Dual inhibition of Src and GSK3 maintains mouse embryonic stem cells, whose differentiation is mechanically regulated by Src signaling

Stem Cells

Volumn 30, Issue 7, 2012, Pages 1394-1404

  Shimizu, Takeshi ^a   Ueda, Jun ^c,d   Ho, Jolene Caifeng ^c   Iwasaki, Katsuhiko ^e   Poellinger, Lorenz ^c   Harada, Ichiro ^e   Sawada, Yasuhiro ^a,b  

^a NATIONAL UNIVERSITY OF SINGAPORE   (Singapore)

^b NATIONAL UNIVERSITY OF SINGAPORE   (Singapore)

^c NATIONAL UNIVERSITY OF SINGAPORE   (Singapore)

^d OSAKA UNIVERSITY   (Japan)

^e TOKYO INSTITUTE OF TECHNOLOGY   (Japan)

Author keywords

Cell signaling; Differentiation; Embryonic stem cells; Pluripotency

Indexed keywords

FOCAL ADHESION KINASE; GLYCOGEN SYNTHASE KINASE 3; HEPATOCYTE NUCLEAR FACTOR 3BETA; KRUPPEL LIKE FACTOR 4; MITOGEN ACTIVATED PROTEIN KINASE; OCTAMER TRANSCRIPTION FACTOR 4; STEROID RECEPTOR COACTIVATOR 1; TRANSCRIPTION FACTOR GATA 6; TRANSCRIPTION FACTOR SOX2; TYROSINE;

ANIMAL CELL; ARTICLE; CELL DIFFERENTIATION; CONTROLLED STUDY; ELASTICITY; EMBRYO; EMBRYONIC STEM CELL; MECHANOTRANSDUCTION; MOUSE; NONHUMAN; PHENOTYPE; PLURIPOTENT STEM CELL; PROTEIN PHOSPHORYLATION;

ANIMALS; CELL DIFFERENTIATION; EMBRYONIC STEM CELLS; ENZYME INHIBITORS; GLYCOGEN SYNTHASE KINASE 3; IMMUNOBLOTTING; MICE; MITOGEN-ACTIVATED PROTEIN KINASES; RNA INTERFERENCE; SHC SIGNALING ADAPTOR PROTEINS; SRC-FAMILY KINASES;

MUS;

EID: 84862897338     PISSN: 10665099     EISSN: None     Source Type: Journal    
DOI: 10.1002/stem.1119     Document Type: Article

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