Glycyrrhetinic acid-modified chitosan/poly(ethylene glycol) nanoparticles for liver-targeted delivery

Biomaterials

Volumn 31, Issue 17, 2010, Pages 4748-4756

  Tian, Qin ^a   Zhang, Chuang Nian ^a   Wang, Xiu Hua ^a   Wang, Wei ^a   Huang, Wei ^a   Cha, Rui Tao ^a   Wang, Chun Hong ^a   Yuan, Zhi ^a   Liu, Min ^b   Wan, Hai Ying ^b   Tang, Hua ^b  

^a NANKAI UNIVERSITY   (China)

^b TIANJIN MEDICAL UNIVERSITY   (China)

Author keywords

Chitosan; Glycyrrhetinic acid; Liver targeting; Poly(ethylene glycol)

Indexed keywords

BIODISTRIBUTIONS; CELLULAR UPTAKE; CYTOTOXIC; DOXORUBICIN; GELATION PROCESS; GLYCYRRHETINIC ACID; HEPATIC CARCINOMA; IN-VITRO; INHIBITORY CONCENTRATION; NEOPLASTIC EFFECTS; TARGETED DELIVERY; TARGETED DRUG DELIVERY; TUMOR GROWTH; ZETA POTENTIAL MEASUREMENTS;

ACIDS; CHITIN; CHITOSAN; COAGULATION; COMPUTERIZED TOMOGRAPHY; DRUG DELIVERY; DYNAMIC LIGHT SCATTERING; ETHYLENE; ETHYLENE GLYCOL; GELATION; GENETIC ALGORITHMS; LIVER; MULTIPHOTON PROCESSES; POLYETHYLENE GLYCOLS; POLYETHYLENE OXIDES; SINGLE PHOTON EMISSION COMPUTED TOMOGRAPHY; ZETA POTENTIAL;

NANOPARTICLES;

CHITOSAN; DOXORUBICIN; GLYCYRRHETINIC ACID; GLYCYRRHIZIC ACID; MACROGOL; NANOPARTICLE;

ANIMAL EXPERIMENT; ANIMAL MODEL; ANTINEOPLASTIC ACTIVITY; ARTICLE; CONTROLLED STUDY; CYTOTOXICITY TEST; DRUG ACCUMULATION; DRUG DELIVERY SYSTEM; DRUG EXCRETION; DRUG HALF LIFE; DRUG STRUCTURE; DRUG TARGETING; GELATION; GROWTH INHIBITION; HUMAN; HUMAN CELL; IC 50; INFRARED SPECTROSCOPY; LIGHT SCATTERING; LIVER; LIVER TUMOR; MOUSE; NONHUMAN; PRIORITY JOURNAL; RAT; SINGLE PHOTON EMISSION COMPUTER TOMOGRAPHY; TUMOR GROWTH; ZETA POTENTIAL;

ANIMALS; CELL LINE, TUMOR; CHITOSAN; DOXORUBICIN; DRUG CARRIERS; GLYCYRRHETINIC ACID; HUMANS; INJECTIONS; LIVER; MICE; MICE, INBRED BALB C; MICE, NUDE; MICROSCOPY, ELECTRON, TRANSMISSION; NANOPARTICLES; POLYETHYLENE GLYCOLS; SPECTROSCOPY, FOURIER TRANSFORM INFRARED;

MUS;

EID: 77951057911     PISSN: 01429612     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.biomaterials.2010.02.042     Document Type: Article

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