Hepatocellular carcinoma dually-targeted nanoparticles for reduction triggered intracellular delivery of doxorubicin

International Journal of Pharmaceutics

Volumn 478, Issue 2, 2015, Pages 553-568

  Mezghrani, Omar ^a   Tang, Yue ^a   Ke, Xue ^a   Chen, Yi ^a   Hu, Danrong ^a   Tu, Jiasheng ^a   Zhao, Li ^a   Bourkaib, Nadia ^a  

^a CHINA PHARMACEUTICAL UNIVERSITY   (China)

Author keywords

Antitumor efficacy; Dual ligand targeting; Glycyrrhetinic acid; Hepatocellular carcinoma targeting; Hyaluronic acid; Redox responsive

Indexed keywords

DOXORUBICIN; GLUTATHIONE; GLYCYRRHETINIC ACID; HYALURONIC ACID; HYALURONIC ACID CYSTAMINE GLYCYRRHETINIC NANOPARTICEL; HYALURONIC ACID ETHYLENEDIAMINE GLYCYRRHETINIC NANOPARTICLE; NANOPARTICLE; UNCLASSIFIED DRUG; ANTINEOPLASTIC AGENT; HYALURONIC ACID CYSTAMINE GLYCYRRHETINIC ACID CONJUGATE DOXORUBICIN NANOPARTICLE; HYALURONIC ACID ETHYLENEDIAMINE GLYCYRRHETINIC ACID CONJUGATE DOXORUBICIN NANOPARTICLE; ANTINEOPLASTIC ANTIBIOTIC; CYSTAMINE; EDETIC ACID;

ANIMAL EXPERIMENT; ANIMAL MODEL; ANTINEOPLASTIC ACTIVITY; ARTICLE; BREAST CANCER; CANCER CELL; CONFOCAL LASER MICROSCOPY; CONJUGATE; CONTROLLED STUDY; DRUG CONJUGATION; DRUG DELIVERY SYSTEM; DRUG DISTRIBUTION; DRUG RELEASE; HEPATOCELLULAR CARCINOMA CELL LINE; HEPATOMA CELL; HEPG2 CELL LINE; HUMAN; HUMAN CELL; HYDROPHOBICITY; IC50; IN VITRO STUDY; IN VIVO STUDY; INFRARED SPECTROSCOPY; INTRACELLULAR DELIVERY; LIGHT SCATTERING; LIVER CELL CARCINOMA; MALE; NANOENCAPSULATION; NONHUMAN; OXIDATION REDUCTION POTENTIAL; PARTICLE SIZE; PROTON NUCLEAR MAGNETIC RESONANCE; ROOM TEMPERATURE; TUMOR VOLUME; TUMOR XENOGRAFT; ZETA POTENTIAL; ANIMAL CELL; BREAST CANCER CELL LINE; CELL LABELING; CYTOTOXICITY; DRUG POTENCY; MOUSE; NEAR INFRARED SPECTROSCOPY; PRIORITY JOURNAL; ANIMAL; CARCINOMA, HEPATOCELLULAR; CHEMISTRY; DRUG EFFECTS; DRUG SCREENING; ENDOCYTOSIS; LIVER NEOPLASMS; NUDE MOUSE; OXIDATION REDUCTION REACTION; PATHOLOGY; TUMOR CELL LINE;

ANIMALS; ANTIBIOTICS, ANTINEOPLASTIC; CARCINOMA, HEPATOCELLULAR; CELL LINE, TUMOR; CYSTAMINE; DOXORUBICIN; DRUG LIBERATION; EDETIC ACID; ENDOCYTOSIS; GLYCYRRHETINIC ACID; HUMANS; HYALURONIC ACID; LIVER NEOPLASMS; MICE, NUDE; NANOPARTICLES; OXIDATION-REDUCTION; TUMOR BURDEN; XENOGRAFT MODEL ANTITUMOR ASSAYS;

EID: 84917711148     PISSN: 03785173     EISSN: 18733476     Source Type: Journal    
DOI: 10.1016/j.ijpharm.2014.10.041     Document Type: Article

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