-
2
-
-
84929512769
-
The mystery of chronic lymphocytic leukemia (CLL): Why is it absent in Asians and what does this tell us about etiology, pathogenesis and biology
-
Yang, S. M., Li, J. Y., Gale, R. P., & Huang, X. J. The mystery of chronic lymphocytic leukemia (CLL): why is it absent in Asians and what does this tell us about etiology, pathogenesis and biology? Blood Rev. 29, 205-213 (2015
-
(2015)
Blood Rev
, vol.29
, pp. 205-213
-
-
Yang, S.M.1
Li, J.Y.2
Gale, R.P.3
Huang, X.J.4
-
3
-
-
3242736321
-
Familial risk of lymphoproliferative tumors in families of patients with chronic lymphocytic leukemia: Results from the swedish family-cancer database
-
Goldin, L. R., Pfeiffer, R. M., Li, X., & Hemminki, K. Familial risk of lymphoproliferative tumors in families of patients with chronic lymphocytic leukemia: results from the Swedish Family-Cancer Database. Blood 104, 1850-1854 (2004
-
(2004)
Blood
, vol.104
, pp. 1850-1854
-
-
Goldin, L.R.1
Pfeiffer, R.M.2
Li, X.3
Hemminki, K.4
-
4
-
-
45149100665
-
Guidelines for the diagnosis and treatment of chronic lymphocytic leukemia: A report from the international workshop on chronic lymphocytic leukemia updating the national cancer institute-working group 1996 guidelines
-
Hallek, M., et al. Guidelines for the diagnosis and treatment of chronic lymphocytic leukemia: a report from the International Workshop on Chronic Lymphocytic Leukemia updating the National Cancer Institute-Working Group 1996 guidelines. Blood 111, 5446-5456 (2008
-
(2008)
Blood
, vol.111
, pp. 5446-5456
-
-
Hallek, M.1
-
5
-
-
84928253067
-
Chronic lymphocytic leukemia: 2015 update on diagnosis, risk stratification, and treatment
-
Hallek, M. Chronic lymphocytic leukemia: 2015 update on diagnosis, risk stratification, and treatment. Am. J. Hematol. 90, 446-460 (2015
-
(2015)
Am. J. Hematol
, vol.90
, pp. 446-460
-
-
Hallek, M.1
-
6
-
-
79955961315
-
The 2008 WHO classification of lymphoid neoplasms and beyond: Evolving concepts and practical applications
-
Campo, E., et al. The 2008 WHO classification of lymphoid neoplasms and beyond: evolving concepts and practical applications. Blood 117, 5019-5032 (2011
-
(2011)
Blood
, vol.117
, pp. 5019-5032
-
-
Campo, E.1
-
7
-
-
0033567968
-
Ig v gene mutation status and CD38 expression as novel prognostic indicators in chronic lymphocytic leukemia
-
Damle, R. N., et al. Ig V gene mutation status and CD38 expression as novel prognostic indicators in chronic lymphocytic leukemia. Blood 94, 1840-1847 (1999
-
(1999)
Blood
, vol.94
, pp. 1840-1847
-
-
Damle, R.N.1
-
8
-
-
0033567907
-
Unmutated Ig VH genes are associated with a more aggressive form of chronic lymphocytic leukemia
-
Hamblin, T. J., Davis, Z., Gardiner, A., Oscier, D. G., & Stevenson, F. K. Unmutated Ig VH genes are associated with a more aggressive form of chronic lymphocytic leukemia. Blood 94, 1848-1854 (1999
-
(1999)
Blood
, vol.94
, pp. 1848-1854
-
-
Hamblin, T.J.1
Davis, Z.2
Gardiner, A.3
Oscier, D.G.4
Stevenson, F.K.5
-
9
-
-
84937847194
-
Monoclonal B cell lymphocytosis and early-stage chronic lymphocytic leukemia: Diagnosis, natural history, and risk stratification
-
Strati, P., & Shanafelt, T. D. Monoclonal B cell lymphocytosis and early-stage chronic lymphocytic leukemia: diagnosis, natural history, and risk stratification. Blood 126, 454-462 (2015
-
(2015)
Blood
, vol.126
, pp. 454-462
-
-
Strati, P.1
Shanafelt, T.D.2
-
10
-
-
79954999804
-
Understanding and managing ultra high-risk chronic lymphocytic leukemia
-
Stilgenbauer, S., & Zenz, T. Understanding and managing ultra high-risk chronic lymphocytic leukemia. Hematol. Am. Soc. Hematol. Educ. Program 2010, 481-488 (2010
-
(2010)
Hematol. Am. Soc. Hematol. Educ. Program
, vol.2010
, pp. 481-488
-
-
Stilgenbauer, S.1
Zenz, T.2
-
12
-
-
33744800308
-
Clinical outcomes and prognostic factors in patients with Richter's syndrome treated with chemotherapy or chemoimmunotherapy with or without stem-cell transplantation
-
Tsimberidou, A. M., et al. Clinical outcomes and prognostic factors in patients with Richter's syndrome treated with chemotherapy or chemoimmunotherapy with or without stem-cell transplantation. J. Clin. Oncol. 24, 2343-2351 (2006
-
(2006)
J. Clin. Oncol
, vol.24
, pp. 2343-2351
-
-
Tsimberidou, A.M.1
-
13
-
-
77957664665
-
Addition of rituximab to fludarabine and cyclophosphamide in patients with chronic lymphocytic leukaemia: A randomised, open-label, phase 3 trial
-
Hallek, M., et al. Addition of rituximab to fludarabine and cyclophosphamide in patients with chronic lymphocytic leukaemia: a randomised, open-label, phase 3 trial. Lancet 376, 1164-1174 (2010
-
(2010)
Lancet
, vol.376
, pp. 1164-1174
-
-
Hallek, M.1
-
14
-
-
84897055483
-
Targeting Bruton's tyrosine kinase in B cell malignancies
-
Hendriks, R. W., Yuvaraj, S., & Kil, L. P. Targeting Bruton's tyrosine kinase in B cell malignancies. Nat. Rev. Cancer 14, 219-232 (2014
-
(2014)
Nat. Rev. Cancer
, vol.14
, pp. 219-232
-
-
Hendriks, R.W.1
Yuvaraj, S.2
Kil, L.P.3
-
15
-
-
84879748062
-
Targeting BTK with ibrutinib in relapsed chronic lymphocytic leukemia
-
Byrd, J. C., et al. Targeting BTK with ibrutinib in relapsed chronic lymphocytic leukemia. N. Engl. J. Med. 369, 32-42 (2013
-
(2013)
N. Engl. J. Med
, vol.369
, pp. 32-42
-
-
Byrd, J.C.1
-
16
-
-
84904252369
-
Ibrutinib versus ofatumumab in previously treated chronic lymphoid leukemia
-
Byrd, J. C., et al. Ibrutinib versus ofatumumab in previously treated chronic lymphoid leukemia. N. Engl. J. Med. 371, 213-223 (2014
-
(2014)
N. Engl. J. Med
, vol.371
, pp. 213-223
-
-
Byrd, J.C.1
-
17
-
-
84921740802
-
Ibrutinib for previously untreated and relapsed or refractory chronic lymphocytic leukaemia with TP53 aberrations: A phase 2, single-Arm trial
-
Farooqui, M. Z., et al. Ibrutinib for previously untreated and relapsed or refractory chronic lymphocytic leukaemia with TP53 aberrations: a phase 2, single-Arm trial. Lancet Oncol. 16, 169-176 (2015
-
(2015)
Lancet Oncol
, vol.16
, pp. 169-176
-
-
Farooqui, M.Z.1
-
18
-
-
84950133717
-
Ibrutinib as initial therapy for patients with chronic lymphocytic leukemia
-
Burger, J. A., et al. Ibrutinib as initial therapy for patients with chronic lymphocytic leukemia. N. Engl. J. Med. 373, 2425-2437 (2015
-
(2015)
N. Engl. J. Med
, vol.373
, pp. 2425-2437
-
-
Burger, J.A.1
-
19
-
-
84896692766
-
Idelalisib and rituximab in relapsed chronic lymphocytic leukemia
-
Furman, R. R., et al. Idelalisib and rituximab in relapsed chronic lymphocytic leukemia. N. Engl. J. Med. 370, 997-1007 (2014
-
(2014)
N. Engl. J. Med
, vol.370
, pp. 997-1007
-
-
Furman, R.R.1
-
20
-
-
84901712964
-
Idelalisib, an inhibitor of phosphatidylinositol 3 kinase p110δ, for relapsed/refractory chronic lymphocytic leukemia
-
Brown, J. R., et al. Idelalisib, an inhibitor of phosphatidylinositol 3 kinase p110δ, for relapsed/refractory chronic lymphocytic leukemia. Blood 123, 3390-3397 (2014
-
(2014)
Blood
, vol.123
, pp. 3390-3397
-
-
Brown, J.R.1
-
21
-
-
84924659807
-
Update on a Phase 2 study of idelalisib in combination with rituximab in treatment-naïve patients =65 years with chronic lymphocytic leukemia (CLL) or small lymphocytic lymphoma (SLL
-
O'Brien, S., et al. Update on a Phase 2 study of idelalisib in combination with rituximab in treatment-naïve patients =65 years with chronic lymphocytic leukemia (CLL) or small lymphocytic lymphoma (SLL). Blood 124, 1994a (2014
-
(2014)
Blood
, vol.124
, pp. 1994a
-
-
O'Brien, S.1
-
22
-
-
84951268355
-
A phase 2 study of idelalisib plus rituximab in treatment-naive older patients with chronic lymphocytic leukemia
-
O'Brien, S. M., et al. A phase 2 study of idelalisib plus rituximab in treatment-naive older patients with chronic lymphocytic leukemia. Blood 126, 2686-2694 (2015
-
(2015)
Blood
, vol.126
, pp. 2686-2694
-
-
O'Brien, S.M.1
-
23
-
-
84955481177
-
Acalabrutinib (ACP 196) in relapsed chronic lymphocytic leukemia
-
Byrd, J. C., et al. Acalabrutinib (ACP 196) in relapsed chronic lymphocytic leukemia. N. Engl. J. Med. 374, 323-332 (2015
-
(2015)
N. Engl. J. Med
, vol.374
, pp. 323-332
-
-
Byrd, J.C.1
-
24
-
-
84873540049
-
ABT 199, a potent and selective BCL 2 inhibitor, achieves antitumor activity while sparing platelets
-
Souers, A. J., et al. ABT 199, a potent and selective BCL 2 inhibitor, achieves antitumor activity while sparing platelets. Nat. Med. 19, 202-208 (2013
-
(2013)
Nat. Med
, vol.19
, pp. 202-208
-
-
Souers, A.J.1
-
25
-
-
84897946259
-
-
No authors listed] ABT 199 shows effectiveness in CLL
-
No authors listed] ABT 199 shows effectiveness in CLL. Cancer Discov. 4, OF7 (2014
-
(2014)
Cancer Discov
, vol.4
, pp. OF7
-
-
-
26
-
-
84955491187
-
Targeting BCL2 with venetoclax in relapsed chronic lymphocytic leukemia
-
Roberts, A. W., et al. Targeting BCL2 with venetoclax in relapsed chronic lymphocytic leukemia. N. Engl. J. Med. 374, 311-322 (2016
-
(2016)
N. Engl. J. Med
, vol.374
, pp. 311-322
-
-
Roberts, A.W.1
-
27
-
-
70350734809
-
The microenvironment in mature B cell malignancies: A target for new treatment strategies
-
Burger, J. A., Ghia, P., Rosenwald, A., & Caligaris-Cappio, F. The microenvironment in mature B cell malignancies: a target for new treatment strategies. Blood 114, 3367-3375 (2009
-
(2009)
Blood
, vol.114
, pp. 3367-3375
-
-
Burger, J.A.1
Ghia, P.2
Rosenwald, A.3
Caligaris-Cappio, F.4
-
28
-
-
84888440844
-
B cell receptor signaling in chronic lymphocytic leukemia
-
Burger, J. A., & Chiorazzi, N. B cell receptor signaling in chronic lymphocytic leukemia. Trends Immunol. 34, 592-601 (2013
