The strategies for treating primary hepatocellular carcinoma with portal vein tumor thrombus

International Journal of Surgery

Volumn 20, Issue , 2015, Pages 8-16

  Zhang, Zong Ming ^a   Lai, Eric C H ^b   Zhang, Chong ^a   Yu, Hong Wei ^a   Liu, Zhuo ^a   Wan, Bo Jiang ^a   Liu, Li Min ^a   Tian, Zu Hao ^a   Deng, Hai ^a   Sun, Qiu Hong ^a   Chen, Xiao Ping ^c  

^a CAPITAL MEDICAL UNIVERSITY   (China)

^b PAMELA YOUDE NETHERSOLE EASTERN HOSPITAL   (Hong Kong)

^c HUAZHONG UNIVERSITY OF SCIENCE AND TECHNOLOGY   (China)

Author keywords

Hepatocellular carcinoma (HCC); Portal vein tumor thrombus (PVTT); Therapeutic strategy

Indexed keywords

SORAFENIB; YTTRIUM 90;

ARTIFICIAL EMBOLISM; CANCER CHEMOTHERAPY; CANCER PALLIATIVE THERAPY; CANCER PROGNOSIS; CANCER SURVIVAL; CHEMOEMBOLIZATION; COMPUTER ASSISTED RADIOTHERAPY; HUMAN; LIVER CELL CARCINOMA; LIVER RESECTION; META ANALYSIS; MOLECULARLY TARGETED THERAPY; PORTAL VEIN CHEMOEMBOLIZATION; PORTAL VEIN THROMBOSIS; PORTAL VEIN TUMOR THROMBUS; PRIMARY TUMOR; PRIORITY JOURNAL; QUALITY OF LIFE; RADIOFREQUENCY ABLATION; RENAL ARTERY STENT; REVIEW; STEREOTACTIC BODY RADIATION THERAPY; SURVIVAL RATE; SURVIVAL TIME; SYSTEMATIC REVIEW; THROMBECTOMY; TRANSARTERIAL CHEMOEMBOLIZATION; TRANSARTERIAL RADIOEMBOLIZATION; TUMOR THROMBUS; ULTRASONIC DISRUPTION; CARCINOMA, HEPATOCELLULAR; CATHETER ABLATION; HIGH INTENSITY FOCUSED ULTRASOUND; LIVER NEOPLASMS; MALE; MIDDLE AGED; MULTIMODALITY CANCER THERAPY; PATHOLOGY; PORTAL VEIN; PROCEDURES; PROGNOSIS; THROMBOSIS; TREATMENT OUTCOME; TUMOR EMBOLISM;

CARCINOMA, HEPATOCELLULAR; CATHETER ABLATION; CHEMOEMBOLIZATION, THERAPEUTIC; COMBINED MODALITY THERAPY; HEPATECTOMY; HIGH-INTENSITY FOCUSED ULTRASOUND ABLATION; HUMANS; LIVER NEOPLASMS; MALE; MIDDLE AGED; NEOPLASTIC CELLS, CIRCULATING; PORTAL VEIN; PROGNOSIS; QUALITY OF LIFE; RADIOTHERAPY, CONFORMAL; THROMBOSIS; TREATMENT OUTCOME;

EID: 84938799057     PISSN: 17439191     EISSN: 17439159     Source Type: Journal    
DOI: 10.1016/j.ijsu.2015.05.009     Document Type: Review

References (64)

