glycyrrhizin and 18beta-glycyrrhetinic acid are potent modulators of bile acid-induced cytotoxicity in rat hepatocytes
    • Gumpricht, E.; Dahl, R.; Devereaux, M. W.; Sokol, R. J. Licorice compounds glycyrrhizin and 18beta-glycyrrhetinic acid are potent modulators of bile acid-induced cytotoxicity in rat hepatocytes J. Biol. Chem. 2005, 280, 10556-10563 10.1074/jbc.M411673200
    • (2005) J. Biol. Chem. , vol.280 , pp. 10556-10563
    • Gumpricht, E.1    Dahl, R.2    Devereaux, M.W.3    Sokol, R.J.4
  • 36
    • 0036730869 scopus 로고    scopus 로고
    • Hepatoprotective effects of 18beta-glycyrrhetinic acid on carbon tetrachloride-induced liver injury: Inhibition of cytochrome P450 2E1 expression
    • Jeong, H. G.; You, H. J.; Park, S. J.; Moon, A. R.; Chung, Y. C.; Kang, S. K.; Chun, H. K. Hepatoprotective effects of 18beta-glycyrrhetinic acid on carbon tetrachloride-induced liver injury: inhibition of cytochrome P450 2E1 expression Pharmacol. Res. 2002, 46, 221-227 10.1016/S1043-6618(02)00121-4
    • (2002) Pharmacol. Res. , vol.46 , pp. 221-227
    • Jeong, H.G.1    You, H.J.2    Park, S.J.3    Moon, A.R.4    Chung, Y.C.5    Kang, S.K.6    Chun, H.K.7
  • 37
    • 84872288510 scopus 로고    scopus 로고
    • The protective effect of glycyrrhetinic acid on carbon tetrachloride-induced chronic liver fibrosis in mice via upregulation of Nrf2
    • Chen, S.; Zou, L.; Li, L.; Wu, T. The protective effect of glycyrrhetinic acid on carbon tetrachloride-induced chronic liver fibrosis in mice via upregulation of Nrf2 PLoS One 2013, 8, e53662 10.1371/journal.pone.0053662
    • (2013) PLoS One , vol.8 , pp. e53662
    • Chen, S.1    Zou, L.2    Li, L.3    Wu, T.4
  • 38
    • 84923899961 scopus 로고    scopus 로고
    • Modulating effect of lipid bilayer-carotenoid interactions on the property of liposome encapsulation
    • Xia, S.; Tan, C.; Zhang, Y.; Abbas, S.; Feng, B.; Zhang, X.; Qin, F. Modulating effect of lipid bilayer-carotenoid interactions on the property of liposome encapsulation Colloids Surf., B 2015, 128, 172-180 10.1016/j.colsurfb.2015.02.004
    • (2015) Colloids Surf., B , vol.128 , pp. 172-180
    • Xia, S.1    Tan, C.2    Zhang, Y.3    Abbas, S.4    Feng, B.5    Zhang, X.6    Qin, F.7
  • 39
    • 84910011319 scopus 로고    scopus 로고
    • A wogonin-loaded glycyrrhetinic acid-modified liposome for hepatic targeting with anti-tumor effects
    • Tian, J.; Wang, L.; Ke, X. A wogonin-loaded glycyrrhetinic acid-modified liposome for hepatic targeting with anti-tumor effects Drug Delivery 2014, 21, 553-559 10.3109/10717544.2013.853850
    • (2014) Drug Delivery , vol.21 , pp. 553-559
    • Tian, J.1    Wang, L.2    Ke, X.3
  • 40
    • 3042698432 scopus 로고    scopus 로고
    • [Preparation of liposomes surface-modified with glycyrrhetinic acid targeting to hepatocytes]
    • Mao, S. J.; Hou, S. X.; Jin, H.; Zhang, L. K.; Jiang, B. [Preparation of liposomes surface-modified with glycyrrhetinic acid targeting to hepatocytes] Zhongguo Zhongyao Zazhi 2003, 28, 328-331