-
(2013)
Trends Immunol
, vol.34
, pp. 592-601
-
-
Burger, J.A.1
Chiorazzi, N.2
-
29
-
-
84905980544
-
Immunogenetic studies of chronic lymphocytic leukemia: Revelations and speculations about ontogeny and clinical evolution
-
Vardi, A., et al. Immunogenetic studies of chronic lymphocytic leukemia: revelations and speculations about ontogeny and clinical evolution. Cancer Res. 74, 4211-4216 (2014
-
(2014)
Cancer Res
, vol.74
, pp. 4211-4216
-
-
Vardi, A.1
-
30
-
-
84955174210
-
Microenvironment interactions and B cell receptor signaling in chronic lymphocytic leukemia: Implications for disease pathogenesis and treatment
-
Ten Hacken, E., & Burger, J. A. Microenvironment interactions and B cell receptor signaling in chronic lymphocytic leukemia: implications for disease pathogenesis and treatment. Biochim. Biophys. Acta 1863, 401-413 (2015
-
(2015)
Biochim. Biophys. Acta
, vol.1863
, pp. 401-413
-
-
Ten Hacken, E.1
Burger, J.A.2
-
31
-
-
80051589767
-
Self-renewing hematopoietic stem cell is the primary target in pathogenesis of human chronic lymphocytic leukemia
-
Kikushige, Y., et al. Self-renewing hematopoietic stem cell is the primary target in pathogenesis of human chronic lymphocytic leukemia. Cancer Cell 20, 246-259 (2011
-
(2011)
Cancer Cell
, vol.20
, pp. 246-259
-
-
Kikushige, Y.1
-
32
-
-
84906908742
-
Acquired initiating mutations in early hematopoietic cells of CLL patients
-
Damm, F., et al. Acquired initiating mutations in early hematopoietic cells of CLL patients. Cancer Discov. 4, 1088-1101 (2014
-
(2014)
Cancer Discov
, vol.4
, pp. 1088-1101
-
-
Damm, F.1
-
33
-
-
84920024296
-
Clonal hematopoiesis and blood-cancer risk inferred from blood DNA sequence
-
Genovese, G., et al. Clonal hematopoiesis and blood-cancer risk inferred from blood DNA sequence. N. Engl. J. Med. 371, 2477-2487 (2014
-
(2014)
N. Engl. J. Med
, vol.371
, pp. 2477-2487
-
-
Genovese, G.1
-
34
-
-
84920053873
-
Age-related clonal hematopoiesis associated with adverse outcomes
-
Jaiswal, S., et al. Age-related clonal hematopoiesis associated with adverse outcomes. N. Engl. J. Med. 371, 2488-2498 (2014
-
(2014)
N. Engl. J. Med
, vol.371
, pp. 2488-2498
-
-
Jaiswal, S.1
-
35
-
-
0028149568
-
The immunological profile of B cell disorders and proposal of a scoring system for the diagnosis of CLL
-
Matutes, E., et al. The immunological profile of B cell disorders and proposal of a scoring system for the diagnosis of CLL. Leukemia 8, 1640-1645 (1994
-
(1994)
Leukemia
, vol.8
, pp. 1640-1645
-
-
Matutes, E.1
-
36
-
-
0020054334
-
Infrequent normal B lymphocytes express features of B chronic lymphocytic leukemia
-
Caligaris-Cappio, F., Gobbi, M., Bofill, M., & Janossy, G. Infrequent normal B lymphocytes express features of B chronic lymphocytic leukemia. J. Exp. Med. 155, 623-628 (1982
-
(1982)
J. Exp. Med
, vol.155
, pp. 623-628
-
-
Caligaris-Cappio, F.1
Gobbi, M.2
Bofill, M.3
Janossy, G.4
-
37
-
-
0345590220
-
Ly 1 B cell clones similar to human chronic lymphocytic leukemias routinely develop in older normal mice and young autoimmune (New Zealand Black-related) animals
-
Stall, A. M., et al. Ly 1 B cell clones similar to human chronic lymphocytic leukemias routinely develop in older normal mice and young autoimmune (New Zealand Black-related) animals. Proc. Natl Acad. Sci. USA 85, 7312-7316 (1988
-
(1988)
Proc. Natl Acad. Sci. USA
, vol.85
, pp. 7312-7316
-
-
Stall, A.M.1
-
38
-
-
0029990349
-
B chronic lymphocytic leukemia: A malignancy of anti-self B cells
-
Caligaris-Cappio, F. B chronic lymphocytic leukemia: a malignancy of anti-self B cells. Blood 87, 2615-2620 (1996
-
(1996)
Blood
, vol.87
, pp. 2615-2620
-
-
Caligaris-Cappio, F.1
-
39
-
-
78650600361
-
The double life of a B-1 cell: Self-reactivity selects for protective effector functions
-
Baumgarth, N. The double life of a B-1 cell: self-reactivity selects for protective effector functions. Nat. Rev. Immunol. 11, 34-46 (2011
-
(2011)
Nat. Rev. Immunol
, vol.11
, pp. 34-46
-
-
Baumgarth, N.1
-
40
-
-
0035803464
-
Gene expression profiling of B cell chronic lymphocytic leukemia reveals a homogeneous phenotype related to memory B cells
-
Klein, U., et al. Gene expression profiling of B cell chronic lymphocytic leukemia reveals a homogeneous phenotype related to memory B cells. J. Exp. Med. 194, 1625-1638 (2001
-
(2001)
J. Exp. Med
, vol.194
, pp. 1625-1638
-
-
Klein, U.1
-
41
-
-
0035803371
-
Relation of gene expression phenotype to immunoglobulin mutation genotype in B cell chronic lymphocytic leukemia
-
Rosenwald, A., et al. Relation of gene expression phenotype to immunoglobulin mutation genotype in B cell chronic lymphocytic leukemia. J. Exp. Med. 194, 1639-1647 (2001
-
(2001)
J. Exp. Med
, vol.194
, pp. 1639-1647
-
-
Rosenwald, A.1
-
42
-
-
0032476611
-
Human immunoglobulin (Ig)M+IgD+ peripheral blood B cells expressing the CD27 cell surface antigen carry somatically mutated variable region genes: CD27 as a general marker for somatically mutated (memory) B cells
-
Klein, U., Rajewsky, K., & Kuppers, R. Human immunoglobulin (Ig)M+IgD+ peripheral blood B cells expressing the CD27 cell surface antigen carry somatically mutated variable region genes: CD27 as a general marker for somatically mutated (memory) B cells. J. Exp. Med. 188, 1679-1689 (1998
-
(1998)
J. Exp. Med
, vol.188
, pp. 1679-1689
-
-
Klein, U.1
Rajewsky, K.2
Kuppers, R.3
-
43
-
-
84872342533
-
Cellular origin and pathophysiology of chronic lymphocytic leukemia
-
Seifert, M., et al. Cellular origin and pathophysiology of chronic lymphocytic leukemia. J. Exp. Med. 209, 2183-2198 (2012
-
(2012)
J. Exp. Med
, vol.209
, pp. 2183-2198
-
-
Seifert, M.1
-
44
-
-
84868198427
-
Epigenomic analysis detects widespread gene-body DNA hypomethylation in chronic lymphocytic leukemia
-
Kulis, M., et al. Epigenomic analysis detects widespread gene-body DNA hypomethylation in chronic lymphocytic leukemia. Nat. Genet. 44, 1236-1242 (2012
-
(2012)
Nat. Genet
, vol.44
, pp. 1236-1242
-
-
Kulis, M.1
-
45
-
-
79951498701
-
Cellular origin(s) of chronic lymphocytic leukemia: Cautionary notes and additional considerations and possibilities
-
Chiorazzi, N., & Ferrarini, M. Cellular origin(s) of chronic lymphocytic leukemia: cautionary notes and additional considerations and possibilities. Blood 117, 1781-1791 (2011
-
(2011)
Blood
, vol.117
, pp. 1781-1791
-
-
Chiorazzi, N.1
Ferrarini, M.2
-
46
-
-
74949107027
-
The normal IGHV1 69 derived B cell repertoire contains stereotypic patterns characteristic of unmutated CLL
-
Forconi, F., et al. The normal IGHV1 69 derived B cell repertoire contains stereotypic patterns characteristic of unmutated CLL. Blood 115, 71-77 (2010
-
(2010)
Blood
, vol.115
, pp. 71-77
-
-
Forconi, F.1
-
47
-
-
84866152172
-
Chronic lymphocytic leukaemia is driven by antigen-independent cell-Autonomous signalling
-
Duhren-von Minden, M., et al. Chronic lymphocytic leukaemia is driven by antigen-independent cell-Autonomous signalling. Nature 489, 309-312 (2012
-
(2012)
Nature
, vol.489
, pp. 309-312
-
-
Duhren-Von Minden, M.1
-
48
-
-
0037076279
-
Human chronic lymphocytic leukemia modeled in mouse by targeted TCL1 expression
-
Bichi, R., et al. Human chronic lymphocytic leukemia modeled in mouse by targeted TCL1 expression. Proc. Natl Acad. Sci. USA 99, 6955-6960 (2002
-
(2002)
Proc. Natl Acad. Sci. USA
, vol.99
, pp. 6955-6960
-
-
Bichi, R.1
-
49
-
-
84934444071
-
Inherited susceptibility to CLL
-
Speedy, H. E., Sava, G., & Houlston, R. S. Inherited susceptibility to CLL. Adv. Exp. Med. Biol. 792, 293-308 (2013
-
(2013)
Adv. Exp. Med. Biol
, vol.792
, pp. 293-308
-
-
Speedy, H.E.1
Sava, G.2
Houlston, R.S.3
-
50
-
-
66049151296
-
Elevated risk of chronic lymphocytic leukemia and other indolent non-Hodgkin's lymphomas among relatives of patients with chronic lymphocytic leukemia
-
Goldin, L. R., Bjorkholm, M., Kristinsson, S. Y., Turesson, I., & Landgren, O. Elevated risk of chronic lymphocytic leukemia and other indolent non-Hodgkin's lymphomas among relatives of patients with chronic lymphocytic leukemia. Haematologica 94, 647-653 (2009
-
(2009)
Haematologica
, vol.94
, pp. 647-653
-
-
Goldin, L.R.1
Bjorkholm, M.2
Kristinsson, S.Y.3
Turesson, I.4
Landgren, O.5
-
51
-
-
34249314024
-
Downregulation of death-Associated protein kinase 1 (DAPK1) in chronic lymphocytic leukemia
-
Raval, A., et al. Downregulation of death-Associated protein kinase 1 (DAPK1) in chronic lymphocytic leukemia. Cell 129, 879-890 (2007
-
(2007)
Cell
, vol.129
, pp. 879-890
-
-
Raval, A.1
-
52
-
-
52949139429
-
A genome-wide association study identifies six susceptibility loci for chronic lymphocytic leukemia
-
Di Bernardo, M. C., et al. A genome-wide association study identifies six susceptibility loci for chronic lymphocytic leukemia. Nat. Genet. 40, 1204-1210 (2008
-
(2008)
Nat. Genet
, vol.40
, pp. 1204-1210
-
-
Di Bernardo, M.C.1
-
53
-
-
75749138023
-
Common variants at 2q37.3, 8q24.21, 15q21.3 and 16q24.1 influence chronic lymphocytic leukemia risk
-
Crowther-Swanepoel, D., et al. Common variants at 2q37.3, 8q24.21, 15q21.3 and 16q24.1 influence chronic lymphocytic leukemia risk. Nat. Genet. 42, 132-136 (2010
-
(2010)
Nat. Genet
, vol.42
, pp. 132-136
-
-
Crowther-Swanepoel, D.1
-
54
-
-
84864471868
-
Common variation at 6p21.31 (BAK1) influences the risk of chronic lymphocytic leukemia
-
Slager, S. L., et al. Common variation at 6p21.31 (BAK1) influences the risk of chronic lymphocytic leukemia. Blood 120, 843-846 (2012
-
(2012)
Blood
, vol.120
, pp. 843-846
