Activin/Nodal signaling and NANOG orchestrate human embryonic stem cell fate decisions by controlling the H3K4me3 chromatin mark

Genes and Development

Volumn 29, Issue 7, 2015, Pages 702-717

  Bertero, Alessandro ^a   Madrigal, Pedro ^a,b   Galli, Antonella ^b   Hubner, Nina C ^c   Moreno, Inmaculada ^d   Burks, Deborah ^d   Brown, Stephanie ^a   Pedersen, Roger A ^a   Gaffney, Daniel ^b   Mendjan, Sasha ^a   Pauklin, Siim ^a   Vallier, Ludovic ^a,b  

^a UNIVERSITY OF CAMBRIDGE   (United Kingdom)

^b WELLCOME TRUST SANGER INSTITUTE   (United Kingdom)

^c RADBOUD UNIVERSITY NIJMEGEN   (Netherlands)

^d CENTRO DE INVESTIGACIÓN PRÍNCIPE FELIPE   (Spain)

Author keywords

Activin Nodal; DPY30; H3K4me3; hESCs; NANOG; SMAD2 3

Indexed keywords

4 [4 (1,3 BENZODIOXOL 5 YL) 5 (2 PYRIDINYL) 1H IMIDAZOL 2 YL]BENZAMIDE; ACTIVIN; CER1 PROTEIN; DPPA4 PROTEIN; FGF8 PROTEIN; GROWTH DIFFERENTIATION FACTOR 3; HISTONE H3; LEFTY1 PROTEIN; LEFTY2 PROTEIN; NODAL SIGNALING PROTEIN; OCTAMER TRANSCRIPTION FACTOR 4; PRDM14 PROTEIN; PROTEIN; SHORT HAIRPIN RNA; SMAD2 PROTEIN; SMAD3 PROTEIN; TRANSCRIPTION FACTOR NANOG; UNCLASSIFIED DRUG; WNT3 PROTEIN; CHROMATIN; HISTONE; HISTONE LYSINE METHYLTRANSFERASE; HISTONE METHYLTRANSFERASE; HOMEODOMAIN PROTEIN; NANOG PROTEIN, HUMAN; PROTEIN NODAL;

ARTICLE; BINDING SITE; CELL DIFFERENTIATION; CELL FATE; CELL PROLIFERATION; CELL RENEWAL; CHROMATIN; CHROMATIN IMMUNOPRECIPITATION; ECTODERM; EMBRYO; EMBRYONIC STEM CELL; ENDODERM; ENHANCER REGION; ENZYME ACTIVE SITE; FLOW CYTOMETRY; GASTRULATION; GENE EXPRESSION; GENE SILENCING; GERM LAYER; HISTONE DEMETHYLATION; HISTONE METHYLATION; HUMAN; HUMAN CELL; IMMUNOHISTOCHEMISTRY; MESODERM; MICROARRAY ANALYSIS; MOUSE; NEUROECTODERM; NONHUMAN; NUCLEOSOME; PHENOTYPE; PLURIPOTENT STEM CELL; PRIMITIVE STREAK; PRIORITY JOURNAL; PROMOTER REGION; PROTEIN PHOSPHORYLATION; SIGNAL TRANSDUCTION; TRANSCRIPTION INITIATION SITE; TRANSIENT TRANSFECTION; WESTERN BLOTTING; ANIMAL; ANIMAL EMBRYO; CELL CULTURE; GENETIC EPIGENESIS; GENETICS; METABOLISM;

MUS;

ACTIVINS; ANIMALS; CELL DIFFERENTIATION; CELLS, CULTURED; CHROMATIN; EMBRYO, MAMMALIAN; EMBRYONIC STEM CELLS; EPIGENESIS, GENETIC; HISTONE-LYSINE N-METHYLTRANSFERASE; HISTONES; HOMEODOMAIN PROTEINS; HUMANS; MICE; NODAL PROTEIN; SIGNAL TRANSDUCTION; SMAD2 PROTEIN; SMAD3 PROTEIN;

EID: 84926314123     PISSN: 08909369     EISSN: 15495477     Source Type: Journal    
DOI: 10.1101/gad.255984.114     Document Type: Article

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