    • (2003) Zhongguo Zhongyao Zazhi , vol.28 , pp. 328-331
    • Mao, S.J.1    Hou, S.X.2    Jin, H.3    Zhang, L.K.4    Jiang, B.5
  • 41
    • 34548226035 scopus 로고    scopus 로고
    • Preparation, characterization and uptake by primary cultured rat hepatocytes of liposomes surface-modified with glycyrrhetinic acid
    • Mao, S. J.; Bi, Y. Q.; Jin, H.; Wei, D. P.; He, R.; Hou, S. X. Preparation, characterization and uptake by primary cultured rat hepatocytes of liposomes surface-modified with glycyrrhetinic acid Pharmazie 2007, 62, 614-619
    • (2007) Pharmazie , vol.62 , pp. 614-619
    • Mao, S.J.1    Bi, Y.Q.2    Jin, H.3    Wei, D.P.4    He, R.5    Hou, S.X.6
  • 42
    • 84861059344 scopus 로고    scopus 로고
    • The anti-tumor performance of docetaxel liposomes surface-modified with glycyrrhetinic acid
    • Li, J.; Xu, H.; Ke, X.; Tian, J. The anti-tumor performance of docetaxel liposomes surface-modified with glycyrrhetinic acid J. Drug Targeting 2012, 20, 467-473 10.3109/1061186X.2012.685475
    • (2012) J. Drug Targeting , vol.20 , pp. 467-473
    • Li, J.1    Xu, H.2    Ke, X.3    Tian, J.4
  • 44
    • 34250189716 scopus 로고    scopus 로고
    • Cationic Liposomes as non-viral carriers of gene medicines: Resolved issues, open questions, and future promises
    • Karmali, P. P.; Chaudhuri, A. Cationic Liposomes as non-viral carriers of gene medicines: Resolved issues, open questions, and future promises Med. Res. Rev. 2007, 27, 696-722 10.1002/med.20090
    • (2007) Med. Res. Rev. , vol.27 , pp. 696-722
    • Karmali, P.P.1    Chaudhuri, A.2
  • 45
    • 77955980913 scopus 로고    scopus 로고
    • Development of glycyrrhetinic acid-modified stealth cationic liposomes for gene delivery
    • He, Z. Y.; Zheng, X.; Wu, X. H.; Song, X. R.; He, G.; Wu, W. F.; Yu, S.; Mao, S. J.; Wei, Y. Q. Development of glycyrrhetinic acid-modified stealth cationic liposomes for gene delivery Int. J. Pharm. 2010, 397, 147-154 10.1016/j.ijpharm.2010.06.029
    • (2010) Int. J. Pharm. , vol.397 , pp. 147-154
    • He, Z.Y.1    Zheng, X.2    Wu, X.H.3    Song, X.R.4    He, G.5    Wu, W.F.6    Yu, S.7    Mao, S.J.8    Wei, Y.Q.9
  • 46
    • 84862069884 scopus 로고    scopus 로고
    • Amphiphilic polymeric micelles as the nanocarrier for peroral delivery of poorly soluble anticancer drugs
    • Tian, Y.; Mao, S. Amphiphilic polymeric micelles as the nanocarrier for peroral delivery of poorly soluble anticancer drugs Expert Opin. Drug Delivery 2012, 9, 687-700 10.1517/17425247.2012.681299
    • (2012) Expert Opin. Drug Delivery , vol.9 , pp. 687-700
    • Tian, Y.1    Mao, S.2
  • 47
    • 0035850224 scopus 로고    scopus 로고
    • Structure and design of polymeric surfactant-based drug delivery systems
    • Torchilin, V. P. Structure and design of polymeric surfactant-based drug delivery systems J. Controlled Release 2001, 73, 137-172 10.1016/S0168-3659(01)00299-1
    • (2001) J. Controlled Release , vol.73 , pp. 137-172
    • Torchilin, V.P.1
  • 48
    • 84893839358 scopus 로고    scopus 로고