-
-
Slager, S.L.1
-
55
-
-
84881023533
-
Genome-wide association study identifies multiple risk loci for chronic lymphocytic leukemia
-
Berndt, S. I., et al. Genome-wide association study identifies multiple risk loci for chronic lymphocytic leukemia. Nat. Genet. 45, 868-876 (2013
-
(2013)
Nat. Genet
, vol.45
, pp. 868-876
-
-
Berndt, S.I.1
-
56
-
-
84891371778
-
A genome-wide association study identifies multiple susceptibility loci for chronic lymphocytic leukemia
-
Speedy, H. E., et al. A genome-wide association study identifies multiple susceptibility loci for chronic lymphocytic leukemia. Nat. Genet. 46, 56-60 (2014
-
(2014)
Nat. Genet
, vol.46
, pp. 56-60
-
-
Speedy, H.E.1
-
57
-
-
65649123826
-
IRF4: Immunity malignancy therapy
-
Shaffer, A. L., Emre, N. C., Romesser, P. B., & Staudt, L. M. IRF4: Immunity. Malignancy! Therapy? Clin. Cancer Res. 15, 2954-2961 (2009
-
(2009)
Clin. Cancer Res
, vol.15
, pp. 2954-2961
-
-
Shaffer, A.L.1
Emre, N.C.2
Romesser, P.B.3
Staudt, L.M.4
-
58
-
-
84859713325
-
The diverse roles of IRF4 in late germinal center B cell differentiation
-
De Silva, N. S., Simonetti, G., Heise, N., & Klein, U. The diverse roles of IRF4 in late germinal center B cell differentiation. Immunol. Rev. 247, 73-92 (2012
-
(2012)
Immunol. Rev
, vol.247
, pp. 73-92
-
-
De Silva, N.S.1
Simonetti, G.2
Heise, N.3
Klein, U.4
-
59
-
-
84890808213
-
IRF4 controls the positioning of mature B cells in the lymphoid microenvironments by regulating NOTCH2 expression and activity
-
Simonetti, G., et al. IRF4 controls the positioning of mature B cells in the lymphoid microenvironments by regulating NOTCH2 expression and activity. J. Exp. Med. 210, 2887-2902 (2013
-
(2013)
J. Exp. Med
, vol.210
, pp. 2887-2902
-
-
Simonetti, G.1
-
60
-
-
84888211403
-
A role for IRF4 in the development of CLL
-
Shukla, V., Ma, S., Hardy, R. R., Joshi, S. S., & Lu, R. A role for IRF4 in the development of CLL. Blood 122, 2848-2855 (2013
-
(2013)
Blood
, vol.122
, pp. 2848-2855
-
-
Shukla, V.1
Ma, S.2
Hardy, R.R.3
Joshi, S.S.4
Lu, R.5
-
61
-
-
84945248976
-
Non-coding recurrent mutations in chronic lymphocytic leukaemia
-
Puente, X. S., et al. Non-coding recurrent mutations in chronic lymphocytic leukaemia. Nature 526, 519-524 (2015
-
(2015)
Nature
, vol.526
, pp. 519-524
-
-
Puente, X.S.1
-
62
-
-
0034727833
-
Genomic aberrations and survival in chronic lymphocytic leukemia
-
Dohner, H., et al. Genomic aberrations and survival in chronic lymphocytic leukemia. N. Engl. J. Med. 343, 1910-1916 (2000
-
(2000)
N. Engl. J. Med
, vol.343
, pp. 1910-1916
-
-
Dohner, H.1
-
63
-
-
79960353160
-
Analysis of the chronic lymphocytic leukemia coding genome: Role of NOTCH1 mutational activation
-
Fabbri, G., et al. Analysis of the chronic lymphocytic leukemia coding genome: role of NOTCH1 mutational activation. J. Exp. Med. 208, 1389-1401 (2011
-
(2011)
J. Exp. Med
, vol.208
, pp. 1389-1401
-
-
Fabbri, G.1
-
64
-
-
79960036578
-
Whole-genome sequencing identifies recurrent mutations in chronic lymphocytic leukaemia
-
Puente, X. S., et al. Whole-genome sequencing identifies recurrent mutations in chronic lymphocytic leukaemia. Nature 475, 101-105 (2011
-
(2011)
Nature
, vol.475
, pp. 101-105
-
-
Puente, X.S.1
-
65
-
-
84855370035
-
SF3B1 and other novel cancer genes in chronic lymphocytic leukemia
-
Wang, L., et al. SF3B1 and other novel cancer genes in chronic lymphocytic leukemia. N. Engl. J. Med. 365, 2497-2506 (2011
-
(2011)
N. Engl. J. Med
, vol.365
, pp. 2497-2506
-
-
Wang, L.1
-
66
-
-
84555171449
-
Exome sequencing identifies recurrent mutations of the splicing factor SF3B1 gene in chronic lymphocytic leukemia
-
Quesada, V., et al. Exome sequencing identifies recurrent mutations of the splicing factor SF3B1 gene in chronic lymphocytic leukemia. Nat. Genet. 44, 47-52 (2012
-
(2012)
Nat. Genet
, vol.44
, pp. 47-52
-
-
Quesada, V.1
-
67
-
-
84874102335
-
Evolution and impact of subclonal mutations in chronic lymphocytic leukemia
-
Landau, D. A., et al. Evolution and impact of subclonal mutations in chronic lymphocytic leukemia. Cell 152, 714-726 (2013
-
(2013)
Cell
, vol.152
, pp. 714-726
-
-
Landau, D.A.1
-
68
-
-
84945302209
-
Mutations driving CLL and their evolution in progression and relapse
-
Landau, D. A., et al. Mutations driving CLL and their evolution in progression and relapse. Nature 526, 525-530 (2015
-
(2015)
Nature
, vol.526
, pp. 525-530
-
-
Landau, D.A.1
-
69
-
-
84875490185
-
Cancer genome landscapes
-
Vogelstein, B., et al. Cancer genome landscapes. Science 339, 1546-1558 (2013
-
(2013)
Science
, vol.339
, pp. 1546-1558
-
-
Vogelstein, B.1
-
70
-
-
84882837534
-
Signatures of mutational processes in human cancer
-
Alexandrov, L. B., et al. Signatures of mutational processes in human cancer. Nature 500, 415-421 (2013
-
(2013)
Nature
, vol.500
, pp. 415-421
-
-
Alexandrov, L.B.1
-
71
-
-
80052936981
-
Acquired genomic copy number aberrations and survival in chronic lymphocytic leukemia
-
Ouillette, P., et al. Acquired genomic copy number aberrations and survival in chronic lymphocytic leukemia. Blood 118, 3051-3061 (2011
-
(2011)
Blood
, vol.118
, pp. 3051-3061
-
-
Ouillette, P.1
-
72
-
-
84870763388
-
High-resolution genomic profiling of chronic lymphocytic leukemia reveals new recurrent genomic alterations
-
Edelmann, J., et al. High-resolution genomic profiling of chronic lymphocytic leukemia reveals new recurrent genomic alterations. Blood 120, 4783-4794 (2012
-
(2012)
Blood
, vol.120
, pp. 4783-4794
-
-
Edelmann, J.1
-
73
-
-
0036234455
-
Somatic hypermutation of immunoglobulin genes: Merging mechanisms for genetic diversity
-
Suppl
-
Papavasiliou, F. N., & Schatz, D. G. Somatic hypermutation of immunoglobulin genes: merging mechanisms for genetic diversity. Cell 109 (Suppl.), S35-S44 (2002
-
(2002)
Cell
, vol.109
, pp. S35-S44
-
-
Papavasiliou, F.N.1
Schatz, D.G.2
-
74
-
-
84862865669
-
Immunoglobulin class-switch DNA recombination: Induction, targeting and beyond
-
Xu, Z., Zan, H., Pone, E. J., Mai, T., & Casali, P. Immunoglobulin class-switch DNA recombination: induction, targeting and beyond. Nat. Rev. Immunol. 12, 517-531 (2012
-
(2012)
Nat. Rev. Immunol
, vol.12
, pp. 517-531
-
-
Xu, Z.1
Zan, H.2
Pone, E.J.3
Mai, T.4
Casali, P.5
-
75
-
-
79953164038
-
Recombination centres and the orchestration of V(D J recombination
-
Schatz, D. G., & Ji, Y. Recombination centres and the orchestration of V(D)J recombination. Nat. Rev. Immunol. 11, 251-263 (2011
-
(2011)
Nat. Rev. Immunol
, vol.11
, pp. 251-263
-
-
Schatz, D.G.1
Ji, Y.2
-
76
-
-
84892871843
-
Signaling the end of chronic lymphocytic leukemia: New frontline treatment strategies
-
Hallek, M. Signaling the end of chronic lymphocytic leukemia: new frontline treatment strategies. Blood 122, 3723-3734 (2013
-
(2013)
Blood
, vol.122
, pp. 3723-3734
-
-
Hallek, M.1
-
77
-
-
49249119141
-
Monoclonal B cell lymphocytosis and chronic lymphocytic leukemia
-
Rawstron, A. C., et al. Monoclonal B cell lymphocytosis and chronic lymphocytic leukemia. N. Engl. J. Med. 359, 575-583 (2008
-
(2008)
N. Engl. J. Med
, vol.359
, pp. 575-583
-
-
Rawstron, A.C.1
-
78
-
-
73649116987
-
The DLEU2/miR 15a/16 1 cluster controls B cell proliferation and its deletion leads to chronic lymphocytic leukemia
-
Klein, U., et al. The DLEU2/miR 15a/16 1 cluster controls B cell proliferation and its deletion leads to chronic lymphocytic leukemia. Cancer Cell 17, 28-40 (2010
-
(2010)
Cancer Cell
, vol.17
, pp. 28-40
-
-
Klein, U.1
-
79
-
-
0035312968
-
Nucleotide sequence, transcription map, and mutation analysis of the 13q14 chromosomal region deleted in B cell chronic lymphocytic leukemia
-
Migliazza, A., et al. Nucleotide sequence, transcription map, and mutation analysis of the 13q14 chromosomal region deleted in B cell chronic lymphocytic leukemia. Blood 97, 2098-2104 (2001
-
(2001)
Blood
, vol.97
, pp. 2098-2104
-
-
Migliazza, A.1
-
80
-
-
0031570685
-
Cloning and gene mapping of the chromosome 13q14 region deleted in chronic lymphocytic leukemia
-
Kalachikov, S., et al. Cloning and gene mapping of the chromosome 13q14 region deleted in chronic lymphocytic leukemia. Genomics 42, 369-377 (1997
-
(1997)
Genomics
, vol.42
, pp. 369-377
-
-
Kalachikov, S.1
-
81
-
-
18744396337
-
Frequent deletions and down-regulation of micro-RNA genes miR15 and miR16 at 13q14 in chronic lymphocytic leukemia
-
Calin, G. A., et al. Frequent deletions and down-regulation of micro-RNA genes miR15 and miR16 at 13q14 in chronic lymphocytic leukemia. Proc. Natl Acad. Sci. USA 99, 15524-15529 (2002
-
(2002)
Proc. Natl Acad. Sci. USA
, vol.99
, pp. 15524-15529
-
-
Calin, G.A.1
-
82
-
-
77952993039
-
13q14 deletions in CLL involve cooperating tumor suppressors
-
Palamarchuk, A., et al. 13q14 deletions in CLL involve cooperating tumor suppressors. Blood 115, 3916-3922 (2010
-
(2010)
Blood
, vol.115
, pp. 3916-3922
-
-
Palamarchuk, A.1
-
83
-
-
0347355522
-
Characterization of a novel B CLL candidate gene-DLEU7-located in the 13q14 tumor suppressor locus
-
Hammarsund, M., et al. Characterization of a novel B CLL candidate gene-DLEU7-located in the 13q14 tumor suppressor locus. FEBS Lett. 556, 75-80 (2004
-
(2004)
FEBS Lett
, vol.556
, pp. 75-80
-
-
Hammarsund, M.1
-
84
-
-
0036624880
-
Down-regulation of candidate tumor suppressor genes within chromosome band 13q14.3 is independent of the DNA methylation pattern in B cell chronic lymphocytic leukemia
-
Mertens, D., et al. Down-regulation of candidate tumor suppressor genes within chromosome band 13q14.3 is independent of the DNA methylation pattern in B cell chronic lymphocytic leukemia. Blood 99, 4116-4121 (2002
