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Volumn 35, Issue 11, 2014, Pages 556-566

Prodrug-based nanoparticulate drug delivery strategies for cancer therapy

Author keywords

cancer therapy; combination therapy; hybrid nanoassemblies; prodrug nanoassemblies; stimuli responsive

Indexed keywords

ANTINEOPLASTIC AGENT; CAMPTOTHECIN; CARBOHYDRATE; CHITOSAN; CISPLATIN; COPOLYMER; CURCUMIN; DOCETAXEL; DOXORUBICIN; ETOPOSIDE; FIRTECAN; FLUOROURACIL; GEMCITABINE; HEPARIN; HYALURONIC ACID; MACROGOL; MACROGOL 4000; METHOTREXATE; NANOPARTICLE; OXALIPLATIN; PACLITAXEL; POLYAMINOACID; POLYETHYLENE GLYCOL CYCLODEXTRIN COPOLYMER; POLYGLACTIN; POLYPEPTIDE; PRODRUG; PULLULAN; SALINOMYCIN; TIOGUANINE; UNCLASSIFIED DRUG; UNINDEXED DRUG; DRUG CARRIER;

EID: 84908362233     PISSN: 01656147     EISSN: 18733735     Source Type: Journal    
DOI: 10.1016/j.tips.2014.09.008     Document Type: Review
Times cited : (292)

References (110)
  • 1
    • 79953027196 scopus 로고    scopus 로고
    • Prodrug-based intracellular delivery of anticancer agents
    • L. Bildstein Prodrug-based intracellular delivery of anticancer agents Adv. Drug Deliv. Rev. 63 2011 3 23
    • (2011) Adv. Drug Deliv. Rev. , vol.63 , pp. 3-23
    • Bildstein, L.1
  • 2
    • 84888199558 scopus 로고    scopus 로고
    • Nanotechnology approaches for personalized treatment of multidrug resistant cancers
    • T. Minko Nanotechnology approaches for personalized treatment of multidrug resistant cancers Adv. Drug Deliv. Rev. 65 2013 1880 1895
    • (2013) Adv. Drug Deliv. Rev. , vol.65 , pp. 1880-1895
    • Minko, T.1
  • 3
    • 84896699451 scopus 로고    scopus 로고
    • Cancer nanotechnology: The impact of passive and active targeting in the era of modern cancer biology
    • N. Bertrand Cancer nanotechnology: the impact of passive and active targeting in the era of modern cancer biology Adv. Drug Deliv. Rev. 66 2014 2 25
    • (2014) Adv. Drug Deliv. Rev. , vol.66 , pp. 2-25
    • Bertrand, N.1
  • 4
    • 84887237617 scopus 로고    scopus 로고
    • Nanotechnology in cancer therapy
    • B. Aslan Nanotechnology in cancer therapy J. Drug Target. 21 2013 904 913
    • (2013) J. Drug Target. , vol.21 , pp. 904-913
    • Aslan, B.1
  • 5
    • 84872720942 scopus 로고    scopus 로고
    • The holistic 3 M modality of drug delivery nanosystems for cancer therapy
    • J. Sun The holistic 3 M modality of drug delivery nanosystems for cancer therapy Nanoscale 5 2013 845 859
    • (2013) Nanoscale , vol.5 , pp. 845-859
    • Sun, J.1
  • 6
    • 79960671231 scopus 로고    scopus 로고
    • Prodrugs - From serendipity to rational design
    • K.M. Huttunen Prodrugs - from serendipity to rational design Pharmacol. Rev. 63 2011 750 771
    • (2011) Pharmacol. Rev. , vol.63 , pp. 750-771
    • Huttunen, K.M.1
  • 7
    • 84885103639 scopus 로고    scopus 로고
    • Prodrug micelle-based nanomedicine for cancer treatment
    • Y. Mi Prodrug micelle-based nanomedicine for cancer treatment Nanomedicine 8 2013 1559 1562
    • (2013) Nanomedicine , vol.8 , pp. 1559-1562
    • Mi, Y.1
  • 8
    • 84893472129 scopus 로고    scopus 로고
    • Recent trends in the design of anticancer polymer prodrug nanocarriers
    • V. Delplace Recent trends in the design of anticancer polymer prodrug nanocarriers Polym. Chem. 5 2014 1529 1544
    • (2014) Polym. Chem. , vol.5 , pp. 1529-1544
    • Delplace, V.1
  • 9
    • 84869869313 scopus 로고    scopus 로고
    • A review of polysaccharide cytotoxic drug conjugates for cancer therapy
    • N. Goodarzi A review of polysaccharide cytotoxic drug conjugates for cancer therapy Carbohydr. Polym. 92 2013 1280 1293
    • (2013) Carbohydr. Polym. , vol.92 , pp. 1280-1293
    • Goodarzi, N.1
  • 10
    • 84862064067 scopus 로고    scopus 로고
    • Nanoparticles as delivery carriers for anticancer prodrugs
    • J.Y. Fang, and S.A. Al-Suwayeh Nanoparticles as delivery carriers for anticancer prodrugs Expert Opin. Drug Deliv. 9 2012 657 669
    • (2012) Expert Opin. Drug Deliv. , vol.9 , pp. 657-669
    • Fang, J.Y.1    Al-Suwayeh, S.A.2
  • 11
    • 84889086366 scopus 로고    scopus 로고
    • Polymer-drug conjugates: Present state of play and future perspectives
    • X. Pang Polymer-drug conjugates: present state of play and future perspectives Drug Discov. Today 18 2013 1316 1322
    • (2013) Drug Discov. Today , vol.18 , pp. 1316-1322
    • Pang, X.1
  • 12
    • 70349987594 scopus 로고    scopus 로고
    • Development of HPMA copolymer-anticancer conjugates: Clinical experience and lessons learnt
    • R. Duncan Development of HPMA copolymer-anticancer conjugates: clinical experience and lessons learnt Adv. Drug Deliv. Rev. 61 2009 1131 1148
    • (2009) Adv. Drug Deliv. Rev. , vol.61 , pp. 1131-1148
    • Duncan, R.1
  • 13
    • 80052517546 scopus 로고    scopus 로고
    • Biodegradable star HPMA polymer-drug conjugates: Biodegradability, distribution and anti-tumor efficacy
    • T. Etrych Biodegradable star HPMA polymer-drug conjugates: Biodegradability, distribution and anti-tumor efficacy J. Control. Release 154 2011 241 248
    • (2011) J. Control. Release , vol.154 , pp. 241-248
    • Etrych, T.1
  • 14
    • 77955252647 scopus 로고    scopus 로고
    • HPMA copolymer conjugates of paclitaxel and docetaxel with pH-controlled drug release
    • T. Etrych HPMA copolymer conjugates of paclitaxel and docetaxel with pH-controlled drug release Mol. Pharm. 7 2010 1015 1026
    • (2010) Mol. Pharm. , vol.7 , pp. 1015-1026
    • Etrych, T.1
  • 15