    • Glycyrrhetinic Acid-Poly(ethylene glycol)-glycyrrhetinic Acid Tri-Block Conjugates Based Self-Assembled Micelles for Hepatic Targeted Delivery of Poorly Water Soluble Drug
    • Wu, F.; Xu, T.; Liu, C.; Chen, C.; Song, X.; Zheng, Y.; He, G. Glycyrrhetinic Acid-Poly(ethylene glycol)-glycyrrhetinic Acid Tri-Block Conjugates Based Self-Assembled Micelles for Hepatic Targeted Delivery of Poorly Water Soluble Drug Sci. World J. 2013, 2013, 1 10.1155/2013/913654
    • (2013) Sci. World J. , vol.2013 , pp. 1
    • Wu, F.1    Xu, T.2    Liu, C.3    Chen, C.4    Song, X.5    Zheng, Y.6    He, G.7
  • 49
    • 84953881102 scopus 로고    scopus 로고
    • Preparation and characterization of glycyrrhetinic acid-modified stearic acid-grafted chitosan micelles
    • Chen, Q.; Sun, Y.; Wang, J.; Yan, G.; Cui, Z.; Yin, H.; Wei, H. Preparation and characterization of glycyrrhetinic acid-modified stearic acid-grafted chitosan micelles Artif. Cells, Nanomed., Biotechnol. 2015, 43, 217 10.3109/21691401.2013.845570
    • (2015) Artif. Cells, Nanomed., Biotechnol. , vol.43 , pp. 217
    • Chen, Q.1    Sun, Y.2    Wang, J.3    Yan, G.4    Cui, Z.5    Yin, H.6    Wei, H.7
  • 51
    • 84942294489 scopus 로고    scopus 로고
    • Glycyrrhetinic Acid-Mediated Polymeric Drug Delivery Targeting the Acidic Microenvironment of Hepatocellular Carcinoma
    • Zhang, J.; Zhang, M.; Ji, J.; Fang, X.; Pan, X.; Wang, Y.; Wu, C.; Chen, M. Glycyrrhetinic Acid-Mediated Polymeric Drug Delivery Targeting the Acidic Microenvironment of Hepatocellular Carcinoma Pharm. Res. 2015, 32, 3376 10.1007/s11095-015-1714-2
    • (2015) Pharm. Res. , vol.32 , pp. 3376
    • Zhang, J.1    Zhang, M.2    Ji, J.3    Fang, X.4    Pan, X.5    Wang, Y.6    Wu, C.7    Chen, M.8
  • 52
    • 84856328422 scopus 로고    scopus 로고
    • Synthesis and characterization of star-shaped poly (lactide-co-glycolide) and its drug-loaded microspheres
    • Ouyang, C. P.; Liu, Q.; Zhao, S. X.; Ma, G. L.; Zhang, Z. P.; Song, C. X. Synthesis and characterization of star-shaped poly (lactide-co-glycolide) and its drug-loaded microspheres Polym. Bull. 2012, 68, 27-36 10.1007/s00289-011-0516-x
    • (2012) Polym. Bull. , vol.68 , pp. 27-36
    • Ouyang, C.P.1    Liu, Q.2    Zhao, S.X.3    Ma, G.L.4    Zhang, Z.P.5    Song, C.X.6
  • 53
    • 84901283345 scopus 로고    scopus 로고
    • Synthesis and Characterization of Star-Shaped Block Copolymer sPCL-b-PEG-GA
    • Zhang, Y.; Zhao, Q.; Shao, H. W.; Zhang, S. Y.; Han, X. Y. Synthesis and Characterization of Star-Shaped Block Copolymer sPCL-b-PEG-GA Adv. Mater. Sci. Eng. 2014, 2014, 1 10.1155/2014/107375
    • (2014) Adv. Mater. Sci. Eng. , vol.2014 , pp. 1
    • Zhang, Y.1    Zhao, Q.2    Shao, H.W.3    Zhang, S.Y.4    Han, X.Y.5
  • 54
    • 84955472462 scopus 로고    scopus 로고
    • Nanocarriers for cancer-targeted drug delivery
    • Kumari, P.; Ghosh, B.; Biswas, S. Nanocarriers for cancer-targeted drug delivery J. Drug Target. 2015, 1-13 10.3109/1061186X.2015.1051049
    • (2015) J. Drug Target. , pp. 1-13
    • Kumari, P.1    Ghosh, B.2    Biswas, S.3
