Transarterial chemoembolization of hepatocellular carcinoma-agents and drugs: An overview. Part 2

Expert Opinion on Drug Delivery

Volumn 10, Issue 6, 2013, Pages 799-810

  Giunchedi, Paolo ^a   Maestri, Marcello ^b   Gavini, Elisabetta ^a   Dionigi, Paolo ^b   Rassu, Giovanna ^a  

^a UNIVERSITY OF SASSARI   (Italy)

^b FONDAZIONE IRCCS POLICLINICO SAN MATTEO   (Italy)

Author keywords

Controlled drug release; HCC; Local therapy; Polymeric microparticles; TACE

Indexed keywords

CALCITRIOL; CHITOSAN; CISPLATIN; DOXORUBICIN; EPIRUBICIN; FLUOROURACIL; IRINOTECAN; METHOTREXATE; MICROSPHERE; MITOMYCIN; PACLITAXEL; POLYGLACTIN; POLYLACTIDE;

BIOCOMPATIBILITY; BIODEGRADABILITY; CHEMICAL COMPOSITION; CHEMOEMBOLIZATION; CONTROLLED DRUG RELEASE; DEACETYLATION; DERIVATIZATION; DRUG DELIVERY SYSTEM; DRUG SOLUBILITY; EMULSION; FREEZE DRYING; HUMAN; HYDROPHILICITY; LIVER CELL CARCINOMA; NONHUMAN; PARTICLE SIZE; REVIEW;

ANIMALS; ANTINEOPLASTIC AGENTS; CARCINOMA, HEPATOCELLULAR; CHEMOEMBOLIZATION, THERAPEUTIC; DELAYED-ACTION PREPARATIONS; HUMANS; INFUSIONS, INTRA-ARTERIAL; LIVER NEOPLASMS; PROGNOSIS;

EID: 84878059220     PISSN: 17425247     EISSN: 17447593     Source Type: Journal    
DOI: 10.1517/17425247.2013.796359     Document Type: Review

References (85)