1. Torre L.A., Bray F., Siegel R.L., et al. Global cancer statistics, 2012. CA Cancer J. Clin. 2015, 65(2):87-108.
2. Takizawa D., Kakizaki S., Sohara N., et al. Hepatocellular carcinoma with portal vein tumor thrombosis: clinical characteristics, prognosis, and patient survival analysis. Dig. Dis. Sci. 2007, 52(11):3290-3295.
3. Lin D.X., Zhang Q.Y., Li X., et al. An aggressive approach leads to improved survival in hepatocellular carcinoma patients with portal vein tumor thrombus. J. Cancer Res. Clin. Oncol. 2011, 137(1):139-149.
4. Cheng S.Q., Wu M.C., Chen H., et al. Tumor thrombus types influence the prognosis of hepatocellular carcinoma with the tumor thrombi in the portal vein. Hepatogastroenterology 2007, 54(74):499-502.
5. Shi J., Lai E.C., Li N., et al. A new classification for hepatocellular carcinoma portal vein tumor thrombus. J. Hepatobiliary Pancreat. Sci. 2011, 18(1):74-80.
6. Peng M.H., Shang L.M. Surgical treatment of hepatocellular carcinoma complicated with portal vein tumor thrombus. Chin. J. Bases Clin. Gen. Surg. 2012, 19(3):237-239. [Article in Chinese].
7. Liu P.H., Lee Y.H., Hsia C.Y., et al. Surgical resection versus transarterial chemoembolization for hepatocellular carcinoma with portal vein tumor thrombosis: a propensity score analysis. Ann. Surg. Oncol. 2014, 21(6):1825-1833.
8. Chok K.S., Cheung T.T., Chan S.S., et al. Surgical outcomes in hepatocellular carcinoma patients with portal vein tumor thrombosis. World J. Surg. 2014, 38(2):490-496.
9. Li H., Li B., Wei Y. Hepatocellular carcinoma patients with left portal vein tumor thrombus may benefit from left hemi-hepatectomy with caudate lobectomy. Hepatogastroenterology 2013, 60(126):1451-1455.
10. Tang Q.H., Li A.J., Yang G.M., et al. Surgical resection versus conformal radiotherapy combined with TACE for resectable hepatocellular carcinoma with portal vein tumor thrombus: a comparative study. World J. Surg. 2013, 37(6):1362-1370.
11. Kashiwazaki M., Hama N., Takiuchi D., et al. Resection and postoperative multidisciplinary treatment for hepatocellular carcinoma with massive portal venous tumor thrombus-a single-center experience. Gan Kagaku Ryoho 2013, 40(12):1675-1677. [Article in Japanese].
12. Peng Z.W., Guo P.R., Zhang Y.J., et al. Hepatic resection versus transcatheter arterial chemoembolization for the treatment of hepatocellular carcinoma with portal vein tumor thrombus. Cancer 2012, 118(19):4725-4736.
13. Zhou Q., Wang Y., Zhou X., et al. Prognostic analysis for treatment modalities in hepatocellular carcinomas with portal vein tumor thrombi. Asian Pac J. Cancer Prev. 2011, 12(11):2847-2850.
14. Wu Z.J., Cai J., Xu A.B., et al. Combined three-dimensional conformal radiotherapy plus transcatheter arterial chemoembolization and surgical intervention for portal vein tumor thrombus in patients with hepatocellular carcinoma. Zhonghua Yi Xue Za Zhi 2011, 91(40):2841-2844. [Article in Chinese].
15. Shi J., Lai E.C., Li N., et al. Surgical treatment of hepatocellular carcinoma with portal vein tumor thrombus. Ann. Surg. Oncol. 2010, 17(8):2073-2080.
16. Peng B.G., He Q., Li J.P., et al. Adjuvant transcatheter arterial chemoembolization improves efficacy of hepatectomy for patients with hepatocellular carcinoma and portal vein tumor thrombus. Am. J. Surg. 2009, 198(3):313-318.
17. Liang L.J., Hu W.J., Yin X.Y., et al. Adjuvant intraportal venous chemotherapy for patients with hepatocellular carcinoma and portal vein tumor thrombi following hepatectomy plus portal thrombectomy. World J. Surg. 2008, 32(4):627-631.