  • 55
    • 84991720153 scopus 로고    scopus 로고
    • Development, optimization and characterization of glycyrrhetinic acid-chitosan nanoparticles of atorvastatin for liver targeting
    • Rohilla, R.; Garg, T.; Bariwal, J.; Goyal, A. K.; Rath, G. Development, optimization and characterization of glycyrrhetinic acid-chitosan nanoparticles of atorvastatin for liver targeting Drug Delivery 2014, 1-8 10.3109/10717544.2014.977460
    • (2014) Drug Delivery , pp. 1-8
    • Rohilla, R.1    Garg, T.2    Bariwal, J.3    Goyal, A.K.4    Rath, G.5
  • 56
    • 77951057911 scopus 로고    scopus 로고
    • Glycyrrhetinic acid-modified chitosan/poly(ethylene glycol) nanoparticles for liver-targeted delivery
    • Tian, Q.; Zhang, C. N.; Wang, X. H.; Wang, W.; Huang, W.; Cha, R. T.; Wang, C. H.; Yuan, Z.; Liu, M.; Wan, H. Y.; Tang, H. Glycyrrhetinic acid-modified chitosan/poly(ethylene glycol) nanoparticles for liver-targeted delivery Biomaterials 2010, 31, 4748-4756 10.1016/j.biomaterials.2010.02.042
    • (2010) Biomaterials , vol.31 , pp. 4748-4756
    • Tian, Q.1    Zhang, C.N.2    Wang, X.H.3    Wang, W.4    Huang, W.5    Cha, R.T.6    Wang, C.H.7    Yuan, Z.8    Liu, M.9    Wan, H.Y.10    Tang, H.11
  • 57
    • 84908123317 scopus 로고    scopus 로고
    • Self-assembled nanoparticles of glycyrrhetic acid-modified pullulan as a novel carrier of curcumin
    • Yuan, R.; Zheng, F.; Zhong, S.; Tao, X.; Zhang, Y.; Gao, F.; Yao, F.; Chen, J.; Chen, Y.; Shi, G. Self-assembled nanoparticles of glycyrrhetic acid-modified pullulan as a novel carrier of curcumin Molecules 2014, 19, 13305-13318 10.3390/molecules190913305
    • (2014) Molecules , vol.19 , pp. 13305-13318
    • Yuan, R.1    Zheng, F.2    Zhong, S.3    Tao, X.4    Zhang, Y.5    Gao, F.6    Yao, F.7    Chen, J.8    Chen, Y.9    Shi, G.10
  • 58
    • 84855739069 scopus 로고    scopus 로고
    • Doxorubicin-loaded glycyrrhetinic acid-modified alginate nanoparticles for liver tumor chemotherapy
    • Zhang, C.; Wang, W.; Liu, T.; Wu, Y.; Guo, H.; Wang, P.; Tian, Q.; Wang, Y.; Yuan, Z. Doxorubicin-loaded glycyrrhetinic acid-modified alginate nanoparticles for liver tumor chemotherapy Biomaterials 2012, 33, 2187-2196 10.1016/j.biomaterials.2011.11.045
    • (2012) Biomaterials , vol.33 , pp. 2187-2196
    • Zhang, C.1    Wang, W.2    Liu, T.3    Wu, Y.4    Guo, H.5    Wang, P.6    Tian, Q.7    Wang, Y.8    Yuan, Z.9
  • 59
    • 84917711148 scopus 로고    scopus 로고
    • Hepatocellular carcinoma dually-targeted nanoparticles for reduction triggered intracellular delivery of doxorubicin
    • Mezghrani, O.; Tang, Y.; Ke, X.; Chen, Y.; Hu, D.; Tu, J.; Zhao, L.; Bourkaib, N. Hepatocellular carcinoma dually-targeted nanoparticles for reduction triggered intracellular delivery of doxorubicin Int. J. Pharm. 2015, 478, 553-568 10.1016/j.ijpharm.2014.10.041
    • (2015) Int. J. Pharm. , vol.478 , pp. 553-568
    • Mezghrani, O.1    Tang, Y.2    Ke, X.3    Chen, Y.4    Hu, D.5    Tu, J.6    Zhao, L.7    Bourkaib, N.8
  • 60