1. Kerr DJ. Microparticulate drug delivery systems as an adjunct to cancer treatment. Cancer Drug Deliv 1987;4:55-61
2. Lewis AL, Dreher MR. Locoregional drug delivery using image-guided intraarterial drug eluting bead therapy. J Control Release 2012;161:338-50
3. Lewis AL, Gonzalez MV, Lloyd AW, et al. DC Bead: in vitro characterization of a drug-delivery device for Transarterial Chemoembolization. J Vasc Interv Radiol 2006;17:335-42
4. Taylor RR, Tang Y, Gonzalez MV, et al. Irinotecan drug eluting beads for use in chemoembolization: in vitro and in vivo evaluation of drug release properties. Eur J Pharm Sci 2007;30:7-14
5. Liapi E, Geschwind JF. Transcatheter arterial chemoembolization for liver cancer: is it time to distinguish conventional from drug-eluting chemoembolization? Cardiovasc Intervent Radiol 2011;34:37-49
6. Gopferich A. Polymer degradation and erosion: mechanisms and applications. Eur J Pharm Biopharm 1996;42:1-11
7. Giunchedi P, Conti B, Scalia S, et al. In vitro degradation study of polyester microspheres by a new HPLC method for monomer release determination. J Control Release 1998;56:53-62
8. Uyen Nguyen TL, Tey SY, Pourgholami MH, et al. Synthesis of semi-biodegradable crosslinked microspheres for the delivery of 1,25 dihydroxyvitamin D3 for the treatment of hepatocellular carcinoma. Eur Polym J 2007;43:1754-67
9. Jack CR Jr, Forbes G, Dewanjee MK, et al. Polyvinyl alcohol sponge for embolotherapy: particle size and morphology. Am J Neuroradiol 1985;6:595-7
10. Derdeyn CP, Moran CJ, Cross DT, et al. Polyvinyl alcohol particle size and suspension characteristics. Am J Neuroradiol 1995;16:1335-43
11. Illum L, Davis SS. The targeting of drugs parenterally by use of microspheres. J Parenter Sci Technol 1982;36:242-8
12. Bastian P, Bartkowski R, Kohler H, et al. Chemo-embolization of experimental liver metastases. Part I: distribution of biodegradable microspheres of different sizes in an animal model for the locoregional therapy. Eur J Pharm Biopharm 1998;46:243-54
13. Huppert P. Current concepts in transarterial chemoembolization of hepatocellular carcinoma. Abdom Imaging 2011;36:677-83
14. Laurent A. Microspheres and nonspherical particles for embolization. Tech Vasc Interv Radiol 2007;10:248-56
15. Tam KY, Leung KC, Wang YX. Chemoembolization agents for cancer treatment. Eur J Pharm Sci 2011;44:1-10
16. Siskin GP, Dowling K, Virmani R, et al. Pathologic evaluation of a spherical polyvinyl alcohol embolic agent in a porcine renal model. J Vasc Interv Radiol 2003;14:89-98
17. Wu YN, Mng WJ, Liu YY, et al. Preparation and in vitro evaluation of gelatin microspheres for embolization. J Chin Pharm Sci 2012;21:242-50
18. Nicolini A, Crespi S, Martinetti L. Drug delivery embolization systems: a physician's perspective. Expert Opin Drug Deliv 2011;8:1071-84
19. Aliberti C, Tilli M, Benea G, et al. Trans-arterial chemoembolization (TACE) of liver metastases from colorectal cancer using irinotecan eluting beads: preliminary results. Anticancer Res 2006;26:3793-5
20. Tang Y, Taylor RR, Gonzalez MV, et al. Evaluation of irinotecan drug eluting beads: a new drug-device combination product for the chemoembolization of hepatic metastases. J Control Release 2006;116:e55-6
21. Martin RC, Robbins K, Tomalty D, et al. Transarterial chemoembolisation (TACE) using irinotecan-loaded beads for the treatment of unresectable metastases to the liver in patients with colorectal cancer: an interim report. World J Surg Oncol 2009;7:80
22. Borovac T, Pelage JP, Kasselouri A, et al. Release of ibuprofen from beads for embolization: in vitro and in vivo studies. J Control Release 2006;115:266-74
23. Sharma KV, Dreher MR, Tang Y, et al. Development of imageable beads for transcatheter embolotherapy. J Vasc Interv Radiol 2010;21:865-76
24. Bae YH, Park K. Targeted drug delivery to tumors: myths, reality and possibility. J Control Release 2011;153:198-205
25. Lammers T, Hennink WE, Storm G. Tumour-targeted nanomedicines: principles and practice. Br J Cancer 2008;99:392-7
26. Maeda H, Matsumura Y. Tumoritropic and lymphotropic principles of macromolecular drugs. Crit Rev Ther Drug Carrier Syst 1989;6:193-210
27. Matsumura Y, Maeda H. A new concept for macromolecular therapeutics in cancer-chemotherapy -mechanism of tumoritropic accumulation of proteins and the antitumor agent smancs. Cancer Res 1986;46:6387-92
28. Seymour LW. Passive tumor targeting of solublemacromolecules and drug conjugates. Crit Rev Ther Drug Carrier Syst 1992;9:135-87
29. Li L, Wang H, Ong ZY, et al. Polymerand lipid-based nanoparticle therapeutics for the treatment of liver diseases. Nano Today 2010;5:296-312
30. Lammers T, Kiessling F, Hennink WE, et al. Drug targeting to tumors: principles, pitfalls and (pre-) clinical progress. J Control Release 2012;161:175-87
31. Tadavarthy SM, Moller JH, Amplatz K. Polyvinyl alcohol (Ivalon) -a new embolic material. Am J Roentgenol Radium Ther Nucl Med 1975;125:609-16
32. Coldwell DM, Stokes KR, Yakes WF. Embolotherapy: agents, clinical applications, and techniques. Radiographics 1994;14:645-6
