Antioxidant and hepatoprotective effect of Penthorum chinense Pursh extract against t-BHP-induced liver damage in L02 cells

Molecules

Volumn 20, Issue 4, 2015, Pages 6443-6453

  Hu, Yangyang ^a   Wang, Shengpeng ^a   Wang, Anqi ^a   Lin, Ligen ^a   Chen, Meiwan ^a   Wang, Yitao ^a  

^a China Macau University of Science and Technology Zhuhai MUST Science and Technology Research Institute   (Macao)

Author keywords

Apoptosis; Hepatoprotective effect; Penthorum chinense Pursh; ROS

Indexed keywords

ANTIOXIDANT; PLANT EXTRACT; PROTECTIVE AGENT; REACTIVE NITROGEN SPECIES; REACTIVE OXYGEN METABOLITE; TERT BUTYL HYDROPEROXIDE;

APOPTOSIS; CELL LINE; CHEMISTRY; DRUG EFFECTS; DRUG-INDUCED LIVER INJURY; HIGH PERFORMANCE LIQUID CHROMATOGRAPHY; HUMAN; METABOLISM; OXIDATIVE STRESS; VASCULAR PLANT;

ANTIOXIDANTS; APOPTOSIS; CELL LINE; CHROMATOGRAPHY, HIGH PRESSURE LIQUID; DRUG-INDUCED LIVER INJURY; HUMANS; OXIDATIVE STRESS; PLANT EXTRACTS; PROTECTIVE AGENTS; REACTIVE NITROGEN SPECIES; REACTIVE OXYGEN SPECIES; TERT-BUTYLHYDROPEROXIDE; TRACHEOBIONTA;

EID: 84928752915     PISSN: None     EISSN: 14203049     Source Type: Journal    
DOI: 10.3390/molecules20046443     Document Type: Article

References (29)