    • 79960522976 scopus 로고    scopus 로고
    • Self-assembling nanomicelles of a novel camptothecin prodrug engineered with a redox-responsive release mechanism
    • X.Q. Li Self-assembling nanomicelles of a novel camptothecin prodrug engineered with a redox-responsive release mechanism Chem. Commun. (Camb.) 47 2011 8647 8649
    • (2011) Chem. Commun. (Camb.) , vol.47 , pp. 8647-8649
    • Li, X.Q.1
  • 16
    • 70849096524 scopus 로고    scopus 로고
    • Novel anti-tumor strategy: PEG-hydroxycamptothecin conjugate loaded transferrin-PEG-nanoparticles
    • M. Hong Novel anti-tumor strategy: PEG-hydroxycamptothecin conjugate loaded transferrin-PEG-nanoparticles J. Control. Release 141 2010 22 29
    • (2010) J. Control. Release , vol.141 , pp. 22-29
    • Hong, M.1
  • 17
    • 84885716472 scopus 로고    scopus 로고
    • Enhanced anticancer activity of nanopreparation containing an MMP2-sensitive PEG-drug conjugate and cell-penetrating moiety
    • L. Zhu Enhanced anticancer activity of nanopreparation containing an MMP2-sensitive PEG-drug conjugate and cell-penetrating moiety Proc. Natl. Acad. Sci. U.S.A. 110 2013 17047 17052
    • (2013) Proc. Natl. Acad. Sci. U.S.A. , vol.110 , pp. 17047-17052
    • Zhu, L.1
  • 18
    • 84888355194 scopus 로고    scopus 로고
    • Polyprodrug amphiphiles: Hierarchical assemblies for shape-regulated cellular internalization, trafficking, and drug delivery
    • X. Hu Polyprodrug amphiphiles: hierarchical assemblies for shape-regulated cellular internalization, trafficking, and drug delivery J. Am. Chem. Soc. 135 2013 17617 17629
    • (2013) J. Am. Chem. Soc. , vol.135 , pp. 17617-17629
    • Hu, X.1
  • 19
    • 84877625601 scopus 로고    scopus 로고
    • Linear-dendritic drug conjugates forming long-circulating nanorods for cancer-drug delivery
    • Z. Zhou Linear-dendritic drug conjugates forming long-circulating nanorods for cancer-drug delivery Biomaterials 34 2013 5722 5735
    • (2013) Biomaterials , vol.34 , pp. 5722-5735
    • Zhou, Z.1
  • 20
    • 79960096264 scopus 로고    scopus 로고
    • Preclinical to clinical development of the novel camptothecin nanopharmaceutical CRLX101
    • S. Svenson Preclinical to clinical development of the novel camptothecin nanopharmaceutical CRLX101 J. Control. Release 153 2011 49 55
    • (2011) J. Control. Release , vol.153 , pp. 49-55
    • Svenson, S.1
  • 21
    • 33750549679 scopus 로고    scopus 로고
    • Novel SN-38-incorporating polymeric micelles, NK012, eradicate vascular endothelial growth factor-secreting bulky tumors
    • F. Koizumi Novel SN-38-incorporating polymeric micelles, NK012, eradicate vascular endothelial growth factor-secreting bulky tumors Cancer Res. 66 2011 10048 10056
    • (2011) Cancer Res. , vol.66 , pp. 10048-10056
    • Koizumi, F.1
  • 22
    • 84885172782 scopus 로고    scopus 로고
    • Targeted co-delivery of docetaxel, cisplatin and herceptin by vitamin e TPGS-cisplatin prodrug nanoparticles for multimodality treatment of cancer
    • Y. Mi Targeted co-delivery of docetaxel, cisplatin and herceptin by vitamin E TPGS-cisplatin prodrug nanoparticles for multimodality treatment of cancer J. Control. Release 169 2013 185 192
    • (2013) J. Control. Release , vol.169 , pp. 185-192
    • Mi, Y.1
  • 23
    • 84863565467 scopus 로고    scopus 로고
    • A prodrug strategy to deliver cisplatin(IV) and paclitaxel in nanomicelles to improve efficacy and tolerance
    • H. Xiao A prodrug strategy to deliver cisplatin(IV) and paclitaxel in nanomicelles to improve efficacy and tolerance Biomaterials 33 2012 6507 6519
    • (2012) Biomaterials , vol.33 , pp. 6507-6519
    • Xiao, H.1
  • 24
    • 75749101439 scopus 로고    scopus 로고
    • Polymer-cisplatin conjugate nanoparticles for acid-responsive drug delivery
    • S. Aryal Polymer-cisplatin conjugate nanoparticles for acid-responsive drug delivery ACS Nano 4 2010 251 258
    • (2010) ACS Nano , vol.4 , pp. 251-258
    • Aryal, S.1
  • 25
    • 84870714279 scopus 로고    scopus 로고
    • The potential of self-assembled, pH-responsive nanoparticles of mPEGylated peptide dendron-doxorubicin conjugates for cancer therapy
    • W. She The potential of self-assembled, pH-responsive nanoparticles of mPEGylated peptide dendron-doxorubicin conjugates for cancer therapy Biomaterials 34 2013 1613 1623
    • (2013) Biomaterials , vol.34 , pp. 1613-1623
    • She, W.1
  • 26
    • 84897887451 scopus 로고    scopus 로고
    • Core-cross-linked micellar nanoparticles from a linear-dendritic prodrug for dual-responsive drug delivery
    • Y. Zhang Core-cross-linked micellar nanoparticles from a linear-dendritic prodrug for dual-responsive drug delivery Polym. Chem. 5 2014 2801 2808
    • (2014) Polym. Chem. , vol.5 , pp. 2801-2808
    • Zhang, Y.1
  • 27
    • 80053983003 scopus 로고    scopus 로고
    • Acid-activatable prodrug nanogels for efficient intracellular doxorubicin release
    • F. Zhan Acid-activatable prodrug nanogels for efficient intracellular doxorubicin release Biomacromolecules 12 2011 3612 3620
    • (2011) Biomacromolecules , vol.12 , pp. 3612-3620
    • Zhan, F.1
  • 28
    • 77955768765 scopus 로고    scopus 로고
    • Core-crosslinked polymeric micelles with controlled release of covalently entrapped doxorubicin
    • M. Talelli Core-crosslinked polymeric micelles with controlled release of covalently entrapped doxorubicin Biomaterials 31 2010 7797 7804
    • (2010) Biomaterials , vol.31 , pp. 7797-7804
    • Talelli, M.1
  • 29
    • 0035816145 scopus 로고    scopus 로고
