-
1
-
-
84872967522
-
Cancer statistics, 2013
-
Siegel,R. et al. (2013) Cancer statistics, 2013. Cancer J. Clin., 63, 11-30.
-
(2013)
Cancer J. Clin.
, vol.63
, pp. 11-30
-
-
Siegel, R.1
-
2
-
-
84863707351
-
Cancer treatment and survivorship statistics, 2012
-
Siegel,R. et al. (2012) Cancer treatment and survivorship statistics, 2012. Cancer J. Clin., 62, 220-241.
-
(2012)
Cancer J. Clin.
, vol.62
, pp. 220-241
-
-
Siegel, R.1
-
3
-
-
84893348242
-
-
Prostate cancer facts and statistics on the American Cancer Society website
-
Prostate cancer facts and statistics on the American Cancer Society website. http://www.cancer.org/cancer/prostatecancer/index.
-
-
-
-
4
-
-
67650917081
-
PTEN genomic deletion is associated with p-Akt and AR signalling in poorer outcome, hormone refractory prostate cancer
-
Sircar,K. et al. (2009) PTEN genomic deletion is associated with p-Akt and AR signalling in poorer outcome, hormone refractory prostate cancer. J. Pathol., 218, 505-513.
-
(2009)
J. Pathol.
, vol.218
, pp. 505-513
-
-
Sircar, K.1
-
5
-
-
65649118955
-
PTEN deficiency is fully penetrant for prostate adenocarcinoma in C57BL/6 mice via mTOR-dependent growth
-
Blando,J. et al. (2009) PTEN deficiency is fully penetrant for prostate adenocarcinoma in C57BL/6 mice via mTOR-dependent growth. Am. J. Pathol., 174, 1869-1879.
-
(2009)
Am. J. Pathol.
, vol.174
, pp. 1869-1879
-
-
Blando, J.1
-
6
-
-
79551516441
-
Faithfull modeling of PTEN loss driven diseases in the mouse
-
Nardella,C. et al. (2010) Faithfull modeling of PTEN loss driven diseases in the mouse. Curr. Top. Microbiol. Immunol., 347, 135-168.
-
(2010)
Curr. Top. Microbiol. Immunol.
, vol.347
, pp. 135-168
-
-
Nardella, C.1
-
7
-
-
0036968347
-
Activation of the PI3K/Akt pathway and chemotherapeutic resistance
-
West,K.A. et al. (2002) Activation of the PI3K/Akt pathway and chemotherapeutic resistance. Drug Resist. Updat., 5, 234-248.
-
(2002)
Drug Resist. Updat.
, vol.5
, pp. 234-248
-
-
West, K.A.1
-
8
-
-
84870376109
-
Cancer genetics and genomics of human FOX family genes
-
Katoh,M. et al. (2013) Cancer genetics and genomics of human FOX family genes. Cancer Lett., 328, 198-206.
-
(2013)
Cancer Lett.
, vol.328
, pp. 198-206
-
-
Katoh, M.1
-
9
-
-
84860420398
-
FoxO family members in cancer
-
Zhang,Y. et al. (2011) FoxO family members in cancer. Cancer Biol. Ther., 12, 253-259.
-
(2011)
Cancer Biol. Ther.
, vol.12
, pp. 253-259
-
-
Zhang, Y.1
-
10
-
-
80455176679
-
Applications of post-translational modifications of FoxO family proteins in biological functions
-
Zhao,Y. et al. (2011) Applications of post-translational modifications of FoxO family proteins in biological functions. J. Mol. Cell Biol., 3, 276-282.
-
(2011)
J. Mol. Cell Biol.
, vol.3
, pp. 276-282
-
-
Zhao, Y.1
-
11
-
-
80052970809
-
FoxO transcription factors; Regulation by AKT and 14-3-3 proteins
-
Tzivion,G. et al. (2011) FoxO transcription factors; Regulation by AKT and 14-3-3 proteins. Biochim. Biophys. Acta, 1813, 1938-1945.
-
(2011)
Biochim. Biophys. Acta
, vol.1813
, pp. 1938-1945
-
-
Tzivion, G.1
-
12
-
-
10744230034
-
FoxO3a transcriptional regulation of Bim controls apoptosis in paclitaxel-treated breast cancer cell lines
-
Sunters,A. et al. (2003) FoxO3a transcriptional regulation of Bim controls apoptosis in paclitaxel-treated breast cancer cell lines. J. Biol. Chem., 278, 49795-49805.