1. Feng, H.; Wang, Z.M.; Dong, G.Y.; Wu, Z. Studies on chemical constitutents from Penthorum chinense Pursh. Zhongguo Zhong Yao Za Zhi 2001, 26, 260-262.
2. Lu, Q.; Jiang, M.H.; Jiang, J.G.; Zhang, R.F.; Zhang, M.W. Isolation and identification of compounds from Penthorum chinense Pursh with antioxidant and antihepatocarcinoma properties. J. Agric. Food Chem. 2012, 60, 11097-11103.
3. Yan, L.J. Positive oxidative stress in aging and aging-related disease tolerance. Redox Biol. 2014, 2C, 165-169.
4. Kruidenier, L.; Verspaget, H.W. Review article: Oxidative stress as a pathogenic factor in inflammatory bowel disease - Radicals or ridiculous? Aliment. Pharmacol. Ther. 2002, 16, 1997-2015.
5. Hu, S.Q.; Han, R.W.; Mak, S.H.; Han, Y.F. Protection against 1-methyl-4-phenylpyridinium ion (MPP+)-induced apoptosis by water extract of ginseng (Panax ginseng CA Meyer) in SH-SY5Y cells. J. Ethnopharmacol. 2011, 135, 34-42.
6. Tang, W.; Jiang, Y.F.; Ponnusamy, M.; Diallo, M. Role of Nrf2 in chronic liver disease. World J. Gastroenterol. 2014, 20, 13079-13087.
7. Kaplowitz, N. Mechanisms of liver cell injury. J. Hepatol. 2000, 32, 39-47.
8. Mandelker, L. Introduction to oxidative stress and mitochondrial dysfunction. Vet. Clin. North Am. Small Anim. Pract. 2008, 38, 1-30.
9. Pineiro-Carrero, V.M.; Pinero, E.O. Liver. Pediatrics 2004, 113, 1097-1106.
10. Rush, G.F.; Gorski, J.R.; Ripple, M.G.; Sowinski, J.; Bugelski, P.; Hewitt, W.R. Organic hydroperoxide-induced lipid-peroxidation and cell-death in isolated hepatocytes. Toxicol. Appl. Pharmacol. 1985, 78, 473-483.
11. Kim, Y.S.; Hwang, J.W.; Sung, S.H.; Jeon, Y.J.; Jeong, J.H.; Jeon, B.T.; Moon, S.H.; Park, P.J. Antioxidant activity and protective effect of extract of Celosia cristata L. flower on tert-butyl hydroperoxide-induced oxidative hepatotoxicity. Food Chem. 2015, 168, 572-579.
12. Zeng, Q.H.; Zhang, X.W.; Xu, X.L.; Jiang, M.H.; Xu, K.P.; Piao, J.H.; Zhu, L.; Chen, J.; Jiang, J.G. Antioxidant and anticomplement functions of flavonoids extracted from Penthorum chinense Pursh. Food Funct. 2013, 4, 1811-1818.
13. Cao, Y.; Jiang, Y.; Zhang, D.; Wang, M.; Chen, W.; Su, H.; Wang, Y.; Wan, J. Protective effects of Penthorum chinense Pursh against chronic ethanol-induced liver injury in mice. J. Ethnopharmacol. 2015, 161, 92-98.
14. Sena, L.A.; Chandel, N.S. Physiological roles of mitochondrial reactive oxygen species. Mol. Cell 2012, 48, 158-167.
15. Cho, B.O.; Ryu, H.W.; So, Y.; Jin, C.H.; Baek, J.Y.; Park, K.H.; Byun, E.H.; Jeong, I.Y. Hepatoprotective effect of 2,3-dehydrosilybin on carbon tetrachloride-induced liver injury in rats. Food Chem. 2013, 138, 107-115.
16. Mates, J.M. Effects of antioxidant enzymes in the molecular control of reactive oxygen species toxicology. Toxicology 2000, 153, 83-104.
17. Zhang, T.; Chen, Y.M.; Zhang, G.L. Novel neolignan from Penthorum chinense. J. Integr. Plant Biol. 2007, 49, 1611-1614.
18. Alia, M.; Ramos, S.; Mateos, R.; Granado-Serrano, A.B.; Bravo, L.; Goya, L. Quercetin protects human hepatoma HepG2 against oxidative stress induced by tert-butyl hydroperoxide. Toxicol. Appl. Pharmacol. 2006, 212, 110-118.
19. Raj, L.; Ide, T.; Gurkar, A.U.; Foley, M.; Schenone, M.; Li, X.Y.; Tolliday, N.J.; Golub, T.R.; Carr, S.A.; Shamji, A.F.; et al. Selective killing of cancer cells by a small molecule targeting the stress response to ROS. Nature 2011, 475, 231-234.
20. Shen, C.H.; Tung, S.Y.; Huang, W.S.; Lu, C.C.; Lee, K.C.; Hsieh, Y.Y.; Chang, P.J.; Liang, H.F.; Chen, J.H.; Lin, T.H.; et al. Exploring the effects of tert-butylhydroperoxide induced liver injury using proteomic approach. Toxicology 2014, 316, 61-70.
21. Sievers, C.; Platt, N.; Perry, V.H.; Coleman, M.P.; Conforti, L. Neurites undergoing Wallerian degeneration show an apoptotic-like process with Annexin V positive staining and loss of mitochondrial membrane potential. Neurosci. Res. 2003, 46, 161-169.
22. Kan, S.F.; Huang, W.J.; Lin, L.C.; Wang, P.S. Inhibitory effects of evodiamine on the growth of human prostate cancer cell line LNCaP. Int. J. Cancer 2004, 110, 641-651.
23. Lazebnik, Y.A.; Kaufmann, S.H.; Desnoyers, S.; Poirier, G.G.; Earnshaw, W.C. Cleavage of poly(ADP-ribose) polymerase by a proteinase with properties like ICE. Nature 1994, 371, 346-347.
24. Lin, W.; Wang, S.; Ho, Y.; Kuo, H.; Lee, Y.; Tseng, T. Ethyl acetate extract of Wedelia chinensis inhibits tert-butyl hydroperoxide-induced damage in PC12 cells and D-galactose-induced neuronal cell loss in mice. BMC Complement. Altern. Med. 2014, 14, 491.
25. Yang, J.; Liu, X.S.; Bhalla, K.; Kim, C.N.; Ibrado, A.M.; Cai, J.Y.; Peng, T.I.; Jones, D.P.; Wang, X.D. Prevention of apoptosis by Bcl-2: Release of cytochrome c from mitochondria blocked. Science 1997, 275, 1129-1132.
26. Green, D.R.; Chipuk, J.E. Apoptosis: Stabbed in the BAX. Nature 2008, 455, 1047-1049.
27. Ewings, K.E.; Wiggins, C.M.; Cook, S.J. Bim and the pro-survival Bcl-2 proteins: Opposites attract, ERK repels. Cell Cycle 2007, 6, 2236-2240.
28. Wang, S.; Zhong, Z.; Wan, J.; Tan, W.; Wu, G.; Chen, M.; Wang, Y. Oridonin induces apoptosis, inhibits migration and invasion on highly-metastatic human breast cancer cells. Am. J. Chin. Med. 2013, 41, 177-196.
29. Zhong, Z.F.; Chen, X.P.; Tan, W.; Xu, Z.T.; Zhou, K.Y.; Wu, T.; Cui, L.; Wang, Y.T. Germacrone inhibits the proliferation of breast cancer cell lines by inducing cell cycle arrest and promoting apoptosis. Eur. J. Pharmacol. 2011, 667, 50-55.