-
(2002)
Blood
, vol.99
, pp. 4116-4121
-
-
Mertens, D.1
-
85
-
-
84891882468
-
Defective DROSHA processing contributes to downregulation of MiR 15/-16 in chronic lymphocytic leukemia
-
Allegra, D., et al. Defective DROSHA processing contributes to downregulation of MiR 15/-16 in chronic lymphocytic leukemia. Leukemia 28, 99-107 (2013
-
(2013)
Leukemia
, vol.28
, pp. 99-107
-
-
Allegra, D.1
-
86
-
-
38949184406
-
Integrated genomic profiling of chronic lymphocytic leukemia identifies subtypes of deletion 13q14
-
Ouillette, P., et al Integrated genomic profiling of chronic lymphocytic leukemia identifies subtypes of deletion 13q14. Cancer Res. 68, 1012-1021 (2008
-
(2008)
Cancer Res
, vol.68
, pp. 1012-1021
-
-
Ouillette, P.1
-
87
-
-
80455140244
-
The prognostic significance of various 13q14 deletions in chronic lymphocytic leukemia
-
Ouillette, P., et al. The prognostic significance of various 13q14 deletions in chronic lymphocytic leukemia. Clin. Cancer Res. 17, 6778-6790 (2011
-
(2011)
Clin. Cancer Res
, vol.17
, pp. 6778-6790
-
-
Ouillette, P.1
-
88
-
-
79958038921
-
13q14 deletion size and number of deleted cells both influence prognosis in chronic lymphocytic leukemia
-
Dal Bo, M., et al. 13q14 deletion size and number of deleted cells both influence prognosis in chronic lymphocytic leukemia. Genes Chromosomes Cancer 50, 633-643 (2011
-
(2011)
Genes Chromosomes Cancer
, vol.50
, pp. 633-643
-
-
Dal Bo, M.1
-
89
-
-
84859205415
-
Functional dissection of the chromosome 13q14 tumor-suppressor locus using transgenic mouse lines
-
Lia, M., et al. Functional dissection of the chromosome 13q14 tumor-suppressor locus using transgenic mouse lines. Blood 119, 2981-2990 (2012
-
(2012)
Blood
, vol.119
, pp. 2981-2990
-
-
Lia, M.1
-
90
-
-
25444520537
-
MiR 15 and miR 16 induce apoptosis by targeting BCL2
-
Cimmino, A., et al. miR 15 and miR 16 induce apoptosis by targeting BCL2. Proc. Natl Acad. Sci. USA 102, 13944-13949 (2005
-
(2005)
Proc. Natl Acad. Sci. USA
, vol.102
, pp. 13944-13949
-
-
Cimmino, A.1
-
91
-
-
84857739865
-
NOTCH1 mutations in +12 chronic lymphocytic leukemia (CLL) confer an unfavorable prognosis, induce a distinctive transcriptional profiling and refine the intermediate prognosis of +12 CLL
-
Del Giudice, I., et al. NOTCH1 mutations in +12 chronic lymphocytic leukemia (CLL) confer an unfavorable prognosis, induce a distinctive transcriptional profiling and refine the intermediate prognosis of +12 CLL. Haematologica 97, 437-441 (2012
-
(2012)
Haematologica
, vol.97
, pp. 437-441
-
-
Del Giudice, I.1
-
92
-
-
84937516435
-
Second cancers and Richter transformation are the leading causes of death in patients with trisomy 12 chronic lymphocytic leukemia
-
Strati, P., et al. Second cancers and Richter transformation are the leading causes of death in patients with trisomy 12 chronic lymphocytic leukemia. Clin. Lymphoma Myeloma Leuk. 15, 420-427 (2015
-
(2015)
Clin. Lymphoma Myeloma Leuk
, vol.15
, pp. 420-427
-
-
Strati, P.1
-
93
-
-
84891038503
-
Two main genetic pathways lead to the transformation of chronic lymphocytic leukemia to Richter syndrome
-
Chigrinova, E., et al. Two main genetic pathways lead to the transformation of chronic lymphocytic leukemia to Richter syndrome. Blood 122, 2673-2682 (2013
-
(2013)
Blood
, vol.122
, pp. 2673-2682
-
-
Chigrinova, E.1
-
94
-
-
84886851785
-
Genetic lesions associated with chronic lymphocytic leukemia transformation to Richter syndrome
-
Fabbri, G., et al. Genetic lesions associated with chronic lymphocytic leukemia transformation to Richter syndrome. J. Exp. Med. 210, 2273-2288 (2013
-
(2013)
J. Exp. Med
, vol.210
, pp. 2273-2288
-
-
Fabbri, G.1
-
95
-
-
80755127112
-
Multivariable model for time to first treatment in patients with chronic lymphocytic leukemia
-
Wierda, W. G., et al. Multivariable model for time to first treatment in patients with chronic lymphocytic leukemia. J. Clin. Oncol. 29, 4088-4095 (2011
-
(2011)
J. Clin. Oncol
, vol.29
, pp. 4088-4095
-
-
Wierda, W.G.1
-
96
-
-
84901220752
-
The role of ATM mutations and 11q deletions in disease progression in chronic lymphocytic leukemia
-
Stankovic, T., & Skowronska, A. The role of ATM mutations and 11q deletions in disease progression in chronic lymphocytic leukemia. Leuk. Lymphoma 55, 1227-1239 (2014
-
(2014)
Leuk. Lymphoma
, vol.55
, pp. 1227-1239
-
-
Stankovic, T.1
Skowronska, A.2
-
97
-
-
84875423827
-
The ATM protein kinase: Regulating the cellular response to genotoxic stress, and more
-
Shiloh, Y., & Ziv, Y. The ATM protein kinase: regulating the cellular response to genotoxic stress, and more. Nat. Rev. Mol. Cell Biol. 14, 197-210 (2013
-
(2013)
Nat. Rev. Mol. Cell Biol
, vol.14
, pp. 197-210
-
-
Shiloh, Y.1
Ziv, Y.2
-
98
-
-
84871798242
-
Biallelic ATM inactivation significantly reduces survival in patients treated on the United Kingdom leukemia research fund chronic lymphocytic leukemia 4 trial
-
Skowronska, A., et al. Biallelic ATM inactivation significantly reduces survival in patients treated on the United Kingdom Leukemia Research Fund Chronic Lymphocytic Leukemia 4 trial. J. Clin. Oncol. 30, 4524-4532 (2012
-
(2012)
J. Clin. Oncol
, vol.30
, pp. 4524-4532
-
-
Skowronska, A.1
-
99
-
-
0033513587
-
Inactivation of ataxia telangiectasia mutated gene in B cell chronic lymphocytic leukaemia
-
Stankovic, T., et al. Inactivation of ataxia telangiectasia mutated gene in B cell chronic lymphocytic leukaemia. Lancet 353, 26-29 (1999
-
(1999)
Lancet
, vol.353
, pp. 26-29
-
-
Stankovic, T.1
-
100
-
-
0032944319
-
ATM mutations in B cell chronic lymphocytic leukemia
-
Bullrich, F., et al. ATM mutations in B cell chronic lymphocytic leukemia. Cancer Res. 59, 24-27 (1999
-
(1999)
Cancer Res
, vol.59
, pp. 24-27
-
-
Bullrich, F.1
-
101
-
-
27644450586
-
Mutations in the ATM gene lead to impaired overall and treatment-free survival that is independent of IGVH mutation status in patients with B CLL
-
Austen, B., et al. Mutations in the ATM gene lead to impaired overall and treatment-free survival that is independent of IGVH mutation status in patients with B CLL. Blood 106, 3175-3182 (2005
-
(2005)
Blood
, vol.106
, pp. 3175-3182
-
-
Austen, B.1
-
102
-
-
36849045647
-
Mutation status of the residual ATM allele is an important determinant of the cellular response to chemotherapy and survival in patients with chronic lymphocytic leukemia containing an 11q deletion
-
Austen, B., et al. Mutation status of the residual ATM allele is an important determinant of the cellular response to chemotherapy and survival in patients with chronic lymphocytic leukemia containing an 11q deletion. J. Clin. Oncol. 25, 5448-5457 (2007
-
(2007)
J. Clin. Oncol
, vol.25
, pp. 5448-5457
-
-
Austen, B.1
-
103
-
-
84855231198
-
ATM gene alterations in chronic lymphocytic leukemia patients induce a distinct gene expression profile and predict disease progression
-
Guarini, A., et al. ATM gene alterations in chronic lymphocytic leukemia patients induce a distinct gene expression profile and predict disease progression. Haematologica 97, 47-55 (2012
-
(2012)
Haematologica
, vol.97
, pp. 47-55
-
-
Guarini, A.1
-
104
-
-
84858859064
-
Disruption of BIRC3 associates with fludarabine chemorefractoriness in TP53 wild-Type chronic lymphocytic leukemia
-
Rossi, D., et al. Disruption of BIRC3 associates with fludarabine chemorefractoriness in TP53 wild-Type chronic lymphocytic leukemia. Blood 119, 2854-2862 (2012
-
(2012)
Blood
, vol.119
, pp. 2854-2862
-
-
Rossi, D.1
-
105
-
-
0025951144
-
P53 mutations in human lymphoid malignancies: Association with Burkitt lymphoma and chronic lymphocytic leukemia
-
Gaidano, G., et al. p53 mutations in human lymphoid malignancies: association with Burkitt lymphoma and chronic lymphocytic leukemia. Proc. Natl Acad. Sci. USA 88, 5413-5417 (1991
-
(1991)
Proc. Natl Acad. Sci. USA
, vol.88
, pp. 5413-5417
-
-
Gaidano, G.1
-
106
-
-
0028172868
-
P53 mutations are associated with resistance to chemotherapy and short survival in hematologic malignancies
-
Wattel, E., et al. p53 mutations are associated with resistance to chemotherapy and short survival in hematologic malignancies. Blood 84, 3148-3157 (1994
-
(1994)
Blood
, vol.84
, pp. 3148-3157
-
-
Wattel, E.1
-
107
-
-
0028987180
-
P53 gene deletion predicts for poor survival and non-response to therapy with purine analogs in chronic B cell leukemias
-
Dohner, H., et al. p53 gene deletion predicts for poor survival and non-response to therapy with purine analogs in chronic B cell leukemias. Blood 85, 1580-1589 (1995
-
(1995)
Blood
, vol.85
, pp. 1580-1589
-
-
Dohner, H.1
-
108
-
-
76049087341
-
Aggressive chronic lymphocytic leukemia with elevated genomic complexity is associated with multiple gene defects in the response to DNA double-strand breaks
-
Ouillette, P., et al. Aggressive chronic lymphocytic leukemia with elevated genomic complexity is associated with multiple gene defects in the response to DNA double-strand breaks. Clin. Cancer Res. 16, 835-847 (2010
-
(2010)
Clin. Cancer Res
, vol.16
, pp. 835-847
-
-
Ouillette, P.1
-
109
-
-
67650882993
-
Treatment resistance in chronic lymphocytic leukemia: The role of the p53 pathway
-
Zenz, T., et al. Treatment resistance in chronic lymphocytic leukemia: the role of the p53 pathway. Leuk. Lymphoma 50, 510-513 (2009
-
(2009)
Leuk. Lymphoma
, vol.50
, pp. 510-513
-
-
Zenz, T.1
-
110
-
-
70350511471
-