    • Development of the polymer micelle carrier system for doxorubicin
    • T. Nakanishi Development of the polymer micelle carrier system for doxorubicin J. Control. Release 74 2001 295 302
    • (2001) J. Control. Release , vol.74 , pp. 295-302
    • Nakanishi, T.1
  • 30
    • 84866158450 scopus 로고    scopus 로고
    • Co-delivery of daunomycin and oxaliplatin by biodegradable polymers for safer and more efficacious combination therapy
    • H. Xiao Co-delivery of daunomycin and oxaliplatin by biodegradable polymers for safer and more efficacious combination therapy J. Control. Release 163 2012 304 314
    • (2012) J. Control. Release , vol.163 , pp. 304-314
    • Xiao, H.1
  • 31
    • 84875799880 scopus 로고    scopus 로고
    • Poly (ethylene oxide)-block-polyphosphester-based paclitaxel conjugates as a platform for ultra-high paclitaxel-loaded multifunctional nanoparticles
    • S.Y. Zhang Poly (ethylene oxide)-block-polyphosphester-based paclitaxel conjugates as a platform for ultra-high paclitaxel-loaded multifunctional nanoparticles Chem. Sci. 4 2013 2122 2126
    • (2013) Chem. Sci. , vol.4 , pp. 2122-2126
    • Zhang, S.Y.1
  • 32
    • 84881563127 scopus 로고    scopus 로고
    • Acetal-linked paclitaxel prodrug micellar nanoparticles as a versatile and potent platform for cancer therapy
    • Y. Gu Acetal-linked paclitaxel prodrug micellar nanoparticles as a versatile and potent platform for cancer therapy Biomacromolecules 14 2013 2772 2780
    • (2013) Biomacromolecules , vol.14 , pp. 2772-2780
    • Gu, Y.1
  • 33
    • 84887697617 scopus 로고    scopus 로고
    • Photosensitive Pt(IV)-azide prodrug-loaded nanoparticles exhibit controlled drug release and enhanced efficacy in vivo
    • H. Xiao Photosensitive Pt(IV)-azide prodrug-loaded nanoparticles exhibit controlled drug release and enhanced efficacy in vivo J. Control. Release 173 2014 11 17
    • (2014) J. Control. Release , vol.173 , pp. 11-17
    • Xiao, H.1
  • 34
    • 84870216836 scopus 로고    scopus 로고
    • Reduction-sensitive thioguanine prodrug micelles
    • A.J. van der Vlies Reduction-sensitive thioguanine prodrug micelles Mol. Pharm. 9 2012 2812 2818
    • (2012) Mol. Pharm. , vol.9 , pp. 2812-2818
    • Van Der Vlies, A.J.1
  • 35
    • 84876484728 scopus 로고    scopus 로고
    • Hyaluronic acid-based nanogel-drug conjugates with enhanced anticancer activity designed for the targeting of CD44-positive and drug-resistant tumors
    • X. Wei Hyaluronic acid-based nanogel-drug conjugates with enhanced anticancer activity designed for the targeting of CD44-positive and drug-resistant tumors Bioconjug. Chem. 24 2013 658 668
    • (2013) Bioconjug. Chem. , vol.24 , pp. 658-668
    • Wei, X.1
  • 36
    • 84865654435 scopus 로고    scopus 로고
    • A docetaxel-carboxymethylcellulose nanoparticle outperforms the approved taxane nanoformulation, Abraxane, in mouse tumor models with significant control of metastases
    • M.J. Ernsting A docetaxel-carboxymethylcellulose nanoparticle outperforms the approved taxane nanoformulation, Abraxane, in mouse tumor models with significant control of metastases J. Control. Release 162 2012 575 581
    • (2012) J. Control. Release , vol.162 , pp. 575-581
    • Ernsting, M.J.1
  • 37
    • 83355169562 scopus 로고    scopus 로고
    • Preclinical pharmacokinetic, biodistribution, and anti-cancer efficacy studies of a docetaxel-carboxymethylcellulose nanoparticle in mouse models
    • M.J. Ernsting Preclinical pharmacokinetic, biodistribution, and anti-cancer efficacy studies of a docetaxel-carboxymethylcellulose nanoparticle in mouse models Biomaterials 33 2012 1445 1454
    • (2012) Biomaterials , vol.33 , pp. 1445-1454
    • Ernsting, M.J.1
  • 38
    • 84901981475 scopus 로고    scopus 로고
    • A prodrug strategy based on chitosan for efficient intracellular anticancer drug delivery
    • C. Chen A prodrug strategy based on chitosan for efficient intracellular anticancer drug delivery Nanotechnology 25 2014 255101
    • (2014) Nanotechnology , vol.25 , pp. 255101
    • Chen, C.1
  • 39
    • 84872395372 scopus 로고    scopus 로고
    • Dendronized heparin-doxorubicin conjugate based nanoparticle as pH-responsive drug delivery system for cancer therapy
    • W. She Dendronized heparin-doxorubicin conjugate based nanoparticle as pH-responsive drug delivery system for cancer therapy Biomaterials 34 2013 2252 2264
    • (2013) Biomaterials , vol.34 , pp. 2252-2264
    • She, W.1
  • 40
    • 84896397828 scopus 로고    scopus 로고
    • Tailored doxorubicin-hyaluronan conjugate as a potent anticancer glyco-drug: An alternative to prodrug approach
    • O.P. Oommen Tailored doxorubicin-hyaluronan conjugate as a potent anticancer glyco-drug: an alternative to prodrug approach Macromol. Biosci. 14 2013 327 333
    • (2013) Macromol. Biosci. , vol.14 , pp. 327-333
    • Oommen, O.P.1
  • 41
    • 84888637931 scopus 로고    scopus 로고
    • High drug loading pH-sensitive pullulan-DOX conjugate nanoparticles for hepatic targeting
    • H. Li High drug loading pH-sensitive pullulan-DOX conjugate nanoparticles for hepatic targeting J. Biomed. Mater. Res. A 102 2014 150 159
    • (2014) J. Biomed. Mater. Res. A , vol.102 , pp. 150-159
    • Li, H.1
  • 42
    • 84879600243 scopus 로고    scopus 로고
    • PH-sensitive pullulan-based nanoparticle carrier of methotrexate and combretastatin A4 for the combination therapy against hepatocellular carcinoma
