Trisomy 12 chronic lymphocytic leukemia cells exhibit upregulation of integrin signaling that is modulated by NOTCH1 mutations

Blood

Volumn 123, Issue 26, 2014, Pages 4101-4110

  Riches, John C ^a   O'Donovan, Conor J ^a   Kingdon, Sarah J ^a   McClanahan, Fabienne ^a   Clear, Andrew J ^a   Neuberg, Donna S ^b   Werner, Lillian ^b   Croce, Carlo M ^c   Ramsay, Alan G ^a   Rassenti, Laura Z ^d   Kipps, Thomas J ^d   Gribben, John G ^a  

^a QUEEN MARY UNIVERSITY OF LONDON   (United Kingdom)

^b DANA FARBER CANCER INSTITUTE   (United States)

^c THE OHIO STATE UNIVERSITY WEXNER MEDICAL CENTER   (United States)

^d UNIVERSITY OF CALIFORNIA SAN DIEGO   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

BETA1 INTEGRIN; CD11B ANTIGEN; CD18 ANTIGEN; CD323 ANTIGEN; CELL ADHESION MOLECULE; INTEGRIN; LYMPHOCYTE FUNCTION ASSOCIATED ANTIGEN 1; NOTCH1 RECEPTOR; PROTEIN KINASE ZAP 70; RAP1 PROTEIN; RAS PROTEIN; UNCLASSIFIED DRUG; VERY LATE ACTIVATION ANTIGEN;

ADULT; AGED; ARTICLE; CANCER PROGNOSIS; CELL ADHESION; CELL MOTILITY; CHRONIC LYMPHATIC LEUKEMIA; CONTROLLED STUDY; HUMAN; HUMAN CELL; HUMAN TISSUE; IMMUNOFLUORESCENCE; IMMUNOHISTOCHEMISTRY; LEUKEMIA CELL; LEUKOCYTE ADHERENCE; LYMPHOCYTE SUBPOPULATION; MAJOR CLINICAL STUDY; PRIORITY JOURNAL; PROTEIN EXPRESSION; SIGNAL TRANSDUCTION; TRISOMY 12; UPREGULATION;

AGED; CELL MOVEMENT; CHROMOSOMES, HUMAN, PAIR 12; GENE EXPRESSION REGULATION, LEUKEMIC; GUANINE NUCLEOTIDE EXCHANGE FACTORS; HUMANS; INTEGRINS; LEUKEMIA, LYMPHOCYTIC, CHRONIC, B-CELL; MALE; MIDDLE AGED; MUTATION; NEOPLASM PROTEINS; NEOPLASTIC CELLS, CIRCULATING; RAP GTP-BINDING PROTEINS; RECEPTOR, NOTCH1; SIGNAL TRANSDUCTION; TRISOMY; UP-REGULATION;

EID: 84903639208     PISSN: 00064971     EISSN: 15280020     Source Type: Journal    
DOI: 10.1182/blood-2014-01-552307     Document Type: Article

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