Detailed analysis of p53 pathway defects in fludarabine-refractory chronic lymphocytic leukemia (CLL): Dissecting the contribution of 17p deletion, TP53 mutation, 53 p21 dysfunction, and miR34a in a prospective clinical trial
-
Zenz, T., et al. Detailed analysis of p53 pathway defects in fludarabine-refractory chronic lymphocytic leukemia (CLL): dissecting the contribution of 17p deletion, TP53 mutation, 53 p21 dysfunction, and miR34a in a prospective clinical trial. Blood 114, 2589-2597 (2009
-
(2009)
Blood
, vol.114
, pp. 2589-2597
-
-
Zenz, T.1
-
111
-
-
79953117852
-
The genetics of Richter syndrome reveals disease heterogeneity and predicts survival after transformation
-
Rossi, D., et al. The genetics of Richter syndrome reveals disease heterogeneity and predicts survival after transformation. Blood 117, 3391-3401 (2011
-
(2011)
Blood
, vol.117
, pp. 3391-3401
-
-
Rossi, D.1
-
112
-
-
54049141334
-
Monoallelic TP53 inactivation is associated with poor prognosis in chronic lymphocytic leukemia: Results from a detailed genetic characterization with long-Term follow up
-
Zenz, T., et al Monoallelic TP53 inactivation is associated with poor prognosis in chronic lymphocytic leukemia: results from a detailed genetic characterization with long-Term follow up. Blood 112, 3322-3329 (2008
-
(2008)
Blood
, vol.112
, pp. 3322-3329
-
-
Zenz, T.1
-
113
-
-
58249117812
-
The detection of TP53 mutations in chronic lymphocytic leukemia independently predicts rapid disease progression and is highly correlated with a complex aberrant karyotype
-
Dicker, F., et al. The detection of TP53 mutations in chronic lymphocytic leukemia independently predicts rapid disease progression and is highly correlated with a complex aberrant karyotype. Leukemia 23, 117-124 (2009
-
(2009)
Leukemia
, vol.23
, pp. 117-124
-
-
Dicker, F.1
-
114
-
-
61549089361
-
The prognostic value of TP53 mutations in chronic lymphocytic leukemia is independent of Del17p13: Implications for overall survival and chemorefractoriness
-
Rossi, D., et al. The prognostic value of TP53 mutations in chronic lymphocytic leukemia is independent of Del17p13: implications for overall survival and chemorefractoriness. Clin. Cancer Res. 15, 995-1004 (2009
-
(2009)
Clin. Cancer Res
, vol.15
, pp. 995-1004
-
-
Rossi, D.1
-
115
-
-
73949135028
-
Monoallelic and biallelic inactivation of TP53 gene in chronic lymphocytic leukemia: Selection, impact on survival, and response to DNA damage
-
Malcikova, J., et al. Monoallelic and biallelic inactivation of TP53 gene in chronic lymphocytic leukemia: selection, impact on survival, and response to DNA damage. Blood 114, 5307-5314 (2009
-
(2009)
Blood
, vol.114
, pp. 5307-5314
-
-
Malcikova, J.1
-
116
-
-
79551504914
-
TP53 mutation and survival in chronic lymphocytic leukemia
-
Zenz, T., et al. TP53 mutation and survival in chronic lymphocytic leukemia. J. Clin. Oncol. 28, 4473-4479 (2010
-
(2010)
J. Clin. Oncol
, vol.28
, pp. 4473-4479
-
-
Zenz, T.1
-
117
-
-
84863778287
-
ERIC recommendations on TP53 mutation analysis in chronic lymphocytic leukemia
-
Pospisilova, S., et al. ERIC recommendations on TP53 mutation analysis in chronic lymphocytic leukemia. Leukemia 26, 1458-1461 (2012
-
(2012)
Leukemia
, vol.26
, pp. 1458-1461
-
-
Pospisilova, S.1
-
118
-
-
84899087266
-
Clinical impact of small TP53 mutated subclones in chronic lymphocytic leukemia
-
Rossi, D., et al. Clinical impact of small TP53 mutated subclones in chronic lymphocytic leukemia. Blood 123, 2139-2147 (2014
-
(2014)
Blood
, vol.123
, pp. 2139-2147
-
-
Rossi, D.1
-
119
-
-
84927634190
-
Detailed analysis of therapy-driven clonal evolution of TP53 mutations in chronic lymphocytic leukemia
-
Malcikova, J., et al. Detailed analysis of therapy-driven clonal evolution of TP53 mutations in chronic lymphocytic leukemia. Leukemia 29, 877-885 (2015
-
(2015)
Leukemia
, vol.29
, pp. 877-885
-
-
Malcikova, J.1
-
120
-
-
84977926214
-
Presence of multiple recurrent mutations revealed by targeted NGS confers poor trial outcome of relapsed/refractory CLL
-
Guieze, R., et al. Presence of multiple recurrent mutations revealed by targeted NGS confers poor trial outcome of relapsed/refractory CLL. Blood 126, 2210-2217 (2015
-
(2015)
Blood
, vol.126
, pp. 2210-2217
-
-
Guieze, R.1
-
121
-
-
77449089365
-
A new genetic lesion in B CLL: A NOTCH1 PEST domain mutation
-
Di Ianni, M., et al. A new genetic lesion in B CLL: a NOTCH1 PEST domain mutation. Br. J. Haematol. 146, 689-691 (2009
-
(2009)
Br. J. Haematol
, vol.146
, pp. 689-691
-
-
Di Ianni, M.1
-
122
-
-
84903639208
-
Trisomy 12 chronic lymphocytic leukemia cells exhibit upregulation of integrin signaling that is modulated by NOTCH1 mutations
-
Riches, J. C., et al. Trisomy 12 chronic lymphocytic leukemia cells exhibit upregulation of integrin signaling that is modulated by NOTCH1 mutations. Blood 123, 4101-4110 (2014
-
(2014)
Blood
, vol.123
, pp. 4101-4110
-
-
Riches, J.C.1
-
123
-
-
64249172203
-
The canonical Notch signaling pathway: Unfolding the activation mechanism
-
Kopan, R., & Ilagan, M. X. The canonical Notch signaling pathway: unfolding the activation mechanism. Cell 137, 216-233 (2009
-
(2009)
Cell
, vol.137
, pp. 216-233
-
-
Kopan, R.1
Ilagan, M.X.2
-
124
-
-
5044225888
-
Activating mutations of NOTCH1 in human T cell acute lymphoblastic leukemia
-
Weng, A. P., et al. Activating mutations of NOTCH1 in human T cell acute lymphoblastic leukemia. Science 306, 269-271 (2004
-
(2004)
Science
, vol.306
, pp. 269-271
-
-
Weng, A.P.1
-
125
-
-
34547780475
-
FBW7 mutations in leukemic cells mediate NOTCH pathway activation and resistance to gamma-secretase inhibitors
-
O'Neil, J., et al. FBW7 mutations in leukemic cells mediate NOTCH pathway activation and resistance to gamma-secretase inhibitors. J. Exp. Med. 204, 1813-1824 (2007
-
(2007)
J. Exp. Med
, vol.204
, pp. 1813-1824
-
-
O'Neil, J.1
-
126
-
-
34547820257
-
The SCFFBW7 ubiquitin ligase complex as a tumor suppressor in T cell leukemia
-
Thompson, B. J., et al. The SCFFBW7 ubiquitin ligase complex as a tumor suppressor in T cell leukemia. J. Exp. Med. 204, 1825-1835 (2007
-
(2007)
J. Exp. Med
, vol.204
, pp. 1825-1835
-
-
Thompson, B.J.1
-
127
-
-
59649083306
-
Constitutively activated Notch signaling is involved in survival and apoptosis resistance of B CLL cells
-
Rosati, E., et al. Constitutively activated Notch signaling is involved in survival and apoptosis resistance of B CLL cells. Blood 113, 856-865 (2009
-
(2009)
Blood
, vol.113
, pp. 856-865
-
-
Rosati, E.1
-
128
-
-
84899902477
-
Functional impact of NOTCH1 mutations in chronic lymphocytic leukemia
-
Arruga, F., et al. Functional impact of NOTCH1 mutations in chronic lymphocytic leukemia. Leukemia 28, 1060-1070 (2013
-
(2013)
Leukemia
, vol.28
, pp. 1060-1070
-
-
Arruga, F.1
-
129
-
-
78650213618
-
Alternative promoter usage at the Notch1 locus supports ligand-independent signaling in T cell development and leukemogenesis
-
Gomez-del Arco, P., et al. Alternative promoter usage at the Notch1 locus supports ligand-independent signaling in T cell development and leukemogenesis. Immunity 33, 685-698 (2010
-
(2010)
Immunity
, vol.33
, pp. 685-698
-
-
Gomez-Del Arco, P.1
-
130
-
-
78650335900
-
Deletion-based mechanisms of Notch1 activation in T ALL: Key roles for RAG recombinase and a conserved internal translational start site in Notch1
-
Ashworth, T D., et al. Deletion-based mechanisms of Notch1 activation in T ALL: key roles for RAG recombinase and a conserved internal translational start site in Notch1. Blood 116, 5455-5464 (2010
-
(2010)
Blood
, vol.116
, pp. 5455-5464
-
-
Ashworth, T.D.1
-
131
-
-
78650379575
-
Oncogenic activation of the Notch1 gene by deletion of its promoter in Ikaros-deficient T ALL
-
Jeannet, R., et al. Oncogenic activation of the Notch1 gene by deletion of its promoter in Ikaros-deficient T ALL. Blood 116, 5443-5454 (2010
-
(2010)
Blood
, vol.116
, pp. 5443-5454
-
-
Jeannet, R.1
-
132
-
-
85027948869
-
Distinct TCR signaling pathways drive proliferation and cytokine production in T cells
-
Guy, C. S., et al. Distinct TCR signaling pathways drive proliferation and cytokine production in T cells. Nat. Immunol. 14, 262-270 (2013
-
(2013)
Nat. Immunol
, vol.14
, pp. 262-270
-
-
Guy, C.S.1
-
133
-
-
67949120665
-
Endocytic regulation of Notch signaling
-
Fortini, M. E., & Bilder, D. Endocytic regulation of Notch signaling. Curr. Opin. Genet. Dev. 19, 323-328 (2009
-
(2009)
Curr. Opin. Genet. Dev
, vol.19
, pp. 323-328
-
-
Fortini, M.E.1
Bilder, D.2
-
134
-
-
84926325566
-
Insulin growth factor 1 receptor expression is associated with NOTCH1 mutation, trisomy 12 and aggressive clinical course in chronic lymphocytic leukaemia
-
Maura, F., et al. Insulin growth factor 1 receptor expression is associated with NOTCH1 mutation, trisomy 12 and aggressive clinical course in chronic lymphocytic leukaemia. PLoS ONE 10, e0118801 (2015
-
(2015)
PLoS ONE
, vol.10
, pp. e0118801
-
-
Maura, F.1
-
135
-
-
84953366342
-
NOTCH1 mutations associate with low CD20 level in chronic lymphocytic leukemia: Evidence for a NOTCH1 mutation-driven epigenetic dysregulation
-
Pozzo, F., et al. NOTCH1 mutations associate with low CD20 level in chronic lymphocytic leukemia: evidence for a NOTCH1 mutation-driven epigenetic dysregulation. Leukemia 30, 182-189 (2015
-
(2015)
Leukemia
, vol.30
, pp. 182-189
-
-
Pozzo, F.1
-
136
-
-
84901408966
-
Gene mutations and treatment outcome in chronic lymphocytic leukemia: Results from the CLL8 trial
-
Stilgenbauer, S., et al. Gene mutations and treatment outcome in chronic lymphocytic leukemia: results from the CLL8 trial. Blood 123, 3247-3254 (2014