    • Y. Wang pH-sensitive pullulan-based nanoparticle carrier of methotrexate and combretastatin A4 for the combination therapy against hepatocellular carcinoma Biomaterials 34 2013 7181 7190
    • (2013) Biomaterials , vol.34 , pp. 7181-7190
    • Wang, Y.1
  • 43
    • 72449141425 scopus 로고    scopus 로고
    • Heparin-paclitaxel conjugates as drug delivery system: Synthesis, self-assembly property, drug release, and antitumor activity
    • Y. Wang Heparin-paclitaxel conjugates as drug delivery system: synthesis, self-assembly property, drug release, and antitumor activity Bioconjug. Chem. 20 2009 2214 2221
    • (2009) Bioconjug. Chem. , vol.20 , pp. 2214-2221
    • Wang, Y.1
  • 44
    • 77949269580 scopus 로고    scopus 로고
    • The use of amino acid linkers in the conjugation of paclitaxel with hyaluronic acid as drug delivery system: Synthesis, self-assembled property, drug release, and in vitro efficiency
    • D. Xin The use of amino acid linkers in the conjugation of paclitaxel with hyaluronic acid as drug delivery system: synthesis, self-assembled property, drug release, and in vitro efficiency Pharm. Res. 27 2010 380 389
    • (2010) Pharm. Res. , vol.27 , pp. 380-389
    • Xin, D.1
  • 45
    • 70549101139 scopus 로고    scopus 로고
    • Self-assembling chimeric polypeptide-doxorubicin conjugate nanoparticles that abolish tumours after a single injection
    • J.A. MacKay Self-assembling chimeric polypeptide-doxorubicin conjugate nanoparticles that abolish tumours after a single injection Nat. Mater. 8 2009 993 999
    • (2009) Nat. Mater. , vol.8 , pp. 993-999
    • Mackay, J.A.1
  • 46
    • 84881669612 scopus 로고    scopus 로고
    • Biodegradable and amphiphilic block copolymer-doxorubicin conjugate as polymeric nanoscale drug delivery vehicle for breast cancer therapy
    • Y. Yang Biodegradable and amphiphilic block copolymer-doxorubicin conjugate as polymeric nanoscale drug delivery vehicle for breast cancer therapy Biomaterials 34 2013 8430 8443
    • (2013) Biomaterials , vol.34 , pp. 8430-8443
    • Yang, Y.1
  • 47
    • 84891553985 scopus 로고    scopus 로고
    • A facile approach for dual-responsive prodrug nanogels based on dendritic polyglycerols with minimal leaching
    • X. Zhang A facile approach for dual-responsive prodrug nanogels based on dendritic polyglycerols with minimal leaching J. Control. Release 174 2014 209 216
    • (2014) J. Control. Release , vol.174 , pp. 209-216
    • Zhang, X.1
  • 48
    • 84880814226 scopus 로고    scopus 로고
    • Smart pH-sensitive and temporal-controlled polymeric micelles for effective combination therapy of doxorubicin and disulfiram
    • X. Duan Smart pH-sensitive and temporal-controlled polymeric micelles for effective combination therapy of doxorubicin and disulfiram ACS Nano 7 2013 5858 5869
    • (2013) ACS Nano , vol.7 , pp. 5858-5869
    • Duan, X.1
  • 49
    • 84873390333 scopus 로고    scopus 로고
    • Nanoparticles with in vivo anticancer activity from polymer prodrug amphiphiles prepared by living radical polymerization
    • S. Harrisson Nanoparticles with in vivo anticancer activity from polymer prodrug amphiphiles prepared by living radical polymerization Angew. Chem. Int. Ed. Engl. 52 2013 1678 1682
    • (2013) Angew. Chem. Int. Ed. Engl. , vol.52 , pp. 1678-1682
    • Harrisson, S.1
  • 50
    • 84903289431 scopus 로고    scopus 로고
    • Significant tumor growth inhibition from naturally occurring lipid-containing polymer prodrug nanoparticles obtained by the drug-initiated method
    • A. Maksimenko Significant tumor growth inhibition from naturally occurring lipid-containing polymer prodrug nanoparticles obtained by the drug-initiated method Chem. Mater. 26 2014 3606 3609
    • (2014) Chem. Mater. , vol.26 , pp. 3606-3609
    • Maksimenko, A.1
  • 51
    • 84881566593 scopus 로고    scopus 로고
    • Polymer prodrug nanoparticles based on naturally occurring isoprenoid for anticancer therapy
    • D. Trung Bui Polymer prodrug nanoparticles based on naturally occurring isoprenoid for anticancer therapy Biomacromolecules 14 2013 2837 2847
    • (2013) Biomacromolecules , vol.14 , pp. 2837-2847
    • Trung Bui, D.1
  • 52
    • 84896781593 scopus 로고    scopus 로고
    • Tailor-made gemcitabine prodrug nanoparticles from well-defined drug-polymer amphiphiles prepared by controlled living radical polymerization for cancer chemotherapy
    • W. Wang Tailor-made gemcitabine prodrug nanoparticles from well-defined drug-polymer amphiphiles prepared by controlled living radical polymerization for cancer chemotherapy J. Mater. Chem. B 2 2014 1891 1901
    • (2014) J. Mater. Chem. B , vol.2 , pp. 1891-1901
    • Wang, W.1
  • 53
    • 79958788003 scopus 로고    scopus 로고
    • Polymeric micelles with water-insoluble drug as hydrophobic moiety for drug delivery
    • G. Li Polymeric micelles with water-insoluble drug as hydrophobic moiety for drug delivery Biomacromolecules 12 2011 2016 2026
    • (2011) Biomacromolecules , vol.12 , pp. 2016-2026
    • Li, G.1
  • 54
    • 84889243226 scopus 로고    scopus 로고
    • Design, synthesis and biological assessment of a triazine dendrimer with approximately 16 paclitaxel groups and 8 PEG groups
    • C. Lee Design, synthesis and biological assessment of a triazine dendrimer with approximately 16 paclitaxel groups and 8 PEG groups Mol. Pharm. 10 2013 4452 4461
    • (2013) Mol. Pharm. , vol.10 , pp. 4452-4461
    • Lee, C.1
  • 55
    • 84862618443 scopus 로고    scopus 로고
    • Effect of molecular weight of PGG-paclitaxel conjugates on in vitro and in vivo efficacy