18. Chen X.P., Qiu F.Z., Wu Z.D., et al. Effects of location and extension of portal vein tumor thrombus on long-term outcomes of surgical treatment for hepatocellular carcinoma. Ann. Surg. Oncol. 2006, 13(7):940-946.
19. Schwarz R.E., Abou-Alfa G.K., Geschwind J.F., et al. American Hepato-Pancreato-Biliary association; society of surgical oncology; society for surgery of the alimentary tract, nonoperarive therapies for combined modality treatment of hepatocelular cancer: expect consensus statement. HPB (Oxford) 2010, 12(5):313-320.
20. Matsui O., Miyayama S. Interventional oncology: new options for interstitial treatments and intravascular approaches: superselective TACE using iodized oil for HCC: rationale, technique and outcome. J. Hepatobiliary Pancreat. Sci. 2010, 17:407-409.
21. Kim J.H., Yoon H.K., Kim S.Y., et al. Transcatheter arterial chemoembolization vs chemoinfusion for unresectable hepatocellular carcinoma in patients with major portal vein thrombosis. Aliment. Pharmacol. Ther. 2009, 29(12):1291-1298.
22. Chen L.W., Chien R.N., Fang K.M., et al. Elucidating therapeutic effects on patients with hepatocellular carcinoma and main portal vein thrombosis. Hepatogastroenterology 2010, 57(98):228-231.
23. Hirooka M., Koizumi Y., Kisaka Y., et al. Mass reduction by radiofrequency ablation before hepatic arterial infusion chemotherapy improved prognosis for patients with huge hepatocellular carcinoma and portal vein thrombus. Am. J. Roentgenol. 2010, 194(2):W221-W226.
24. Kuroda M., Kobayashi Y., Urawa N., et al. Hepatic arterial infusion of 5-fluorouracil in combination with subcutaneous interferon-alpha for advanced hepatocellular carcinoma. Hepatogastroenterology 2007, 54(74):518-521.
25. Kulik L.M., Carr B.I., Mulcahy M.F., et al. Safety and efficacy of 90Y radiotherapy for hepatocellular carcinoma with and without portal vein thrombosis. Hepatology 2008, 47(1):71-81.
26. Tsai A.L., Burke C.T., Kennedy A.S., et al. Use of yttrium-90 microspheres in patients with advanced hepatocellular carcinoma and portal vein thrombosis. J. Vasc. Interv. Radiol. 2010, 21(9):1377-1384.
27. Iñarrairaegui M., Pardo F., Bilbao J.I., et al. Response to radioembolization with yttrium-90 resin microspheres may allow surgical treatment with curative intent and prolonged survival in previously unresectable hepatocellular carcinoma. Eur. J. Surg. Oncol. 2012, 38(7):594-601.
28. Saxena A., Meteling B., Kapoor J., Golani S., Danta M., Morris D.L., Bester L. Yttrium-90 radioembolization is a safe and effective treatment for unresectable hepatocellular carcinoma: a single centre experience of 45 consecutive patients. Int. J. Surg. 2014, 12(12):1403-1408.
29. Ettorre G.M., Laurenzi A., Vennarecci G. Downstaging hepatocellular carcinoma with Yttrium-90 radioembolization: resection or transplantation?. Eur. J. Surg. Oncol. 2014, 40(6):789-790.
30. Izaki K., Sugimoto K., Sugimura K., et al. Transcatheter arterial embolization for advanced tumor thrombus with marked arterioportal or arteriovenous shunt complicating hepatocellular carcinoma. Radiat. Med. 2004, 22(3):155-162.
31. Zhang Y.W., Naren T.G., Gao F., et al. Color doppler guided percutaneous oily chemoembolization for the treatment of portal vein tumor thrombus in HCC patients. Chin. J. Interv. Imaging Ther. 2009, 6(2):167-169. [Article in Chinese].
32. Pan Q.X., Zhuang J.L., Zeng Z.X. Percutaneous transhepatic portal vein tube insertion and chemotherapy under ultrasonographic guide in the treatment of 38 hepatocellular carcinoma patients with portal vein tumor thrombus. Clin. Med. J. China 2004, 11(4):565-566. [Article in Chinese].
