메뉴 건너뛰기




Volumn 6, Issue , 2016, Pages

Inhibition of the STAT3 signaling pathway contributes to apigenin-mediated anti-metastatic effect in melanoma

Author keywords

[No Author keywords available]

Indexed keywords

APIGENIN; GELATINASE A; GELATINASE B; SMALL INTERFERING RNA; STAT3 PROTEIN; TWIST RELATED PROTEIN 1; VASCULOTROPIN A;

EID: 84959432630     PISSN: None     EISSN: 20452322     Source Type: Journal    
DOI: 10.1038/srep21731     Document Type: Article
Times cited : (123)

References (61)
  • 1
    • 84871438875 scopus 로고    scopus 로고
    • Emerging molecular targets in melanoma invasion and metastasis
    • Orgaz, J. L. & Sanz-Moreno, V. Emerging molecular targets in melanoma invasion and metastasis. Pigment Cell Melanoma Res 26, 39-57, (2013).
    • (2013) Pigment Cell Melanoma Res , vol.26 , pp. 39-57
    • Orgaz, J.L.1    Sanz-Moreno, V.2
  • 2
    • 84904155440 scopus 로고    scopus 로고
    • Cancer treatment and survivorship statistics, 2014
    • DeSantis, C. E. et al. Cancer treatment and survivorship statistics, 2014. CA Cancer J Clin 64, 252-271, (2014).
    • (2014) CA Cancer J Clin , vol.64 , pp. 252-271
    • DeSantis, C.E.1
  • 3
    • 84864285704 scopus 로고    scopus 로고
    • Dabrafenib in BRAF-mutated metastatic melanoma: A multicentre, open-label, phase 3 randomised controlled trial
    • Hauschild, A. et al. Dabrafenib in BRAF-mutated metastatic melanoma: a multicentre, open-label, phase 3 randomised controlled trial. Lancet 380, 358-365, (2012).
    • (2012) Lancet , vol.380 , pp. 358-365
    • Hauschild, A.1
  • 4
    • 84874255652 scopus 로고    scopus 로고
    • Immunomodulatory therapy for melanoma: Ipilimumab and beyond
    • Callahan, M. K., Postow, M. A. & Wolchok, J. D. Immunomodulatory therapy for melanoma: ipilimumab and beyond. Clin Dermatol 31, 191-199, (2013).
    • (2013) Clin Dermatol , vol.31 , pp. 191-199
    • Callahan, M.K.1    Postow, M.A.2    Wolchok, J.D.3
  • 5
    • 84870932911 scopus 로고    scopus 로고
    • Management of toxicities associated with high-dose interleukin-2 and biochemotherapy
    • Poust, J. C., Woolery, J. E. & Green, M. R. Management of toxicities associated with high-dose interleukin-2 and biochemotherapy. Anticancer Drugs 24, 1-13, (2013).
    • (2013) Anticancer Drugs , vol.24 , pp. 1-13
    • Poust, J.C.1    Woolery, J.E.2    Green, M.R.3
  • 6
    • 84875706825 scopus 로고    scopus 로고
    • Resistance to BRAF-targeted therapy in melanoma
    • Sullivan, R. J. & Flaherty, K. T. Resistance to BRAF-targeted therapy in melanoma. Eur J Cancer 49, 1297-1304, (2013).
    • (2013) Eur J Cancer , vol.49 , pp. 1297-1304
    • Sullivan, R.J.1    Flaherty, K.T.2
  • 7
    • 21544473172 scopus 로고    scopus 로고
    • Targeting STAT3 affects melanoma on multiple fronts
    • Kortylewski, M., Jove, R. & Yu, H. Targeting STAT3 affects melanoma on multiple fronts. Cancer Metastasis Rev 24, 315-327, (2005).
    • (2005) Cancer Metastasis Rev , vol.24 , pp. 315-327
    • Kortylewski, M.1    Jove, R.2    Yu, H.3
  • 8
    • 33645532055 scopus 로고    scopus 로고
    • Activation of stat3 in human melanoma promotes brain metastasis
    • Xie, T. X. et al. Activation of stat3 in human melanoma promotes brain metastasis. Cancer Res 66, 3188-3196, (2006).
