Glycyrrhetinic Acid-Mediated Polymeric Drug Delivery Targeting the Acidic Microenvironment of Hepatocellular Carcinoma

Pharmaceutical Research

Volumn 32, Issue 10, 2015, Pages 3376-3390

  Zhang, Jinming ^a   Zhang, Min ^b   Ji, Juan ^c   Fang, Xiefan ^d   Pan, Xin ^c   Wang, Yitao ^a   Wu, Chuanbin ^c   Chen, Meiwan ^a  

^a University of Macau   (Macao)

^b SOUTH CHINA UNIVERSITY OF TECHNOLOGY   (China)

^c SUN YAT SEN UNIVERSITY   (China)

^d UNIVERSITY OF FLORIDA COLLEGE OF MEDICINE   (United States)

Author keywords

andrographolide; glycyrrhetinic acid; hepatocellular carcinoma; micelles; pH sensitive

Indexed keywords

ANDROGRAPHOLIDE; ANTINEOPLASTIC AGENT; COPOLYMER; GLYCYRRHETINIC ACID; POLYHISTIDINE; ACID; DRUG CARRIER; HISTIDINE; LACTIC ACID; MACROGOL DERIVATIVE; MICELLE; POLYESTER; POLYETHYLENE GLYCOL-POLY(LACTIDE-CO-GLYCOLIDE); POLYGLYCOLIC ACID; POLYLACTIC ACID-POLYGLYCOLIC ACID COPOLYMER;

ACIDIC MICROENVIRONMENT; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ANTINEOPLASTIC ACTIVITY; ARTICLE; CANCER INHIBITION; CELL PROLIFERATION; CONJUGATION; DRUG ACCUMULATION; DRUG DELIVERY SYSTEM; DRUG RELEASE; ENCAPSULATION; HUMAN; HUMAN CELL; HUMAN CELL CULTURE; IN VITRO STUDY; IN VIVO STUDY; LIVER CANCER CELL LINE; LIVER CELL CARCINOMA; MOUSE; NONHUMAN; PRIORITY JOURNAL; RECEPTOR BINDING; SYNTHESIS; TUMOR MICROENVIRONMENT; ANIMAL; BAGG ALBINO MOUSE; CARCINOMA, HEPATOCELLULAR; CHEMISTRY; DRUG EFFECTS; LIVER; LIVER NEOPLASMS; MICELLE; NUDE MOUSE; PH; PROCEDURES; TUMOR CELL LINE;

ACIDS; ANIMALS; ANTINEOPLASTIC AGENTS; CARCINOMA, HEPATOCELLULAR; CELL LINE, TUMOR; DRUG CARRIERS; DRUG DELIVERY SYSTEMS; GLYCYRRHETINIC ACID; HISTIDINE; HUMANS; HYDROGEN-ION CONCENTRATION; LACTIC ACID; LIVER; LIVER NEOPLASMS; MICE; MICE, INBRED BALB C; MICE, NUDE; MICELLES; POLYESTERS; POLYETHYLENE GLYCOLS; POLYGLYCOLIC ACID;

EID: 84942294489     PISSN: 07248741     EISSN: 1573904X     Source Type: Journal    
DOI: 10.1007/s11095-015-1714-2     Document Type: Article

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