33. Cui L., Liu X.X., Jiang Y., et al. Comparative study on transcatheter arterial chemoembolization, portal vein embolization and high intensity focused ultrasound sequential therapy for patients. Asian Pac. J. Cancer Prev. 2012, 13(12):6257-6261.
34. Zheng S., Tang Y.M., You L.Y., et al. A three year-followed up of patients with hepatocellular carcinoma complicated by portal vein tumor thrombus receiving TACE and PVC after resection of tumors. J. Clin. Hepatol. 2013, 16(4):351-353. [Article in Chinese].
35. Huang J. Clinical evaluation of double interventional therapy combined with radiotherapy for hepatocellular carcinoma with portal vein tumor thrombus. China Foreign Med. Treat. 2013, 32(22):94-95. [Article in Chinese].
36. Fu X.Z., Li J.G., Lu Y.D., et al. 3-Dimentional conformal hypofractionated radiotherapy for Portal vein tumor thrombus in patients with hepatocellular carcinoma. Pract. J. Cancer 2010, 25(3):295-297. [Article in Chinese].
37. Nakagawa K., Yamashita H., Shiraishi K., et al. Radiation therapy for portal venous invasion by hepatocellular carcinoma. World J. Gastroenterol. 2005, 11(46):7237-7241.
38. Rim C.H., Yang D.S., Park Y.J., et al. Effectiveness of high-dose three-dimensional conformal radiotherapy in hepatocellular carcinoma with portal vein thrombosis. Jpn. J. Clin. Oncol. 2012, 42(8):721-729.
39. Zhang X.B., Wang J.H., Yan Z.P., et al. Hepatocellular carcinoma with main portal vein tumor thrombus: treatment with 3-dimensional conformal radiotherapy after portal vein stenting and transarterial chemoembolization. Cancer 2009, 115(6):1245-1252.
40. Potters L., Kavanagh B., Galvin J.M., et al. American society for therapeutic radiology and oncology; American college of radiology. American Society for Therapeutic Radiology and Oncology (ASTRO) and American College of Radiology (ACR) practice guideline for the performance of stereotactic body radiation therapy. Int. J. Radiat. Oncol. Biol. Phys. 2010, 76(2):326-332.
41. Que J.Y., Lin L.C., Lin K.L., et al. The efficacy of stereotactic body radiation therapy on huge hepatocellular carcinoma unsuitable for other local modalities. Radiat. Oncol. 2014, 9(1):120.
42. Sanuki N., Takeda A., Kunieda E. Role of stereotactic body radiation therapy for hepatocellular carcinoma. World J. Gastroenterol. 2014, 20(12):3100-3111.
43. Ibarra R.A., Rojas D., Snyder L., et al. Multicenter results of stereotactic body radiotherapy (SBRT) for non-resectable primary liver tumors. Acta Oncol. 2012, 51(5):575-583.
44. Ling T.C., Kang J.I., Bush D.A., et al. Proton therapy for hepatocellular carcinoma. Chin. J. Cancer Res. 2012, 24(4):361-367.
45. Hata M., Tokuuye K., Sugahara S., et al. Proton beam therapy for hepatocellular carcinoma with portal vein tumor thrombus. Cancer 2005, 104(4):794-801.
46. Sugahara S., Nakayama H., Fukuda K., et al. Proton-beam therapy for hepatocellular carcinoma associated with portal vein tumor thrombosis. Strahlenther. Onkol. 2009, 185(12):782-788.
47. Kawashima M., Kohno R., Nakachi K., et al. Dose-volume histogram analysis of the safety of proton beam therapy for unresectable hepatocellular carcinoma. Int. J. Radiat. Oncol. Biol. Phys. 2011, 79(5):1479-1486.
48. Lee S.U., Park J.W., Kim T.H., et al. Effectiveness and safety of proton beam therapy for advanced hepatocellular carcinoma with portal vein tumor thrombosis. Strahlenther. Onkol. 2014, 190(9):806-814.