    • 84875673833 scopus 로고    scopus 로고
    • Preparation of 10-hydroxycamptothecin-loaded glycyrrhizic acid-conjugated bovine serum albumin nanoparticles for hepatocellular carcinoma-targeted drug delivery
    • Zu, Y.; Meng, L.; Zhao, X.; Ge, Y.; Yu, X.; Zhang, Y.; Deng, Y. Preparation of 10-hydroxycamptothecin-loaded glycyrrhizic acid-conjugated bovine serum albumin nanoparticles for hepatocellular carcinoma-targeted drug delivery Int. J. Nanomed. 2013, 8, 1207-1222 10.2147/IJN.S40493
    • (2013) Int. J. Nanomed. , vol.8 , pp. 1207-1222
    • Zu, Y.1    Meng, L.2    Zhao, X.3    Ge, Y.4    Yu, X.5    Zhang, Y.6    Deng, Y.7
  • 61
    • 84924366164 scopus 로고    scopus 로고
    • Doxorubicin-loaded glycyrrhetinic acid modified recombinant human serum albumin nanoparticles for targeting liver tumor chemotherapy
    • Qi, W. W.; Yu, H. Y.; Guo, H.; Lou, J.; Wang, Z. M.; Liu, P.; Sapin-Minet, A.; Maincent, P.; Hong, X. C.; Hu, X. M.; Xiao, Y. L. Doxorubicin-loaded glycyrrhetinic acid modified recombinant human serum albumin nanoparticles for targeting liver tumor chemotherapy Mol. Pharmaceutics 2015, 12, 675-683 10.1021/mp500394v
    • (2015) Mol. Pharmaceutics , vol.12 , pp. 675-683
    • Qi, W.W.1    Yu, H.Y.2    Guo, H.3    Lou, J.4    Wang, Z.M.5    Liu, P.6    Sapin-Minet, A.7    Maincent, P.8    Hong, X.C.9    Hu, X.M.10    Xiao, Y.L.11
  • 62
    • 84908179377 scopus 로고    scopus 로고
    • Shieldable tumor targeting based on pH responsive self-assembly/disassembly of gold nanoparticles
    • Tian, Z.; Yang, C.; Wang, W.; Yuan, Z. Shieldable tumor targeting based on pH responsive self-assembly/disassembly of gold nanoparticles ACS Appl. Mater. Interfaces 2014, 6, 17865-17876 10.1021/am5045339
    • (2014) ACS Appl. Mater. Interfaces , vol.6 , pp. 17865-17876
    • Tian, Z.1    Yang, C.2    Wang, W.3    Yuan, Z.4
  • 63
    • 84893489417 scopus 로고    scopus 로고
    • A novel approach for fluorescent visualization of glycyrrhetic acid on a cell with a quantum dot
    • Hou, J.; Shi, Q.; Cao, M.; Pan, P.; Ge, G.; Fan, X.; Bai, G.; Xin, Y. A novel approach for fluorescent visualization of glycyrrhetic acid on a cell with a quantum dot Biochemistry (Moscow) 2014, 79, 25-30 10.1134/S0006297914010040
    • (2014) Biochemistry (Moscow) , vol.79 , pp. 25-30
    • Hou, J.1    Shi, Q.2    Cao, M.3    Pan, P.4    Ge, G.5    Fan, X.6    Bai, G.7    Xin, Y.8
  • 64
    • 77957665375 scopus 로고    scopus 로고
    • Insight into glycyrrhetinic acid: The role of the hydroxyl group on liver targeting
    • Tian, Q.; Wang, X.; Wang, W.; Zhang, C.; Liu, Y.; Yuan, Z. Insight into glycyrrhetinic acid: The role of the hydroxyl group on liver targeting Int. J. Pharm. 2010, 400, 153-157 10.1016/j.ijpharm.2010.08.032
    • (2010) Int. J. Pharm. , vol.400 , pp. 153-157
    • Tian, Q.1    Wang, X.2    Wang, W.3    Zhang, C.4    Liu, Y.5    Yuan, Z.6
  • 65
    • 84908362233 scopus 로고    scopus 로고
    • Prodrug-based nanoparticulate drug delivery strategies for cancer therapy