    • D. Yang Effect of molecular weight of PGG-paclitaxel conjugates on in vitro and in vivo efficacy J. Control. Release 161 2012 124 131
    • (2012) J. Control. Release , vol.161 , pp. 124-131
    • Yang, D.1
  • 56
    • 79956113396 scopus 로고    scopus 로고
    • Nanobody-shell functionalized thermosensitive core-crosslinked polymeric micelles for active drug targeting
    • M. Talelli Nanobody-shell functionalized thermosensitive core-crosslinked polymeric micelles for active drug targeting J. Control. Release 151 2011 183 192
    • (2011) J. Control. Release , vol.151 , pp. 183-192
    • Talelli, M.1
  • 57
    • 77958073029 scopus 로고    scopus 로고
    • Phase i study of NK012, a novel SN-38-incorporating micellar nanoparticle, in adult patients with solid tumors
    • T. Hamaguchi Phase I study of NK012, a novel SN-38-incorporating micellar nanoparticle, in adult patients with solid tumors Clin. Cancer Res. 16 2010 5058 5066
    • (2010) Clin. Cancer Res. , vol.16 , pp. 5058-5066
    • Hamaguchi, T.1
  • 58
    • 10844293438 scopus 로고    scopus 로고
    • Phase i clinical trial and pharmacokinetic evaluation of NK911, a micelle-encapsulated doxorubicin
    • Y. Matsumura Phase I clinical trial and pharmacokinetic evaluation of NK911, a micelle-encapsulated doxorubicin Br. J. Cancer 91 2004 1775 1781
    • (2004) Br. J. Cancer , vol.91 , pp. 1775-1781
    • Matsumura, Y.1
  • 59
    • 84874614722 scopus 로고    scopus 로고
    • Supramolecular nanostructures formed by anticancer drug assembly
    • A.G. Cheetham Supramolecular nanostructures formed by anticancer drug assembly J. Am. Chem. Soc. 135 2013 2907 2910
    • (2013) J. Am. Chem. Soc. , vol.135 , pp. 2907-2910
    • Cheetham, A.G.1
  • 60
    • 77950248056 scopus 로고    scopus 로고
    • Prodrugs forming high drug loading multifunctional nanocapsules for intracellular cancer drug delivery
    • Y. Shen Prodrugs forming high drug loading multifunctional nanocapsules for intracellular cancer drug delivery J. Am. Chem. Soc. 132 2010 4259 4265
    • (2010) J. Am. Chem. Soc. , vol.132 , pp. 4259-4265
    • Shen, Y.1
  • 61
    • 84880139404 scopus 로고    scopus 로고
    • Tumor redox heterogeneity-responsive prodrug nanocapsules for cancer chemotherapy
    • J. Wang Tumor redox heterogeneity-responsive prodrug nanocapsules for cancer chemotherapy Adv. Mater. 25 2013 3670 3676
    • (2013) Adv. Mater. , vol.25 , pp. 3670-3676
    • Wang, J.1
  • 62
    • 84872767316 scopus 로고    scopus 로고
    • Novel SN38 conjugate-forming nanoparticles as anticancer prodrug: In vitro and in vivo studies
    • H. Zhang Novel SN38 conjugate-forming nanoparticles as anticancer prodrug: in vitro and in vivo studies J. Control. Release 166 2013 147 158
    • (2013) J. Control. Release , vol.166 , pp. 147-158
    • Zhang, H.1
  • 63
    • 77956079868 scopus 로고    scopus 로고
    • Amphiphilic curcumin conjugate-forming nanoparticles as anticancer prodrug and drug carriers: In vitro and in vivo effects
    • H. Tang Amphiphilic curcumin conjugate-forming nanoparticles as anticancer prodrug and drug carriers: in vitro and in vivo effects Nanomedicine 5 2010 855 865
    • (2010) Nanomedicine , vol.5 , pp. 855-865
    • Tang, H.1
  • 64
    • 84892710202 scopus 로고    scopus 로고
    • Self-assembling doxorubicin-tocopherol succinate prodrug as a new drug delivery system: Synthesis, characterization, and in vitro and in vivo Anticancer Activity
    • N. Duhem Self-assembling doxorubicin-tocopherol succinate prodrug as a new drug delivery system: synthesis, characterization, and in vitro and in vivo Anticancer Activity Bioconjug. Chem. 25 2013 72 81
    • (2013) Bioconjug. Chem. , vol.25 , pp. 72-81
    • Duhem, N.1
  • 65
    • 84892390177 scopus 로고    scopus 로고
    • Multi-functional envelope-type nanoparticles assembled from amphiphilic peptidic prodrug with improved anti-tumor activity
    • J.X. Chen Multi-functional envelope-type nanoparticles assembled from amphiphilic peptidic prodrug with improved anti-tumor activity ACS Appl. Mater. Interfaces 6 2014 593 598
    • (2014) ACS Appl. Mater. Interfaces , vol.6 , pp. 593-598
    • Chen, J.X.1
  • 66
    • 84876522847 scopus 로고    scopus 로고
    • Self-assembling doxorubicin prodrug forming nanoparticles for cancer chemotherapy: Synthesis and anticancer study in vitro and in vivo
    • P. Gou Self-assembling doxorubicin prodrug forming nanoparticles for cancer chemotherapy: synthesis and anticancer study in vitro and in vivo J. Mater. Chem. B 1 2013 284 292
    • (2013) J. Mater. Chem. B , vol.1 , pp. 284-292
    • Gou, P.1
  • 67
    • 84878239593 scopus 로고    scopus 로고
    • Polyisoprenoyl gemcitabine conjugates self assemble as nanoparticles, useful for cancer therapy
    • A. Maksimenko Polyisoprenoyl gemcitabine conjugates self assemble as nanoparticles, useful for cancer therapy Cancer Lett. 334 2013 346 353
    • (2013) Cancer Lett. , vol.334 , pp. 346-353
    • Maksimenko, A.1
  • 68
    • 84899122590 scopus 로고    scopus 로고
    • Multifunctional squalene-based prodrug nanoparticles for targeted cancer therapy
    • D.T. Bui Multifunctional squalene-based prodrug nanoparticles for targeted cancer therapy Chem. Commun. (Camb.) 50 2014 5336 5338
    • (2014) Chem. Commun. (Camb.) , vol.50 , pp. 5336-5338
    • Bui, D.T.1
  • 69
    • 79951933087 scopus 로고    scopus 로고
    • Squalene based nanocomposites: A new platform for the design of multifunctional pharmaceutical theragnostics