    • (2006) Cancer Res , vol.66 , pp. 3188-3196
    • Xie, T.X.1
  • 9
    • 85047695527 scopus 로고    scopus 로고
    • Constitutive Stat3 activity up-regulates VEGF expression and tumor angiogenesis
    • Niu, G. et al. Constitutive Stat3 activity up-regulates VEGF expression and tumor angiogenesis. Oncogene 21, 2000-2008, (2002).
    • (2002) Oncogene , vol.21 , pp. 2000-2008
    • Niu, G.1
  • 10
    • 18644380911 scopus 로고    scopus 로고
    • Roles of activated Src and Stat3 signaling in melanoma tumor cell growth
    • Niu, G. et al. Roles of activated Src and Stat3 signaling in melanoma tumor cell growth. Oncogene 21, 7001-7010, (2002).
    • (2002) Oncogene , vol.21 , pp. 7001-7010
    • Niu, G.1
  • 11
    • 79957910877 scopus 로고    scopus 로고
    • 6-Bromoindirubin-3′-oxime inhibits JAK/STAT3 signaling and induces apoptosis of human melanoma cells
    • Liu, L. et al. 6-Bromoindirubin-3′-oxime inhibits JAK/STAT3 signaling and induces apoptosis of human melanoma cells. Cancer Res 71, 3972-3979, (2011).
    • (2011) Cancer Res , vol.71 , pp. 3972-3979
    • Liu, L.1
  • 12
    • 1042302005 scopus 로고    scopus 로고
    • The STATs of cancer - new molecular targets come of age
    • Yu, H. & Jove, R. The STATs of cancer - new molecular targets come of age. Nat Rev Cancer 4, 97-105, (2004).
    • (2004) Nat Rev Cancer , vol.4 , pp. 97-105
    • Yu, H.1    Jove, R.2
  • 13
    • 2442685645 scopus 로고    scopus 로고
    • Stat3 activation regulates the expression of matrix metalloproteinase-2 and tumor invasion and metastasis
    • Xie, T. X. et al. Stat3 activation regulates the expression of matrix metalloproteinase-2 and tumor invasion and metastasis. Oncogene 23, 3550-3560, (2004).
    • (2004) Oncogene , vol.23 , pp. 3550-3560
    • Xie, T.X.1
  • 14
    • 84878360680 scopus 로고    scopus 로고
    • Pentoxifylline inhibits melanoma tumor growth and angiogenesis by targeting STAT3 signaling pathway
    • Kamran, M. Z. & Gude, R. P. Pentoxifylline inhibits melanoma tumor growth and angiogenesis by targeting STAT3 signaling pathway. Biomed Pharmacother 67, 399-405, (2013).
    • (2013) Biomed Pharmacother , vol.67 , pp. 399-405
    • Kamran, M.Z.1    Gude, R.P.2
  • 15
    • 50149095987 scopus 로고    scopus 로고
    • Diet and cancer prevention: The roles of observation and experimentation
    • Martinez, M. E., Marshall, J. R. & Giovannucci, E. Diet and cancer prevention: the roles of observation and experimentation. Nat Rev Cancer 8, 694-703, (2008).
    • (2008) Nat Rev Cancer , vol.8 , pp. 694-703
    • Martinez, M.E.1    Marshall, J.R.2    Giovannucci, E.3
  • 16
    • 84903316138 scopus 로고    scopus 로고
    • Nutrition: The future of melanoma prevention?
    • Tong, L. X. & Young, L. C. Nutrition: the future of melanoma prevention? J Am Acad Dermatol 71, 151-160, (2014).
    • (2014) J Am Acad Dermatol , vol.71 , pp. 151-160
    • Tong, L.X.1    Young, L.C.2
  • 17
    • 77953189137 scopus 로고    scopus 로고
    • Apigenin: A promising molecule for cancer prevention
    • Shukla, S. & Gupta, S. Apigenin: a promising molecule for cancer prevention. Pharm Res 27, 962-978, (2010).