    • Luo, C.; Sun, J.; Sun, B.; He, Z. Prodrug-based nanoparticulate drug delivery strategies for cancer therapy Trends Pharmacol. Sci. 2014, 35, 556-566 10.1016/j.tips.2014.09.008
    • (2014) Trends Pharmacol. Sci. , vol.35 , pp. 556-566
    • Luo, C.1    Sun, J.2    Sun, B.3    He, Z.4
  • 66
    • 84887324032 scopus 로고    scopus 로고
    • Synthesis of liver-targeting dual-ligand modified GCGA/5-FU nanoparticles and their characteristics in vitro and in vivo
    • Cheng, M.; Gao, X.; Wang, Y.; Chen, H.; He, B.; Li, Y.; Han, J.; Zhang, Z. Synthesis of liver-targeting dual-ligand modified GCGA/5-FU nanoparticles and their characteristics in vitro and in vivo Int. J. Nanomed. 2013, 8, 4265-4276 10.2147/IJN.S52877
    • (2013) Int. J. Nanomed. , vol.8 , pp. 4265-4276
    • Cheng, M.1    Gao, X.2    Wang, Y.3    Chen, H.4    He, B.5    Li, Y.6    Han, J.7    Zhang, Z.8
  • 67
    • 84877842747 scopus 로고    scopus 로고
    • Functional alginate nanoparticles for efficient intracellular release of doxorubicin and hepatoma carcinoma cell targeting therapy
    • Guo, H.; Lai, Q.; Wang, W.; Wu, Y.; Zhang, C.; Liu, Y.; Yuan, Z. Functional alginate nanoparticles for efficient intracellular release of doxorubicin and hepatoma carcinoma cell targeting therapy Int. J. Pharm. 2013, 451, 1-11 10.1016/j.ijpharm.2013.04.025
    • (2013) Int. J. Pharm. , vol.451 , pp. 1-11
    • Guo, H.1    Lai, Q.2    Wang, W.3    Wu, Y.4    Zhang, C.5    Liu, Y.6    Yuan, Z.7
  • 68
    • 84996569960 scopus 로고    scopus 로고
    • Albumin corona on nanoparticles - A strategic approach in drug delivery
    • Mariam, J.; Sivakami, S.; Dongre, P. M. Albumin corona on nanoparticles-a strategic approach in drug delivery Drug Delivery 2015, 1-9 10.3109/10717544.2015.1048488
    • (2015) Drug Delivery , pp. 1-9
    • Mariam, J.1    Sivakami, S.2    Dongre, P.M.3
  • 69
    • 0025800812 scopus 로고
    • Permeability Properties of Glycol Chitosan Membrane Modified with Thiol-Groups
    • Kubota, N.; Ohga, K.; Moriguchi, M. Permeability Properties of Glycol Chitosan Membrane Modified with Thiol-Groups J. Appl. Polym. Sci. 1991, 42, 495-501 10.1002/app.1991.070420222
    • (1991) J. Appl. Polym. Sci. , vol.42 , pp. 495-501
    • Kubota, N.1    Ohga, K.2    Moriguchi, M.3
  • 70
    • 84872774920 scopus 로고    scopus 로고
    • Glycyrrhetinic acid-graft-hyaluronic acid conjugate as a carrier for synergistic targeted delivery of antitumor drugs
    • Zhang, L.; Yao, J.; Zhou, J.; Wang, T.; Zhang, Q. Glycyrrhetinic acid-graft-hyaluronic acid conjugate as a carrier for synergistic targeted delivery of antitumor drugs Int. J. Pharm. 2013, 441, 654-664 10.1016/j.ijpharm.2012.10.030
    • (2013) Int. J. Pharm. , vol.441 , pp. 654-664
    • Zhang, L.1    Yao, J.2    Zhou, J.3    Wang, T.4    Zhang, Q.5
  • 71
    • 84861669644 scopus 로고    scopus 로고
    • Doxil(R) - the first FDA-approved nano-drug: Lessons learned
    • Barenholz, Y. Doxil(R) - the first FDA-approved nano-drug: lessons learned J. Controlled Release 2012, 160, 117-134 10.1016/j.jconrel.2012.03.020