-
(2014)
Blood
, vol.123
, pp. 3247-3254
-
-
Stilgenbauer, S.1
-
137
-
-
84872303004
-
Biologic and clinical significance of somatic mutations of SF3B1 in myeloid and lymphoid neoplasms
-
Cazzola, M., et al. Biologic and clinical significance of somatic mutations of SF3B1 in myeloid and lymphoid neoplasms. Blood 121, 260-269 (2013
-
(2013)
Blood
, vol.121
, pp. 260-269
-
-
Cazzola, M.1
-
138
-
-
4444272979
-
Cell signalling and the control of pre-mRNA splicing
-
Shin, C., & Manley, J. L. Cell signalling and the control of pre-mRNA splicing. Nat. Rev. Mol. Cell Biol. 5, 727-738 (2004
-
(2004)
Nat. Rev. Mol. Cell Biol
, vol.5
, pp. 727-738
-
-
Shin, C.1
Manley, J.L.2
-
139
-
-
0038670209
-
Molecular architecture of the multiprotein splicing factor SF3b
-
Golas, M M., Sander, B., Will, C. L., Luhrmann, R., & Stark, H. Molecular architecture of the multiprotein splicing factor SF3b. Science 300, 980-984 (2003
-
(2003)
Science
, vol.300
, pp. 980-984
-
-
Golas, M.M.1
Sander, B.2
Will, C.L.3
Luhrmann, R.4
Stark, H.5
-
140
-
-
84929291816
-
The impact of SF3B1 mutations in CLL on the DNA-damage response
-
Te Raa, G. D., et al. The impact of SF3B1 mutations in CLL on the DNA-damage response. Leukemia 29, 1133-1142 (2015
-
(2015)
Leukemia
, vol.29
, pp. 1133-1142
-
-
Te Raa, G.D.1
-
141
-
-
84880310708
-
Frequent somatic mutations in components of the RNA processing machinery in chronic lymphocytic leukemia
-
Ramsay, A. J., et al. Frequent somatic mutations in components of the RNA processing machinery in chronic lymphocytic leukemia. Leukemia 27, 1600-1603 (2013
-
(2013)
Leukemia
, vol.27
, pp. 1600-1603
-
-
Ramsay, A.J.1
-
142
-
-
84959107133
-
Functional loss of IkappaBepsilon leads to NF ?B deregulation in aggressive chronic lymphocytic leukemia
-
Mansouri, L., et al. Functional loss of IkappaBepsilon leads to NF ?B deregulation in aggressive chronic lymphocytic leukemia. J. Exp. Med. 212, 833-843 (2015
-
(2015)
J. Exp. Med
, vol.212
, pp. 833-843
-
-
Mansouri, L.1
-
143
-
-
34547562418
-
Frequent engagement of the classical and alternative NF ?B pathways by diverse genetic abnormalities in multiple myeloma
-
Annunziata, C. M., et al. Frequent engagement of the classical and alternative NF ?B pathways by diverse genetic abnormalities in multiple myeloma. Cancer Cell 12, 115-130 (2007
-
(2007)
Cancer Cell
, vol.12
, pp. 115-130
-
-
Annunziata, C.M.1
-
144
-
-
34547660308
-
Promiscuous mutations activate the noncanonical NF ?B pathway in multiple myeloma
-
Keats, J. J., et al. Promiscuous mutations activate the noncanonical NF ?B pathway in multiple myeloma. Cancer Cell 12, 131-144 (2007
-
(2007)
Cancer Cell
, vol.12
, pp. 131-144
-
-
Keats, J.J.1
-
145
-
-
80855133512
-
Alteration of BIRC3 and multiple other NF ?B pathway genes in splenic marginal zone lymphoma
-
Rossi, D., et al. Alteration of BIRC3 and multiple other NF ?B pathway genes in splenic marginal zone lymphoma. Blood 118, 4930-4934 (2011
-
(2011)
Blood
, vol.118
, pp. 4930-4934
-
-
Rossi, D.1
-
146
-
-
84858796247
-
Integration of B cell responses through Toll-like receptors and antigen receptors
-
Rawlings, D. J., Schwartz, M. A., Jackson, S. W., & Meyer-Bahlburg, A. Integration of B cell responses through Toll-like receptors and antigen receptors. Nat. Rev. Immunol. 12, 282-294 (2012
-
(2012)
Nat. Rev. Immunol
, vol.12
, pp. 282-294
-
-
Rawlings, D.J.1
Schwartz, M.A.2
Jackson, S.W.3
Meyer-Bahlburg, A.4
-
147
-
-
79551686422
-
Oncogenically active MYD88 mutations in human lymphoma
-
Ngo, V. N., et al. Oncogenically active MYD88 mutations in human lymphoma. Nature 470, 115-119 (2011
-
(2011)
Nature
, vol.470
, pp. 115-119
-
-
Ngo, V.N.1
-
148
-
-
84865475885
-
MYD88 L265P somatic mutation in Waldenstrom's macroglobulinemia
-
Treon, S. P., et al. MYD88 L265P somatic mutation in Waldenstrom's macroglobulinemia. N. Engl. J. Med. 367, 826-833 (2012
-
(2012)
N. Engl. J. Med
, vol.367
, pp. 826-833
-
-
Treon, S.P.1
-
149
-
-
84897493559
-
IkappaBepsilon is a key regulator of B cell expansion by providing negative feedback on cRel and RelA in a stimulus-specific manner
-
Alves, B. N., et al. IkappaBepsilon is a key regulator of B cell expansion by providing negative feedback on cRel and RelA in a stimulus-specific manner. J. Immunol. 192, 3121-3132 (2014
-
(2014)
J. Immunol
, vol.192
, pp. 3121-3132
-
-
Alves, B.N.1
-
150
-
-
78751549662
-
The lymph node microenvironment promotes B cell receptor signaling NF ?B activation, and tumor proliferation in chronic lymphocytic leukemia
-
Herishanu, Y., et al. The lymph node microenvironment promotes B cell receptor signaling, NF ?B activation, and tumor proliferation in chronic lymphocytic leukemia. Blood 117, 563-574 (2011
-
(2011)
Blood
, vol.117
, pp. 563-574
-
-
Herishanu, Y.1
-
151
-
-
0038451396
-
POT1 as a terminal transducer of TRF1 telomere length control
-
Loayza, D., & De Lange, T. POT1 as a terminal transducer of TRF1 telomere length control. Nature 423, 1013-1018 (2003
-
(2003)
Nature
, vol.423
, pp. 1013-1018
-
-
Loayza, D.1
De Lange, T.2
-
152
-
-
12844265975
-
Structure of human POT1 bound to telomeric single-stranded DNA provides a model for chromosome end-protection
-
Lei, M., Podell, E. R., & Cech, T. R. Structure of human POT1 bound to telomeric single-stranded DNA provides a model for chromosome end-protection. Nat. Struct. Mol. Biol. 11, 1223-1229 (2004
-
(2004)
Nat. Struct. Mol. Biol
, vol.11
, pp. 1223-1229
-
-
Lei, M.1
Podell, E.R.2
Cech, T.R.3
-
153
-
-
84878551940
-
POT1 mutations cause telomere dysfunction in chronic lymphocytic leukemia
-
Ramsay, A. J., et al. POT1 mutations cause telomere dysfunction in chronic lymphocytic leukemia. Nat. Genet. 45, 526-530 (2013
-
(2013)
Nat. Genet
, vol.45
, pp. 526-530
-
-
Ramsay, A.J.1
-
154
-
-
84937918437
-
Mutations in CHD2 cause defective association with active chromatin in chronic lymphocytic leukemia
-
Rodriguez, D., et al. Mutations in CHD2 cause defective association with active chromatin in chronic lymphocytic leukemia. Blood 126, 195-202 (2015
-
(2015)
Blood
, vol.126
, pp. 195-202
-
-
Rodriguez, D.1
-
155
-
-
84897585594
-
SAMHD1 is mutated recurrently in chronic lymphocytic leukemia and is involved in response to DNA damage
-
Clifford, R., et al. SAMHD1 is mutated recurrently in chronic lymphocytic leukemia and is involved in response to DNA damage. Blood 123, 1021-1031 (2014
-
(2014)
Blood
, vol.123
, pp. 1021-1031
-
-
Clifford, R.1
-
156
-
-
84905990862
-
Somatic mutation as a mechanism of Wnt/beta-catenin pathway activation in CLL
-
Wang, L., et al. Somatic mutation as a mechanism of Wnt/beta-catenin pathway activation in CLL. Blood 124, 1089-1098 (2014
-
(2014)
Blood
, vol.124
, pp. 1089-1098
-
-
Wang, L.1
-
157
-
-
84255170476
-
The Pax 5 gene: A pluripotent regulator of B cell differentiation and cancer disease
-
O'Brien, P., Morin, P. Jr, Ouellette, R. J., & Robichaud, G. A. The Pax 5 gene: a pluripotent regulator of B cell differentiation and cancer disease. Cancer Res. 71, 7345-7350 (2011
-
(2011)
Cancer Res
, vol.71
, pp. 7345-7350
-
-
O'Brien, P.1
Morin, P.2
Ouellette, R.J.3
Robichaud, G.A.4
-
158
-
-
80053144962
-
A decade of exploring the cancer epigenome-biological and translational implications
-
Baylin, S. B., & Jones, P. A. A decade of exploring the cancer epigenome-biological and translational implications. Nat. Rev. Cancer 11, 726-734 (2011
-
(2011)
Nat. Rev. Cancer
, vol.11
, pp. 726-734
-
-
Baylin, S.B.1
Jones, P.A.2
-
159
-
-
75649133610
-
Differential genome-wide array-based methylation profiles in prognostic subsets of chronic lymphocytic leukemia
-
Kanduri, M., et al. Differential genome-wide array-based methylation profiles in prognostic subsets of chronic lymphocytic leukemia. Blood 115, 296-305 (2010
-
(2010)
Blood
, vol.115
, pp. 296-305
-
-
Kanduri, M.1
-
160
-
-
84873570131
-
450K array analysis of chronic lymphocytic leukemia cells reveals global DNA methylation to be relatively stable over time and similar in resting and proliferative compartments
-
Cahill, N., et al. 450K array analysis of chronic lymphocytic leukemia cells reveals global DNA methylation to be relatively stable over time and similar in resting and proliferative compartments. Leukemia 27, 150-158 (2013
-
(2013)
Leukemia
, vol.27
, pp. 150-158
-
-
Cahill, N.1
-
161
-
-
84919469035
-
Locally disordered methylation forms the basis of intratumor methylome variation in chronic lymphocytic leukemia
-
Landau, D. A., et al. Locally disordered methylation forms the basis of intratumor methylome variation in chronic lymphocytic leukemia. Cancer Cell 26, 813-825 (2014
-
(2014)
Cancer Cell
, vol.26
, pp. 813-825
-
-
Landau, D.A.1
-
162
-
-
84895783051
-
Evolution of DNA methylation is linked to genetic aberrations in chronic lymphocytic leukemia
-
Oakes, C. C., et al. Evolution of DNA methylation is linked to genetic aberrations in chronic lymphocytic leukemia. Cancer Discov. 4, 348-361 (2014
-
(2014)
Cancer Discov
, vol.4
, pp. 348-361
-
-
Oakes, C.C.1
-
163
-
-
84924540077
-
A B cell epigenetic signature defines three biologic subgroups of chronic lymphocytic leukemia with clinical impact
-
Queiros, A. C., et al. A B cell epigenetic signature defines three biologic subgroups of chronic lymphocytic leukemia with clinical impact. Leukemia 29, 598-605 (2015
-
(2015)
Leukemia
, vol.29
, pp. 598-605
-
-
Queiros, A.C.1
-
164
-
-
67651053001
-
Increased frequency (12%) of circulating chronic lymphocytic leukemia-like B cell clones in healthy subjects using a highly sensitive multicolor flow cytometry approach