    • J.L. Arias Squalene based nanocomposites: a new platform for the design of multifunctional pharmaceutical theragnostics ACS Nano 5 2011 1513 1521
    • (2011) ACS Nano , vol.5 , pp. 1513-1521
    • Arias, J.L.1
  • 70
    • 84893435854 scopus 로고    scopus 로고
    • Combined antitumoral therapy with nanoassemblies of bolaform polyisoprenoyl paclitaxel/gemcitabine prodrugs
    • J. Caron Combined antitumoral therapy with nanoassemblies of bolaform polyisoprenoyl paclitaxel/gemcitabine prodrugs Polym. Chem. 5 2014 1662 1673
    • (2014) Polym. Chem. , vol.5 , pp. 1662-1673
    • Caron, J.1
  • 71
    • 84879608357 scopus 로고    scopus 로고
    • Improving the antitumor activity of squalenoyl-paclitaxel conjugate nanoassemblies by manipulating the linker between paclitaxel and squalene
    • J. Caron Improving the antitumor activity of squalenoyl-paclitaxel conjugate nanoassemblies by manipulating the linker between paclitaxel and squalene Adv. Healthc. Mater. 2 2013 172 185
    • (2013) Adv. Healthc. Mater. , vol.2 , pp. 172-185
    • Caron, J.1
  • 72
    • 84888621127 scopus 로고    scopus 로고
    • Novel isoprenoyl nanoassembled prodrug for paclitaxel delivery
    • S. Mura Novel isoprenoyl nanoassembled prodrug for paclitaxel delivery Bioconjug. Chem. 24 2013 1840 1849
    • (2013) Bioconjug. Chem. , vol.24 , pp. 1840-1849
    • Mura, S.1
  • 73
    • 82855172119 scopus 로고    scopus 로고
    • A paclitaxel-conjugated adenovirus vector for targeted drug delivery for tumor therapy
    • L. Shan A paclitaxel-conjugated adenovirus vector for targeted drug delivery for tumor therapy Biomaterials 33 2012 146 162
    • (2012) Biomaterials , vol.33 , pp. 146-162
    • Shan, L.1
  • 74
    • 84862676788 scopus 로고    scopus 로고
    • Squalenoylation: A generic platform for nanoparticular drug delivery
    • D. Desmaele Squalenoylation: a generic platform for nanoparticular drug delivery J. Control. Release 161 2012 609 618
    • (2012) J. Control. Release , vol.161 , pp. 609-618
    • Desmaele, D.1
  • 75
    • 77953288528 scopus 로고    scopus 로고
    • Development of a weak-base docetaxel derivative that can be loaded into lipid nanoparticles
    • I.V. Zhigaltsev Development of a weak-base docetaxel derivative that can be loaded into lipid nanoparticles J. Control. Release 144 2010 332 340
    • (2010) J. Control. Release , vol.144 , pp. 332-340
    • Zhigaltsev, I.V.1
  • 76
    • 84896341106 scopus 로고    scopus 로고
    • Particle replication in nonwetting templates nanoparticles with tumor selective alkyl silyl ether docetaxel prodrug reduces toxicity
    • K.S. Chu Particle replication in nonwetting templates nanoparticles with tumor selective alkyl silyl ether docetaxel prodrug reduces toxicity Nano Lett. 14 2014 1472 1476
    • (2014) Nano Lett. , vol.14 , pp. 1472-1476
    • Chu, K.S.1
  • 77
    • 0035816156 scopus 로고    scopus 로고
    • Tumour targeted delivery of encapsulated dextran-doxorubicin conjugate using chitosan nanoparticles as carrier
    • S. Mitra Tumour targeted delivery of encapsulated dextran-doxorubicin conjugate using chitosan nanoparticles as carrier J. Control. Release 74 2001 317 323
    • (2001) J. Control. Release , vol.74 , pp. 317-323
    • Mitra, S.1
  • 78
    • 37249015356 scopus 로고    scopus 로고
    • Incorporation of novel 1-alkylcarbonyloxymethyl prodrugs of 5-fluorouracil into poly(lactide-co-glycolide) nanoparticles
    • P.A. McCarron, and M. Hall Incorporation of novel 1-alkylcarbonyloxymethyl prodrugs of 5-fluorouracil into poly(lactide-co-glycolide) nanoparticles Int. J. Pharm. 348 2008 115 124
    • (2008) Int. J. Pharm. , vol.348 , pp. 115-124
    • McCarron, P.A.1    Hall, M.2
  • 79
    • 84860860410 scopus 로고    scopus 로고
    • Incorporation and controlled release of silyl ether prodrugs from PRINT nanoparticles
    • M.C. Parrott Incorporation and controlled release of silyl ether prodrugs from PRINT nanoparticles J. Am. Chem. Soc. 134 2012 7978 7982
    • (2012) J. Am. Chem. Soc. , vol.134 , pp. 7978-7982
    • Parrott, M.C.1
  • 80
    • 79953243155 scopus 로고    scopus 로고
    • Preparation and characterization of polymeric pH-sensitive STEALTH(R) nanoparticles for tumor delivery of a lipophilic prodrug of paclitaxel
    • B.B. Lundberg Preparation and characterization of polymeric pH-sensitive STEALTH(R) nanoparticles for tumor delivery of a lipophilic prodrug of paclitaxel Int. J. Pharm. 408 2011 208 212
    • (2011) Int. J. Pharm. , vol.408 , pp. 208-212
    • Lundberg, B.B.1
  • 81
    • 38049110236 scopus 로고    scopus 로고
    • Paclitaxel prodrugs with sustained release and high solubility in poly(ethylene glycol)-b-poly(epsilon-caprolactone) micelle nanocarriers: Pharmacokinetic disposition, tolerability, and cytotoxicity
    • M.L. Forrest Paclitaxel prodrugs with sustained release and high solubility in poly(ethylene glycol)-b-poly(epsilon-caprolactone) micelle nanocarriers: pharmacokinetic disposition, tolerability, and cytotoxicity Pharm. Res. 25 2008 194 206
    • (2008) Pharm. Res. , vol.25 , pp. 194-206
    • Forrest, M.L.1
  • 82
    • 17644366858 scopus 로고    scopus 로고
    • A folate receptor-targeted lipid nanoparticle formulation for a lipophilic paclitaxel prodrug
    • P.J. Stevens A folate receptor-targeted lipid nanoparticle formulation for a lipophilic paclitaxel prodrug Pharm. Res. 21 2004 2153 2157
    • (2004) Pharm. Res. , vol.21 , pp. 2153-2157
    • Stevens, P.J.1
  • 83
    • 84886753316 scopus 로고    scopus 로고