49. Yang M., Fang Z., Yan Z., et al. Transarterial chemoembolisation (TACE) combined with endovascular implantation of an iodine-125 seed strand for the treatment of hepatocellular carcinoma with portal vein tumour thrombosis versus TACE alone: a two-arm, randomised clinical trial. J. Cancer Res. Clin. Oncol. 2014, 140(2):211-219.
50. Zheng J.S., Long J., Sun B., et al. Transcatheter arterial chemoembolization combined with radiofrequency ablation can improve survival of patients with hepatocellular carcinoma with portal vein tumour thrombosis: extending the indication for ablation?. Clin. Radiol. 2014, 69(6):e253-263.
51. Cui L., Wu X.J., Yu Y.Q., et al. Percutaneous portal vein chemoembolization in the treatment of primary hepatic carcinoma with portal vein tumor thrombus. China Oncol. 2005, 15(4):381-382. [Article in Chinese].
52. Ishikawa T., Kubota T., Abe H., et al. Percutaneous transhepatic portal vein stent placement can improve prognosis for hepatocellular carcinoma patients with portal vein tumor thrombosis. Hepatogastroenterology 2014, 61(130):413-416.
53. Luo J., Yan Z., Liu Q., et al. Endovascular placement of iodine-125 seed strand and stent combined with chemoembolization for treatment of hepatocellular carcinoma with tumor thrombus in main portal vein. J. Vasc. Interv. Radiol. 2011, 22(4):479-489.
54. Ming Z.B., Ding W.B., Yuan R.F. Portal vein stenting combined with transcatheter hepatic arterial chemoembolization in treatment of portal vein tumor thrombus in patients with primary hepatic carcinoma. J. Med. Imaging 2009, 19(3):298-300. [Article in Chinese].
55. Giorgio A., Di Sarno A., de Stefano G., et al. Hepatocellular carcinoma with cirrhosis: are patients with neoplastic main portal vein invasion eligible for percutaneous radiofrequency ablation of both the nodule and the portal venous tumor thrombus?. Am. J. Roentgenol. 2009, 193(4):948-954.
56. Cheng S.Q., Wu M.C., Cui Z.F., et al. An experimental ultrasonic disruption in the treatment of intraportal thrombi of liver cancer. Chin. J. General Surg. 2000, 15(1):24-26.
57. Mearini L. High intensity focused ultrasound , liver disease and bridging therapy. World J. Gastroenterol. 2013, 19(43):7494-7499.
58. Qiu J.B., Li Q.P., Zhou Y. The effects of high intensity focused ultrasound therapy combined with transcatheter hepatic arterial chemoembolization on the patients with hepatocellular carcinoma with portal vein tumor thrombus. Jiangxi Med. J. 2013, 48(12):1174-1176. [Article in Chinese].
59. Katagiri S., Yamamoto M. Multidisciplinary treatments for hepatocellular carcinoma with major portal vein tumor thrombus. Surg. Today 2014, 44(2):219-226.
60. Simpson D., Keating G.M. Sorafenib: in hepatocellular carcinoma. Drugs 2008, 68(2):251-258.
61. Kane R.C., Farrell A.T., Madabushi R., et al. Sorafenib for the treatment of unresectable hepatocellular carcinoma. Oncologist 2009, 14(1):95-100.
62. Jeong S.W., Jang J.Y., Shim K.Y., et al. Practical effect of sorafenib monotherapy on advanced hepatocellular carcinoma and portal vein tumor thrombosis. Gut Liver 2013, 7(6):696-703.
63. Kermiche-Rahali S., Di Fiore A., Drieux F., et al. Complete pathological regression of hepatocellular carcinoma with portal vein thrombosis treated with sorafenib. World J. Surg. Oncol. 2013, 11(1):171-175.
64. Irtan S., Chopin-Laly X., Ronot M., et al. Complete regression of locally advanced hepatocellular carcinoma induced by sorafenib allowing curative resection. Liver Int. 2011, 31(5):740-743.