    • (2010) Pharm Res , vol.27 , pp. 962-978
    • Shukla, S.1    Gupta, S.2
  • 18
    • 0031057115 scopus 로고    scopus 로고
    • Inhibition of ultraviolet light induced skin carcinogenesis in SKH-1 mice by apigenin, a plant flavonoid
    • Birt, D. F., Mitchell, D., Gold, B., Pour, P. & Pinch, H. C. Inhibition of ultraviolet light induced skin carcinogenesis in SKH-1 mice by apigenin, a plant flavonoid. Anticancer Res 17, 85-91 (1997).
    • (1997) Anticancer Res , vol.17 , pp. 85-91
    • Birt, D.F.1    Mitchell, D.2    Gold, B.3    Pour, P.4    Pinch, H.C.5
  • 19
    • 0033873786 scopus 로고    scopus 로고
    • Flavonoids apigenin and quercetin inhibit melanoma growth and metastatic potential
    • Caltagirone, S. et al. Flavonoids apigenin and quercetin inhibit melanoma growth and metastatic potential. Int J Cancer 87, 595-600, (2000).
    • (2000) Int J Cancer , vol.87 , pp. 595-600
    • Caltagirone, S.1
  • 20
    • 33644926465 scopus 로고    scopus 로고
    • Flavonoids inhibit melanoma lung metastasis by impairing tumor cells endothelium interactions
    • Piantelli, M. et al. Flavonoids inhibit melanoma lung metastasis by impairing tumor cells endothelium interactions. J Cell Physiol 207, 23-29, (2006).
    • (2006) J Cell Physiol , vol.207 , pp. 23-29
    • Piantelli, M.1
  • 21
    • 84878992867 scopus 로고    scopus 로고
    • Molecular basis for the action of a dietary flavonoid revealed by the comprehensive identification of apigenin human targets
    • Arango, D. et al. Molecular basis for the action of a dietary flavonoid revealed by the comprehensive identification of apigenin human targets. Proc Natl Acad Sci USA 110, E2153-2162, (2013).
    • (2013) Proc Natl Acad Sci USA , vol.110 , pp. E2153-2162
    • Arango, D.1
  • 22
    • 84906314590 scopus 로고    scopus 로고
    • Induction of caspase-dependent apoptosis by apigenin by inhibiting STAT3 signaling in HER2-overexpressing MDAMB-453 breast cancer cells
    • Seo, H. S. et al. Induction of caspase-dependent apoptosis by apigenin by inhibiting STAT3 signaling in HER2-overexpressing MDAMB-453 breast cancer cells. Anticancer Res 34, 2869-2882, (2014).
    • (2014) Anticancer Res , vol.34 , pp. 2869-2882
    • Seo, H.S.1
  • 23
    • 79953038110 scopus 로고    scopus 로고
    • Cytotoxicity of apigenin on leukemia cell lines: Implications for prevention and therapy
    • Ruela-de-Sousa, R. R. et al. Cytotoxicity of apigenin on leukemia cell lines: implications for prevention and therapy. Cell Death Dis 1, e19, (2010).
    • (2010) Cell Death Dis , vol.1 , pp. e19
    • Ruela-De-Sousa, R.R.1
  • 24
    • 84868363095 scopus 로고    scopus 로고
    • A novel 7-bromoindirubin with potent anticancer activity suppresses survival of human melanoma cells associated with inhibition of STAT3 and Akt signaling
    • Liu, L. et al. A novel 7-bromoindirubin with potent anticancer activity suppresses survival of human melanoma cells associated with inhibition of STAT3 and Akt signaling. Cancer Biol Ther 13, 1255-1261, (2012).
    • (2012) Cancer Biol Ther , vol.13 , pp. 1255-1261
    • Liu, L.1
  • 25
    • 0029112154 scopus 로고
    • Inhibition of lung metastasis in mice induced by B16F10 melanoma cells by polyphenolic compounds
    • Menon, L. G., Kuttan, R. & Kuttan, G. Inhibition of lung metastasis in mice induced by B16F10 melanoma cells by polyphenolic compounds. Cancer Lett 95, 221-225 (1995).