-
Nieto, W. G., et al. Increased frequency (12%) of circulating chronic lymphocytic leukemia-like B cell clones in healthy subjects using a highly sensitive multicolor flow cytometry approach. Blood 114, 33-37 (2009
-
(2009)
Blood
, vol.114
, pp. 33-37
-
-
Nieto, W.G.1
-
165
-
-
84879774711
-
Immunogenetics shows that not all MBL are equal: The larger the clone, the more similar to CLL
-
Vardi, A., et al. Immunogenetics shows that not all MBL are equal: the larger the clone, the more similar to CLL. Blood 121, 4521-4528 (2013
-
(2013)
Blood
, vol.121
, pp. 4521-4528
-
-
Vardi, A.1
-
166
-
-
60549113518
-
B cell clones as early markers for chronic lymphocytic leukemia
-
Landgren, O., et al. B cell clones as early markers for chronic lymphocytic leukemia. N. Engl. J. Med. 360, 659-667 (2009
-
(2009)
N. Engl. J. Med
, vol.360
, pp. 659-667
-
-
Landgren, O.1
-
167
-
-
84900487705
-
High-Throughput sequencing for the identification of NOTCH1 mutations in early stage chronic lymphocytic leukaemia: Biological and clinical implications
-
Lionetti, M., et al. High-Throughput sequencing for the identification of NOTCH1 mutations in early stage chronic lymphocytic leukaemia: biological and clinical implications. Br. J. Haematol. 165, 629-639 (2014
-
(2014)
Br. J. Haematol
, vol.165
, pp. 629-639
-
-
Lionetti, M.1
-
168
-
-
84926984290
-
Monoclonal B cell lymphocytosis is characterized by mutations in CLL putative driver genes and clonal heterogeneity many years before disease progression
-
Ojha, J., et al. Monoclonal B cell lymphocytosis is characterized by mutations in CLL putative driver genes and clonal heterogeneity many years before disease progression. Leukemia 28, 2395-2398 (2014
-
(2014)
Leukemia
, vol.28
, pp. 2395-2398
-
-
Ojha, J.1
-
169
-
-
84927638969
-
Identification of recurrent truncated DDX3X mutations in chronic lymphocytic leukaemia
-
Ojha, J., et al. Identification of recurrent truncated DDX3X mutations in chronic lymphocytic leukaemia. Br. J. Haematol. 169, 445-448 (2015
-
(2015)
Br. J. Haematol
, vol.169
, pp. 445-448
-
-
Ojha, J.1
-
170
-
-
84961289235
-
Deep sequencing identifies genetic heterogeneity and recurrent convergent evolution in chronic lymphocytic leukemia
-
Ojha, J., et al. Deep sequencing identifies genetic heterogeneity and recurrent convergent evolution in chronic lymphocytic leukemia. Blood 125, 492-498 (2015
-
(2015)
Blood
, vol.125
, pp. 492-498
-
-
Ojha, J.1
-
171
-
-
84855854025
-
Mutations of NOTCH1 are an independent predictor of survival in chronic lymphocytic leukemia
-
Rossi, D., et al. Mutations of NOTCH1 are an independent predictor of survival in chronic lymphocytic leukemia. Blood 119, 521-529 (2012
-
(2012)
Blood
, vol.119
, pp. 521-529
-
-
Rossi, D.1
-
172
-
-
84899084563
-
Genetic lesions associated with chronic lymphocytic leukemia chemo-refractoriness
-
Messina, M., et al. Genetic lesions associated with chronic lymphocytic leukemia chemo-refractoriness. Blood 123, 2378-2388 (2014
-
(2014)
Blood
, vol.123
, pp. 2378-2388
-
-
Messina, M.1
-
173
-
-
84874929638
-
Analysis of SF3B1 mutations in monoclonal B cell lymphocytosis
-
Greco, M., et al. Analysis of SF3B1 mutations in monoclonal B cell lymphocytosis. Hematol. Oncol. 31, 54-55 (2013
-
(2013)
Hematol. Oncol
, vol.31
, pp. 54-55
-
-
Greco, M.1
-
174
-
-
84937856647
-
Genomic and epigenomic heterogeneity in chronic lymphocytic leukemia
-
Guieze, R., & Wu, C. J. Genomic and epigenomic heterogeneity in chronic lymphocytic leukemia. Blood 126, 445-453 (2015
-
(2015)
Blood
, vol.126
, pp. 445-453
-
-
Guieze, R.1
Wu, C.J.2
-
175
-
-
84855243926
-
Analysis of NOTCH1 mutations in monoclonal B cell lymphocytosis
-
Rasi, S., et al. Analysis of NOTCH1 mutations in monoclonal B cell lymphocytosis. Haematologica 97, 153-154 (2012
-
(2012)
Haematologica
, vol.97
, pp. 153-154
-
-
Rasi, S.1
-
176
-
-
84255160977
-
Mutations of the SF3B1 splicing factor in chronic lymphocytic leukemia: Association with progression and fludarabine-refractoriness
-
Rossi, D., et al. Mutations of the SF3B1 splicing factor in chronic lymphocytic leukemia: association with progression and fludarabine-refractoriness. Blood 118, 6904-6908 (2011
-
(2011)
Blood
, vol.118
, pp. 6904-6908
-
-
Rossi, D.1
-
177
-
-
84991237207
-
Tumor evolutionary directed graphs and the history of chronic lymphocytic leukemia
-
Wang, J., et al. Tumor evolutionary directed graphs and the history of chronic lymphocytic leukemia. eLife http://doi.dx.org/10.7554/eLife.02869 (2014
-
(2014)
ELife
-
-
Wang, J.1
-
178
-
-
84872032663
-
The impact of initial fludarabine therapy on transformation to Richter syndrome or prolymphocytic leukemia in patients with chronic lymphocytic leukemia: Analysis of an intergroup trial (CALGB 9011
-
Solh, M., et al. The impact of initial fludarabine therapy on transformation to Richter syndrome or prolymphocytic leukemia in patients with chronic lymphocytic leukemia: analysis of an intergroup trial (CALGB 9011). Leuk. Lymphoma 54, 252-254 (2013
-
(2013)
Leuk. Lymphoma
, vol.54
, pp. 252-254
-
-
Solh, M.1
-
179
-
-
84890436856
-
Prognostic impact and landscape of NOTCH1 mutations in chronic lymphocytic leukemia (CLL): A study on 852 patients
-
Weissmann, S., et al. Prognostic impact and landscape of NOTCH1 mutations in chronic lymphocytic leukemia (CLL): a study on 852 patients. Leukemia 27, 2393-2396 (2013
-
(2013)
Leukemia
, vol.27
, pp. 2393-2396
-
-
Weissmann, S.1
-
180
-
-
84877635463
-
NOTCH1 mutations identify a genetic subgroup of chronic lymphocytic leukemia patients with high risk of transformation and poor outcome
-
Villamor, N., et al. NOTCH1 mutations identify a genetic subgroup of chronic lymphocytic leukemia patients with high risk of transformation and poor outcome. Leukemia 27, 1100-1106 (2013
-
(2013)
Leukemia
, vol.27
, pp. 1100-1106
-
-
Villamor, N.1
-
181
-
-
77951139188
-
Therapeutic antibody targeting of individual Notch receptors
-
Wu, Y., et al. Therapeutic antibody targeting of individual Notch receptors. Nature 464, 1052-1057 (2010
-
(2010)
Nature
, vol.464
, pp. 1052-1057
-
-
Wu, Y.1
-
182
-
-
84866028455
-
Integrative analysis reveals an outcome-Associated and targetable pattern of p53 and cell cycle deregulation in diffuse large B cell lymphoma
-
Monti, S., et al. Integrative analysis reveals an outcome-Associated and targetable pattern of p53 and cell cycle deregulation in diffuse large B cell lymphoma. Cancer Cell 22, 359-372 (2012
-
(2012)
Cancer Cell
, vol.22
, pp. 359-372
-
-
Monti, S.1
-
183
-
-
67650393955
-
Stereotyped B cell receptor is an independent risk factor of chronic lymphocytic leukemia transformation to Richter syndrome
-
Rossi, D., et al. Stereotyped B cell receptor is an independent risk factor of chronic lymphocytic leukemia transformation to Richter syndrome. Clin. Cancer Res. 15, 4415-4422 (2009
-
(2009)
Clin. Cancer Res
, vol.15
, pp. 4415-4422
-
-
Rossi, D.1
-
184
-
-
84881266955
-
Association between molecular lesions and specific B cell receptor subsets in chronic lymphocytic leukemia
-
Rossi, D., et al. Association between molecular lesions and specific B cell receptor subsets in chronic lymphocytic leukemia. Blood 121, 4902-4905 (2013
-
(2013)
Blood
, vol.121
, pp. 4902-4905
-
-
Rossi, D.1
-
185
-
-
84930966113
-
Excessive antigen reactivity may underlie the clinical aggressiveness of chronic lymphocytic leukemia stereotyped subset #8
-
Gounari, M., et al Excessive antigen reactivity may underlie the clinical aggressiveness of chronic lymphocytic leukemia stereotyped subset #8. Blood 125, 3580-3587 (2015
-
(2015)
Blood
, vol.125
, pp. 3580-3587
-
-
Gounari, M.1
-
186
-
-
84874428346
-
Integrated mutational and cytogenetic analysis identifies new prognostic subgroups in chronic lymphocytic leukemia
-
Rossi, D., et al. Integrated mutational and cytogenetic analysis identifies new prognostic subgroups in chronic lymphocytic leukemia. Blood 121, 1403-1412 (2013
-
(2013)
Blood
, vol.121
, pp. 1403-1412
-
-
Rossi, D.1
-
187
-
-
84891866590
-
SF3B1 mutations correlated to cytogenetics and mutations in NOTCH1, FBXW7, MYD88, XPO1 and TP53 in 1160 untreated CLL patients
-
Jeromin, S., et al. SF3B1 mutations correlated to cytogenetics and mutations in NOTCH1, FBXW7, MYD88, XPO1 and TP53 in 1160 untreated CLL patients. Leukemia 28, 108-117 (2014
-
(2014)
Leukemia
, vol.28
, pp. 108-117
-
-
Jeromin, S.1
-
188
-
-
84922529491
-
Recurrent mutations refine prognosis in chronic lymphocytic leukemia
-
Baliakas, P., et al. Recurrent mutations refine prognosis in chronic lymphocytic leukemia. Leukemia 29, 329-336 (2015
-
(2015)
Leukemia
, vol.29
, pp. 329-336
-
-
Baliakas, P.1
-
189
-
-
84872469222
-
The clinical significance of NOTCH1 and SF3B1 mutations in the UK LRF CLL4 trial
-
Oscier, D. G., et al. The clinical significance of NOTCH1 and SF3B1 mutations in the UK LRF CLL4 trial. Blood 121, 468-475 (2013
-
(2013)
Blood
, vol.121
, pp. 468-475
-
-
Oscier, D.G.1
-
190
-
-
84887204270
-
NOTCH1 SF3B1, and TP53 mutations in fludarabine-refractory CLL patients treated with alemtuzumab: Results from the CLL2H trial of the GCLLSG
-
Schnaiter, A., et al. NOTCH1, SF3B1, and TP53 mutations in fludarabine-refractory CLL patients treated with alemtuzumab: results from the CLL2H trial of the GCLLSG. Blood 122, 1266-1270 (2013
-
(2013)
Blood
, vol.122
, pp. 1266-1270
-
-
Schnaiter, A.1
-
191
-
-
84879173666
-
TP53 SF3B1, and NOTCH1 mutations and outcome of allotransplantation for chronic lymphocytic leukemia: Six-year follow up of the GCLLSG CLL3X trial