33. Kettenbach J, Stadler A, Katzler IV, et al. Drug-loaded microspheres for the treatment of liver cancer: review of current results. Cardiovasc Intervent Radiol 2008;31:468-76
34. Lee KH, Liapi E, Ventura VP, et al. Evaluation of different calibrated spherical polyvinyl alcohol microspheres in transcatheter arterial chemoembolization: VX2 tumor model in rabbit liver. J Vasc Interv Radiol 2008;19:1065-9
35. Liu Z, Cheung R, Wu XY, et al. A study of doxorubicin loading onto and release from sulfopropyl dextran ion-exchange microspheres. J Control Release 2001;77:213-24
36. Biondi M, Fusco S, Lewis AL, Netti PA. New insights into the mechanisms of the interactions between doxorubicin and the ion-exchange hydrogel DC Bead-for use in transarterial chemoembolization (TACE). J Biomater Sci Polym Ed 2012;23:333-54
37. Lewis AL, Holden RR. DC bead embolic drug-eluting bead: clinical application in the locoregional treatment of tumours. Expert Opin Drug Deliv 2011;8:153-69
38. Grosso M, Vignali C, Quaretti P, et al. Transarterial chemoembolization for hepatocellular carcinoma with drug-eluting microspheres: preliminary results from an Italian multicenter study. Cardiovasc Intervent Radiol 2008;31:1141-9
39. Jordan O, Denys A, De Baere T, et al. Comparative study of chemoembolization loadable beads: in vitro drug release and physical properties of DC bead and Hepasphere loaded with doxorubicin and irinotecan. J Vasc Interv Radiol 2010;21:1084-90
40. Lee K.H, Liapi EA, Cornell C, et al. Doxorubicin-loaded quadrasphere microspheres: plasma pharmacokinetics and intratumoral drug concentration in an animal model of liver cancer. Cardiovasc Interv Radiol 2010;33:576-82
41. Gupta S, Wright KC, Ensor J, et al. Hepatic arterial embolization with doxorubicin-loaded superabsorbent polymer microspheres in a rabbit liver tumor model. Cardiovasc Intervent Radiol 2011;34:1021-30
42. Rand T, Loewe C, Schoder M, et al. Arterial embolization of unresectable hepatocellular carcinoma with use of microspheres, lipiodol, and cyanoacrylate. Cardiovasc Intervent Radiol 2005;28:313-18
43. Georgiades CS, Hong K, D'Angelo M, et al. Safety and efficacy of transarterial chemoembolization in patients with unresectable hepatocellular carcinoma and portal vein thrombosis. J Vasc Interv Radiol 2005;16:1653-9
44. Bonomo G, Pedicini V, Monfardini L, et al. Bland embolization in patients with unresectable hepatocellular carcinoma using precise, tightly size-calibrated, anti-inflammatory microparticles: first clinical experience and one-year follow-up. Cardiovasc Intervent Radiol 2010;33:552-9
45. Verret V, Ghegediban SH, Wassef M, et al. The arterial distribution of Embozene and Embosphere microspheres in sheep kidney and uterus embolization models. J Vasc Interv Radiol 2011;22:220-8
46. Kirchhoff TD, Bleck JS, Dettmer A, et al. Transarterial chemoembolization using degradable starch microspheres and iodized oil in the treatment of advanced hepatocellular carcinoma: evaluation of tumor response, toxicity, and survival. Hepatobiliary Pancreat Dis Int 2007;6:259-66
47. Murata S, Tajima H, Ichikawa K, et al. Oily chemoembolization combined with degradable starch microspheres for HCC with cirrhosis. Hepatogastroenterology 2008;55:1041-6
48. Li BZ, Wang LJ, Li D, et al. Preparation and characterization of crosslinked starch microspheres using a two-stage water-in-water emulsion method. Carbohydr Polym 2012;88:912-16
49. Ichihara T, Sakamoto K, Moil K, et al. Transcatheter arterial chemoembolization therapy for hepatocellular carcinoma using polylactic acid microspheres containing aclarubicin hydrochloride. Cancer Res 1989;49:4357-62
50. Spenlehauer G, Vert M, Benoit JP, et al. Biodegradation cisplatin microspheres prepared by the solvent evaporation method: morphology and release characteristics. J Control Release 1988;7:217-29
51. Grandfils C, Flandroy P, Jerome R. Control of the biodegradation rate of poly(DL-lactide) microparticles intended as chemoembolization materials. J Control Release 1996;38:109-22
52. Okada H, Toguchi H. Biodegradable microspheres in drug delivery. Crit Rev Ther Drug Carrier Syst 1995;12:1-99
53. Liu ZK, Wei SL, Lan CQ, et al. Characteristics of CDDP-PLA microspheres in vitro and in vivo. Yao Xue Xue Bao 1993;28:792-7; Article in Chinese
54. Hariharan M, Price JC. Solvent, emulsifier and drug concentration factors in poly (D,L-lactic acid) microspheres containing hexamethylmelamine. J Microencapsul 2002;19:95-109
55. Burt HM, Jackson JK, Bains SK, et al. Controlled delivery of taxol from microspheres composed of a blend of ethylene-vinyl acetate copolymer and poly (D,L-lactic acid). Cancer Lett 1995;88:73-9
56. Liu X, Heng WS, Li Q, et al. Novel polymeric microspheres containing norcantharidin for chemoembolization. J Control Release 2006;116:35-41
57. Borchard G, Junginger HE. Modern drug delivery applications of chitosan. Adv Drug Deliv Rev 2001;52:103-50