    • (1995) Cancer Lett , vol.95 , pp. 221-225
    • Menon, L.G.1    Kuttan, R.2    Kuttan, G.3
  • 26
    • 84862488979 scopus 로고    scopus 로고
    • Oral administration of apigenin inhibits metastasis through AKT/P70S6K1/MMP-9 pathway in orthotopic ovarian tumor model
    • He, J. et al. Oral administration of apigenin inhibits metastasis through AKT/P70S6K1/MMP-9 pathway in orthotopic ovarian tumor model. Int J Mol Sci 13, 7271-7282, (2012).
    • (2012) Int J Mol Sci , vol.13 , pp. 7271-7282
    • He, J.1
  • 27
    • 84862309686 scopus 로고    scopus 로고
    • Flavonoids, a ubiquitous dietary phenolic subclass, exert extensive in vitro anti-invasive and in vivo antimetastatic activities
    • Weng, C. J. & Yen, G. C. Flavonoids, a ubiquitous dietary phenolic subclass, exert extensive in vitro anti-invasive and in vivo antimetastatic activities. Cancer Metastasis Rev 31, 323-351, (2012).
    • (2012) Cancer Metastasis Rev , vol.31 , pp. 323-351
    • Weng, C.J.1    Yen, G.C.2
  • 29
    • 84858636221 scopus 로고    scopus 로고
    • Overexpression of the MIR-34 family suppresses invasive growth of malignant melanoma with the wild-type p53 gene
    • Yamazaki, H. et al. Overexpression of the miR-34 family suppresses invasive growth of malignant melanoma with the wild-type p53 gene. Exp Ther Med 3, 793-796, (2012).
    • (2012) Exp Ther Med , vol.3 , pp. 793-796
    • Yamazaki, H.1
  • 30
    • 38849199799 scopus 로고    scopus 로고
    • STAT3 as a target for inducing apoptosis in solid and hematological tumors
    • Al Zaid Siddiquee, K. & Turkson, J. STAT3 as a target for inducing apoptosis in solid and hematological tumors. Cell Res 18, 254-267, (2008).
    • (2008) Cell Res , vol.18 , pp. 254-267
    • Al Zaid Siddiquee, K.1    Turkson, J.2
  • 32
    • 35148832569 scopus 로고    scopus 로고
    • Epidermal growth factor receptor cooperates with signal transducer and activator of transcription 3 to induce epithelial-mesenchymal transition in cancer cells via up-regulation of TWIST gene expression
    • Lo, H. W. et al. Epidermal growth factor receptor cooperates with signal transducer and activator of transcription 3 to induce epithelial-mesenchymal transition in cancer cells via up-regulation of TWIST gene expression. Cancer Res 67, 9066-9076, (2007).
    • (2007) Cancer Res , vol.67 , pp. 9066-9076
    • Lo, H.W.1
  • 33
    • 4043052971 scopus 로고    scopus 로고
    • Epithelial-mesenchymal transitions: Twist in development and metastasis
    • Kang, Y. & Massague, J. Epithelial-mesenchymal transitions: twist in development and metastasis. Cell 118, 277-279, (2004).
    • (2004) Cell , vol.118 , pp. 277-279
    • Kang, Y.1    Massague, J.2
  • 34
    • 67650999875 scopus 로고    scopus 로고
    • The basics of epithelial-mesenchymal transition
    • Kalluri, R. & Weinberg, R. A. The basics of epithelial-mesenchymal transition. J Clin Invest 119, 1420-1428, (2009).
    • (2009) J Clin Invest , vol.119 , pp. 1420-1428
    • Kalluri, R.1    Weinberg, R.A.2
  • 35
    • 27644473229 scopus 로고    scopus 로고
    • Epithelial-mesenchymal transition
    • Radisky, D. C. Epithelial-mesenchymal transition. J Cell Sci 118, 4325-4326, (2005).
    • (2005) J Cell Sci , vol.118 , pp. 4325-4326
    • Radisky, D.C.1
  • 36
    • 84892933053 scopus 로고    scopus 로고
    • Quercetin exerts anti-melanoma activities and inhibits STAT3 signaling
    • Cao, H. H. et al. Quercetin exerts anti-melanoma activities and inhibits STAT3 signaling. Biochem Pharmacol 87, 424-434, (2014).