    • Enhanced cytotoxicity to cancer cells by mitochondria-targeting MWCNTs containing platinum(IV) prodrug of cisplatin
    • S.L. Yoong Enhanced cytotoxicity to cancer cells by mitochondria-targeting MWCNTs containing platinum(IV) prodrug of cisplatin Biomaterials 35 2014 748 759
    • (2014) Biomaterials , vol.35 , pp. 748-759
    • Yoong, S.L.1
  • 84
    • 84882677746 scopus 로고    scopus 로고
    • Cyclodextrin capped gold nanoparticles as a delivery vehicle for a prodrug of cisplatin
    • Y. Shi Cyclodextrin capped gold nanoparticles as a delivery vehicle for a prodrug of cisplatin Inorg. Chem. 52 2013 9418 9426
    • (2013) Inorg. Chem. , vol.52 , pp. 9418-9426
    • Shi, Y.1
  • 85
    • 79952165883 scopus 로고    scopus 로고
    • Targeted delivery of a cisplatin prodrug for safer and more effective prostate cancer therapy in vivo
    • S. Dhar Targeted delivery of a cisplatin prodrug for safer and more effective prostate cancer therapy in vivo Proc. Natl. Acad. Sci. U.S.A. 108 2011 1850 1855
    • (2011) Proc. Natl. Acad. Sci. U.S.A. , vol.108 , pp. 1850-1855
    • Dhar, S.1
  • 86
    • 84887443743 scopus 로고    scopus 로고
    • Enhancing tumor cell response to chemotherapy through nanoparticle-mediated codelivery of siRNA and cisplatin prodrug
    • X. Xu Enhancing tumor cell response to chemotherapy through nanoparticle-mediated codelivery of siRNA and cisplatin prodrug Proc. Natl. Acad. Sci. U.S.A. 110 2013 18638 18643
    • (2013) Proc. Natl. Acad. Sci. U.S.A. , vol.110 , pp. 18638-18643
    • Xu, X.1
  • 87
    • 84870218444 scopus 로고    scopus 로고
    • Conjugate of Pt(IV)-histone deacetylase inhibitor as a prodrug for cancer chemotherapy
    • J. Yang Conjugate of Pt(IV)-histone deacetylase inhibitor as a prodrug for cancer chemotherapy Mol. Pharm. 9 2012 2793 2800
    • (2012) Mol. Pharm. , vol.9 , pp. 2793-2800
    • Yang, J.1
  • 88
    • 84864646989 scopus 로고    scopus 로고
    • Alpha(V)beta(3) integrin-targeted PLGA-PEG nanoparticles for enhanced anti-tumor efficacy of a Pt(IV) prodrug
    • N. Graf alpha(V)beta(3) integrin-targeted PLGA-PEG nanoparticles for enhanced anti-tumor efficacy of a Pt(IV) prodrug ACS Nano 6 2012 4530 4539
    • (2012) ACS Nano , vol.6 , pp. 4530-4539
    • Graf, N.1
  • 89
    • 78149260773 scopus 로고    scopus 로고
    • Engineering of self-assembled nanoparticle platform for precisely controlled combination drug therapy
    • N. Kolishetti Engineering of self-assembled nanoparticle platform for precisely controlled combination drug therapy Proc. Natl. Acad. Sci. U.S.A. 107 2010 17939 17944
    • (2010) Proc. Natl. Acad. Sci. U.S.A. , vol.107 , pp. 17939-17944
    • Kolishetti, N.1
  • 90
    • 84890645415 scopus 로고    scopus 로고
    • In vivo multimodality imaging and cancer therapy by near-infrared light-triggered trans-platinum pro-drug-conjugated upconversion nanoparticles
    • Y. Dai In vivo multimodality imaging and cancer therapy by near-infrared light-triggered trans-platinum pro-drug-conjugated upconversion nanoparticles J. Am. Chem. Soc. 135 2013 18920 18929
    • (2013) J. Am. Chem. Soc. , vol.135 , pp. 18920-18929
    • Dai, Y.1
  • 91
    • 84891862865 scopus 로고    scopus 로고
    • Enhanced splicing correction effect by an oligo-aspartic acid-PNA conjugate and cationic carrier complexes
    • Y.M. Bae Enhanced splicing correction effect by an oligo-aspartic acid-PNA conjugate and cationic carrier complexes J. Control. Release 175 2014 54 62
    • (2014) J. Control. Release , vol.175 , pp. 54-62
    • Bae, Y.M.1
  • 92
    • 44949198237 scopus 로고    scopus 로고
    • Modulating the therapeutic activity of nanoparticle delivered paclitaxel by manipulating the hydrophobicity of prodrug conjugates
    • S.M. Ansell Modulating the therapeutic activity of nanoparticle delivered paclitaxel by manipulating the hydrophobicity of prodrug conjugates J. Med. Chem. 51 2008 3288 3296
    • (2008) J. Med. Chem. , vol.51 , pp. 3288-3296
    • Ansell, S.M.1
  • 93
    • 84881454232 scopus 로고    scopus 로고
    • Functional block copolymer assemblies responsive to tumor and intracellular microenvironments for site-specific drug delivery and enhanced imaging performance
    • Z. Ge, and S. Liu Functional block copolymer assemblies responsive to tumor and intracellular microenvironments for site-specific drug delivery and enhanced imaging performance Chem. Soc. Rev. 42 2013 7289 7325
    • (2013) Chem. Soc. Rev. , vol.42 , pp. 7289-7325
    • Ge, Z.1    Liu, S.2
  • 94
    • 84904413273 scopus 로고    scopus 로고
    • Engineering responsive polymer building blocks with host-guest molecular recognition for functional applications
    • J. Hu, and S. Liu Engineering responsive polymer building blocks with host-guest molecular recognition for functional applications Acc. Chem. Res. 47 2014 2084 2095
    • (2014) Acc. Chem. Res. , vol.47 , pp. 2084-2095
    • Hu, J.1    Liu, S.2
  • 95
    • 84888206128 scopus 로고    scopus 로고
    • Reversal of multidrug resistance by stimuli-responsive drug delivery systems for therapy of tumor
    • Q. Yin Reversal of multidrug resistance by stimuli-responsive drug delivery systems for therapy of tumor Adv. Drug Deliv. Rev. 65 2013 1699 1715
    • (2013) Adv. Drug Deliv. Rev. , vol.65 , pp. 1699-1715
    • Yin, Q.1
  • 96
    • 84873325849 scopus 로고    scopus 로고
    • Self-assembly of thermally responsive nanoparticles of a genetically encoded peptide polymer by drug conjugation