58. Bonferoni MC, Giunchedi P, Scalia S, et al. Chitosan gels for the vaginal delivery of lactic acid: relevance of formulation parameters to mucoadhesion and release mechanisms. AAPS PharmSciTech 2006.7(4):article104 Available from: http://www.pharmscitech. com
59. Kim JS, Kwak BK, Shim HJ, et al. Preparation of doxorubicin-containing chitosan microspheres for transcatheter arterial chemoembolization of hepatocellular carcinoma. J Microencapsul 2007;24:408-19
60. Denkbas EB, Seyyal M, Piskin E. 5-fluorouracil loaded chitosan microspheres for chemoembolization. J Microencapsul 1999;16:741-9
61. Li S, Wang XT, Zhang XB, et al. Studies on alginate-chitosan microcapsules and renal arterial embolization in rabbits. J Control Release 2002;84:87-98
62. Erog?lu M, Kursakliog?lu H, Misirli Y, et al. Chitosan-coated alginate microspheres for embolization and/or chemoembolization: in vivo studies. J Microencapsul 2006;23:367-76
63. Misirli Y, Ozturk E, Kursakliog?lu H, et al. Preparation and characterization of Mitomycin-C loaded chitosan-coated alginate microspheres for chemoembolization. J Microencapsul 2005;22:167-78
64. Kyotani S, Nishioka Y, Okamura M, et al. A study of embolizing materials for chemo-embolization therapy of hepatocellular carcinoma: antitumor effect of cis-diamminedichloroplatinum (II) albumin microspheres, containing chitin and treated with chitosan on rabbits with VX2 hepatic tumors. Chem Pharm Bull 1992;40:2814-16
65. Nishioka Y, Kyotani S, Okamura M, et al. A study of embolizing materials for chemo-embolization therapy of hepatocellular carcinoma: embolic effect of cisplatin albumin microspheres using chitin and chitosan in dogs, and changes of cisplatin content in blood and tissue. Chem Pharm Bull 1992;40:267-8
66. Weng L, Le HC, Lin J, et al. Doxorubicin loading and eluting characteristics of bioresorbable hydrogel microspheres: in vitro study. Int J Pharm 2001;409:185-93.
67. Weng L, Le HC, Talaie R, et al. Bioresorbable hydrogel microspheres for transcatheter embolization: preparation and in vitro evaluation. J Vasc Interv Radiol 2011b;22:1464-70
68. Schwarz A, Zhang H, Metcalfe A, et al. Transcatheter embolization using degradable crosslinked hydrogels. Biomaterials 2004;25:5209-15
69. Kim JH, Chung JW, Han JK, et al. Transcatheter arterial embolization of the internal mammary artery in hepatocellular carcinoma. J Vasc Interv Radiol 1995;6:75-7
70. Kanematsu T, Inokuchi K, Sugimachi K, et al. Selective effects of lipiodolized antitumor agents. J Surg Oncol 1984;25:218-26
71. Nakamura H, Hashimoto T, Oi H, et al. Transcatheter oily chemoembolization of hepatocellular carcinoma. Radiology 1989;170:783-6
72. Bhattacharya S, Novell JR, Winslet MC, et al. Iodized oil in the treatment of hepatocellular carcinoma. Br J Surg 1994;81:1563-71
73. Abada HT, Jafar G. Gelatine sponge particles: handling characteristics for endovascular use. Tech Vasc Interv Radiol 2007;10:257-60
74. Sonomura T. Optimal size of embolic material in transcatheter arterial embolization of the liver. Nippon Igaku Hoshasen Gakkai Zasshi 1994;54:489-99
75. Yamashita N, Saitou K, Takagi A, et al. Preparation and characterization of gelatin sponge millispheres injectable through microcatheters. Med Devices Evid Res 2009;2:19-25
76. Tabata Y, Ikada Y. Synthesis of gelatin microspheres containing interferon. Pharm Res 1989;6:422-7
77. Makuuchi M, Sukigara M, Mori T, et al. Bile duct necrosis: complication of transcatheter hepatic arterial embolization. Radiology 1985;156:331-4
78. Chan AO, Yuen MF, Hui CK, et al. A prospective study regarding the complications of transcatheter intraarterial lipiodol chemoembolization in patients with hepatocellular carcinoma. Cancer 2002;94:1747-52
79. Nitta N, Shinichi O, Toyohiko T, et al. Gelatin microspheres: initial clinical experience for the transcatheter arterial embolization. Eur J Radiol 2008;67:536-40
80. Ohta S, Nitta N, Sonoda A, et al. Prolonged local persistence of cisplatin-loaded gelatin microspheres and their chemoembolic anti-cancer effect in rabbits. Eur J Radiol 2009;72:534-40
81. Louail B, Sapoval M, Bonneau M, et al. A new porcine sponge material for temporary embolization: an experimental short-term pilot study in swine. Cardiovasc Intervent Radiol 2006;29:826-31
82. Lee KH, Liapi E, Vossen JA, et al. Arterial embolization in an animal model of liver cancer: evaluation with MR Imaging and implication for therapy. J Vasc Interv Radiol 2008;19:1490-6
83. Saralidze K, Knetsch MLW, van Hooy-Corstjens CSJ, et al. Radio-opaque and surface-functionalozed polymer microparticles: potentially safer biomaterials for different injection therapies. Biomacromolecules 2006;7:2991-6
84. Saralidze K, Knetsch ML, van Berkel RG, et al. Radiopaque microspheres for improved transarterial chemical embolization (TACE). J Control Release 2011;152(Suppl 1):74-5
85. Pouponneau P, Leroux J-C, Martel S. Magnetic nanoparticles encapsulated into biodegradable microparticles steered with an upgraded magnetic resonance imaging system for tumor chemoembolization. Biomaterials 2009;30:6327-32