    • (2014) Biochem Pharmacol , vol.87 , pp. 424-434
    • Cao, H.H.1
  • 37
    • 84937549341 scopus 로고    scopus 로고
    • Inhibition of STAT3 signalling contributes to the antimelanoma action of atractylenolide II
    • Fu, X. Q. et al. Inhibition of STAT3 signalling contributes to the antimelanoma action of atractylenolide II. Exp Dermatol 23, 855-857, (2014).
    • (2014) Exp Dermatol , vol.23 , pp. 855-857
    • Fu, X.Q.1
  • 38
    • 84885635044 scopus 로고    scopus 로고
    • The herbal compound cryptotanshinone restores sensitivity in cancer cells that are resistant to the tumor necrosis factor-related apoptosis-inducing ligand
    • Tse, A. K. et al. The herbal compound cryptotanshinone restores sensitivity in cancer cells that are resistant to the tumor necrosis factor-related apoptosis-inducing ligand. J Biol Chem 288, 29923-29933, (2013).
    • (2013) J Biol Chem , vol.288 , pp. 29923-29933
    • Tse, A.K.1
  • 39
    • 84863403861 scopus 로고    scopus 로고
    • Acute exposure of apigenin induces hepatotoxicity in Swiss mice
    • Singh, P., Mishra, S. K., Noel, S., Sharma, S. & Rath, S. K. Acute exposure of apigenin induces hepatotoxicity in Swiss mice. PLoS One 7, e31964, (2012).
    • (2012) PLoS One , vol.7
    • Singh, P.1    Mishra, S.K.2    Noel, S.3    Sharma, S.4    Rath, S.K.5
  • 40
    • 0035812747 scopus 로고    scopus 로고
    • Selective growth-inhibitory, cell-cycle deregulatory and apoptotic response of apigenin in normal versus human prostate carcinoma cells
    • Gupta, S., Afaq, F. & Mukhtar, H. Selective growth-inhibitory, cell-cycle deregulatory and apoptotic response of apigenin in normal versus human prostate carcinoma cells. Biochem Biophys Res Commun 287, 914-920, (2001).
    • (2001) Biochem Biophys Res Commun , vol.287 , pp. 914-920
    • Gupta, S.1    Afaq, F.2    Mukhtar, H.3
  • 41
    • 84865300150 scopus 로고    scopus 로고
    • Biopharmaceutics classification and intestinal absorption study of apigenin
    • Zhang, J., Liu, D., Huang, Y., Gao, Y. & Qian, S. Biopharmaceutics classification and intestinal absorption study of apigenin. Int J Pharm 436, 311-317, (2012).
    • (2012) Int J Pharm , vol.436 , pp. 311-317
    • Zhang, J.1    Liu, D.2    Huang, Y.3    Gao, Y.4    Qian, S.5
  • 42
    • 11144278688 scopus 로고    scopus 로고
    • Pharmacokinetics and metabolism of apigenin in female and male rats after a single oral administration
    • Gradolatto, A. et al. Pharmacokinetics and metabolism of apigenin in female and male rats after a single oral administration. Drug Metab Dispos 33, 49-54, (2005).
    • (2005) Drug Metab Dispos , vol.33 , pp. 49-54
    • Gradolatto, A.1
  • 43
    • 84893387803 scopus 로고    scopus 로고
    • Apigenin inhibits prostate cancer progression in TRAMP mice via targeting PI3K/Akt/FoxO pathway
    • Shukla, S. et al. Apigenin inhibits prostate cancer progression in TRAMP mice via targeting PI3K/Akt/FoxO pathway. Carcinogenesis 35, 452-460, (2014).
    • (2014) Carcinogenesis , vol.35 , pp. 452-460
    • Shukla, S.1
  • 44
    • 84873423351 scopus 로고    scopus 로고
    • Preparation of apigenin nanocrystals using supercritical antisolvent process for dissolution and bioavailability enhancement
    • Zhang, J., Huang, Y., Liu, D., Gao, Y. & Qian, S. Preparation of apigenin nanocrystals using supercritical antisolvent process for dissolution and bioavailability enhancement. Eur J Pharm Sci 48, 740-747, (2013).