    • (2012) J. Controlled Release , vol.160 , pp. 117-134
    • Barenholz, Y.1
  • 72
    • 79960925147 scopus 로고    scopus 로고
    • Targeted drug delivery to tumors: Myths, reality and possibility
    • Bae, Y. H.; Park, K. Targeted drug delivery to tumors: myths, reality and possibility J. Controlled Release 2011, 153, 198-205 10.1016/j.jconrel.2011.06.001
    • (2011) J. Controlled Release , vol.153 , pp. 198-205
    • Bae, Y.H.1    Park, K.2
  • 73
    • 72749085025 scopus 로고    scopus 로고
    • Enhanced distribution and extended elimination of glycyrrhetinic acid in mice liver by mPEG-PLA modified (mPEGylated) liposome
    • Li, J.; Yu, H.; Li, S.; Wang, G. J. Enhanced distribution and extended elimination of glycyrrhetinic acid in mice liver by mPEG-PLA modified (mPEGylated) liposome J. Pharm. Biomed. Anal. 2010, 51, 1147-1153 10.1016/j.jpba.2009.11.005
    • (2010) J. Pharm. Biomed. Anal. , vol.51 , pp. 1147-1153
    • Li, J.1    Yu, H.2    Li, S.3    Wang, G.J.4
  • 74
    • 84947914340 scopus 로고    scopus 로고
    • Enhanced Cellular Cytotoxicity and Antibacterial Activity of 18-beta-Glycyrrhetinic Acid by Albumin-conjugated PLGA Nanoparticles
    • Darvishi, B.; Manoochehri, S.; Esfandyari-Manesh, M.; Samadi, N.; Amini, M.; Atyabi, F.; Dinarvand, R. Enhanced Cellular Cytotoxicity and Antibacterial Activity of 18-beta-Glycyrrhetinic Acid by Albumin-conjugated PLGA Nanoparticles Drug Res. (Stuttgart, Ger.) 2015, 65, 617 10.1055/s-0034-1390487
    • (2015) Drug Res. (Stuttgart, Ger.) , vol.65 , pp. 617
    • Darvishi, B.1    Manoochehri, S.2    Esfandyari-Manesh, M.3    Samadi, N.4    Amini, M.5    Atyabi, F.6    Dinarvand, R.7
  • 75
    • 84892155656 scopus 로고    scopus 로고
    • Development of Salvianolic acid B-Tanshinone II A-Glycyrrhetinic acid compound liposomes: Formulation optimization and its effects on proliferation of hepatic stellate cells
    • Lin, J. H.; Wang, X. L.; Wu, Q.; Dai, J. D.; Guan, H. D.; Cao, W.; He, L. Y.; Wang, Y. R. Development of Salvianolic acid B-Tanshinone II A-Glycyrrhetinic acid compound liposomes: Formulation optimization and its effects on proliferation of hepatic stellate cells Int. J. Pharm. 2014, 462, 11-18 10.1016/j.ijpharm.2013.12.040
    • (2014) Int. J. Pharm. , vol.462 , pp. 11-18
    • Lin, J.H.1    Wang, X.L.2    Wu, Q.3    Dai, J.D.4    Guan, H.D.5    Cao, W.6    He, L.Y.7    Wang, Y.R.8
  • 77
    • 84863626736 scopus 로고    scopus 로고
    • Optimization on condition of glycyrrhetinic acid liposome by RSM and the research of its immunological activity
    • Zhao, X.; Liu, J.; Hu, Y.; Fan, Y.; Wang, D.; Yuan, J.; Xu, L.; Cui, L.; Jing, Z. Optimization on condition of glycyrrhetinic acid liposome by RSM and the research of its immunological activity Int. J. Biol. Macromol. 2012, 51, 299-304 10.1016/j.ijbiomac.2012.05.005
    • (2012) Int. J. Biol. Macromol. , vol.51 , pp. 299-304
    • Zhao, X.1    Liu, J.2    Hu, Y.3    Fan, Y.4    Wang, D.5    Yuan, J.6    Xu, L.7    Cui, L.8    Jing, Z.9


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.