-
(2003)
J. Biol. Chem.
, vol.278
, pp. 49795-49805
-
-
Sunters, A.1
-
13
-
-
34548686330
-
Forkhead protein FKHR and its phosphorylated form p-FKHR in human prostate cancer
-
Li,R. et al. (2007) Forkhead protein FKHR and its phosphorylated form p-FKHR in human prostate cancer. Hum. Pathol., 38, 1501-1507.
-
(2007)
Hum. Pathol.
, vol.38
, pp. 1501-1507
-
-
Li, R.1
-
14
-
-
67649421062
-
Deregulation of FOXO3A during prostate cancer progression
-
Shukla,S. et al. (2009) Deregulation of FOXO3A during prostate cancer progression. Int. J. Oncol., 34, 1613-1620.
-
(2009)
Int. J. Oncol.
, vol.34
, pp. 1613-1620
-
-
Shukla, S.1
-
15
-
-
17144430994
-
The progression of LNCaP human prostate cancer cells to androgen independence involves decreased FOXO3a expression and reduced p27KIP1 promoter transactivation
-
Lynch,R.L. et al. (2005) The progression of LNCaP human prostate cancer cells to androgen independence involves decreased FOXO3a expression and reduced p27KIP1 promoter transactivation. Mol. Cancer Res., 3, 163-169.
-
(2005)
Mol. Cancer Res.
, vol.3
, pp. 163-169
-
-
Lynch, R.L.1
-
16
-
-
16444380327
-
Induction of prosurvival molecules by apoptotic stimuli: involvement of FOXO3a and ROS
-
Liu,J.W. et al. (2005) Induction of prosurvival molecules by apoptotic stimuli: involvement of FOXO3a and ROS. Oncogene, 24, 2020-2031.
-
(2005)
Oncogene
, vol.24
, pp. 2020-2031
-
-
Liu, J.W.1
-
17
-
-
25844486505
-
Induction of androgen receptor expression by phosphatidylinositol 3-kinase/Akt downstream substrate, FOXO3a, and their roles in apoptosis of LNCaP prostate cancer cells
-
Yang,L. et al. (2005) Induction of androgen receptor expression by phosphatidylinositol 3-kinase/Akt downstream substrate, FOXO3a, and their roles in apoptosis of LNCaP prostate cancer cells. J. Biol. Chem., 280, 33558-33565.
-
(2005)
J. Biol. Chem.
, vol.280
, pp. 33558-33565
-
-
Yang, L.1
-
18
-
-
78650774201
-
Resveratrol induces growth arrest and apoptosis through activation of FOXO transcription factors in prostate cancer cells
-
Chen,Q. et al. (2010) Resveratrol induces growth arrest and apoptosis through activation of FOXO transcription factors in prostate cancer cells. PLoS One, 5, e15288.
-
(2010)
PLoS One
, vol.5
-
-
Chen, Q.1
-
19
-
-
58149234401
-
Sulforaphane enhances the therapeutic potential of TRAIL in prostate cancer orthotopic model through regulation of apoptosis, metastasis, and angiogenesis
-
Shankar,S. et al. (2008) Sulforaphane enhances the therapeutic potential of TRAIL in prostate cancer orthotopic model through regulation of apoptosis, metastasis, and angiogenesis. Clin. Cancer Res., 14, 6855-6866.
-
(2008)
Clin. Cancer Res.
, vol.14
, pp. 6855-6866
-
-
Shankar, S.1
-
20
-
-
34547135737
-
Regulation of FOXO3a/beta-catenin/GSK-3beta signaling by 3,3'-diindolylmethane contributes to inhibition of cell proliferation and induction of apoptosis in prostate cancer cells
-
Li,Y. et al. (2007) Regulation of FOXO3a/beta-catenin/GSK-3beta signaling by 3,3'-diindolylmethane contributes to inhibition of cell proliferation and induction of apoptosis in prostate cancer cells. J. Biol. Chem., 282, 21542-21550.
-
(2007)
J. Biol. Chem.
, vol.282
, pp. 21542-21550
-
-
Li, Y.1
-
21
-
-
77953189137
-
Apigenin: a promising molecule for cancer prevention
-
Shukla,S. et al. (2010) Apigenin: a promising molecule for cancer prevention. Pharm. Res., 27, 962-978.