    • (2013) Eur J Pharm Sci , vol.48 , pp. 740-747
    • Zhang, J.1    Huang, Y.2    Liu, D.3    Gao, Y.4    Qian, S.5
  • 45
    • 79551665812 scopus 로고    scopus 로고
    • Preparation of novel apigenin-enriched, liposomal and non-liposomal, antiinflammatory topical formulations as substitutes for corticosteroid therapy
    • Arsic, I. et al. Preparation of novel apigenin-enriched, liposomal and non-liposomal, antiinflammatory topical formulations as substitutes for corticosteroid therapy. Phytother Res 25, 228-233, (2011).
    • (2011) Phytother Res , vol.25 , pp. 228-233
    • Arsic, I.1
  • 46
    • 84900819986 scopus 로고    scopus 로고
    • Enhanced bioavailability of apigenin via preparation of a carbon nanopowder solid dispersion
    • Ding, S. M. et al. Enhanced bioavailability of apigenin via preparation of a carbon nanopowder solid dispersion. Int J Nanomedicine 9, 2327-2333, (2014).
    • (2014) Int J Nanomedicine , vol.9 , pp. 2327-2333
    • Ding, S.M.1
  • 47
    • 79960104514 scopus 로고    scopus 로고
    • Gambogic acid inhibits STAT3 phosphorylation through activation of protein tyrosine phosphatase SHP-1: Potential role in proliferation and apoptosis
    • Prasad, S., Pandey, M. K., Yadav, V. R. & Aggarwal, B. B. Gambogic acid inhibits STAT3 phosphorylation through activation of protein tyrosine phosphatase SHP-1: potential role in proliferation and apoptosis. Cancer Prev Res (Phila) 4, 1084-1094, (2011).
    • (2011) Cancer Prev Res (Phila) , vol.4 , pp. 1084-1094
    • Prasad, S.1    Pandey, M.K.2    Yadav, V.R.3    Aggarwal, B.B.4
  • 48
    • 84869987776 scopus 로고    scopus 로고
    • MMP2 expression is a prognostic marker for primary melanoma patients
    • Rotte, A., Martinka, M. & Li, G. MMP2 expression is a prognostic marker for primary melanoma patients. Cell Oncol (Dordr) 35, 207-216, (2012).
    • (2012) Cell Oncol (Dordr) , vol.35 , pp. 207-216
    • Rotte, A.1    Martinka, M.2    Li, G.3
  • 49
    • 22344448889 scopus 로고    scopus 로고
    • High serum levels of matrix metalloproteinase-9 and matrix metalloproteinase-1 are associated with rapid progression in patients with metastatic melanoma
    • Nikkola, J. et al. High serum levels of matrix metalloproteinase-9 and matrix metalloproteinase-1 are associated with rapid progression in patients with metastatic melanoma. Clin Cancer Res 11, 5158-5166, (2005).
    • (2005) Clin Cancer Res , vol.11 , pp. 5158-5166
    • Nikkola, J.1
  • 50
    • 0031969264 scopus 로고    scopus 로고
    • Angiogenesis and tumor metastasis
    • Zetter, B. R. Angiogenesis and tumor metastasis. Annu Rev Med 49, 407-424, (1998).
    • (1998) Annu Rev Med , vol.49 , pp. 407-424
    • Zetter, B.R.1
  • 51
    • 14944346331 scopus 로고    scopus 로고
    • Prognostic value of serum VEGF in melanoma patients: A pilot study
    • Ascierto, P. A. et al. Prognostic value of serum VEGF in melanoma patients: a pilot study. Anticancer Res 24, 4255-4258 (2004).
    • (2004) Anticancer Res , vol.24 , pp. 4255-4258
    • Ascierto, P.A.1
  • 52
    • 0037435011 scopus 로고    scopus 로고
    • Interleukin-6 promotes cervical tumor growth by VEGF-dependent angiogenesis via a STAT3 pathway
    • Wei, L. H. et al. Interleukin-6 promotes cervical tumor growth by VEGF-dependent angiogenesis via a STAT3 pathway. Oncogene 22, 1517-1527, (2003).