-
Dreger, P., et al. TP53, SF3B1, and NOTCH1 mutations and outcome of allotransplantation for chronic lymphocytic leukemia: six-year follow up of the GCLLSG CLL3X trial. Blood 121, 3284-3288 (2013
-
(2013)
Blood
, vol.121
, pp. 3284-3288
-
-
Dreger, P.1
-
192
-
-
84994504370
-
Etiology of ibrutinib therapy discontinuation and outcomes in patients with chronic lymphocytic leukemia
-
Maddocks, K. J., et al. Etiology of ibrutinib therapy discontinuation and outcomes in patients with chronic lymphocytic leukemia. JAMA Oncol. 1, 80-87 (2015
-
(2015)
JAMA Oncol
, vol.1
, pp. 80-87
-
-
Maddocks, K.J.1
-
193
-
-
84927732048
-
Three-year follow up of treatment-naive and previously treated patients with CLL and SLL receiving single-Agent ibrutinib
-
Byrd, J. C., et al. Three-year follow up of treatment-naive and previously treated patients with CLL and SLL receiving single-Agent ibrutinib. Blood 125, 2497-2506 (2015
-
(2015)
Blood
, vol.125
, pp. 2497-2506
-
-
Byrd, J.C.1
-
194
-
-
84902183019
-
Resistance mechanisms for the Bruton's tyrosine kinase inhibitor ibrutinib
-
Woyach, J. A., et al. Resistance mechanisms for the Bruton's tyrosine kinase inhibitor ibrutinib. N. Engl. J. Med. 370, 2286-2294 (2014
-
(2014)
N. Engl. J. Med
, vol.370
, pp. 2286-2294
-
-
Woyach, J.A.1
-
195
-
-
84937841721
-
Hypermorphic mutation of phospholipase C, ? 2 acquired in ibrutinib-resistant CLL confers BTK independency upon B cell receptor activation
-
Liu, T. M., et al. Hypermorphic mutation of phospholipase C, ?2 acquired in ibrutinib-resistant CLL confers BTK independency upon B cell receptor activation. Blood 126, 61-68 (2015
-
(2015)
Blood
, vol.126
, pp. 61-68
-
-
Liu, T.M.1
-
196
-
-
84927656208
-
Functional characterization of BTK(C481S) mutation that confers ibrutinib resistance: Exploration of alternative kinase inhibitors
-
Cheng, S., et al. Functional characterization of BTK(C481S) mutation that confers ibrutinib resistance: exploration of alternative kinase inhibitors. Leukemia 29, 895-900 (2015
-
(2015)
Leukemia
, vol.29
, pp. 895-900
-
-
Cheng, S.1
-
197
-
-
84919483332
-
Ibrutinib-naive chronic lymphocytic leukemia lacks Bruton tyrosine kinase mutations associated with treatment resistance
-
Fama, R., et al. Ibrutinib-naive chronic lymphocytic leukemia lacks Bruton tyrosine kinase mutations associated with treatment resistance. Blood 124, 3831-3833 (2014
-
(2014)
Blood
, vol.124
, pp. 3831-3833
-
-
Fama, R.1
-
198
-
-
0036682481
-
Several types of mutations of the Abl gene can be found in chronic myeloid leukemia patients resistant to STI571, and they can pre-exist to the onset of treatment
-
Roche-Lestienne, C., et al. Several types of mutations of the Abl gene can be found in chronic myeloid leukemia patients resistant to STI571, and they can pre-exist to the onset of treatment. Blood 100, 1014-1018 (2002
-
(2002)
Blood
, vol.100
, pp. 1014-1018
-
-
Roche-Lestienne, C.1
-
199
-
-
0038156170
-
Presence of the BCR-ABL mutation Glu255Lys prior to STI571 (imatinib) treatment in patients with Ph+ acute lymphoblastic leukemia
-
Hofmann, W. K., et al. Presence of the BCR-ABL mutation Glu255Lys prior to STI571 (imatinib) treatment in patients with Ph+ acute lymphoblastic leukemia. Blood 102, 659-661 (2003
-
(2003)
Blood
, vol.102
, pp. 659-661
-
-
Hofmann, W.K.1
-
200
-
-
84899626029
-
Therapeutic modulation of Notch signalling-Are we there yet
-
Andersson, E. R., & Lendahl, U. Therapeutic modulation of Notch signalling-Are we there yet? Nat. Rev. Drug Discov. 13, 357-378 (2014
-
(2014)
Nat. Rev. Drug Discov
, vol.13
, pp. 357-378
-
-
Andersson, E.R.1
Lendahl, U.2
-
201
-
-
34548095157
-
Spliceostatin A targets SF3b and inhibits both splicing and nuclear retention of pre-mRNA
-
Kaida, D., et al. Spliceostatin A targets SF3b and inhibits both splicing and nuclear retention of pre-mRNA. Nat. Chem. Biol. 3, 576-583 (2007
-
(2007)
Nat. Chem. Biol
, vol.3
, pp. 576-583
-
-
Kaida, D.1
-
202
-
-
84959358645
-
The SF3B1 inhibitor spliceostatin A (SSA) elicits apoptosis in chronic lymphocytic leukemia cells through downregulation of Mcl 1
-
Larrayoz, M., et al The SF3B1 inhibitor spliceostatin A (SSA) elicits apoptosis in chronic lymphocytic leukemia cells through downregulation of Mcl 1. Leukemia 30, 351-360 (2016
-
(2016)
Leukemia
, vol.30
, pp. 351-360
-
-
Larrayoz, M.1
-
203
-
-
0028822481
-
Chronic lymphocytic leukemia
-
Rozman, C., & Montserrat, E. Chronic lymphocytic leukemia. N. Engl. J. Med. 333, 1052-1057 (1995
-
(1995)
N. Engl. J. Med
, vol.333
, pp. 1052-1057
-
-
Rozman, C.1
Montserrat, E.2
-
204
-
-
0019427092
-
A new prognostic classification of chronic lymphocytic leukemia derived from a multivariate survival analysis
-
Binet, J. L., et al. A new prognostic classification of chronic lymphocytic leukemia derived from a multivariate survival analysis. Cancer 48, 198-206 (1981
-
(1981)
Cancer
, vol.48
, pp. 198-206
-
-
Binet, J.L.1
-
205
-
-
0016740933
-
Clinical staging of chronic lymphocytic leukemia
-
Rai, K. R., et al. Clinical staging of chronic lymphocytic leukemia. Blood 46, 219-234 (1975
-
(1975)
Blood
, vol.46
, pp. 219-234
-
-
Rai, K.R.1
-
206
-
-
0019052682
-
Immunohistologic analysis of the organization of normal lymphoid tissue and non-Hodgkin's lymphomas
-
Stein, H., et al. Immunohistologic analysis of the organization of normal lymphoid tissue and non-Hodgkin's lymphomas. J. Histochem. Cytochem. 28, 746-760 (1980
-
(1980)
J. Histochem. Cytochem
, vol.28
, pp. 746-760
-
-
Stein, H.1
-
207
-
-
0033485625
-
Chronic lymphocytic leukemia B cells express functional CXCR4 chemokine receptors that mediate spontaneous migration beneath bone marrow stromal cells
-
Burger, J. A., Burger, M., & Kipps, T. J. Chronic lymphocytic leukemia B cells express functional CXCR4 chemokine receptors that mediate spontaneous migration beneath bone marrow stromal cells. Blood 94, 3658-3667 (1999
-
(1999)
Blood
, vol.94
, pp. 3658-3667
-
-
Burger, J.A.1
Burger, M.2
Kipps, T.J.3
-
208
-
-
73349126115
-
Diverse marrow stromal cells protect CLL cells from spontaneous and drug-induced apoptosis: Development of a reliable and reproducible system to assess stromal cell adhesion-mediated drug resistance
-
Kurtova, A. V., et al. Diverse marrow stromal cells protect CLL cells from spontaneous and drug-induced apoptosis: development of a reliable and reproducible system to assess stromal cell adhesion-mediated drug resistance. Blood 114, 4441-4450 (2009
-
(2009)
Blood
, vol.114
, pp. 4441-4450
-
-
Kurtova, A.V.1
-
209
-
-
0032055818
-
Chronic lymphocytic leukemic B cells but not normal B cells are rescued from apoptosis by contact with normal bone marrow stromal cells
-
Lagneaux, L., Delforge, A., Bron, D., De Bruyn, C., & Stryckmans, P. Chronic lymphocytic leukemic B cells but not normal B cells are rescued from apoptosis by contact with normal bone marrow stromal cells. Blood 91, 2387-2396 (1998
-
(1998)
Blood
, vol.91
, pp. 2387-2396
-
-
Lagneaux, L.1
Delforge, A.2
Bron, D.3
De Bruyn, C.4
Stryckmans, P.5
-
210
-
-
84872387409
-
Protein kinase c beta-dependent activation of NF ?B in stromal cells is indispensable for the survival of chronic lymphocytic leukemia B cells in vivo
-
Lutzny, G., et al. Protein kinase c beta-dependent activation of NF ?B in stromal cells is indispensable for the survival of chronic lymphocytic leukemia B cells in vivo. Cancer Cell 23, 77-92 (2013
-
(2013)
Cancer Cell
, vol.23
, pp. 77-92
-
-
Lutzny, G.1
-
212
-
-
84859398461
-
Nurture versus nature: The microenvironment in chronic lymphocytic leukemia
-
Burger, J. A. Nurture versus nature: the microenvironment in chronic lymphocytic leukemia. Hematol. Am. Soc. Hematol. Educ. Program 2011, 96-103 (2011
-
(2011)
Hematol. Am. Soc. Hematol. Educ. Program
, vol.2011
, pp. 96-103
-
-
Burger, J.A.1
-
213
-
-
0021013632
-
Immunohistologic study of bone marrow involvement in B chronic lymphocytic leukemia
-
Pizzolo, G., et al. Immunohistologic study of bone marrow involvement in B chronic lymphocytic leukemia. Blood 62, 1289-1296 (1983
-
(1983)
Blood
, vol.62
, pp. 1289-1296
-
-
Pizzolo, G.1
-
214
-
-
0036099832
-
Chronic lymphocytic leukemia B cells are endowed with the capacity to attract CD4+ CD40L+ T cells by producing CCL22
-
Ghia, P., et al. Chronic lymphocytic leukemia B cells are endowed with the capacity to attract CD4+, CD40L+ T cells by producing CCL22. Eur. J. Immunol. 32, 1403-1413 (2002
-
(2002)
Eur. J. Immunol
, vol.32
, pp. 1403-1413
-
-
Ghia, P.1
-
215
-
-
46749145421
-
CD38 expression in chronic lymphocytic leukemia is regulated by the tumor microenvironment
-
Patten, P. E., et al. CD38 expression in chronic lymphocytic leukemia is regulated by the tumor microenvironment. Blood 111, 5173-5181 (2008
-
(2008)
Blood
, vol.111
, pp. 5173-5181
-
-
Patten, P.E.1
-
216
-
-
84881613238
-
Chronic lymphocytic leukemia cells are activated and proliferate in response to specific T helper cells
-
Os, A., et al. Chronic lymphocytic leukemia cells are activated and proliferate in response to specific T helper cells. Cell Rep. 4, 566-577 (2013
-
(2013)
Cell Rep
, vol.4
, pp. 566-577
-
-
Os, A.1
-
217
-
-
79956275845
-
A novel adoptive transfer model of chronic lymphocytic leukemia suggests a key role for T lymphocytes in the disease
-
Bagnara, D., et al. A novel adoptive transfer model of chronic lymphocytic leukemia suggests a key role for T lymphocytes in the disease. Blood 117, 5463-5472 (2011
-
(2011)
Blood
, vol.117
, pp. 5463-5472
-
-
Bagnara, D.1
|