NOTCH1 mutations in +12 chronic lymphocytic leukemia (CLL) confer an unfavorable prognosis, induce a distinctive transcriptional profiling and refine the intermediate prognosis of +12 CLL

Haematologica

Volumn 97, Issue 3, 2012, Pages 437-441

  Del Giudice, Ilaria ^a   Rossi, Davide ^b   Chiaretti, Sabina ^a   Marinelli, Marilisa ^a   Tavolaro, Simona ^a   Gabrielli, Sara ^a   Laurenti, Luca ^c   Marasca, Roberto ^d   Rasi, Silvia ^b   Fangazio, Marco ^b   Guarini, Anna ^a   Gaidano, Gianluca ^b   Foà, Robin ^a  

^a SAPIENZA UNIVERSITY OF ROME   (Italy)

^b UNIVERSITY OF EASTERN PIEDMONT   (Italy)

^c CATHOLIC UNIVERSITY   (Italy)

^d UNIVERSITY OF MODENA AND REGGIO EMILIA   (Italy)

Author keywords

Chronic lymphocytic leukemia; Gene expression profile; NOTCH1 mutations; Prognosis; Trisomy 12

Indexed keywords

NOTCH1 RECEPTOR;

ADULT; AGED; ARTICLE; CANCER SURVIVAL; CHRONIC LYMPHATIC LEUKEMIA; COHORT ANALYSIS; CONTROLLED STUDY; FEMALE; GENE DISRUPTION; GENE EXPRESSION PROFILING; GENE FREQUENCY; GENE MUTATION; HUMAN; IGHV GENE; IMMUNOPHENOTYPING; MAJOR CLINICAL STUDY; MALE; MUTATIONAL ANALYSIS; NOTCH1 GENE; ONCOGENE; OVERALL SURVIVAL; PROGNOSIS; TRANSCRIPTION REGULATION;

AGED; CHROMOSOMES, HUMAN, PAIR 12; FEMALE; GENE EXPRESSION PROFILING; HUMANS; LEUKEMIA, LYMPHOCYTIC, CHRONIC, B-CELL; MALE; MIDDLE AGED; MUTATION; MUTATION RATE; PROGNOSIS; RECEPTOR, NOTCH1; SURVIVAL ANALYSIS; TRANSCRIPTION, GENETIC; TRISOMY;

EID: 84857739865     PISSN: 03906078     EISSN: 15928721     Source Type: Journal    
DOI: 10.3324/haematol.2011.060129     Document Type: Article

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