    • (2003) Oncogene , vol.22 , pp. 1517-1527
    • Wei, L.H.1
  • 53
    • 70350500225 scopus 로고    scopus 로고
    • STATs in cancer inflammation and immunity: A leading role for STAT3
    • Yu, H., Pardoll, D. & Jove, R. STATs in cancer inflammation and immunity: a leading role for STAT3. Nat Rev Cancer 9, 798-809, (2009).
    • (2009) Nat Rev Cancer , vol.9 , pp. 798-809
    • Yu, H.1    Pardoll, D.2    Jove, R.3
  • 54
    • 33845865825 scopus 로고    scopus 로고
    • Crosstalk between cancer and immune cells: Role of STAT3 in the tumour microenvironment
    • Yu, H., Kortylewski, M. & Pardoll, D. Crosstalk between cancer and immune cells: role of STAT3 in the tumour microenvironment. Nat Rev Immunol 7, 41-51, (2007).
    • (2007) Nat Rev Immunol , vol.7 , pp. 41-51
    • Yu, H.1    Kortylewski, M.2    Pardoll, D.3
  • 55
    • 84871234148 scopus 로고    scopus 로고
    • TWIST1 is an ERK1/2 effector that promotes invasion and regulates MMP-1 expression in human melanoma cells
    • Weiss, M. B. et al. TWIST1 is an ERK1/2 effector that promotes invasion and regulates MMP-1 expression in human melanoma cells. Cancer Res 72, 6382-6392, (2012).
    • (2012) Cancer Res , vol.72 , pp. 6382-6392
    • Weiss, M.B.1
  • 56
    • 49249095028 scopus 로고    scopus 로고
    • Twist is required for thrombin-induced tumor angiogenesis and growth
    • Hu, L., Roth, J. M., Brooks, P., Ibrahim, S. & Karpatkin, S. Twist is required for thrombin-induced tumor angiogenesis and growth. Cancer Res 68, 4296-4302, (2008).
    • (2008) Cancer Res , vol.68 , pp. 4296-4302
    • Hu, L.1    Roth, J.M.2    Brooks, P.3    Ibrahim, S.4    Karpatkin, S.5
  • 57
    • 84959416688 scopus 로고    scopus 로고
    • The role of TWIST in angiogenesis and cell migration in giant cell tumor of bone
    • Singh, S., Mak, I. W., Handa, D. & Ghert, M. The Role of TWIST in Angiogenesis and Cell Migration in Giant Cell Tumor of Bone. Advances in Biology 2014 (2014).
    • (2014) Advances in Biology , vol.2014
    • Singh, S.1    Mak, I.W.2    Handa, D.3    Ghert, M.4
  • 58
    • 84862908668 scopus 로고    scopus 로고
    • TWIST expression in hypopharyngeal cancer and the mechanism of TWIST-induced promotion of metastasis
    • Yu, L. et al. TWIST expression in hypopharyngeal cancer and the mechanism of TWIST-induced promotion of metastasis. Oncol Rep 27, 416-422, (2012).
    • (2012) Oncol Rep , vol.27 , pp. 416-422
    • Yu, L.1
  • 60
    • 79953694223 scopus 로고    scopus 로고
    • Effects of sesquiterpenes isolated from largehead atractylodes rhizome on growth, migration, and differentiation of B16 melanoma cells
    • Yan, Y. et al. Effects of sesquiterpenes isolated from largehead atractylodes rhizome on growth, migration, and differentiation of B16 melanoma cells. Integr Cancer Ther 10, 92-100, (2011).
    • (2011) Integr Cancer Ther , vol.10 , pp. 92-100
    • Yan, Y.1
  • 61
    • 84887619001 scopus 로고    scopus 로고
    • Recombinant adenovirus snake venom cystatin inhibits the growth, invasion, and metastasis of B16F10 cells in vitro and in vivo
    • Xie, Q. et al. Recombinant adenovirus snake venom cystatin inhibits the growth, invasion, and metastasis of B16F10 cells in vitro and in vivo. Melanoma Res 23, 444-451, (2013).
    • (2013) Melanoma Res , vol.23 , pp. 444-451
    • Xie, Q.1


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.