-
(2010)
Pharm. Res.
, vol.27
, pp. 962-978
-
-
Shukla, S.1
-
22
-
-
34248157606
-
Apigenin-induced cell cycle arrest is mediated by modulation of MAPK, PI3K-Akt, and loss of cyclin D1 associated retinoblastoma dephosphorylation in human prostate cancer cells
-
Shukla,S. et al. (2007) Apigenin-induced cell cycle arrest is mediated by modulation of MAPK, PI3K-Akt, and loss of cyclin D1 associated retinoblastoma dephosphorylation in human prostate cancer cells. Cell Cycle, 6, 1102-1114.
-
(2007)
Cell Cycle
, vol.6
, pp. 1102-1114
-
-
Shukla, S.1
-
23
-
-
70449711373
-
The chemopreventive bioflavonoid apigenin inhibits prostate cancer cell motility through the focal adhesion kinase/Src signaling mechanism
-
Franzen,C.A. et al. (2009) The chemopreventive bioflavonoid apigenin inhibits prostate cancer cell motility through the focal adhesion kinase/Src signaling mechanism. Cancer Prev. Res. (Phila)., 2, 830-841.
-
(2009)
Cancer Prev. Res. (Phila).
, vol.2
, pp. 830-841
-
-
Franzen, C.A.1
-
24
-
-
50649111640
-
Impact of protein kinase CK2 on inhibitor of apoptosis proteins in prostate cancer cells
-
Wang,G. et al. (2008) Impact of protein kinase CK2 on inhibitor of apoptosis proteins in prostate cancer cells. Mol. Cell. Biochem., 316, 91-97.
-
(2008)
Mol. Cell. Biochem.
, vol.316
, pp. 91-97
-
-
Wang, G.1
-
25
-
-
0842325655
-
Molecular mechanisms for apigenin-induced cellcycle arrest and apoptosis of hormone refractory human prostate carcinoma DU145 cells
-
Shukla,S. et al. (2004) Molecular mechanisms for apigenin-induced cellcycle arrest and apoptosis of hormone refractory human prostate carcinoma DU145 cells. Mol. Carcinog., 39, 114-126.
-
(2004)
Mol. Carcinog.
, vol.39
, pp. 114-126
-
-
Shukla, S.1
-
26
-
-
22144449607
-
Constitutive activation of P I3 K-Akt and NF-kappaB during prostate cancer progression in autochthonous transgenic mouse model
-
Shukla,S. et al. (2005) Constitutive activation of P I3 K-Akt and NF-kappaB during prostate cancer progression in autochthonous transgenic mouse model. Prostate, 64, 224-239.
-
(2005)
Prostate
, vol.64
, pp. 224-239
-
-
Shukla, S.1
-
27
-
-
0032819772
-
Dietary flavonoids: intake, health effects and bioavailability
-
Hollman,P.C. et al. (1999) Dietary flavonoids: intake, health effects and bioavailability. Food Chem. Toxicol., 37, 937-942.
-
(1999)
Food Chem. Toxicol.
, vol.37
, pp. 937-942
-
-
Hollman, P.C.1
-
28
-
-
0038415024
-
Pathobiology of autochthonous prostate cancer in a pre-clinical transgenic mouse model
-
Kaplan-Lefko,P.J. et al. (2003) Pathobiology of autochthonous prostate cancer in a pre-clinical transgenic mouse model. Prostate, 55, 219-237.
-
(2003)
Prostate
, vol.55
, pp. 219-237
-
-
Kaplan-Lefko, P.J.1
-
29
-
-
34547114744
-
Blockade of beta-catenin signaling by plant flavonoid apigenin suppresses prostate carcinogenesis in TRAMP mice
-
Shukla,S. et al. (2007) Blockade of beta-catenin signaling by plant flavonoid apigenin suppresses prostate carcinogenesis in TRAMP mice. Cancer Res., 67, 6925-6935.
-
(2007)
Cancer Res.
, vol.67
, pp. 6925-6935
-
-
Shukla, S.1
-
30
-
-
34548272131
-
Activation of PI3K-Akt signaling pathway promotes prostate cancer cell invasion
-
Shukla,S. et al. (2007) Activation of PI3K-Akt signaling pathway promotes prostate cancer cell invasion. Int. J. Cancer, 121, 1424-1432.
