A wogonin-loaded glycyrrhetinic acid-modified liposome for hepatic targeting with anti-tumor effects

Drug Delivery

Volumn 21, Issue 7, 2014, Pages 553-559

  Tian, Jilai ^a   Wang, Lu ^a   Wang, Lei ^a   Ke, Xue ^a  

^a CHINA PHARMACEUTICAL UNIVERSITY   (China)

Author keywords

Anti tumor; Glycyrrhetinic acid; Hepatocytes; Liposomes; Wogonin

Indexed keywords

GLYCYRRHETINIC ACID; LIPOSOME; WOGONIN; FLAVANONE DERIVATIVE; HERBACEOUS AGENT;

ANTINEOPLASTIC ACTIVITY; ARTICLE; CONTROLLED STUDY; CYTOTOXICITY; DRUG ACCUMULATION; DRUG DISTRIBUTION; DRUG SYNTHESIS; DRUG TARGETING; HEPG2 CELL LINE; HUMAN; HUMAN CELL; IC50; IN VIVO STUDY; MOLECULARLY TARGETED THERAPY; MOUSE; NONHUMAN; ZETA POTENTIAL; ANIMAL; CELL PROLIFERATION; DRUG DELIVERY SYSTEM; DRUG EFFECTS; DRUG SCREENING; FEMALE; INSTITUTE FOR CANCER RESEARCH MOUSE; LIVER CELL; MALE; PHYSIOLOGY; PROCEDURES; TREATMENT OUTCOME;

ANIMALS; CELL PROLIFERATION; DRUG DELIVERY SYSTEMS; DRUGS, CHINESE HERBAL; FEMALE; FLAVANONES; GLYCYRRHETINIC ACID; HEP G2 CELLS; HEPATOCYTES; HUMANS; LIPOSOMES; MALE; MICE; MICE, INBRED ICR; TREATMENT OUTCOME; XENOGRAFT MODEL ANTITUMOR ASSAYS;

EID: 84910011319     PISSN: 10717544     EISSN: 15210464     Source Type: Journal    
DOI: 10.3109/10717544.2013.853850     Document Type: Article

References (33)