    • J.R. McDaniel Self-assembly of thermally responsive nanoparticles of a genetically encoded peptide polymer by drug conjugation Angew. Chem. Int. Ed. Engl. 52 2013 1683 1687
    • (2013) Angew. Chem. Int. Ed. Engl. , vol.52 , pp. 1683-1687
    • McDaniel, J.R.1
  • 97
    • 77954926895 scopus 로고    scopus 로고
    • Stimulus-responsive macromolecules and nanoparticles for cancer drug delivery
    • S.R. MacEwan Stimulus-responsive macromolecules and nanoparticles for cancer drug delivery Nanomedicine 5 2010 793 806
    • (2010) Nanomedicine , vol.5 , pp. 793-806
    • Macewan, S.R.1
  • 98
    • 79955465276 scopus 로고    scopus 로고
    • Block copolymer micelles with acid-labile ortho ester side-chains: Synthesis, characterization, and enhanced drug delivery to human glioma cells
    • R. Tang Block copolymer micelles with acid-labile ortho ester side-chains: synthesis, characterization, and enhanced drug delivery to human glioma cells J. Control. Release 151 2011 18 27
    • (2011) J. Control. Release , vol.151 , pp. 18-27
    • Tang, R.1
  • 99
    • 79958823872 scopus 로고    scopus 로고
    • Stimulus-responsive self-assembly: Reversible, redox-controlled micellization of polyferrocenylsilane diblock copolymers
    • J.C. Eloi Stimulus-responsive self-assembly: reversible, redox-controlled micellization of polyferrocenylsilane diblock copolymers J. Am. Chem. Soc. 133 2011 8903 8913
    • (2011) J. Am. Chem. Soc. , vol.133 , pp. 8903-8913
    • Eloi, J.C.1
  • 100
    • 84891773419 scopus 로고    scopus 로고
    • Complex adaptive therapeutic strategy (CATS) for cancer
    • Y.W. Cho Complex adaptive therapeutic strategy (CATS) for cancer J. Control. Release 175 2014 43 47
    • (2014) J. Control. Release , vol.175 , pp. 43-47
    • Cho, Y.W.1
  • 101
    • 84864138481 scopus 로고    scopus 로고
    • Hybrid nanoparticles for detection and treatment of cancer
    • M.J. Sailor, and J.H. Park Hybrid nanoparticles for detection and treatment of cancer Adv. Mater. 24 2012 3779 3802
    • (2012) Adv. Mater. , vol.24 , pp. 3779-3802
    • Sailor, M.J.1    Park, J.H.2
  • 102
    • 84873903179 scopus 로고    scopus 로고
    • Photo-degradable, protein-polyelectrolyte complex-coated, mesoporous silica nanoparticles for controlled co-release of protein and model drugs
    • X. Wan Photo-degradable, protein-polyelectrolyte complex-coated, mesoporous silica nanoparticles for controlled co-release of protein and model drugs Macromol. Rapid Commun. 34 2013 341 347
    • (2013) Macromol. Rapid Commun. , vol.34 , pp. 341-347
    • Wan, X.1
  • 103
    • 84892574967 scopus 로고    scopus 로고
    • Emerging integrated nanohybrid drug delivery systems to facilitate the intravenous-to-oral switch in cancer chemotherapy
    • C. Luo Emerging integrated nanohybrid drug delivery systems to facilitate the intravenous-to-oral switch in cancer chemotherapy J. Control. Release 176 2014 94 103
    • (2014) J. Control. Release , vol.176 , pp. 94-103
    • Luo, C.1
  • 104
    • 77953683770 scopus 로고    scopus 로고
    • Targeting nanoparticles to cancer
    • M. Wang, and M. Thanou Targeting nanoparticles to cancer Pharmacol. Res. 62 2010 90 99
    • (2010) Pharmacol. Res. , vol.62 , pp. 90-99
    • Wang, M.1    Thanou, M.2
  • 105
    • 79955822004 scopus 로고    scopus 로고
    • Future directions of next-generation novel therapies, combination approaches, and the development of personalized medicine in myeloma
    • C.S. Mitsiades Future directions of next-generation novel therapies, combination approaches, and the development of personalized medicine in myeloma J. Clin. Oncol. 29 2011 1916 1923
    • (2011) J. Clin. Oncol. , vol.29 , pp. 1916-1923
    • Mitsiades, C.S.1
  • 106
    • 84880930108 scopus 로고    scopus 로고
    • Nano-sized polymers and liposomes designed to deliver combination therapy for cancer
    • A. Eldar-Boock Nano-sized polymers and liposomes designed to deliver combination therapy for cancer Curr. Opin. Biotech. 24 2013 682 689
    • (2013) Curr. Opin. Biotech. , vol.24 , pp. 682-689
    • Eldar-Boock, A.1
  • 107
    • 77956651717 scopus 로고    scopus 로고
    • Polymeric nanomedicines for image-guided drug delivery and tumor-targeted combination therapy
    • T. Lammers Polymeric nanomedicines for image-guided drug delivery and tumor-targeted combination therapy Nano Today 5 2010 197 212
    • (2010) Nano Today , vol.5 , pp. 197-212
    • Lammers, T.1
  • 108
    • 70349978292 scopus 로고    scopus 로고
    • Combination therapy: Opportunities and challenges for polymer-drug conjugates as anticancer nanomedicines
    • F. Greco, and M.J. Vicent Combination therapy: opportunities and challenges for polymer-drug conjugates as anticancer nanomedicines Adv. Drug Deliv. Rev. 61 2009 1203 1213
    • (2009) Adv. Drug Deliv. Rev. , vol.61 , pp. 1203-1213
    • Greco, F.1    Vicent, M.J.2
  • 109
    • 84874655664 scopus 로고    scopus 로고
    • Safety and feasibility of targeted agent combinations in solid tumours
    • S.R. Park Safety and feasibility of targeted agent combinations in solid tumours Nat. Rev. Clin. Oncol. 10 2013 154 168
    • (2013) Nat. Rev. Clin. Oncol. , vol.10 , pp. 154-168
    • Park, S.R.1
  • 110
    • 84890814867 scopus 로고    scopus 로고
    • A macromolecular prodrug strategy for combinatorial drug delivery
    • N.N. Li A macromolecular prodrug strategy for combinatorial drug delivery J. Colloid Interface Sci. 417 2014 301 309
    • (2014) J. Colloid Interface Sci. , vol.417 , pp. 301-309
    • Li, N.N.1


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