-
(2007)
Int. J. Cancer
, vol.121
, pp. 1424-1432
-
-
Shukla, S.1
-
31
-
-
84883137971
-
Deregulation of FoxO3a accelerates prostate cancer progression in TRAMP mice
-
Shukla,S. et al. (2013) Deregulation of FoxO3a accelerates prostate cancer progression in TRAMP mice. Prostate, 73, 1507-1517.
-
(2013)
Prostate
, vol.73
, pp. 1507-1517
-
-
Shukla, S.1
-
32
-
-
84862679196
-
Apigenin attenuates insulin-like growth factor-I signaling in an autochthonous mouse prostate cancer model
-
Shukla,S. et al. (2012) Apigenin attenuates insulin-like growth factor-I signaling in an autochthonous mouse prostate cancer model. Pharm. Res., 29, 1506-1517.
-
(2012)
Pharm. Res.
, vol.29
, pp. 1506-1517
-
-
Shukla, S.1
-
33
-
-
77949452524
-
The PKB/AKT pathway in cancer
-
Carnero,A. (2010) The PKB/AKT pathway in cancer. Curr. Pharm. Des., 16, 34-44.
-
(2010)
Curr. Pharm. Des.
, vol.16
, pp. 34-44
-
-
Carnero, A.1
-
34
-
-
27844506524
-
Akt-regulated pathways in prostate cancer
-
Majumder,P.K. et al. (2005) Akt-regulated pathways in prostate cancer. Oncogene, 24, 7465-7474.
-
(2005)
Oncogene
, vol.24
, pp. 7465-7474
-
-
Majumder, P.K.1
-
35
-
-
33745316089
-
Identification of a tumour suppressor network opposing nuclear Akt function
-
Trotman,L.C. et al. (2006) Identification of a tumour suppressor network opposing nuclear Akt function. Nature, 441, 523-527.
-
(2006)
Nature
, vol.441
, pp. 523-527
-
-
Trotman, L.C.1
-
36
-
-
10744222860
-
Prostate-specific deletion of the murine Pten tumor suppressor gene leads to metastatic prostate cancer
-
Wang,S. et al. (2003) Prostate-specific deletion of the murine Pten tumor suppressor gene leads to metastatic prostate cancer. Cancer Cell, 4, 209-221.
-
(2003)
Cancer Cell
, vol.4
, pp. 209-221
-
-
Wang, S.1
-
37
-
-
77953407266
-
Induction of clusterin by AKT-role in cytoprotection against docetaxel in prostate tumor cells
-
Zhong,B. et al. (2010) Induction of clusterin by AKT-role in cytoprotection against docetaxel in prostate tumor cells. Mol. Cancer Ther., 9, 1831-1841.
-
(2010)
Mol. Cancer Ther.
, vol.9
, pp. 1831-1841
-
-
Zhong, B.1
-
38
-
-
84871965129
-
Molecular imaging reveals a role for AKT in resistance to cisplatin for ovarian endometrioid adenocarcinoma
-
Wang,H. et al. (2013) Molecular imaging reveals a role for AKT in resistance to cisplatin for ovarian endometrioid adenocarcinoma. Clin. Cancer Res., 19, 158-169.
-
(2013)
Clin. Cancer Res.
, vol.19
, pp. 158-169
-
-
Wang, H.1
-
39
-
-
84869088946
-
Akt/mTOR signaling pathway is crucial for gemcitabine resistance induced by Annexin II in pancreatic cancer cells
-
Kagawa,S. et al. (2012) Akt/mTOR signaling pathway is crucial for gemcitabine resistance induced by Annexin II in pancreatic cancer cells. J. Surg. Res., 178, 758-767.
-
(2012)
J. Surg. Res.
, vol.178
, pp. 758-767
-
-
Kagawa, S.1
-
40
-
-
2142662252
-
Reciprocal control of Forkhead box O 3a and c-Myc via the phosphatidylinositol 3-kinase pathway coordinately regulates p27Kip1 levels
-
Chandramohan,V. et al. (2004) Reciprocal control of Forkhead box O 3a and c-Myc via the phosphatidylinositol 3-kinase pathway coordinately regulates p27Kip1 levels. J. Immunol., 172, 5522-5527.