1. Cajot S, Butsele KV, Paillard A, et al. (2012). Smart nanocarriers for pH-triggered targeting and release of hydrophobic drugs. Acta Biomater 8:4215-23.
2. Cen P, Ni XL, Yang JX, et al. (2012). Circulating tumor cells in the diagnosis and management of pancreatic cancer. Biochimica et Biophysica Acta 1826:350-6.
3. Chi YS, Cheon BS, Kim HP. (2001). Effect of wogonin, a plant flavones from Scutellaria radix, on the suppression of cyclooxygenase-2 and the induction of inducible nitric oxide synthase in lipopolysaccharidetreated RAW 264.7 cells. Biochem Pharmacol 61:1195-203.
4. Dong P, Zhang Y, Gu J, et al. (2011). Wogonin, an active ingredient of Chinese herb medicine Scutellaria baicalensis, inhibits the mobility and invasion of human gallbladder carcinoma GBC-SD cells by inducing the expression of maspin. J Ethnopharmaco 137:1373-80.
5. Guo Q, Zhao L, You Q, et al. (2007). Anti-hepatitis B virus activity of wogonin in vitro and in vivo. Antivir Res 74:16-24.
6. He ZY, Zheng X, Wu XH, et al. (2010). Development of glycyrrhetinic acid-modified stealth cationic liposomes for gene delivery. Int J Pharm 397:147-54.
7. Himeji M, Ohtsuki T, Fukazawa H, et al. (2007). Difference of growthinhibitory effect of Scutellaria baicalensis-producing flavonoid wogonin among human cancer cells and normal diploid cell. Cancer Lett 245:269-74.
8. Huang KF, Zhang GD, Huang YQ, et al. (2012). Wogonin induces apoptosis and down-regulates survivin in human breast cancer MCF-7 cells by modulating PI3K-AKT pathway. Int Immunopharmacol 12: 334-41.
9. Huang W, Wang W, Wang P, et al. (2010). Glycyrrhetinic acid-modified poly (ethyleneglycol) - b - poly (g - benzyl L-glutamate) micelles for liver targeting therapy. Acta Biomater 6:3927-35.
10. Huang W, Wang W, Wang P, et al. (2011). Glycyrrhetinic acidfunctionalized degradable micelles as liver-targeted drug carrier. J Mater Sci Mater Med 22:853-63.
11. Ilicheva TN, Proniaeva TR, Smetannikov AA, et al. (1998). Content of progesterone, glucocorticoid and glycyrrhizic acid receptors in normal and tumoral human breast tissue. Vopr Onkol 44:390-4.
12. Jain RK, Stylianopoulos T. (2010). Delivering nanomedicine to solid tumors. Nat Rev Clin Oncol 7:653-64.
13. Lee DH, Lee TH, Jung CH, et al. (2012). Wogonin induces apoptosis by activating the AMPK and p53 signaling pathways in human glioblastoma cells. Cell Signal 24:2216-25.
14. Li J, Ke X. (2011). Preparation of docetaxel liposomes surface-modified with glycyrrhetinic acid and its in vitro anti-tumor effect. Pharm Clin Res 19:207-10.
15. Li J, Xu H, Ke X, et al. (2012). The anti-tumor performance of docetaxel liposomes surface-modified with glycyrrhetinic acid. J Drug Target 20:467-73.
16. Lim JS, Yoo M, Kwon HJ, et al. (2010). Wogonin induces differentiation and neurite outgrowth of neural precursor cells. Biochem Bioph Res Co 402:42-7.
17. Li-Weber M. (2009). New therapeutic aspects of flavones: the anticancer properties of Scutellaria and its main active constituents Wogonin, Baicalein and Baicalin. Cancer Treat Rev 35:57-68.
18. Lu CT, Zhao YZ, Wu Y, et al. (2011). Experiment on enhancing antitumor effect of intravenous epirubicin hydrochloride by acoustic cavitation in situ combined with phospholipid-based microbubbles. Cancer Chemother Pharmacol 68:343-8.
19. Lu N, Gao Y, Ling Y, et al. (2008). Wogonin suppresses tumor growth in vivo and VEGF-induced angiogenesis through inhibiting tyrosine phosphorylation of VEGFR2. Life Sci 82:956-63.
20. Mao SJ, Bi YQ, Jin H, et al. (2007). Preparation, characterization and uptake by primary cultured rat hepatocytes of liposomes surfacemodified with glycyrrhetinic acid. Pharmazie 62:614-9.
21. Negishi M, Irie A, Nagata N, et al. (1991). Specific binding of glycyrrhetinic acid to the rat liver membrane. Biochim Biophys Acta 1066:77-82.
22. Park HG, Yoon SY, Choi JY, et al. (2007). Anticonvulsant effect of wogonin isolated from Scutellaria baicalensis. Eur J Pharmacol 574: 112-9.
23. Peng J, Qi Q, You Q, et al. (2009). Subchronic toxicity and plasma pharmacokinetic studies on wogonin, a natural flavonoid, in Beagle dogs. J Ethnopharmacol 124:257-62.
24. Sawant RR, Torchilin VP. (2012). Challenges in development of targeted liposomal therapeutics. AAPS J 14:303-11.
25. Shieh DE, Liu LT, Lin CC. (2000). Antioxidant and free radical scavenging effects of baicalein, baicalin and wogonin. Anticancer Res 20:2861-5.
26. Tian Q, Wang W, He XT, et al. (2009). Glycyrrhetinic acid-modified nanoparticles for drug delivery: preparation and characterization. Chin Sci Bull 54:3121-6.
27. Tian Q, Wang X, Wang W, et al. (2010a). Insight into glycyrrhetinic acid: the role of the hydroxyl group on liver targeting. Int J Pharm 400:153-7.
28. Tian Q, Zhang CN, Wang XH, et al. (2010b). Glycyrrhetinic acidmodified chitosan/poly(ethylene glycol) nanoparticles for livertargeted delivery. Biomaterials 31:4748-56.
29. Tian Q, Wang XH, Wang W, et al. (2012). Self-assembly and liver targeting of sulfate chitosan nanoparticles functionalized with glycyrrhetinic acid. Nanomed Nanotechnol 8:870-9.
30. Yang L, You Q, Yang Y, Guo Q. (2009). Research advances in wogonins anti-tumor effects. J Chin Pharm Univ 40:576-9.
31. Yang XY, Li YX, Li M, et al. (2012). Hyaluronic acid-coated nanostructured lipid carriers for targeting paclitaxel to cancer. Cancer Lett 334:338-45.
32. Zhao L, Chen Z, Zhao Q, et al. (2011a). Developmental toxicity and genotoxicity studies of wogonin. Regul Toxicol Pharm 60:212-7.
33. Zhao YZ, Sun CZ, Lu CT, et al. (2011b). Characterization and antitumor activity of chemical conjugation of doxorubicin in polymeric micelles (DOX-P) in vitro. Cancer Lett 311:187-94.