-
(2004)
J. Immunol.
, vol.172
, pp. 5522-5527
-
-
Chandramohan, V.1
-
41
-
-
33845340834
-
Chronic protein kinase B (PKB/c-akt) activation leads to apoptosis induced by oxidative stress-mediated Foxo3a transcriptional up-regulation
-
van Gorp,A.G. et al. (2006) Chronic protein kinase B (PKB/c-akt) activation leads to apoptosis induced by oxidative stress-mediated Foxo3a transcriptional up-regulation. Cancer Res., 66, 10760-10769.
-
(2006)
Cancer Res.
, vol.66
, pp. 10760-10769
-
-
van Gorp, A.G.1
-
42
-
-
0037136563
-
Forkhead transcription factor FOXO3a protects quiescent cells from oxidative stress
-
Kops,G.J. et al. (2002) Forkhead transcription factor FOXO3a protects quiescent cells from oxidative stress. Nature, 419, 316-321.
-
(2002)
Nature
, vol.419
, pp. 316-321
-
-
Kops, G.J.1
-
43
-
-
42649110670
-
Apigenin-induced prostate cancer cell death is initiated by reactive oxygen species and p53 activation
-
Shukla,S. et al. (2008) Apigenin-induced prostate cancer cell death is initiated by reactive oxygen species and p53 activation. Free Radic. Biol. Med., 44, 1833-1845.
-
(2008)
Free Radic. Biol. Med.
, vol.44
, pp. 1833-1845
-
-
Shukla, S.1
-
44
-
-
84865072242
-
Flavonoids and cancer prevention: a review of the evidence
-
Romagnolo,D.F. et al. (2012) Flavonoids and cancer prevention: a review of the evidence. J. Nutr. Gerontol. Geriatr., 31, 206-238.
-
(2012)
J. Nutr. Gerontol. Geriatr.
, vol.31
, pp. 206-238
-
-
Romagnolo, D.F.1
-
45
-
-
84872540201
-
Flavonoids, flavonoid subclasses and breast cancer risk: a meta-analysis of epidemiologic studies
-
Hui,C. et al. (2013) Flavonoids, flavonoid subclasses and breast cancer risk: a meta-analysis of epidemiologic studies. PLoS One, 8, e54318.
-
(2013)
PLoS One
, vol.8
-
-
Hui, C.1
-
46
-
-
77449159294
-
Dietary flavonoid intake and colorectal cancer: a case-control study
-
Kyle,J.A. et al. (2010) Dietary flavonoid intake and colorectal cancer: a case-control study. Br. J. Nutr., 103, 429-436.
-
(2010)
Br. J. Nutr.
, vol.103
, pp. 429-436
-
-
Kyle, J.A.1
-
47
-
-
33947199690
-
Flavonoids and prostate cancer risk: a study in Italy
-
Bosetti,C. et al. (2006) Flavonoids and prostate cancer risk: a study in Italy. Nutr. Cancer, 56, 123-127.
-
(2006)
Nutr. Cancer
, vol.56
, pp. 123-127
-
-
Bosetti, C.1
-
48
-
-
62449185142
-
Flavonoid intake and ovarian cancer risk in a population-based case-control study
-
Gates,M.A. et al. (2009) Flavonoid intake and ovarian cancer risk in a population-based case-control study. Int. J. Cancer, 124, 1918-1925.
-
(2009)
Int. J. Cancer
, vol.124
, pp. 1918-1925
-
-
Gates, M.A.1
-
49
-
-
33744828685
-
Bioavailability of apigenin from apiin-rich parsley in humans
-
Meyer,H. et al. (2006) Bioavailability of apigenin from apiin-rich parsley in humans. Ann. Nutr. Metab., 50, 167-172.
-
(2006)
Ann. Nutr. Metab.
, vol.50
, pp. 167-172
-
-
Meyer, H.1
-
50
-
-
33644680356
-
Cell-cycle-associated markers and clinical outcome in human epithelial cancers: a tissue microarray study
-
Abdulkader,I. et al. (2005) Cell-cycle-associated markers and clinical outcome in human epithelial cancers: a tissue microarray study. Oncol. Rep., 14, 1527-1531.
-
(2005)
Oncol. Rep.
, vol.14
, pp. 1527-1531
-
-
Abdulkader, I.1
|